Wedelolactone is a lipid of Polyketides (PK) class. Wedelolactone is associated with abnormalities such as CLEFT LIP, CONGENITAL HEALED and Hepatitis. The involved functions are known as Signal Transduction, Cell Cycle Arrest, Apoptosis, luciferase activity and Metabolic Inhibition. Wedelolactone often locates in Protoplasm and Smooth muscle (tissue). The associated genes with Wedelolactone are CFB gene, Candidate Disease Gene, JAK2 gene, STAT2 gene and STAT3 gene.
To understand associated biological information of Wedelolactone, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Wedelolactone is suspected in CLEFT LIP, CONGENITAL HEALED, Hepatitis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Wedelolactone
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alopecia | D000505 | 14 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gao W et al. | Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus. | 2012 | PLoS ONE | pmid:22279582 |
| Rance E et al. | Inhibition of IκB kinase by thalidomide increases hepatitis C virus RNA replication. | 2012 | J. Viral Hepat. | pmid:22239529 |
| Zhang W et al. | Activation of nuclear factor-κB pathway is responsible for tumor necrosis factor-α-induced up-regulation of endothelin B2 receptor expression in vascular smooth muscle cells in vitro. | 2012 | Toxicol. Lett. | pmid:22207076 |
| Dos Santos JI et al. | Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLAâ‚‚ inhibition. | 2011 | PLoS ONE | pmid:22205953 |
| Upadhyay K et al. | Development and characterization of phyto-vesicles of wedelolactone for hepatoprotective activity. | 2012 | Drug Dev Ind Pharm | pmid:22204306 |
| Jie L et al. | Minimally modified LDL upregulates endothelin type B receptors in rat coronary artery via ERK1/2 MAPK and NF-κB pathways. | 2012 | Biochim. Biophys. Acta | pmid:22198514 |
| Li J et al. | Minimally modified LDL upregulates endothelin type B receptors in rat basilar artery. | 2012 | Microvasc. Res. | pmid:22198335 |
| Prakash T et al. | Neuroprotective activity of Wedelia calendulacea on cerebral ischemia/reperfusion induced oxidative stress in rats. | 2011 | Indian J Pharmacol | pmid:22144773 |
| Zerbini LF et al. | Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy. | 2011 | PLoS ONE | pmid:21931671 |
| Bharadwaj U et al. | Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression. | 2011 | Mol. Cancer | pmid:21880146 |