MeSH term | MeSH ID | Detail |
---|---|---|
Glioblastoma | D005909 | 27 associated lipids |
Hypersensitivity, Delayed | D006968 | 43 associated lipids |
Diabetes Mellitus | D003920 | 90 associated lipids |
Total
3
Brazilin is a lipid of Polyketides (PK) class.
We collected disease MeSH terms mapped to the references associated with Brazilin
MeSH term | MeSH ID | Detail |
---|---|---|
Glioblastoma | D005909 | 27 associated lipids |
Hypersensitivity, Delayed | D006968 | 43 associated lipids |
Diabetes Mellitus | D003920 | 90 associated lipids |
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kim SG et al. | Brazilin inhibits activities of protein kinase C and insulin receptor serine kinase in rat liver. | 1998 | Arch. Pharm. Res. | pmid:9875421 |
Hwang GS et al. | Effects of Brazilin on the phospholipase A2 activity and changes of intracellular free calcium concentration in rat platelets. | 1998 | Arch. Pharm. Res. | pmid:9868555 |
Mok MS et al. | Effects of Brazilin on induction of immunological tolerance by sheep red blood cells in C57BL/6 female mice. | 1998 | Arch. Pharm. Res. | pmid:9868554 |
Choi SY et al. | Brazilin modulates immune function mainly by augmenting T cell activity in halothane administered mice. | 1997 | Planta Med. | pmid:9342942 |
Choi SY and Moon CK | Effects of brazilin on the altered immune functions in the early phase of halothane intoxication of C57BL/6 mice. | 1997 | Planta Med. | pmid:9342941 |
Khil LY et al. | Effects of calcium on brazilin-induced glucose transport in isolated rat epididymal adipocytes. | 1997 | Biochem. Pharmacol. | pmid:9296355 |
Moon CK et al. | Effects of Brazilin on glucose oxidation, lipogenesis and therein involved enzymes in adipose tissues from diabetic KK-mice. | 1993 | Life Sci. | pmid:8412489 |
Kim YM et al. | Brazilin stimulates the glucose transport in 3T3-L1 cells. | 1995 | Planta Med. | pmid:7480173 |
Nagai M et al. | [Sappanchalcone from Caesalpinia sappan L., the proposed biosynthetic precursor of brazilin]. | 1984 | Yakugaku Zasshi | pmid:6527222 |
Moon CK et al. | Inhibition of lens-aldose reductase activity by brazilin and haematoxylin. | 1985 | Planta Med. | pmid:3925476 |
Hwang HS and Shim JH | Brazilin and Caesalpinia sappan L. extract protect epidermal keratinocytes from oxidative stress by inducing the expression of GPX7. | 2018 | Chin J Nat Med | pmid:29576056 |
Park MN et al. | Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs. | 2017 | Biomed Res Int | pmid:29181405 |
Guo J et al. | Brazilin inhibits the Zn-mediated aggregation of amyloid β-protein and alleviates cytotoxicity. | 2017 | J. Inorg. Biochem. | pmid:28972932 |
Lee EB et al. | Lifespan-extending and stress resistance properties of brazilin from Caesalpinia sappan in Caenorhabditis elegans. | 2017 | Arch. Pharm. Res. | pmid:28667441 |
Li ZY et al. | Brazilin Ameliorates Diabetic Nephropathy and Inflammation in db/db Mice. | 2017 | Inflammation | pmid:28497277 |
Li M et al. | Brazilin Inhibits Prostatic Acidic Phosphatase Fibrillogenesis and Decreases its Cytotoxicity. | 2017 | Chem Asian J | pmid:28303660 |
Maynez-Rojas MA et al. | Identification of natural red and purple dyes on textiles by Fiber-optics Reflectance Spectroscopy. | 2017 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:28199929 |
He ZJ et al. | Inhibiting ROS-NF-κB-dependent autophagy enhanced brazilin-induced apoptosis in head and neck squamous cell carcinoma. | 2017 | Food Chem. Toxicol. | pmid:28063998 |
Jia Y et al. | Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF-κB signaling pathway. | 2016 | Int. J. Mol. Med. | pmid:27247107 |
Siriangkhawut W et al. | A Green Sequential Injection Spectrophotometric Approach Using Natural Reagent Extracts from Heartwood of Ceasalpinia sappan Linn. for Determination of Aluminium. | 2016 | Anal Sci | pmid:26960614 |
Yan Y et al. | Brazilin isolated from the heartwood of Caesalpinia sappan L induces endothelium-dependent and -independent relaxation of rat aortic rings. | 2015 | Acta Pharmacol. Sin. | pmid:26564314 |
Kim J et al. | Inhibitory effect of brazilin on osteoclast differentiation and its mechanism of action. | 2015 | Int. Immunopharmacol. | pmid:26428849 |
Lee H et al. | Brazilin Limits Inflammatory Responses through Induction of Prosurvival Autophagy in Rheumatoid Fibroblast-Like Synoviocytes. | 2015 | PLoS ONE | pmid:26295477 |
Xu YY and Yin J | Contact dermatitis caused by brazilin in Caesalpinia sappan. | 2015 | Contact Derm. | pmid:25960163 |
Gao XJ et al. | Brazilin plays an anti-inflammatory role with regulating Toll-like receptor 2 and TLR 2 downstream pathways in Staphylococcus aureus-induced mastitis in mice. | 2015 | Int. Immunopharmacol. | pmid:25939535 |
Jung EG et al. | Brazilin isolated from Caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model. | 2015 | BMC Complement Altern Med | pmid:25896410 |
Dapson RW and Bain CL | Brazilwood, sappanwood, brazilin and the red dye brazilein: from textile dyeing and folk medicine to biological staining and musical instruments. | 2015 | Biotech Histochem | pmid:25893688 |
Zhang T et al. | c-Fos is involved in inhibition of human bladder carcinoma T24 cells by brazilin. | 2015 | IUBMB Life | pmid:25865820 |
Nirmal NP and Panichayupakaranant P | Antioxidant, antibacterial, and anti-inflammatory activities of standardized brazilin-rich Caesalpinia sappan extract. | 2015 | Pharm Biol | pmid:25864864 |
Subba Reddy BV et al. | A novel domino cyclization for the stereoselective synthesis of indeno[2,1-c]pyran and cyclopenta[c]pyran derivatives. | 2015 | Org. Biomol. Chem. | pmid:25804904 |
Jung Y and Kim I | A concise synthetic approach to brazilin via Pd-catalyzed allylic arylation. | 2015 | Org. Biomol. Chem. | pmid:25767080 |
Tewtrakul S et al. | Antiinflammatory and Wound Healing Effects of Caesalpinia sappan L. | 2015 | Phytother Res | pmid:25760294 |
Du WJ et al. | Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity. | 2015 | Sci Rep | pmid:25613018 |
Jung Y and Kim I | Total synthesis of brazilin. | 2015 | J. Org. Chem. | pmid:25562504 |
Kim SH et al. | Brazilin Isolated from Caesalpinia sappan suppresses nuclear envelope reassembly by inhibiting barrier-to-autointegration factor phosphorylation. | 2015 | J. Pharmacol. Exp. Ther. | pmid:25369797 |
Uddin GM et al. | One-step isolation of sappanol and brazilin from Caesalpinia sappan and their effects on oxidative stress-induced retinal death. | 2015 | BMB Rep | pmid:25248564 |
Ananth S et al. | Performance of Caesalpinia sappan heartwood extract as photo sensitizer for dye sensitized solar cells. | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25233024 |
Zhang Q et al. | Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells. | 2014 | Chin J Nat Med | pmid:25156286 |
Nirmal NP and Panichayupakaranant P | Anti-Propionibacterium acnes assay-guided purification of brazilin and preparation of brazilin rich extract from Caesalpinia sappan heartwood. | 2014 | Pharm Biol | pmid:24963948 |
Jeon J et al. | Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components. | 2014 | Biochem. Pharmacol. | pmid:24735611 |
Jayakumar T et al. | Brazilin ameliorates high glucose-induced vascular inflammation via inhibiting ROS and CAMs production in human umbilical vein endothelial cells. | 2014 | Biomed Res Int | pmid:24716195 |
Zuo GY et al. | Synergy of aminoglycoside antibiotics by 3-Benzylchroman derivatives from the Chinese drug Caesalpinia sappan against clinical methicillin-resistant Staphylococcus aureus (MRSA). | 2014 | Phytomedicine | pmid:24703330 |
Puchtler H et al. | Application of current chemical concepts to metal-hematein and -brazilein stains. | 1986 | Histochemistry | pmid:2430916 |
Guo J et al. | Inhibitory effects of Brazilin on the vascular smooth muscle cell proliferation and migration induced by PDGF-BB. | 2013 | Am. J. Chin. Med. | pmid:24228601 |
Lu Y et al. | Analysis of brazilin and protosappanin B in sappan lignum by capillary zone electrophoresis with acid barrage stacking. | 2013 | Electrophoresis | pmid:24150968 |
Yan-yan J et al. | A simple high-performance liquid chromatographic method for the determination of brazilin and its application to a pharmacokinetic study in rats. | 2014 | J Ethnopharmacol | pmid:24095700 |
Jia Y et al. | Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of brazilin in rats. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23777611 |
Tong XZ et al. | An LC/MS/MS method for simultaneous quantitation of two homoisoflavones: protosappanin B and brazilin with hypoglycemic activity in rat plasma and its application to a comparative pharmacokinetic study in normal and streptozotocin-treated rats. | 2013 | J Ethnopharmacol | pmid:23707335 |
Wang X et al. | Enantioselective total synthesis of (+)-brazilin, (-)-brazilein and (+)-brazilide A. | 2013 | Chem. Commun. (Camb.) | pmid:23657435 |
Bhakta D et al. | Interaction of plant pigment brazilin with synthetic and natural DNA: spectroscopic and in silico perspective. | 2013 | Interdiscip Sci | pmid:23605640 |
Lee DY et al. | Brazilin inhibits growth and induces apoptosis in human glioblastoma cells. | 2013 | Molecules | pmid:23429418 |
Chang Y et al. | Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets. | 2013 | J. Biomed. Sci. | pmid:23350663 |
Deng Z et al. | A validated LC-MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study. | 2013 | Biomed. Chromatogr. | pmid:23303567 |
Kim B et al. | Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells. | 2012 | J. Agric. Food Chem. | pmid:22967175 |
Lee CC et al. | Antiallergic asthma properties of brazilin through inhibition of TH2 responses in T cells and in a murine model of asthma. | 2012 | J. Agric. Food Chem. | pmid:22920671 |
Lee YR et al. | Brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing the NF-κB pathway in human dermal fibroblasts. | 2012 | Eur. J. Pharmacol. | pmid:22044921 |
Xu P et al. | Separation of four homoisoflavonoids from Caesalpinia sappan by high-speed counter-current chromatography. | 2012 May-Jun | Phytochem Anal | pmid:21853494 |
Chen Y et al. | [Quality standard of Sappan Lignum]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21046730 |
Sasaki Y et al. | Vasorelaxant activity of Sappan Lignum constituents and extracts on rat aorta and mesenteric artery. | 2010 | Biol. Pharm. Bull. | pmid:20823574 |
Cooksey C | Hematoxylin and related compounds--an annotated bibliography concerning their origin, properties, chemistry, and certain applications. | 2010 | Biotech Histochem | pmid:19568968 |
Hu CM et al. | Heme oxygenase-1 mediates the inhibitory actions of brazilin in RAW264.7 macrophages stimulated with lipopolysaccharide. | 2009 | J Ethnopharmacol | pmid:18983903 |
Choi BM et al. | Brazilin and the extract from Caesalpinia sappan L. protect oxidative injury through the expression of heme oxygenase-1. | 2007 | Biofactors | pmid:18525109 |
Choi BM and Kim BR | Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury. | 2008 | Eur. J. Pharmacol. | pmid:18021765 |
Sasaki Y et al. | In vitro study for inhibition of NO production about constituents of Sappan Lignum. | 2007 | Biol. Pharm. Bull. | pmid:17202686 |
Rázga Z and Gábor M | [Edema inhibiting effect of indenochromene derivatives from natural sources]. | 1990 | Acta Pharm Hung | pmid:1691574 |
Yun J et al. | Formation of Cu(II)-brazilin complex in the presence of DNA and its activities as chemical nuclease. | 2006 | J. Inorg. Biochem. | pmid:16797715 |
Huang Y et al. | Synthesis of (+/-)-brazilin using IBX. | 2005 | Org. Lett. | pmid:16354080 |
Hulme AN et al. | Negative ion electrospray mass spectrometry of neoflavonoids. | 2005 | Phytochemistry | pmid:16242737 |
Kwak WJ et al. | Effects of Brx-019 (acetic acid 3,6a,9-triacetoxy-6,6a,7, 11b-tetrahydro-indeno [2,1-c] chromen-10-yl ester), a Brazilin derivative, on T cell-mediated immune responses in multiple low dose streptozotocin-induced diabetic C57BL/6 male mice. | 2005 | Arzneimittelforschung | pmid:16229119 |
You EJ et al. | Effects of brazilin on the production of fructose-2,6-bisphosphate in rat hepatocytes. | 2005 | J Ethnopharmacol | pmid:15994045 |
Bae IK et al. | Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in RAW 264.7 macrophage cells. | 2005 | Eur. J. Pharmacol. | pmid:15862806 |
Lee GY et al. | Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester. | 2005 | Thromb. Res. | pmid:15668191 |
Moon CK et al. | Brazilin protects cultured rat hepatocytes from BrCCl3-induced toxicity. | 1992 | Drug Chem Toxicol | pmid:1555525 |
Xu HX and Lee SF | The antibacterial principle of Caesalpina sappan. | 2004 | Phytother Res | pmid:15476302 |
Won HS et al. | Mechanism of action of Brazilin on gluconeogenesis in isolated rat hepatocytes. | 2004 | Planta Med. | pmid:15368663 |
Hu CM et al. | Induction of vasorelaxation through activation of nitric oxide synthase in endothelial cells by brazilin. | 2003 | Eur. J. Pharmacol. | pmid:12729841 |
Mar W et al. | A DNA strand-nicking principle of a higher plant, Caesalpinia sappan. | 2003 | Arch. Pharm. Res. | pmid:12643592 |
Yang KM et al. | Brazilin augments cellular immunity in multiple low dose streptozotocin (MLD-STZ) induced type I diabetic mice. | 2000 | Arch. Pharm. Res. | pmid:11156186 |
Xie YW et al. | Vasorelaxing effects of Caesalpinia sappan involvement of endogenous nitric oxide. | 2000 | Life Sci. | pmid:11043613 |
Khil LY et al. | Effects of brazilin on GLUT4 recruitment in isolated rat epididymal adipocytes. | 1999 | Biochem. Pharmacol. | pmid:10571244 |
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