| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
Total
3
Brazilin
Brazilin is a lipid of Polyketides (PK) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 476 references associated with Brazilin in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for Brazilin
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Brazilin
NCBI Entrez Crosslinks
All references with Brazilin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hwang HS and Shim JH | Brazilin and Caesalpinia sappan L. extract protect epidermal keratinocytes from oxidative stress by inducing the expression of GPX7. | 2018 | Chin J Nat Med | pmid:29576056 |
| He ZJ et al. | Inhibiting ROS-NF-κB-dependent autophagy enhanced brazilin-induced apoptosis in head and neck squamous cell carcinoma. | 2017 | Food Chem. Toxicol. | pmid:28063998 |
| Park MN et al. | Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs. | 2017 | Biomed Res Int | pmid:29181405 |
| Guo J et al. | Brazilin inhibits the Zn-mediated aggregation of amyloid β-protein and alleviates cytotoxicity. | 2017 | J. Inorg. Biochem. | pmid:28972932 |
| Maynez-Rojas MA et al. | Identification of natural red and purple dyes on textiles by Fiber-optics Reflectance Spectroscopy. | 2017 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:28199929 |
| Lee EB et al. | Lifespan-extending and stress resistance properties of brazilin from Caesalpinia sappan in Caenorhabditis elegans. | 2017 | Arch. Pharm. Res. | pmid:28667441 |
| Li ZY et al. | Brazilin Ameliorates Diabetic Nephropathy and Inflammation in db/db Mice. | 2017 | Inflammation | pmid:28497277 |
| Li M et al. | Brazilin Inhibits Prostatic Acidic Phosphatase Fibrillogenesis and Decreases its Cytotoxicity. | 2017 | Chem Asian J | pmid:28303660 |
| Jia Y et al. | Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF-κB signaling pathway. | 2016 | Int. J. Mol. Med. | pmid:27247107 |
| Siriangkhawut W et al. | A Green Sequential Injection Spectrophotometric Approach Using Natural Reagent Extracts from Heartwood of Ceasalpinia sappan Linn. for Determination of Aluminium. | 2016 | Anal Sci | pmid:26960614 |
| Yan Y et al. | Brazilin isolated from the heartwood of Caesalpinia sappan L induces endothelium-dependent and -independent relaxation of rat aortic rings. | 2015 | Acta Pharmacol. Sin. | pmid:26564314 |
| Lee H et al. | Brazilin Limits Inflammatory Responses through Induction of Prosurvival Autophagy in Rheumatoid Fibroblast-Like Synoviocytes. | 2015 | PLoS ONE | pmid:26295477 |
| Jung EG et al. | Brazilin isolated from Caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model. | 2015 | BMC Complement Altern Med | pmid:25896410 |
| Zhang T et al. | c-Fos is involved in inhibition of human bladder carcinoma T24 cells by brazilin. | 2015 | IUBMB Life | pmid:25865820 |
| Du WJ et al. | Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity. | 2015 | Sci Rep | pmid:25613018 |
| Kim SH et al. | Brazilin Isolated from Caesalpinia sappan suppresses nuclear envelope reassembly by inhibiting barrier-to-autointegration factor phosphorylation. | 2015 | J. Pharmacol. Exp. Ther. | pmid:25369797 |
| Uddin GM et al. | One-step isolation of sappanol and brazilin from Caesalpinia sappan and their effects on oxidative stress-induced retinal death. | 2015 | BMB Rep | pmid:25248564 |
| Kim J et al. | Inhibitory effect of brazilin on osteoclast differentiation and its mechanism of action. | 2015 | Int. Immunopharmacol. | pmid:26428849 |
| Xu YY and Yin J | Contact dermatitis caused by brazilin in Caesalpinia sappan. | 2015 | Contact Derm. | pmid:25960163 |
| Gao XJ et al. | Brazilin plays an anti-inflammatory role with regulating Toll-like receptor 2 and TLR 2 downstream pathways in Staphylococcus aureus-induced mastitis in mice. | 2015 | Int. Immunopharmacol. | pmid:25939535 |
| Dapson RW and Bain CL | Brazilwood, sappanwood, brazilin and the red dye brazilein: from textile dyeing and folk medicine to biological staining and musical instruments. | 2015 | Biotech Histochem | pmid:25893688 |
| Nirmal NP and Panichayupakaranant P | Antioxidant, antibacterial, and anti-inflammatory activities of standardized brazilin-rich Caesalpinia sappan extract. | 2015 | Pharm Biol | pmid:25864864 |
| Subba Reddy BV et al. | A novel domino cyclization for the stereoselective synthesis of indeno[2,1-c]pyran and cyclopenta[c]pyran derivatives. | 2015 | Org. Biomol. Chem. | pmid:25804904 |
| Jung Y and Kim I | A concise synthetic approach to brazilin via Pd-catalyzed allylic arylation. | 2015 | Org. Biomol. Chem. | pmid:25767080 |
| Jung Y and Kim I | Total synthesis of brazilin. | 2015 | J. Org. Chem. | pmid:25562504 |
| Ananth S et al. | Performance of Caesalpinia sappan heartwood extract as photo sensitizer for dye sensitized solar cells. | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25233024 |
| Tewtrakul S et al. | Antiinflammatory and Wound Healing Effects of Caesalpinia sappan L. | 2015 | Phytother Res | pmid:25760294 |
| Jayakumar T et al. | Brazilin ameliorates high glucose-induced vascular inflammation via inhibiting ROS and CAMs production in human umbilical vein endothelial cells. | 2014 | Biomed Res Int | pmid:24716195 |
| Zhang Q et al. | Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells. | 2014 | Chin J Nat Med | pmid:25156286 |
| Nirmal NP and Panichayupakaranant P | Anti-Propionibacterium acnes assay-guided purification of brazilin and preparation of brazilin rich extract from Caesalpinia sappan heartwood. | 2014 | Pharm Biol | pmid:24963948 |
| Zuo GY et al. | Synergy of aminoglycoside antibiotics by 3-Benzylchroman derivatives from the Chinese drug Caesalpinia sappan against clinical methicillin-resistant Staphylococcus aureus (MRSA). | 2014 | Phytomedicine | pmid:24703330 |
| Yan-yan J et al. | A simple high-performance liquid chromatographic method for the determination of brazilin and its application to a pharmacokinetic study in rats. | 2014 | J Ethnopharmacol | pmid:24095700 |
| Jeon J et al. | Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components. | 2014 | Biochem. Pharmacol. | pmid:24735611 |
| Lee DY et al. | Brazilin inhibits growth and induces apoptosis in human glioblastoma cells. | 2013 | Molecules | pmid:23429418 |
| Bhakta D et al. | Interaction of plant pigment brazilin with synthetic and natural DNA: spectroscopic and in silico perspective. | 2013 | Interdiscip Sci | pmid:23605640 |
| Wang X et al. | Enantioselective total synthesis of (+)-brazilin, (-)-brazilein and (+)-brazilide A. | 2013 | Chem. Commun. (Camb.) | pmid:23657435 |
| Chang Y et al. | Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets. | 2013 | J. Biomed. Sci. | pmid:23350663 |
| Deng Z et al. | A validated LC-MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study. | 2013 | Biomed. Chromatogr. | pmid:23303567 |
| Tong XZ et al. | An LC/MS/MS method for simultaneous quantitation of two homoisoflavones: protosappanin B and brazilin with hypoglycemic activity in rat plasma and its application to a comparative pharmacokinetic study in normal and streptozotocin-treated rats. | 2013 | J Ethnopharmacol | pmid:23707335 |
| Jia Y et al. | Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of brazilin in rats. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23777611 |
| Guo J et al. | Inhibitory effects of Brazilin on the vascular smooth muscle cell proliferation and migration induced by PDGF-BB. | 2013 | Am. J. Chin. Med. | pmid:24228601 |
| Lu Y et al. | Analysis of brazilin and protosappanin B in sappan lignum by capillary zone electrophoresis with acid barrage stacking. | 2013 | Electrophoresis | pmid:24150968 |
| Xu P et al. | Separation of four homoisoflavonoids from Caesalpinia sappan by high-speed counter-current chromatography. | 2012 May-Jun | Phytochem Anal | pmid:21853494 |
| Kim B et al. | Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells. | 2012 | J. Agric. Food Chem. | pmid:22967175 |
| Lee YR et al. | Brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing the NF-κB pathway in human dermal fibroblasts. | 2012 | Eur. J. Pharmacol. | pmid:22044921 |
| Lee CC et al. | Antiallergic asthma properties of brazilin through inhibition of TH2 responses in T cells and in a murine model of asthma. | 2012 | J. Agric. Food Chem. | pmid:22920671 |
| Sasaki Y et al. | Vasorelaxant activity of Sappan Lignum constituents and extracts on rat aorta and mesenteric artery. | 2010 | Biol. Pharm. Bull. | pmid:20823574 |
| Chen Y et al. | [Quality standard of Sappan Lignum]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21046730 |
| Cooksey C | Hematoxylin and related compounds--an annotated bibliography concerning their origin, properties, chemistry, and certain applications. | 2010 | Biotech Histochem | pmid:19568968 |
| Hu CM et al. | Heme oxygenase-1 mediates the inhibitory actions of brazilin in RAW264.7 macrophages stimulated with lipopolysaccharide. | 2009 | J Ethnopharmacol | pmid:18983903 |
| Choi BM and Kim BR | Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury. | 2008 | Eur. J. Pharmacol. | pmid:18021765 |
| Choi BM et al. | Brazilin and the extract from Caesalpinia sappan L. protect oxidative injury through the expression of heme oxygenase-1. | 2007 | Biofactors | pmid:18525109 |
| Sasaki Y et al. | In vitro study for inhibition of NO production about constituents of Sappan Lignum. | 2007 | Biol. Pharm. Bull. | pmid:17202686 |
| Yun J et al. | Formation of Cu(II)-brazilin complex in the presence of DNA and its activities as chemical nuclease. | 2006 | J. Inorg. Biochem. | pmid:16797715 |
| Lee GY et al. | Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester. | 2005 | Thromb. Res. | pmid:15668191 |
| Huang Y et al. | Synthesis of (+/-)-brazilin using IBX. | 2005 | Org. Lett. | pmid:16354080 |
| Hulme AN et al. | Negative ion electrospray mass spectrometry of neoflavonoids. | 2005 | Phytochemistry | pmid:16242737 |
| Kwak WJ et al. | Effects of Brx-019 (acetic acid 3,6a,9-triacetoxy-6,6a,7, 11b-tetrahydro-indeno [2,1-c] chromen-10-yl ester), a Brazilin derivative, on T cell-mediated immune responses in multiple low dose streptozotocin-induced diabetic C57BL/6 male mice. | 2005 | Arzneimittelforschung | pmid:16229119 |
| Bae IK et al. | Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in RAW 264.7 macrophage cells. | 2005 | Eur. J. Pharmacol. | pmid:15862806 |
| You EJ et al. | Effects of brazilin on the production of fructose-2,6-bisphosphate in rat hepatocytes. | 2005 | J Ethnopharmacol | pmid:15994045 |
| Won HS et al. | Mechanism of action of Brazilin on gluconeogenesis in isolated rat hepatocytes. | 2004 | Planta Med. | pmid:15368663 |
| Xu HX and Lee SF | The antibacterial principle of Caesalpina sappan. | 2004 | Phytother Res | pmid:15476302 |
| Mar W et al. | A DNA strand-nicking principle of a higher plant, Caesalpinia sappan. | 2003 | Arch. Pharm. Res. | pmid:12643592 |
| Hu CM et al. | Induction of vasorelaxation through activation of nitric oxide synthase in endothelial cells by brazilin. | 2003 | Eur. J. Pharmacol. | pmid:12729841 |
| Yang KM et al. | Brazilin augments cellular immunity in multiple low dose streptozotocin (MLD-STZ) induced type I diabetic mice. | 2000 | Arch. Pharm. Res. | pmid:11156186 |
| Xie YW et al. | Vasorelaxing effects of Caesalpinia sappan involvement of endogenous nitric oxide. | 2000 | Life Sci. | pmid:11043613 |
| Khil LY et al. | Effects of brazilin on GLUT4 recruitment in isolated rat epididymal adipocytes. | 1999 | Biochem. Pharmacol. | pmid:10571244 |
| Hwang GS et al. | Effects of Brazilin on the phospholipase A2 activity and changes of intracellular free calcium concentration in rat platelets. | 1998 | Arch. Pharm. Res. | pmid:9868555 |
| Mok MS et al. | Effects of Brazilin on induction of immunological tolerance by sheep red blood cells in C57BL/6 female mice. | 1998 | Arch. Pharm. Res. | pmid:9868554 |
| Kim SG et al. | Brazilin inhibits activities of protein kinase C and insulin receptor serine kinase in rat liver. | 1998 | Arch. Pharm. Res. | pmid:9875421 |
| Choi SY and Moon CK | Effects of brazilin on the altered immune functions in the early phase of halothane intoxication of C57BL/6 mice. | 1997 | Planta Med. | pmid:9342941 |
| Choi SY et al. | Brazilin modulates immune function mainly by augmenting T cell activity in halothane administered mice. | 1997 | Planta Med. | pmid:9342942 |
| Khil LY et al. | Effects of calcium on brazilin-induced glucose transport in isolated rat epididymal adipocytes. | 1997 | Biochem. Pharmacol. | pmid:9296355 |
| Kim YM et al. | Brazilin stimulates the glucose transport in 3T3-L1 cells. | 1995 | Planta Med. | pmid:7480173 |
| Moon CK et al. | Effects of Brazilin on glucose oxidation, lipogenesis and therein involved enzymes in adipose tissues from diabetic KK-mice. | 1993 | Life Sci. | pmid:8412489 |
| Moon CK et al. | Brazilin protects cultured rat hepatocytes from BrCCl3-induced toxicity. | 1992 | Drug Chem Toxicol | pmid:1555525 |
| Rázga Z and Gábor M | [Edema inhibiting effect of indenochromene derivatives from natural sources]. | 1990 | Acta Pharm Hung | pmid:1691574 |
| Puchtler H et al. | Application of current chemical concepts to metal-hematein and -brazilein stains. | 1986 | Histochemistry | pmid:2430916 |
| Moon CK et al. | Inhibition of lens-aldose reductase activity by brazilin and haematoxylin. | 1985 | Planta Med. | pmid:3925476 |
| Nagai M et al. | [Sappanchalcone from Caesalpinia sappan L., the proposed biosynthetic precursor of brazilin]. | 1984 | Yakugaku Zasshi | pmid:6527222 |
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