MeSH term | MeSH ID | Detail |
---|---|---|
Diabetes Mellitus | D003920 | 90 associated lipids |
Hypersensitivity, Delayed | D006968 | 43 associated lipids |
Glioblastoma | D005909 | 27 associated lipids |
Total
3
Brazilin is a lipid of Polyketides (PK) class.
We collected disease MeSH terms mapped to the references associated with Brazilin
MeSH term | MeSH ID | Detail |
---|---|---|
Diabetes Mellitus | D003920 | 90 associated lipids |
Hypersensitivity, Delayed | D006968 | 43 associated lipids |
Glioblastoma | D005909 | 27 associated lipids |
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid: | ||||
Rázga Z and Gábor M | [Edema inhibiting effect of indenochromene derivatives from natural sources]. | 1990 | Acta Pharm Hung | pmid:1691574 |
Yan Y et al. | Brazilin isolated from the heartwood of Caesalpinia sappan L induces endothelium-dependent and -independent relaxation of rat aortic rings. | 2015 | Acta Pharmacol. Sin. | pmid:26564314 |
Guo J et al. | Inhibitory effects of Brazilin on the vascular smooth muscle cell proliferation and migration induced by PDGF-BB. | 2013 | Am. J. Chin. Med. | pmid:24228601 |
Siriangkhawut W et al. | A Green Sequential Injection Spectrophotometric Approach Using Natural Reagent Extracts from Heartwood of Ceasalpinia sappan Linn. for Determination of Aluminium. | 2016 | Anal Sci | pmid:26960614 |
Hwang GS et al. | Effects of Brazilin on the phospholipase A2 activity and changes of intracellular free calcium concentration in rat platelets. | 1998 | Arch. Pharm. Res. | pmid:9868555 |
Mok MS et al. | Effects of Brazilin on induction of immunological tolerance by sheep red blood cells in C57BL/6 female mice. | 1998 | Arch. Pharm. Res. | pmid:9868554 |
Kim SG et al. | Brazilin inhibits activities of protein kinase C and insulin receptor serine kinase in rat liver. | 1998 | Arch. Pharm. Res. | pmid:9875421 |
Yang KM et al. | Brazilin augments cellular immunity in multiple low dose streptozotocin (MLD-STZ) induced type I diabetic mice. | 2000 | Arch. Pharm. Res. | pmid:11156186 |
Mar W et al. | A DNA strand-nicking principle of a higher plant, Caesalpinia sappan. | 2003 | Arch. Pharm. Res. | pmid:12643592 |
Lee EB et al. | Lifespan-extending and stress resistance properties of brazilin from Caesalpinia sappan in Caenorhabditis elegans. | 2017 | Arch. Pharm. Res. | pmid:28667441 |
Kwak WJ et al. | Effects of Brx-019 (acetic acid 3,6a,9-triacetoxy-6,6a,7, 11b-tetrahydro-indeno [2,1-c] chromen-10-yl ester), a Brazilin derivative, on T cell-mediated immune responses in multiple low dose streptozotocin-induced diabetic C57BL/6 male mice. | 2005 | Arzneimittelforschung | pmid:16229119 |
Khil LY et al. | Effects of calcium on brazilin-induced glucose transport in isolated rat epididymal adipocytes. | 1997 | Biochem. Pharmacol. | pmid:9296355 |
Khil LY et al. | Effects of brazilin on GLUT4 recruitment in isolated rat epididymal adipocytes. | 1999 | Biochem. Pharmacol. | pmid:10571244 |
Jeon J et al. | Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components. | 2014 | Biochem. Pharmacol. | pmid:24735611 |
Choi BM et al. | Brazilin and the extract from Caesalpinia sappan L. protect oxidative injury through the expression of heme oxygenase-1. | 2007 | Biofactors | pmid:18525109 |
Sasaki Y et al. | Vasorelaxant activity of Sappan Lignum constituents and extracts on rat aorta and mesenteric artery. | 2010 | Biol. Pharm. Bull. | pmid:20823574 |
Sasaki Y et al. | In vitro study for inhibition of NO production about constituents of Sappan Lignum. | 2007 | Biol. Pharm. Bull. | pmid:17202686 |
Jayakumar T et al. | Brazilin ameliorates high glucose-induced vascular inflammation via inhibiting ROS and CAMs production in human umbilical vein endothelial cells. | 2014 | Biomed Res Int | pmid:24716195 |
Park MN et al. | Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs. | 2017 | Biomed Res Int | pmid:29181405 |
Deng Z et al. | A validated LC-MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study. | 2013 | Biomed. Chromatogr. | pmid:23303567 |
Dapson RW and Bain CL | Brazilwood, sappanwood, brazilin and the red dye brazilein: from textile dyeing and folk medicine to biological staining and musical instruments. | 2015 | Biotech Histochem | pmid:25893688 |
Cooksey C | Hematoxylin and related compounds--an annotated bibliography concerning their origin, properties, chemistry, and certain applications. | 2010 | Biotech Histochem | pmid:19568968 |
Uddin GM et al. | One-step isolation of sappanol and brazilin from Caesalpinia sappan and their effects on oxidative stress-induced retinal death. | 2015 | BMB Rep | pmid:25248564 |
Jung EG et al. | Brazilin isolated from Caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model. | 2015 | BMC Complement Altern Med | pmid:25896410 |
Li M et al. | Brazilin Inhibits Prostatic Acidic Phosphatase Fibrillogenesis and Decreases its Cytotoxicity. | 2017 | Chem Asian J | pmid:28303660 |
Wang X et al. | Enantioselective total synthesis of (+)-brazilin, (-)-brazilein and (+)-brazilide A. | 2013 | Chem. Commun. (Camb.) | pmid:23657435 |
Zhang Q et al. | Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells. | 2014 | Chin J Nat Med | pmid:25156286 |
Hwang HS and Shim JH | Brazilin and Caesalpinia sappan L. extract protect epidermal keratinocytes from oxidative stress by inducing the expression of GPX7. | 2018 | Chin J Nat Med | pmid:29576056 |
Xu YY and Yin J | Contact dermatitis caused by brazilin in Caesalpinia sappan. | 2015 | Contact Derm. | pmid:25960163 |
Moon CK et al. | Brazilin protects cultured rat hepatocytes from BrCCl3-induced toxicity. | 1992 | Drug Chem Toxicol | pmid:1555525 |
Lu Y et al. | Analysis of brazilin and protosappanin B in sappan lignum by capillary zone electrophoresis with acid barrage stacking. | 2013 | Electrophoresis | pmid:24150968 |
Hu CM et al. | Induction of vasorelaxation through activation of nitric oxide synthase in endothelial cells by brazilin. | 2003 | Eur. J. Pharmacol. | pmid:12729841 |
Lee YR et al. | Brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing the NF-κB pathway in human dermal fibroblasts. | 2012 | Eur. J. Pharmacol. | pmid:22044921 |
Choi BM and Kim BR | Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury. | 2008 | Eur. J. Pharmacol. | pmid:18021765 |
Bae IK et al. | Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in RAW 264.7 macrophage cells. | 2005 | Eur. J. Pharmacol. | pmid:15862806 |
He ZJ et al. | Inhibiting ROS-NF-κB-dependent autophagy enhanced brazilin-induced apoptosis in head and neck squamous cell carcinoma. | 2017 | Food Chem. Toxicol. | pmid:28063998 |
Puchtler H et al. | Application of current chemical concepts to metal-hematein and -brazilein stains. | 1986 | Histochemistry | pmid:2430916 |
Li ZY et al. | Brazilin Ameliorates Diabetic Nephropathy and Inflammation in db/db Mice. | 2017 | Inflammation | pmid:28497277 |
Kim J et al. | Inhibitory effect of brazilin on osteoclast differentiation and its mechanism of action. | 2015 | Int. Immunopharmacol. | pmid:26428849 |
Gao XJ et al. | Brazilin plays an anti-inflammatory role with regulating Toll-like receptor 2 and TLR 2 downstream pathways in Staphylococcus aureus-induced mastitis in mice. | 2015 | Int. Immunopharmacol. | pmid:25939535 |
Jia Y et al. | Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF-κB signaling pathway. | 2016 | Int. J. Mol. Med. | pmid:27247107 |
Bhakta D et al. | Interaction of plant pigment brazilin with synthetic and natural DNA: spectroscopic and in silico perspective. | 2013 | Interdiscip Sci | pmid:23605640 |
Zhang T et al. | c-Fos is involved in inhibition of human bladder carcinoma T24 cells by brazilin. | 2015 | IUBMB Life | pmid:25865820 |
Hu CM et al. | Heme oxygenase-1 mediates the inhibitory actions of brazilin in RAW264.7 macrophages stimulated with lipopolysaccharide. | 2009 | J Ethnopharmacol | pmid:18983903 |
You EJ et al. | Effects of brazilin on the production of fructose-2,6-bisphosphate in rat hepatocytes. | 2005 | J Ethnopharmacol | pmid:15994045 |
Tong XZ et al. | An LC/MS/MS method for simultaneous quantitation of two homoisoflavones: protosappanin B and brazilin with hypoglycemic activity in rat plasma and its application to a comparative pharmacokinetic study in normal and streptozotocin-treated rats. | 2013 | J Ethnopharmacol | pmid:23707335 |
Yan-yan J et al. | A simple high-performance liquid chromatographic method for the determination of brazilin and its application to a pharmacokinetic study in rats. | 2014 | J Ethnopharmacol | pmid:24095700 |
Kim B et al. | Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells. | 2012 | J. Agric. Food Chem. | pmid:22967175 |
Lee CC et al. | Antiallergic asthma properties of brazilin through inhibition of TH2 responses in T cells and in a murine model of asthma. | 2012 | J. Agric. Food Chem. | pmid:22920671 |