Brazilin

Brazilin is a lipid of Polyketides (PK) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 476 references associated with Brazilin in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Brazilin

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Brazilin

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioblastoma D005909 27 associated lipids
Total 3

NCBI Entrez Crosslinks

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Authors Title Published Journal PubMed Link
Hwang HS and Shim JH Brazilin and Caesalpinia sappan L. extract protect epidermal keratinocytes from oxidative stress by inducing the expression of GPX7. 2018 Chin J Nat Med pmid:29576056
He ZJ et al. Inhibiting ROS-NF-κB-dependent autophagy enhanced brazilin-induced apoptosis in head and neck squamous cell carcinoma. 2017 Food Chem. Toxicol. pmid:28063998
Park MN et al. Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs. 2017 Biomed Res Int pmid:29181405
Guo J et al. Brazilin inhibits the Zn-mediated aggregation of amyloid β-protein and alleviates cytotoxicity. 2017 J. Inorg. Biochem. pmid:28972932
Maynez-Rojas MA et al. Identification of natural red and purple dyes on textiles by Fiber-optics Reflectance Spectroscopy. 2017 Spectrochim Acta A Mol Biomol Spectrosc pmid:28199929
Lee EB et al. Lifespan-extending and stress resistance properties of brazilin from Caesalpinia sappan in Caenorhabditis elegans. 2017 Arch. Pharm. Res. pmid:28667441
Li ZY et al. Brazilin Ameliorates Diabetic Nephropathy and Inflammation in db/db Mice. 2017 Inflammation pmid:28497277
Li M et al. Brazilin Inhibits Prostatic Acidic Phosphatase Fibrillogenesis and Decreases its Cytotoxicity. 2017 Chem Asian J pmid:28303660
Jia Y et al. Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF-κB signaling pathway. 2016 Int. J. Mol. Med. pmid:27247107
Siriangkhawut W et al. A Green Sequential Injection Spectrophotometric Approach Using Natural Reagent Extracts from Heartwood of Ceasalpinia sappan Linn. for Determination of Aluminium. 2016 Anal Sci pmid:26960614
Yan Y et al. Brazilin isolated from the heartwood of Caesalpinia sappan L induces endothelium-dependent and -independent relaxation of rat aortic rings. 2015 Acta Pharmacol. Sin. pmid:26564314
Lee H et al. Brazilin Limits Inflammatory Responses through Induction of Prosurvival Autophagy in Rheumatoid Fibroblast-Like Synoviocytes. 2015 PLoS ONE pmid:26295477
Jung EG et al. Brazilin isolated from Caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model. 2015 BMC Complement Altern Med pmid:25896410
Zhang T et al. c-Fos is involved in inhibition of human bladder carcinoma T24 cells by brazilin. 2015 IUBMB Life pmid:25865820
Du WJ et al. Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity. 2015 Sci Rep pmid:25613018
Kim SH et al. Brazilin Isolated from Caesalpinia sappan suppresses nuclear envelope reassembly by inhibiting barrier-to-autointegration factor phosphorylation. 2015 J. Pharmacol. Exp. Ther. pmid:25369797
Uddin GM et al. One-step isolation of sappanol and brazilin from Caesalpinia sappan and their effects on oxidative stress-induced retinal death. 2015 BMB Rep pmid:25248564
Kim J et al. Inhibitory effect of brazilin on osteoclast differentiation and its mechanism of action. 2015 Int. Immunopharmacol. pmid:26428849
Xu YY and Yin J Contact dermatitis caused by brazilin in Caesalpinia sappan. 2015 Contact Derm. pmid:25960163
Gao XJ et al. Brazilin plays an anti-inflammatory role with regulating Toll-like receptor 2 and TLR 2 downstream pathways in Staphylococcus aureus-induced mastitis in mice. 2015 Int. Immunopharmacol. pmid:25939535
Dapson RW and Bain CL Brazilwood, sappanwood, brazilin and the red dye brazilein: from textile dyeing and folk medicine to biological staining and musical instruments. 2015 Biotech Histochem pmid:25893688
Nirmal NP and Panichayupakaranant P Antioxidant, antibacterial, and anti-inflammatory activities of standardized brazilin-rich Caesalpinia sappan extract. 2015 Pharm Biol pmid:25864864
Subba Reddy BV et al. A novel domino cyclization for the stereoselective synthesis of indeno[2,1-c]pyran and cyclopenta[c]pyran derivatives. 2015 Org. Biomol. Chem. pmid:25804904
Jung Y and Kim I A concise synthetic approach to brazilin via Pd-catalyzed allylic arylation. 2015 Org. Biomol. Chem. pmid:25767080
Jung Y and Kim I Total synthesis of brazilin. 2015 J. Org. Chem. pmid:25562504
Ananth S et al. Performance of Caesalpinia sappan heartwood extract as photo sensitizer for dye sensitized solar cells. 2015 Spectrochim Acta A Mol Biomol Spectrosc pmid:25233024
Tewtrakul S et al. Antiinflammatory and Wound Healing Effects of Caesalpinia sappan L. 2015 Phytother Res pmid:25760294
Jayakumar T et al. Brazilin ameliorates high glucose-induced vascular inflammation via inhibiting ROS and CAMs production in human umbilical vein endothelial cells. 2014 Biomed Res Int pmid:24716195
Zhang Q et al. Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells. 2014 Chin J Nat Med pmid:25156286
Nirmal NP and Panichayupakaranant P Anti-Propionibacterium acnes assay-guided purification of brazilin and preparation of brazilin rich extract from Caesalpinia sappan heartwood. 2014 Pharm Biol pmid:24963948
Zuo GY et al. Synergy of aminoglycoside antibiotics by 3-Benzylchroman derivatives from the Chinese drug Caesalpinia sappan against clinical methicillin-resistant Staphylococcus aureus (MRSA). 2014 Phytomedicine pmid:24703330
Yan-yan J et al. A simple high-performance liquid chromatographic method for the determination of brazilin and its application to a pharmacokinetic study in rats. 2014 J Ethnopharmacol pmid:24095700
Jeon J et al. Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components. 2014 Biochem. Pharmacol. pmid:24735611
Lee DY et al. Brazilin inhibits growth and induces apoptosis in human glioblastoma cells. 2013 Molecules pmid:23429418
Bhakta D et al. Interaction of plant pigment brazilin with synthetic and natural DNA: spectroscopic and in silico perspective. 2013 Interdiscip Sci pmid:23605640
Wang X et al. Enantioselective total synthesis of (+)-brazilin, (-)-brazilein and (+)-brazilide A. 2013 Chem. Commun. (Camb.) pmid:23657435
Chang Y et al. Brazilin isolated from Caesalpinia sappan L. acts as a novel collagen receptor agonist in human platelets. 2013 J. Biomed. Sci. pmid:23350663
Deng Z et al. A validated LC-MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study. 2013 Biomed. Chromatogr. pmid:23303567
Tong XZ et al. An LC/MS/MS method for simultaneous quantitation of two homoisoflavones: protosappanin B and brazilin with hypoglycemic activity in rat plasma and its application to a comparative pharmacokinetic study in normal and streptozotocin-treated rats. 2013 J Ethnopharmacol pmid:23707335
Jia Y et al. Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of brazilin in rats. 2013 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:23777611
Guo J et al. Inhibitory effects of Brazilin on the vascular smooth muscle cell proliferation and migration induced by PDGF-BB. 2013 Am. J. Chin. Med. pmid:24228601
Lu Y et al. Analysis of brazilin and protosappanin B in sappan lignum by capillary zone electrophoresis with acid barrage stacking. 2013 Electrophoresis pmid:24150968
Xu P et al. Separation of four homoisoflavonoids from Caesalpinia sappan by high-speed counter-current chromatography. 2012 May-Jun Phytochem Anal pmid:21853494
Kim B et al. Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells. 2012 J. Agric. Food Chem. pmid:22967175
Lee YR et al. Brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing the NF-κB pathway in human dermal fibroblasts. 2012 Eur. J. Pharmacol. pmid:22044921
Lee CC et al. Antiallergic asthma properties of brazilin through inhibition of TH2 responses in T cells and in a murine model of asthma. 2012 J. Agric. Food Chem. pmid:22920671
Sasaki Y et al. Vasorelaxant activity of Sappan Lignum constituents and extracts on rat aorta and mesenteric artery. 2010 Biol. Pharm. Bull. pmid:20823574
Chen Y et al. [Quality standard of Sappan Lignum]. 2010 Zhongguo Zhong Yao Za Zhi pmid:21046730
Cooksey C Hematoxylin and related compounds--an annotated bibliography concerning their origin, properties, chemistry, and certain applications. 2010 Biotech Histochem pmid:19568968
Hu CM et al. Heme oxygenase-1 mediates the inhibitory actions of brazilin in RAW264.7 macrophages stimulated with lipopolysaccharide. 2009 J Ethnopharmacol pmid:18983903