Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cystitis | D003556 | 23 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Robin V et al. | Antipoliovirus flavonoids from Psiadia dentata. | 2001 | Antivir. Chem. Chemother. | pmid:11900347 |
| Itoh A et al. | Flavonoid glycosides from Rhazya orientalis. | 2002 | J. Nat. Prod. | pmid:11908977 |
| Weng S and Lian J | [Determination of isorhamnetine and quercetin in flavone hippophaes tablets by HPLC method]. | 2001 | Zhong Yao Cai | pmid:11917852 |
| Sang S et al. | Antioxidative phenolic compounds isolated from almond skins (Prunus amygdalus Batsch). | 2002 | J. Agric. Food Chem. | pmid:11929314 |
| Frison-Norrie S and Sporns P | Identification and quantification of flavonol glycosides in almond seedcoats using MALDI-TOF MS. | 2002 | J. Agric. Food Chem. | pmid:11982399 |
| Ibarra M et al. | Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria. | 2002 | Planta Med. | pmid:11988852 |
| Tang YP et al. | A new coumaronochromone from Sophora japonica. | 2002 | J Asian Nat Prod Res | pmid:11991186 |
| De Souza KC et al. | LC determination of flavonoids: separation of quercetin, luteolin and 3-O-methylquercetin in Achyrocline satureioides preparations. | 2002 | J Pharm Biomed Anal | pmid:12008157 |
| Nielsen SE et al. | Flavonoids in human urine as biomarkers for intake of fruits and vegetables. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12010860 |
| Schieber A et al. | Detection of isorhamnetin glycosides in extracts of apples (Malus domestica cv. "Brettacher") by HPLC-PDA and HPLC-APCI-MS/MS. | 2002 Mar-Apr | Phytochem Anal | pmid:12018028 |