Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cornish KM et al. | Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. | 2002 | Free Radic. Biol. Med. | pmid:12086683 |
| Rychlińska I and Gudej J | Flavonoid compounds from Pyrus communis L. flowers. | 2002 Jan-Feb | Acta Pol Pharm | pmid:12026113 |
| Smolarz HD | Comparative study on the free flavonoid aglycones in herbs of different species of Polygonum L. | 2002 Mar-Apr | Acta Pol Pharm | pmid:12365607 |
| Schieber A et al. | Detection of isorhamnetin glycosides in extracts of apples (Malus domestica cv. "Brettacher") by HPLC-PDA and HPLC-APCI-MS/MS. | 2002 Mar-Apr | Phytochem Anal | pmid:12018028 |
| Edenharder R and Grünhage D | Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102. | 2003 | Mutat. Res. | pmid:12972054 |
| Hasebe Y et al. | Specific inhibition of hypoxia-inducible factor (HIF)-1 alpha activation and of vascular endothelial growth factor (VEGF) production by flavonoids. | 2003 | Biol. Pharm. Bull. | pmid:14519939 |
| Spencer JP et al. | Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites. | 2003 | Biochem. J. | pmid:12578560 |
| Konstantinopoulou M et al. | Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity. | 2003 | J. Nat. Prod. | pmid:12762812 |
| Lin N et al. | Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. | 2003 | Biochem. Pharmacol. | pmid:12787887 |
| Ko WC et al. | 3-O-methylquercetin more selectively inhibits phosphodiesterase subtype 3. | 2003 | Planta Med. | pmid:12709896 |
| Peterson J et al. | Flavonoid intake and breast cancer risk: a case--control study in Greece. | 2003 | Br. J. Cancer | pmid:14520456 |
| Sesink AL et al. | Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase. | 2003 | J. Nutr. | pmid:12612151 |
| Bauvois B et al. | Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13. | 2003 | J. Med. Chem. | pmid:12930151 |
| Galati EM et al. | Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) mill. Fruit juice: antioxidant and antiulcerogenic activity. | 2003 | J. Agric. Food Chem. | pmid:12903943 |
| EGb 761: ginkgo biloba extract, Ginkor. | 2003 | Drugs R D | pmid:12757407 | |
| Azuma K et al. | Enhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:14730132 |
| Ibarra M et al. | Effects of the flavonoid quercetin and its methylated metabolite isorhamnetin in isolated arteries from spontaneously hypertensive rats. | 2003 | Planta Med. | pmid:14735435 |
| Deng F and Zito SW | Development and validation of a gas chromatographic-mass spectrometric method for simultaneous identification and quantification of marker compounds including bilobalide, ginkgolides and flavonoids in Ginkgo biloba L. extract and pharmaceutical preparations. | 2003 | J Chromatogr A | pmid:12585329 |
| Rösch D et al. | Structure-antioxidant efficiency relationships of phenolic compounds and their contribution to the antioxidant activity of sea buckthorn juice. | 2003 | J. Agric. Food Chem. | pmid:12848490 |
| Manguro LO et al. | Flavonol and drimane-type sesquiterpene glycosides of Warburgia stuhlmannii leaves. | 2003 | Phytochemistry | pmid:12770606 |
| Spencer JP et al. | Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. | 2003 | J. Biol. Chem. | pmid:12826665 |
| Zhu M et al. | [Ginkgo flavones in in vitro metabolism and its clinical application]. | 2003 | Yao Xue Xue Bao | pmid:15040090 |
| Vallejo F et al. | Characterisation of flavonols in broccoli (Brassica oleracea L. var. italica) by liquid chromatography-uV diode-array detection-electrospray ionisation mass spectrometry. | 2004 | J Chromatogr A | pmid:15553143 |
| Brevik A et al. | Urinary excretion of flavonoids reflects even small changes in the dietary intake of fruits and vegetables. | 2004 | Cancer Epidemiol. Biomarkers Prev. | pmid:15159318 |
| Arts IC et al. | The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. | 2004 | Br. J. Nutr. | pmid:15182387 |
| Anzellotti D and Ibrahim RK | Molecular characterization and functional expression of flavonol 6-hydroxylase. | 2004 | BMC Plant Biol. | pmid:15596008 |
| Jones DJ et al. | Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity. | 2004 | Br. J. Cancer | pmid:15292928 |
| Echeverry C et al. | Cytoprotection by neutral fraction of tannat red wine against oxidative stress-induced cell death. | 2004 | J. Agric. Food Chem. | pmid:15563225 |
| Yue ME et al. | Fast determination of flavonoids in Hippophae rhamnoides and its medicinal preparation by capillary zone electrophoresis using dimethyl-beta-cyclodextrin as modifier. | 2004 | Talanta | pmid:18969350 |
| Rösch D et al. | Structural investigations of flavonol glycosides from sea buckthorn (Hippophaë rhamnoides) pomace by NMR spectroscopy and HPLC-ESI-MS(n). | 2004 | J. Agric. Food Chem. | pmid:15212446 |
| Sultanova N et al. | Isotamarixen - a new antioxidant and prolyl endopeptidase-inhibiting triterpenoid from Tamarix hispida. | 2004 | Planta Med. | pmid:14765296 |
| Park YH et al. | Structural requirements of flavonoids for increment of ocular blood flow in the rabbit and retinal function recovery in rat eyes. | 2004 | J Ocul Pharmacol Ther | pmid:15279724 |
| Engler MB et al. | Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. | 2004 | J Am Coll Nutr | pmid:15190043 |
| Sheu JR et al. | Mechanisms involved in the antiplatelet activity of rutin, a glycoside of the flavonol quercetin, in human platelets. | 2004 | J. Agric. Food Chem. | pmid:15237945 |
| Huang TS et al. | Partial purification, kinetic analysis, and amino acid sequence information of a flavonol 3-O-methyltransferase from Serratula tinctoria. | 2004 | Plant Physiol. | pmid:15084728 |
| Yang CL et al. | [Inhibitory effect of isorhmnetin on telomerase activity of HeLa cells]. | 2004 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:15071915 |
| Oh SM and Chung KH | Estrogenic activities of Ginkgo biloba extracts. | 2004 | Life Sci. | pmid:14706564 |
| Kuo If et al. | Effect of Ginkgo biloba extract on rat hepatic microsomal CYP1A activity: role of ginkgolides, bilobalide, and flavonols. | 2004 | Can. J. Physiol. Pharmacol. | pmid:15052306 |
| Chen F and Leick V | The protozoan Tetrahymena as a bioindicator to screen bioactive substances. | 2004 | J. Microbiol. Methods | pmid:15369859 |
| Wang LS et al. | Chemical taxonomy of the Xibei tree peony from China by floral pigmentation. | 2004 | J. Plant Res. | pmid:14685820 |
| Hubbard GP et al. | Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans. | 2004 | J. Thromb. Haemost. | pmid:15613018 |
| Dubber MJ and Kanfer I | High-performance liquid chromatographic determination of selected flavonols in Ginkgo biloba solid oral dosage forms. | 2004 | J Pharm Pharm Sci | pmid:15576009 |
| Ko WC et al. | Suppressive effects of 3-O-methylquercetin on ovalbumin-induced airway hyperresponsiveness. | 2004 | Planta Med. | pmid:15643544 |
| Saito A et al. | Protective effects of quercetin and its metabolites on H2O2-induced chromosomal damage to WIL2-NS cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14981287 |
| Justino GC et al. | Plasma quercetin metabolites: structure-antioxidant activity relationships. | 2004 | Arch. Biochem. Biophys. | pmid:15519302 |
| Dai SJ et al. | [Studies on the flavonoid compounds of Rhododendron anthopogonoides]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15709380 |
| Chen X et al. | [Applications of two-dimensional liquid chromatography coupled to mass spectrometry for the separation and identification of compounds in ginkgo biloba extracts]. | 2005 | Se Pu | pmid:15881366 |
| Wang Y et al. | Simultaneous determination of quercetin, kaempferol and isorhamnetin accumulated human breast cancer cells, by high-performance liquid chromatography. | 2005 | J Pharm Biomed Anal | pmid:15905060 |
| Wang Y et al. | Involvement of P-glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin. | 2005 | J. Pharm. Pharmacol. | pmid:15969930 |
| Chen CY et al. | Flavonoids from almond skins are bioavailable and act synergistically with vitamins C and E to enhance hamster and human LDL resistance to oxidation. | 2005 | J. Nutr. | pmid:15930439 |
| Lee ER et al. | Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. | 2005 | J. Biol. Chem. | pmid:16014620 |
| Zhu F et al. | Effects of total flavonoids of Hippophae rhamnoides L. on intracellular free calcium in cultured vascular smooth muscle cells of spontaneously hypertensive rats and Wistar-Kyoto rats. | 2005 | Chin J Integr Med | pmid:16417780 |
| Yang C et al. | [Effect of isorhmnetin on circadian rhythms of DNA synthesis and expression of c-myc gene in Eca-109 cells of human oesophageal cancer]. | 2005 | Sheng Wu Yi Xue Gong Cheng Xue Za Zhi | pmid:16422106 |
| Ito H et al. | Polyphenol levels in human urine after intake of six different polyphenol-rich beverages. | 2005 | Br. J. Nutr. | pmid:16197573 |
| Sesink AL et al. | Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides. | 2005 | Mol. Pharmacol. | pmid:15749994 |
| Matysik G et al. | The influence of Calendulae officinalis flos extracts on cell cultures, and the chromatographic analysis of extracts. | 2005 | J Pharm Biomed Anal | pmid:15925220 |
| Zhang D et al. | Oleanane triterpenes from Aegiceras corniculatum. | 2005 | Fitoterapia | pmid:15664478 |
| Ludwig-Müller J et al. | Quercetin metabolism in vital and apoptotic human leukaemia cells. | 2005 | Biol. Chem. | pmid:15843173 |
| Peng W et al. | Synthesis of tamarixetin and isorhamnetin 3-O-neohesperidoside. | 2005 | Carbohydr. Res. | pmid:15927167 |
| Galati EM et al. | Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury. | 2005 | Phytother Res | pmid:16220574 |
| Shahat AA et al. | Structural characterization of flavonol di-O-glycosides from Farsetia aegyptia by electrospray ionization and collision-induced dissociation mass spectrometry. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15988729 |
| Xu J et al. | Antiinflammatory constituents from the roots of Smilax bockii warb. | 2005 | Arch. Pharm. Res. | pmid:15918511 |
| Fu SC et al. | Total flavones of Hippophae rhamnoides promotes early restoration of ultimate stress of healing patellar tendon in a rat model. | 2005 | Med Eng Phys | pmid:15823472 |
| Dubber MJ et al. | The simultaneous determination of selected flavonol glycosides and aglycones in Ginkgo biloba oral dosage forms by high-performance liquid chromatography-electrospray ionisation-mass spectrometry. | 2005 | J Pharm Biomed Anal | pmid:15797794 |
| Pistelli L et al. | Lupane-triterpenes from Bupleurum flavum. | 2005 | Nat. Prod. Res. | pmid:16317832 |
| Gutierrez-Lugo MT et al. | Antitubercular sterols from Thalia multiflora Horkel ex Koernicke. | 2005 | Phytother Res | pmid:16261518 |
| Sugihara N et al. | Synergistic effects of flavonoids and ascorbate on enhancement in DNA degradation induced by a bleomycin-Fe complex. | 2005 | Free Radic. Res. | pmid:15788228 |
| Kim DO et al. | Sweet and sour cherry phenolics and their protective effects on neuronal cells. | 2005 | J. Agric. Food Chem. | pmid:16366675 |
| Hibasami H et al. | Isolation of five types of flavonol from seabuckthorn (Hippophae rhamnoides) and induction of apoptosis by some of the flavonols in human promyelotic leukemia HL-60 cells. | 2005 | Int. J. Mol. Med. | pmid:15806302 |
| van Zanden JJ et al. | Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2. | 2005 | Biochem. Pharmacol. | pmid:15670588 |
| Oh HM et al. | Inhibitory activity of isorhamnetin from Persicaria thunbergii on Farnesyl Protein Transferase. | 2005 | Arch. Pharm. Res. | pmid:15789745 |
| Bonaccorsi P et al. | Flavonol glucoside profile of southern Italian red onion (Allium cepa L.). | 2005 | J. Agric. Food Chem. | pmid:15796618 |
| Kim BG et al. | Multiple regiospecific methylations of a flavonoid by plant O-methyltransferases expressed in E. coli. | 2005 | Biotechnol. Lett. | pmid:16328980 |
| Lee HJ et al. | Baicalein attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. | 2005 | Eur. J. Cell Biol. | pmid:16323286 |
| Schulz HU et al. | Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers. | 2005 | Arzneimittelforschung | pmid:16294501 |
| Brusselmans K et al. | Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. | 2005 | J. Biol. Chem. | pmid:15533929 |
| Zhang Y and Zhao YM | [Studies on the chemical constituents in seeds of Atriplex centralasiatica]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16075733 |
| Zhang Q and Cui H | Simultaneous determination of quercetin, kaempferol, and isorhamnetin in phytopharmaceuticals of Hippophae rhamnoides L. by high-performance liquid chromatography with chemiluminescence detection. | 2005 | J Sep Sci | pmid:16116994 |
| Schulz HU et al. | Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. | 2005 | Arzneimittelforschung | pmid:15727160 |
| Lee YS et al. | Inhibitory effects of isorhamnetin-3-O-beta-D-glucoside from Salicornia herbacea on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. | 2005 | Biol. Pharm. Bull. | pmid:15863906 |
| Olszewska M | Flavonoids from Prunus serotina Ehrh. | 2005 Mar-Apr | Acta Pol Pharm | pmid:16161354 |
| Gray D et al. | Determination of flavonol aglycones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography: single laboratory validation. | 2005 May-Jun | J AOAC Int | pmid:16001841 |
| Olszewska M | High-performance liquid chromatographic identification of flavonoid monoglycosides from Prunus serotina ehrh. | 2005 Nov-Dec | Acta Pol Pharm | pmid:16583982 |
| Gray DE et al. | Simultaneous quantification of terpenelactones and flavonol aglycones in hydrolyzed ginkgo biloba extract by liquid chromatography with inline ultraviolet and evaporative light scattering detection. | 2005 Nov-Dec | J AOAC Int | pmid:16526440 |
| Kandaswami C et al. | The antitumor activities of flavonoids. | 2005 Sep-Oct | In Vivo | pmid:16097445 |
| Suomela JP et al. | Absorption of flavonols derived from sea buckthorn (Hippophaë rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans. | 2006 | J. Agric. Food Chem. | pmid:16968106 |
| Phadungkit M and Luanratana O | Anti-Salmonella activity of constituents of Ardisia elliptica Thunb. | 2006 | Nat. Prod. Res. | pmid:16901814 |
| Bao M and Lou Y | Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK. | 2006 | Eur. J. Pharmacol. | pmid:16963021 |
| Hubbard GP et al. | Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. | 2006 | Br. J. Nutr. | pmid:16925853 |
| Romani A et al. | HPLC-DAD/MS characterization of flavonoids and hydroxycinnamic derivatives in turnip tops (Brassica rapa L. Subsp. sylvestris L.). | 2006 | J. Agric. Food Chem. | pmid:16478258 |
| Dragoni S et al. | Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro. | 2006 | Br. J. Pharmacol. | pmid:16444288 |
| Ding S et al. | Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry. | 2006 | Rapid Commun. Mass Spectrom. | pmid:16921563 |
| Shukla SK et al. | Protection from radiation-induced mitochondrial and genomic DNA damage by an extract of Hippophae rhamnoides. | 2006 | Environ. Mol. Mutagen. | pmid:16948057 |
| Mennen LI et al. | Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods. | 2006 | Br. J. Nutr. | pmid:16870009 |
| Lim SS et al. | Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens. | 2006 | Phytother Res | pmid:16881021 |
| Yeskaliyeva B et al. | Bioactive flavonoids and saponins from Climacoptera obtusifolia. | 2006 | Phytochemistry | pmid:16956629 |
| Innocenti G et al. | Cytotoxic constituents from Anagyris foetida leaves. | 2006 | Fitoterapia | pmid:16887297 |
| Mullen W et al. | Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. | 2006 | Br. J. Nutr. | pmid:16869998 |
| Rajaraman G et al. | Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes. | 2006 | Toxicol. Appl. Pharmacol. | pmid:17045319 |
| Mattivi F et al. | Metabolite profiling of grape: Flavonols and anthocyanins. | 2006 | J. Agric. Food Chem. | pmid:17002441 |