Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Shoab SS et al. | Effect of oral micronized purified flavonoid fraction treatment on leukocyte adhesion molecule expression in patients with chronic venous disease: a pilot study. | 2000 | J. Vasc. Surg. | pmid:10709057 |
| Morrice PC et al. | High-performance liquid chromatographic determination of quercetin and isorhamnetin in rat tissues using beta-glucuronidase and acid hydrolysis. | 2000 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10718659 |
| Zielińska M et al. | Antioxidative activity of flavonoids in stimulated human neutrophils. | 2000 | Folia Histochem. Cytobiol. | pmid:10763121 |
| Ader P et al. | Bioavailability and metabolism of the flavonol quercetin in the pig. | 2000 | Free Radic. Biol. Med. | pmid:10832067 |
| Fu G et al. | [Determination of flavonoids in the leaves of Hippophae L. by HPLC]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11038967 |
| Moreira AS et al. | Antiinflammatory activity of extracts and fractions from the leaves of Gochnatia polymorpha. | 2000 | Phytother Res | pmid:11114003 |
| Schneider H et al. | Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria. | 2000 | J. Appl. Microbiol. | pmid:11123476 |
| Wu TS et al. | New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris. | 2001 | Bioorg. Med. Chem. | pmid:11197349 |
| Morand C et al. | Respective bioavailability of quercetin aglycone and its glycosides in a rat model. | 2000 | Biofactors | pmid:11216481 |
| Piskula MK | Factors affecting flavonoids absorption. | 2000 | Biofactors | pmid:11216483 |
| Meng Z et al. | Effect of five flavonoid compounds isolated from Quercus dentata Thunb on superoxide generation in human neutrophils and phosphorylation of neutrophil proteins. | 2001 | Clin. Chim. Acta | pmid:11282099 |
| Graefe EU et al. | Pharmacokinetics and bioavailability of quercetin glycosides in humans. | 2001 | J Clin Pharmacol | pmid:11361045 |
| Murota K et al. | Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2. | 2000 | Arch. Biochem. Biophys. | pmid:11368329 |
| Calzada F et al. | Antiprotozoal activity of the constituents of Conyza filaginoides. | 2001 | J. Nat. Prod. | pmid:11374974 |
| Zielińska M et al. | The flavonoids, quercetin and isorhamnetin 3-O-acylglucosides diminish neutrophil oxidative metabolism and lipid peroxidation. | 2001 | Acta Biochim. Pol. | pmid:11440168 |
| Lou H et al. | Alkaloids and flavonoids from peanut skins. | 2001 | Planta Med. | pmid:11458452 |
| Cermak R et al. | The impact of different flavonoid classes on colonic CI- secretion in rats. | 2001 | Biochem. Pharmacol. | pmid:11597584 |
| Gudej J and Nazaruk J | Flavonol glycosides from the flowers of Bellis perennis. | 2001 | Fitoterapia | pmid:11677029 |
| Spencer JP et al. | Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts. | 2001 | Free Radic. Biol. Med. | pmid:11677047 |
| Sikorska M and Matławska I | Kaempferol, isorhamnetin and their glycosides in the flowers of Asclepias syriaca L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693731 |
| Sharaf M et al. | Two flavonol 5-O-glycosides from the roots of Leuzea carthamoides. | 2001 | Fitoterapia | pmid:11731123 |
| Tang Y et al. | Coumaroyl flavonol glycosides from the leaves of Ginkgo biloba. | 2001 | Phytochemistry | pmid:11738417 |
| Lu J et al. | Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils. | 2002 | Clin. Chim. Acta | pmid:11750278 |
| Cichewicz RH and Nair MG | Isolation and characterization of stelladerol, a new antioxidant naphthalene glycoside, and other antioxidant glycosides from edible daylily (hemerocallis) flowers. | 2002 | J. Agric. Food Chem. | pmid:11754548 |
| Wenisch C and Biffignandi PM | Effect of bioflavonoids (trihydroxyethylrutin and disodium flavodate) in vitro on neutrophil reactive oxygen production and phagocytic ability assessed by flow cytometry. | 2001 | Curr Med Res Opin | pmid:11759181 |
| Rietjens IM et al. | Structure activity relationships for the chemical behaviour and toxicity of electrophilic quinones/quinone methides. | 2001 | Adv. Exp. Med. Biol. | pmid:11764920 |
| Ko WC et al. | Mechanisms of relaxant action of 3-O-methylquercetin in isolated guinea pig trachea. | 2002 | Planta Med. | pmid:11842323 |
| Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
| Azuma K et al. | Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. | 2002 | J. Agric. Food Chem. | pmid:11879062 |
| Robin V et al. | Antipoliovirus flavonoids from Psiadia dentata. | 2001 | Antivir. Chem. Chemother. | pmid:11900347 |
| Itoh A et al. | Flavonoid glycosides from Rhazya orientalis. | 2002 | J. Nat. Prod. | pmid:11908977 |
| Weng S and Lian J | [Determination of isorhamnetine and quercetin in flavone hippophaes tablets by HPLC method]. | 2001 | Zhong Yao Cai | pmid:11917852 |
| Sang S et al. | Antioxidative phenolic compounds isolated from almond skins (Prunus amygdalus Batsch). | 2002 | J. Agric. Food Chem. | pmid:11929314 |
| Frison-Norrie S and Sporns P | Identification and quantification of flavonol glycosides in almond seedcoats using MALDI-TOF MS. | 2002 | J. Agric. Food Chem. | pmid:11982399 |
| Ibarra M et al. | Cardiovascular effects of isorhamnetin and quercetin in isolated rat and porcine vascular smooth muscle and isolated rat atria. | 2002 | Planta Med. | pmid:11988852 |
| Tang YP et al. | A new coumaronochromone from Sophora japonica. | 2002 | J Asian Nat Prod Res | pmid:11991186 |
| De Souza KC et al. | LC determination of flavonoids: separation of quercetin, luteolin and 3-O-methylquercetin in Achyrocline satureioides preparations. | 2002 | J Pharm Biomed Anal | pmid:12008157 |
| Nielsen SE et al. | Flavonoids in human urine as biomarkers for intake of fruits and vegetables. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12010860 |
| Schieber A et al. | Detection of isorhamnetin glycosides in extracts of apples (Malus domestica cv. "Brettacher") by HPLC-PDA and HPLC-APCI-MS/MS. | 2002 Mar-Apr | Phytochem Anal | pmid:12018028 |
| Rychlińska I and Gudej J | Flavonoid compounds from Pyrus communis L. flowers. | 2002 Jan-Feb | Acta Pol Pharm | pmid:12026113 |
| Zou L et al. | Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products. | 2002 | Phytomedicine | pmid:12046870 |
| Pérez-VizcaÃno F et al. | Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12065701 |
| Cornish KM et al. | Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. | 2002 | Free Radic. Biol. Med. | pmid:12086683 |
| Shirai M et al. | Effect of quercetin and its conjugated metabolite on the hydrogen peroxide-induced intracellular production of reactive oxygen species in mouse fibroblasts. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12092810 |
| el-Mousallami AM et al. | Acylated flavonol diglucosides from Lotus polyphyllos. | 2002 | Phytochemistry | pmid:12150804 |
| Li W and Fitzloff JF | Simultaneous determination of terpene lactones and flavonoid aglycones in Ginkgo biloba by high-performance liquid chromatography with evaporative light scattering detection. | 2002 | J Pharm Biomed Anal | pmid:12151066 |
| Apers S et al. | Characterisation of new oligoglycosidic compounds in two Chinese medicinal herbs. | Phytochem Anal | pmid:12184172 | |
| Yoshikawa M et al. | New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume. | 2002 | J. Nat. Prod. | pmid:12193020 |
| Yokozawa T et al. | Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes. | 2002 | J. Agric. Food Chem. | pmid:12207497 |