Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Šarić Mustapić D et al. | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. | 2018 | Molecules | pmid:30301254 |
| Qi F et al. | Anti-inflammatory effects of isorhamnetin on LPS-stimulated human gingival fibroblasts by activating Nrf2 signaling pathway. | 2018 | Microb. Pathog. | pmid:29704670 |
| Lu X et al. | Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice. | 2018 | Biomed. Pharmacother. | pmid:29684859 |
| Quintero-Soto MF et al. | Phenolic profiles and their contribution to the antioxidant activity of selected chickpea genotypes from Mexico and ICRISAT collections. | 2018 | Plant Foods Hum Nutr | pmid:29516285 |
| Wu Q et al. | Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. | 2018 | J. Agric. Food Chem. | pmid:29905475 |
| Zhu JX et al. | Quercetin, Kaempferol and Isorhamnetin in Elaeagnus pungens Thunb. Leaf: Pharmacological Activities and Quantitative Determination Studies. | 2018 | Chem. Biodivers. | pmid:29802806 |
| Zhao TT et al. | Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes. | 2018 | Gene | pmid:29730426 |
| Yamauchi K and Mitsunaga T | Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model. | 2018 | J Nat Med | pmid:29442220 |
| Shi H et al. | Isorhamnetin, the active constituent of a Chinese herb Hippophae rhamnoides L, is a potent suppressor of dendritic-cell maturation and trafficking. | 2018 | Int. Immunopharmacol. | pmid:29272818 |
| Wang J et al. | Isorhamnetin prevents H2O2‑induced oxidative stress in human retinal pigment epithelial cells. | 2018 | Mol Med Rep | pmid:29115489 |
| Bouratoua A et al. | Chemical composition and antioxidant activity of aerial parts of Ferula longipes Coss. ex Bonnier and Maury. | 2018 | Nat. Prod. Res. | pmid:28714345 |
| Bhattacharya D et al. | Antibacterial activity of polyphenolic fraction of Kombucha against Vibrio cholerae: targeting cell membrane. | 2018 | Lett. Appl. Microbiol. | pmid:29193174 |
| Olennikov DN et al. | Isorhamnetin and Quercetin Derivatives as Anti-Acetylcholinesterase Principles of Marigold (Calendula officinalis) Flowers and Preparations. | 2017 | Int J Mol Sci | pmid:28767066 |
| Qiu L et al. | Protective effects of isorhamnetin on N2a cell against endoplasmic reticulum stress-induced injury is mediated by PKCε. | 2017 | Biomed. Pharmacother. | pmid:28715866 |
| Ressaissi A et al. | Isorhamnetin derivatives and piscidic acid for hypercholesterolemia: cholesterol permeability, HMG-CoA reductase inhibition, and docking studies. | 2017 | Arch. Pharm. Res. | pmid:28936788 |
| Shi W et al. | Bioactive flavonoids from Flos Sophorae. | 2017 | J Nat Med | pmid:28357634 |
| Gao L et al. | Isorhamnetin protects against cardiac hypertrophy through blocking PI3K-AKT pathway. | 2017 | Mol. Cell. Biochem. | pmid:28176246 |
| Guo R et al. | Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophaë rhamnoides L.) berries. | 2017 | Food Chem | pmid:27979305 |
| Neveux S et al. | Natural Compounds as Occult Ototoxins? Ginkgo biloba Flavonoids Moderately Damage Lateral Line Hair Cells. | 2017 | J. Assoc. Res. Otolaryngol. | pmid:27896487 |
| Tian Y et al. | Phenolic compounds extracted by acidic aqueous ethanol from berries and leaves of different berry plants. | 2017 | Food Chem | pmid:27855899 |
| Mudrić SŽ et al. | The polyphenolics and carbohydrates as indicators of botanical and geographical origin of Serbian autochthonous clones of red spice paprika. | 2017 | Food Chem | pmid:27664689 |
| Ferreres F et al. | HPLC-DAD-ESI/MS(n) profiling of phenolic compounds from Lathyrus cicera L. seeds. | 2017 | Food Chem | pmid:27507525 |
| Burak C et al. | Higher plasma quercetin levels following oral administration of an onion skin extract compared with pure quercetin dihydrate in humans. | 2017 | Eur J Nutr | pmid:26482244 |
| Mikulic-Petkovsek M et al. | Bioactive Components and Antioxidant Capacity of Fruits from Nine Sorbus Genotypes. | 2017 | J. Food Sci. | pmid:28182841 |
| Östlund J et al. | In vitro inhibition of human CYP2E1 and CYP3A by quercetin and myricetin in hepatic microsomes is not gender dependent. | 2017 | Toxicology | pmid:28232125 |
| Wang JY et al. | Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. | 2017 | BMC Syst Biol | pmid:29145845 |
| Antunes-Ricardo M et al. | Bioaccessibility, Intestinal Permeability and Plasma Stability of Isorhamnetin Glycosides from Opuntia ficus-indica (L.). | 2017 | Int J Mol Sci | pmid:28829356 |
| Li J et al. | Isorhamnetin inhibits IL‑1β‑induced expression of inflammatory mediators in human chondrocytes. | 2017 | Mol Med Rep | pmid:28731170 |
| Seo S et al. | Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1α Accumulation. | 2016 | Biol. Pharm. Bull. | pmid:27803454 |
| Ford CT et al. | Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes. | 2016 | Br. J. Nutr. | pmid:26984113 |
| Liu JL et al. | Optimization of Microwave-Assisted Extraction Conditions for Five Major Bioactive Compounds from Flos Sophorae Immaturus (Cultivars of Sophora japonica L.) Using Response Surface Methodology. | 2016 | Molecules | pmid:26950107 |
| Chen JH et al. | Estrogenic effects of flavonoid components in Xiaoyao powder. | 2016 | Genet. Mol. Res. | pmid:26909969 |
| Simirgiotis MJ et al. | Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC-Q/Orbitrap/MS/MS). | 2016 | Molecules | pmid:26784158 |
| Zhang Y et al. | Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency. | 2016 | Sci Rep | pmid:26775807 |
| Jiang L et al. | Isorhamnetin Attenuates Staphylococcus aureus-Induced Lung Cell Injury by Inhibiting Alpha-Hemolysin Expression. | 2016 | J. Microbiol. Biotechnol. | pmid:26643966 |
| Li W et al. | The protective role of isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen-glucose deprivation. | 2016 | J. Neurochem. | pmid:26578299 |
| Yang JH et al. | Isorhamnetin attenuates liver fibrosis by inhibiting TGF-β/Smad signaling and relieving oxidative stress. | 2016 | Eur. J. Pharmacol. | pmid:27151496 |
| Ma YC et al. | An effective identification and quantification method for Ginkgo biloba flavonol glycosides with targeted evaluation of adulterated products. | 2016 | Phytomedicine | pmid:27002408 |
| Mata A et al. | Contribution to the characterization of Opuntia spp. juices by LC-DAD-ESI-MS/MS. | 2016 | Food Chem | pmid:27211682 |
| Lee YG et al. | Change in Flavonoid Composition and Antioxidative Activity during Fermentation of Onion (Allium cepa L.) by Leuconostoc mesenteroides with Different Salt Concentrations. | 2016 | J. Food Sci. | pmid:27175820 |
| Zhao JJ et al. | Treatment with Isorhamnetin Protects the Brain Against Ischemic Injury in Mice. | 2016 | Neurochem. Res. | pmid:27161367 |
| Li Y et al. | Isorhamnetin ameliorates LPS-induced inflammatory response through downregulation of NF-κB signaling. | 2016 | Inflammation | pmid:27138362 |
| Park JY et al. | Isorhamnetin-3-O-Glucuronide Suppresses JNK and p38 Activation and Increases Heme-Oxygenase-1 in Lipopolysaccharide-Challenged RAW264.7 Cells. | 2016 | Drug Dev. Res. | pmid:27113811 |
| Jnawali HN et al. | Antituberculosis Activity of a Naturally Occurring Flavonoid, Isorhamnetin. | 2016 | J. Nat. Prod. | pmid:26974691 |
| Huang L et al. | Protective Effects of Isorhamnetin on Cardiomyocytes Against Anoxia/Reoxygenation-induced Injury Is Mediated by SIRT1. | 2016 | J. Cardiovasc. Pharmacol. | pmid:26859194 |
| Choi YH | The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation. | 2016 | Gen. Physiol. Biophys. | pmid:26830132 |
| Brock MT et al. | Genetic architecture, biochemical underpinnings and ecological impact of floral UV patterning. | 2016 | Mol. Ecol. | pmid:26800256 |
| Yang Y and Li D | Investigation on the interaction between isorhamnetin and bovine liver catalase by spectroscopic techniques under different pH conditions. | 2016 | Luminescence | pmid:26748824 |
| Juániz I et al. | Influence of heat treatment on antioxidant capacity and (poly)phenolic compounds of selected vegetables. | 2016 | Food Chem | pmid:26616976 |
| Chi G et al. | Isorhamnetin protects mice from lipopolysaccharide-induced acute lung injury via the inhibition of inflammatory responses. | 2016 | Inflamm. Res. | pmid:26525359 |
| Yang B et al. | Protective Effect of Isorhamnetin on Lipopolysaccharide-Induced Acute Lung Injury in Mice. | 2016 | Inflammation | pmid:26276127 |
| Duan J et al. | A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration. | 2016 | Eur J Drug Metab Pharmacokinet | pmid:25613316 |
| Lau AJ et al. | Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:27041117 |
| Liu H et al. | Solid-phase extraction of flavonoids in honey samples using carbamate-embedded triacontyl-modified silica sorbent. | 2016 | Food Chem | pmid:26988475 |
| Fatima T et al. | Metabolite profiling and expression analysis of flavonoid, vitamin C and tocopherol biosynthesis genes in the antioxidant-rich sea buckthorn (Hippophae rhamnoides L.). | 2015 | Phytochemistry | pmid:26318327 |
| Hu S et al. | Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen‑activated protein kinase kinase signaling pathways. | 2015 | Mol Med Rep | pmid:26502751 |
| Park YJ et al. | Inhibitory Aromatase Effects of Flavonoids from Ginkgo Biloba Extracts on Estrogen Biosynthesis. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26434836 |
| Ruan Y et al. | Autophagy inhibition enhances isorhamnetin‑induced mitochondria‑dependent apoptosis in non‑small cell lung cancer cells. | 2015 | Mol Med Rep | pmid:26238746 |
| Cariddi LN et al. | In Vitro and In Vivo Cytogenotoxic Effects of Hot Aqueous Extract of Achyrocline satureioides (Lam.) DC. | 2015 | Biomed Res Int | pmid:26078941 |
| Chen TL et al. | Protective effects of isorhamnetin on apoptosis and inflammation in TNF-α-induced HUVECs injury. | 2015 | Int J Clin Exp Pathol | pmid:26045738 |
| Sun Q et al. | Urinary Excretion of Select Dietary Polyphenol Metabolites Is Associated with a Lower Risk of Type 2 Diabetes in Proximate but Not Remote Follow-Up in a Prospective Investigation in 2 Cohorts of US Women. | 2015 | J. Nutr. | pmid:25904735 |
| Li Q et al. | Anti-proliferation effects of isorhamnetin on lung cancer cells in vitro and in vivo. | 2015 | Asian Pac. J. Cancer Prev. | pmid:25854402 |
| Antunes-Ricardo M et al. | Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica. | 2015 | Biomed Res Int | pmid:25821823 |
| Abdal Dayem A et al. | Antiviral effect of methylated flavonol isorhamnetin against influenza. | 2015 | PLoS ONE | pmid:25806943 |
| Luo Y et al. | Isorhamnetin attenuates atherosclerosis by inhibiting macrophage apoptosis via PI3K/AKT activation and HO-1 induction. | 2015 | PLoS ONE | pmid:25799286 |
| Zhang BY et al. | Isorhamnetin flavonoid synergistically enhances the anticancer activity and apoptosis induction by cis-platin and carboplatin in non-small cell lung carcinoma (NSCLC). | 2015 | Int J Clin Exp Pathol | pmid:25755690 |
| Daubney J et al. | Cardioprotective and cardiotoxic effects of quercetin and two of its in vivo metabolites on differentiated h9c2 cardiomyocytes. | 2015 | Basic Clin. Pharmacol. Toxicol. | pmid:25203460 |
| Lau AJ and Chang TK | 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease. | 2015 | Pharmacol. Res. | pmid:26238175 |
| Messer JG et al. | Quercetin Metabolites Up-Regulate the Antioxidant Response in Osteoblasts Isolated From Fetal Rat Calvaria. | 2015 | J. Cell. Biochem. | pmid:25716194 |
| Jimenez R et al. | Quercetin and its metabolites inhibit the membrane NADPH oxidase activity in vascular smooth muscle cells from normotensive and spontaneously hypertensive rats. | 2015 | Food Funct | pmid:25562607 |
| Sabbagh G and Berakdar N | Docking studies of flavonoid compounds as inhibitors of β-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli. | 2015 | J. Mol. Graph. Model. | pmid:26292066 |
| Li C et al. | Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2/9. | 2015 | Nutr Cancer | pmid:26359917 |
| Iida A et al. | Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid β-induced cytotoxicity and amyloid β aggregation. | 2015 | Biosci. Biotechnol. Biochem. | pmid:25965116 |
| Nishijima T et al. | Simultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects. | 2015 | Br. J. Nutr. | pmid:25865751 |
| Manu KA et al. | Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer. | 2015 | Cancer Lett. | pmid:25827070 |
| Xie Y et al. | Comparison of isorhamnetin absorption properties in total flavones of Hippophae rhamnoides L. with its pure form in a Caco-2 cell model mediated by multidrug resistance-associated protein. | 2015 | Eur J Pharm Sci | pmid:25813735 |
| Maciej J et al. | Bioavailability of the flavonol quercetin in neonatal calves after oral administration of quercetin aglycone or rutin. | 2015 | J. Dairy Sci. | pmid:25795488 |
| Shaheen N et al. | Separation of isorhamnetin 3-sulphate and astragalin from Flaveria bidentis (L.) Kuntze using macroporous resin and followed by high-speed countercurrent chromatography. | 2015 | J Sep Sci | pmid:25763770 |
| Wiczkowski W et al. | Quercetin and isorhamnetin aglycones are the main metabolites of dietary quercetin in cerebrospinal fluid. | 2015 | Mol Nutr Food Res | pmid:25727325 |
| RodrÃguez-RodrÃguez C et al. | The effect of isorhamnetin glycosides extracted from Opuntia ficus-indica in a mouse model of diet induced obesity. | 2015 | Food Funct | pmid:25588195 |
| Wang H et al. | A phospholipid complex to improve the oral bioavailability of flavonoids. | 2015 | Drug Dev Ind Pharm | pmid:25496311 |
| Mihajlovic L et al. | Composition of polyphenol and polyamide compounds in common ragweed (Ambrosia artemisiifolia L.) pollen and sub-pollen particles. | 2015 | Phytochemistry | pmid:25468540 |
| Wang W et al. | Enhanced dissolution rate and oral bioavailability of Ginkgo biloba extract by preparing solid dispersion via hot-melt extrusion. | 2015 | Fitoterapia | pmid:25446043 |
| Dou W et al. | Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway. | 2014 | J. Nutr. Biochem. | pmid:24913217 |
| Yamauchi K et al. | Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. | 2014 | Bioorg. Med. Chem. | pmid:24853321 |
| Seo K et al. | The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1. | 2014 | Inflammation | pmid:24337631 |
| Yang JH et al. | Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24211276 |
| Li C et al. | Isorhamnetin suppresses colon cancer cell growth through the PI3K‑Akt‑mTOR pathway. | 2014 | Mol Med Rep | pmid:24398569 |
| Kawasaki T et al. | Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1. | 2014 | Biol. Pharm. Bull. | pmid:24492725 |
| Bidone J et al. | Simultaneous quantification of flavonoids from Achyrocline satureioides by a polar-reversed phase LC method--application to skin permeation/retention studies. | 2014 | Pharmazie | pmid:24601216 |
| Somerset S and Papier K | A food frequency questionnaire validated for estimating dietary flavonoid intake in an Australian population. | 2014 | Nutr Cancer | pmid:25207829 |
| Morris JB et al. | Flavonol content, oil%, and fatty acid composition variability in seeds of Teramnus labialis and T. uncinatus accessions with nutraceutical potential. | 2014 | J Diet Suppl | pmid:25054688 |
| Antunes-Ricardo M et al. | Induction of apoptosis in colon cancer cells treated with isorhamnetin glycosides from Opuntia ficus-indica pads. | 2014 | Plant Foods Hum Nutr | pmid:25186940 |
| Bakır T et al. | Antioxidant/prooxidant effects of α-tocopherol, quercetin and isorhamnetin on linoleic acid peroxidation induced by Cu(II) and H2O2. | 2014 | Int J Food Sci Nutr | pmid:24152374 |
| Perez A et al. | The flavonoid quercetin induces acute vasodilator effects in healthy volunteers: correlation with beta-glucuronidase activity. | 2014 | Pharmacol. Res. | pmid:25076013 |
| Dong GZ et al. | AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction. | 2014 | Eur. J. Pharmacol. | pmid:24972246 |
| Jayashankar B et al. | Supercritical extract of Seabuckthorn Leaves (SCE200ET) inhibited endotoxemia by reducing inflammatory cytokines and nitric oxide synthase 2 expression. | 2014 | Int. Immunopharmacol. | pmid:24594274 |
| Duan J et al. | Transport characteristics of isorhamnetin across intestinal Caco-2 cell monolayers and the effects of transporters on it. | 2014 | Food Chem. Toxicol. | pmid:24525098 |
| Xie Y et al. | Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L. | 2014 | Fitoterapia | pmid:24462958 |
| Kim JH et al. | Enzyme-assisted extraction of cactus bioactive molecules under high hydrostatic pressure. | 2014 | J. Sci. Food Agric. | pmid:23893871 |