Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sikorska M and Matławska I | Kaempferol, isorhamnetin and their glycosides in the flowers of Asclepias syriaca L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693731 |
| Sharaf M et al. | Two flavonol 5-O-glycosides from the roots of Leuzea carthamoides. | 2001 | Fitoterapia | pmid:11731123 |
| Tang Y et al. | Coumaroyl flavonol glycosides from the leaves of Ginkgo biloba. | 2001 | Phytochemistry | pmid:11738417 |
| Lu J et al. | Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils. | 2002 | Clin. Chim. Acta | pmid:11750278 |
| Cichewicz RH and Nair MG | Isolation and characterization of stelladerol, a new antioxidant naphthalene glycoside, and other antioxidant glycosides from edible daylily (hemerocallis) flowers. | 2002 | J. Agric. Food Chem. | pmid:11754548 |
| Wenisch C and Biffignandi PM | Effect of bioflavonoids (trihydroxyethylrutin and disodium flavodate) in vitro on neutrophil reactive oxygen production and phagocytic ability assessed by flow cytometry. | 2001 | Curr Med Res Opin | pmid:11759181 |
| Rietjens IM et al. | Structure activity relationships for the chemical behaviour and toxicity of electrophilic quinones/quinone methides. | 2001 | Adv. Exp. Med. Biol. | pmid:11764920 |
| Ko WC et al. | Mechanisms of relaxant action of 3-O-methylquercetin in isolated guinea pig trachea. | 2002 | Planta Med. | pmid:11842323 |
| Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
| Azuma K et al. | Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. | 2002 | J. Agric. Food Chem. | pmid:11879062 |