Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lopez Pila JM et al. | Lack of evidence for strand-specific inhibition of poliovirus RNA synthesis by 3-methylquercetin. | 1989 | Antiviral Res. | pmid:2540709 |
| Liu Q et al. | [Chemical constituents of Bupleurum Longicaule Wall. ex DC. var. giraldii Wolff]. | 1990 | Zhongguo Zhong Yao Za Zhi | pmid:2206389 |
| Luo S and Jin H | [Chemical constituents of the aerial parts of six species of Bupleurum genus medicinally used in south-west region of China]. | 1991 | Zhongguo Zhong Yao Za Zhi | pmid:1786097 |
| Gracza L | [Constituents of Asarum europeum L. Communication No. 18. Dynamics of the synthesis of flavonoids]. | 1991 | Acta Pharm Hung | pmid:1887803 |
| Lamaison JL et al. | [Presence of isorhamnetin 3-glucoside and 3-rutinoside in Sambucus nigra L. flowers]. | 1991 | Ann Pharm Fr | pmid:1841526 |
| Miniscalco A et al. | Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1602384 |
| Chanoine JP and Braverman LE | The role of transthyretin in the transport of thyroid hormone to cerebrospinal fluid and brain. | 1992 | Acta Med. Austriaca | pmid:1519447 |
| Czeczot H | The effect of flavonoids on the mutagenic activity of aromatic amines. | 1992 | Acta Biochim. Pol. | pmid:1441824 |
| Matławska I et al. | [Flavonoids in Arabis Caucasica Willd. (Cruciferae). Part I. Heterozygote similar to quercetin and isorhamnetin]. | 1992 | Acta Pol Pharm | pmid:16092411 |
| Mahmood N et al. | Inhibition of HIV infection by flavanoids. | 1993 | Antiviral Res. | pmid:8279812 |