Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sundararajan R et al. | Cytisus scoparius link--a natural antioxidant. | 2006 | BMC Complement Altern Med | pmid:16542432 |
| Suomela JP et al. | Absorption of flavonols derived from sea buckthorn (Hippophaë rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans. | 2006 | J. Agric. Food Chem. | pmid:16968106 |
| Phadungkit M and Luanratana O | Anti-Salmonella activity of constituents of Ardisia elliptica Thunb. | 2006 | Nat. Prod. Res. | pmid:16901814 |
| Bao M and Lou Y | Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK. | 2006 | Eur. J. Pharmacol. | pmid:16963021 |
| Grimm T et al. | Single and multiple dose pharmacokinetics of maritime pine bark extract (pycnogenol) after oral administration to healthy volunteers. | 2006 | BMC Clin Pharmacol | pmid:16887024 |
| Hubbard GP et al. | Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. | 2006 | Br. J. Nutr. | pmid:16925853 |
| Romani A et al. | HPLC-DAD/MS characterization of flavonoids and hydroxycinnamic derivatives in turnip tops (Brassica rapa L. Subsp. sylvestris L.). | 2006 | J. Agric. Food Chem. | pmid:16478258 |
| Dragoni S et al. | Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro. | 2006 | Br. J. Pharmacol. | pmid:16444288 |
| Ding S et al. | Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry. | 2006 | Rapid Commun. Mass Spectrom. | pmid:16921563 |
| Shukla SK et al. | Protection from radiation-induced mitochondrial and genomic DNA damage by an extract of Hippophae rhamnoides. | 2006 | Environ. Mol. Mutagen. | pmid:16948057 |
| Bao M and Lou Y | Flavonoids from seabuckthorn protect endothelial cells (EA.hy926) from oxidized low-density lipoprotein induced injuries via regulation of LOX-1 and eNOS expression. | 2006 | J. Cardiovasc. Pharmacol. | pmid:16891912 |
| Zu Y et al. | Simultaneous determination of catechin, rutin, quercetin kaempferol and isorhamnetin in the extract of sea buckthorn (Hippophae rhamnoides L.) leaves by RP-HPLC with DAD. | 2006 | J Pharm Biomed Anal | pmid:16520013 |
| Mennen LI et al. | Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods. | 2006 | Br. J. Nutr. | pmid:16870009 |
| Milbury PE et al. | Determination of flavonoids and phenolics and their distribution in almonds. | 2006 | J. Agric. Food Chem. | pmid:16819912 |
| Lim SS et al. | Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens. | 2006 | Phytother Res | pmid:16881021 |
| Ma B et al. | Integrated isotachophoretic preconcentration with zone electrophoresis separation on a quartz microchip for UV detection of flavonoids. | 2006 | Electrophoresis | pmid:17117378 |
| Yeskaliyeva B et al. | Bioactive flavonoids and saponins from Climacoptera obtusifolia. | 2006 | Phytochemistry | pmid:16956629 |
| Innocenti G et al. | Cytotoxic constituents from Anagyris foetida leaves. | 2006 | Fitoterapia | pmid:16887297 |
| Dubber MJ and Kanfer I | Application of reverse-flow micellar electrokinetic chromatography for the simultaneous determination of flavonols and terpene trilactones in Ginkgo biloba dosage forms. | 2006 | J Chromatogr A | pmid:16720026 |
| Mullen W et al. | Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. | 2006 | Br. J. Nutr. | pmid:16869998 |
| Saleem M et al. | Secondary metabolites from Opuntia ficus-indica var. saboten. | 2006 | Phytochemistry | pmid:16762382 |
| Tian X et al. | The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O-beta-D-xylopyranosyl-(1-6) -beta-D-glucopyranoside in the human intestinal cell line caco-2. | 2006 | Pharm. Res. | pmid:16832612 |
| Chang TK et al. | Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes. | 2006 | Drug Metab. Dispos. | pmid:16258077 |
| Rajaraman G et al. | Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes. | 2006 | Toxicol. Appl. Pharmacol. | pmid:17045319 |
| Mattivi F et al. | Metabolite profiling of grape: Flavonols and anthocyanins. | 2006 | J. Agric. Food Chem. | pmid:17002441 |
| Sembries S et al. | Physiological effects of extraction juices from apple, grape, and red beet pomaces in rats. | 2006 | J. Agric. Food Chem. | pmid:17177570 |
| Chang TK et al. | Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16226778 |
| Jiang JS et al. | Mechanisms of suppression of nitric oxide production by 3-O-methylquercetin in RAW 264.7 cells. | 2006 | J Ethnopharmacol | pmid:16213685 |
| Küpeli E et al. | Effect of Cistus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice. | 2006 | J Ethnopharmacol | pmid:16216454 |
| Young JM et al. | Comparative effects of enzogenol and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers. | 2006 | Free Radic. Res. | pmid:16298763 |
| Azuma K et al. | Lowering effects of onion intake on oxidative stress biomarkers in streptozotocin-induced diabetic rats. | 2007 | J Clin Biochem Nutr | pmid:18188415 |
| Stracke R et al. | Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling. | 2007 | Plant J. | pmid:17419845 |
| Lan K et al. | Quantitative determination of isorhamnetin, quercetin and kaempferol in rat plasma by liquid chromatography with electrospray ionization tandem mass spectrometry and its application to the pharmacokinetic study of isorhamnetin. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17154349 |
| Angeloni C et al. | Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress. | 2007 | Biochimie | pmid:17045724 |
| Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
| Liu R et al. | [Inhibitory effect of isorhamnetin and hesperidin on the oxidation of high-density lipoproteins (HDL) induced by Cu2+]. | 2007 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:18095596 |
| Choi CW et al. | Antioxidant constituents and a new triterpenoid glycoside from Flos Lonicerae. | 2007 | Arch. Pharm. Res. | pmid:17328234 |
| Slimestad R et al. | Onions: a source of unique dietary flavonoids. | 2007 | J. Agric. Food Chem. | pmid:17997520 |
| Curir P et al. | Pavietin, a coumarin from Aesculus pavia with antifungal activity. | 2007 | J. Nat. Prod. | pmid:17914881 |
| Harbaum B et al. | Identification of flavonoids and hydroxycinnamic acids in pak choi varieties (Brassica campestris L. ssp. chinensis var. communis) by HPLC-ESI-MSn and NMR and their quantification by HPLC-DAD. | 2007 | J. Agric. Food Chem. | pmid:17848079 |
| Dongmo AB et al. | Flavonoids from Acacia pennata and their cyclooxygenase (COX-1 and COX-2) inhibitory activities. | 2007 | Planta Med. | pmid:17823873 |
| Fico G et al. | Comparative phytochemical and morphological analyses of three Italian Primula species. | 2007 | Phytochemistry | pmid:17544462 |
| Luo M et al. | Separation and determination of flavonoids in Lamiophlomis rotata by capillary electrophoresis using borate as electrolyte. | 2007 | J Pharm Biomed Anal | pmid:17512689 |
| Sayed HM et al. | A new steroid glycoside and furochromones from Cyperus rotundus L. | 2007 | Nat. Prod. Res. | pmid:17479423 |
| Chen C et al. | High-performance liquid chromatographic fingerprint analysis for different origins of sea buckthorn berries. | 2007 | J Chromatogr A | pmid:17449044 |
| Flamini G | Flavonoids and other compounds from the aerial parts of Viola etrusca. | 2007 | Chem. Biodivers. | pmid:17311226 |
| Zhao Y et al. | A sensitive method for the detection and quantification of ginkgo flavonols from plasma. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17300134 |
| Kim JH and Mullin CA | An isorhamnetin rhamnoglycoside serves as a costimulant for sugars and amino acids in feeding responses of adult western corn rootworms (Diabrotica virgifera virgifera) to corn (Zea mays) pollen. | 2007 | J. Chem. Ecol. | pmid:17268822 |
| Rigano D et al. | Antibacterial activity of flavonoids and phenylpropanoids from Marrubium globosum ssp. libanoticum. | 2007 | Phytother Res | pmid:17186490 |
| Ninfali P et al. | Characterization and biological activity of the main flavonoids from Swiss Chard (Beta vulgaris subspecies cycla). | 2007 | Phytomedicine | pmid:16698256 |
| Numa AM et al. | Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype. | 2007 | Can. J. Physiol. Pharmacol. | pmid:18066130 |
| Yamaguchi M et al. | Effects of flavonoid on calcium content in femoral tissue culture and parathyroid hormone-stimulated osteoclastogenesis in bone marrow culture in vitro. | 2007 | Mol. Cell. Biochem. | pmid:17541507 |
| Nadova S et al. | Flavonoids potentiate the efficacy of cytarabine through modulation of drug-induced apoptosis. | 2007 | Neoplasma | pmid:17447850 |
| Cannac M et al. | The influence of tissue handling on the flavonoid content of the aquatic plant Posidonia oceanica. | 2007 | J. Chem. Ecol. | pmid:17404815 |
| Castillo-Muñoz N et al. | Flavonol profiles of Vitis vinifera red grapes and their single-cultivar wines. | 2007 | J. Agric. Food Chem. | pmid:17263504 |
| Fiorentino A et al. | Reactive oxygen species scavenging activity of flavone glycosides from Melilotus neapolitana. | 2007 | Molecules | pmid:17846577 |
| Liu R et al. | [Inhibitory effect of Isorhamnetin and Hesperidin on LDL oxidation induced by Cu2+]. | 2007 | Zhong Yao Cai | pmid:17918439 |
| Sanchez M et al. | Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta. | 2007 | J. Nutr. | pmid:17374653 |
| Ma G et al. | The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells. | 2007 | Chem. Biol. Interact. | pmid:17368593 |
| Küpeli E and Yesilada E | Flavonoids with anti-inflammatory and antinociceptive activity from Cistus laurifolius L. leaves through bioassay-guided procedures. | 2007 | J Ethnopharmacol | pmid:17540523 |
| Huang XA et al. | [Phytochemical investigation on Lysimachia fortunei]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583199 |
| Park J et al. | Onion flesh and onion peel enhance antioxidant status in aged rats. | 2007 | J. Nutr. Sci. Vitaminol. | pmid:17484375 |
| Franke L et al. | Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. | 2007 | J. Med. Chem. | pmid:17461565 |
| Chawla R et al. | Radioprotective and antioxidant activity of fractionated extracts of berries of Hippophae rhamnoides. | 2007 | J Med Food | pmid:17472473 |
| Tundis R et al. | Inhibitory effects on the digestive enzyme alpha-amylase of three Salsola species (Chenopodiaceae) in vitro. | 2007 | Pharmazie | pmid:17663200 |
| Tamura M et al. | Effect of pectin enhancement on plasma quercetin and fecal flora in rutin-supplemented mice. | 2007 | J. Food Sci. | pmid:18034749 |
| Jiang JS et al. | Potent suppressive effects of 3-O-methylquercetin 5,7,3',4'-O-tetraacetate on ovalbumin-induced airway hyperresponsiveness. | 2007 | Planta Med. | pmid:17823872 |
| Dufour C and Loonis M | Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. | 2007 | Biochim. Biophys. Acta | pmid:17428609 |
| Gray D et al. | Evaluation of a method to determine flavonol aglycones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography: collaborative study. | 2007 Jan-Feb | J AOAC Int | pmid:17373435 |
| Wang D et al. | Preparation and characterization of solid lipid nanoparticles loaded with total flavones of Hippophae rhamnoides (TFH). | 2007 Mar-Apr | PDA J Pharm Sci Technol | pmid:17479719 |
| Vijayaraghavan R et al. | Comparative evaluation of some flavonoids and tocopherol acetate against the systemic toxicity induced by sulphur mustard. | 2008 | Indian J Pharmacol | pmid:20040938 |
| Yang RY et al. | Content and distribution of flavonoids among 91 edible plant species. | 2008 | Asia Pac J Clin Nutr | pmid:18296355 |
| Igarashi K et al. | Comparison of the preventive activity of isorhamnetin glycosides from atsumi-kabu (red turnip, Brassica, campestris L.) leaves on carbon tetrachloride-induced liver injury in mice. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18323640 |
| Babenko NA and Shakhova EG | Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells. | 2008 | Lipids Health Dis | pmid:18226198 |
| Nirmal J et al. | Evaluation of behavioural and antioxidant activity of Cytisus scoparius Link in rats exposed to chronic unpredictable mild stress. | 2008 | BMC Complement Altern Med | pmid:18435835 |
| Zhao Y et al. | Simultaneous determination of ginkgo flavonoids and terpenoids in plasma: ammonium formate in LC mobile phase enhancing electrospray ionization efficiency and capacity. | 2008 | J. Am. Soc. Mass Spectrom. | pmid:18155919 |
| Vukics V et al. | Analysis of heartsease (Viola tricolor L.) flavonoid glycosides by micro-liquid chromatography coupled to multistage mass spectrometry. | 2008 | J Chromatogr A | pmid:18514209 |
| Ye LM et al. | [Determination of isorhamnetin in Hippophae rhamnoides Linn from West Sichuan plateau using near infrared diffuse reflectance spectroscopy]. | 2008 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:18479014 |
| Wang XM et al. | Two new flavonol glycosides from Sarcopyramis bodinieri var. delicate. | 2008 | Molecules | pmid:18596665 |
| Papiez MA et al. | The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats. | 2008 | Food Chem. Toxicol. | pmid:18602965 |
| Paulke A et al. | St. John's wort flavonoids and their metabolites show antidepressant activity and accumulate in brain after multiple oral doses. | 2008 | Pharmazie | pmid:18468390 |
| Olszewska M | Separation of quercetin, sexangularetin, kaempferol and isorhamnetin for simultaneous HPLC determination of flavonoid aglycones in inflorescences, leaves and fruits of three Sorbus species. | 2008 | J Pharm Biomed Anal | pmid:18635332 |
| López-Posadas R et al. | Effect of flavonoids on rat splenocytes, a structure-activity relationship study. | 2008 | Biochem. Pharmacol. | pmid:18590707 |
| Moiteiro C et al. | HPLC quantification of dye flavonoids in Reseda luteola L. from Portugal. | 2008 | J Sep Sci | pmid:19003809 |
| Kong CS et al. | Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells. | 2008 | Toxicol In Vitro | pmid:18715546 |
| Vafeiadou K et al. | Glial metabolism of quercetin reduces its neurotoxic potential. | 2008 | Arch. Biochem. Biophys. | pmid:18675775 |
| Ferreres F et al. | New phenolic compounds and antioxidant potential of Catharanthus roseus. | 2008 | J. Agric. Food Chem. | pmid:18850714 |
| Hanhineva K et al. | Non-targeted analysis of spatial metabolite composition in strawberry (Fragariaxananassa) flowers. | 2008 | Phytochemistry | pmid:18774147 |
| Fuentes-Alventosa JM et al. | Flavonoid profile of green asparagus genotypes. | 2008 | J. Agric. Food Chem. | pmid:18656928 |
| Ameho CK et al. | Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats. | 2008 | J. Nutr. Biochem. | pmid:17904346 |
| Mennen LI et al. | Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects - variability and possible use as biomarkers of polyphenol intake. | 2008 | Eur J Clin Nutr | pmid:17426744 |
| Somerset SM and Johannot L | Dietary flavonoid sources in Australian adults. | 2008 | Nutr Cancer | pmid:18584477 |
| Griesser M et al. | Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle. | 2008 | J. Exp. Bot. | pmid:18487633 |
| Santos MR et al. | Influence of the metabolic profile on the in vivo antioxidant activity of quercetin under a low dosage oral regimen in rats. | 2008 | Br. J. Pharmacol. | pmid:18311191 |
| Silva BB et al. | Chemical composition and botanical origin of red propolis, a new type of brazilian propolis. | 2008 | Evid Based Complement Alternat Med | pmid:18830449 |
| Suzuki H et al. | Metabolic profiling of flavonoids in Lotus japonicus using liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry. | 2008 | Phytochemistry | pmid:17669449 |
| Steffen Y et al. | Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. | 2008 | Arch. Biochem. Biophys. | pmid:17996190 |
| Kim JY et al. | In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18178435 |
| Sobolev VS et al. | Spermidine and flavonoid conjugates from peanut (Arachis hypogaea) flowers. | 2008 | J. Agric. Food Chem. | pmid:18412366 |
| Zeng Z et al. | Recent advances in the compound-oriented and pattern-oriented approaches to the quality control of herbal medicines. | 2008 | Chin Med | pmid:18680568 |