Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wenisch C and Biffignandi PM | Effect of bioflavonoids (trihydroxyethylrutin and disodium flavodate) in vitro on neutrophil reactive oxygen production and phagocytic ability assessed by flow cytometry. | 2001 | Curr Med Res Opin | pmid:11759181 |
| Wu TS et al. | New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris. | 2001 | Bioorg. Med. Chem. | pmid:11197349 |
| Meng Z et al. | Effect of five flavonoid compounds isolated from Quercus dentata Thunb on superoxide generation in human neutrophils and phosphorylation of neutrophil proteins. | 2001 | Clin. Chim. Acta | pmid:11282099 |
| Graefe EU et al. | Pharmacokinetics and bioavailability of quercetin glycosides in humans. | 2001 | J Clin Pharmacol | pmid:11361045 |
| Lou H et al. | Alkaloids and flavonoids from peanut skins. | 2001 | Planta Med. | pmid:11458452 |
| Li B et al. | [The effects of quercetin and isorhamnetin on oxidative modification of VLDL induced by Cu2+]. | 2001 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:12600108 |
| Sharaf M et al. | Two flavonol 5-O-glycosides from the roots of Leuzea carthamoides. | 2001 | Fitoterapia | pmid:11731123 |
| Cermak R et al. | The impact of different flavonoid classes on colonic CI- secretion in rats. | 2001 | Biochem. Pharmacol. | pmid:11597584 |
| Calzada F et al. | Antiprotozoal activity of the constituents of Conyza filaginoides. | 2001 | J. Nat. Prod. | pmid:11374974 |
| Sikorska M and Matławska I | Kaempferol, isorhamnetin and their glycosides in the flowers of Asclepias syriaca L. | 2001 Jul-Aug | Acta Pol Pharm | pmid:11693731 |
| Nazaruk J and Gudej J | Qualitative and quantitative chromatographic investigation of flavonoids in Bellis perennis L. | 2001 Sep-Oct | Acta Pol Pharm | pmid:11876448 |
| Ko WC et al. | Mechanisms of relaxant action of 3-O-methylquercetin in isolated guinea pig trachea. | 2002 | Planta Med. | pmid:11842323 |
| Lin WH et al. | Polyphenolic compounds from the leaves of Koelreuteria paniculata Laxm. | 2002 | J Asian Nat Prod Res | pmid:12450257 |
| Lu J et al. | Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils. | 2002 | Clin. Chim. Acta | pmid:11750278 |
| Choi JS et al. | Further isolation of peroxynitrite and 1,1-diphenyl-2-picrylhydrazyl radical scavenging isorhamnetin 7-O-glucoside from the leaves of Brassica juncea L. | 2002 | Arch. Pharm. Res. | pmid:12433194 |
| Yoshikawa M et al. | New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Prunus mume. | 2002 | J. Nat. Prod. | pmid:12193020 |
| Li W and Fitzloff JF | Simultaneous determination of terpene lactones and flavonoid aglycones in Ginkgo biloba by high-performance liquid chromatography with evaporative light scattering detection. | 2002 | J Pharm Biomed Anal | pmid:12151066 |
| el-Mousallami AM et al. | Acylated flavonol diglucosides from Lotus polyphyllos. | 2002 | Phytochemistry | pmid:12150804 |
| Sasaki K and Takahashi T | A flavonoid from Brassica rapa flower as the UV-absorbing nectar guide. | 2002 | Phytochemistry | pmid:12359520 |
| Cantos E et al. | Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS. | 2002 | J. Agric. Food Chem. | pmid:12236700 |