Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen X et al. | [Applications of two-dimensional liquid chromatography coupled to mass spectrometry for the separation and identification of compounds in ginkgo biloba extracts]. | 2005 | Se Pu | pmid:15881366 |
| Wang Y et al. | Simultaneous determination of quercetin, kaempferol and isorhamnetin accumulated human breast cancer cells, by high-performance liquid chromatography. | 2005 | J Pharm Biomed Anal | pmid:15905060 |
| Wang Y et al. | Involvement of P-glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin. | 2005 | J. Pharm. Pharmacol. | pmid:15969930 |
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| Hibasami H et al. | Isolation of five types of flavonol from seabuckthorn (Hippophae rhamnoides) and induction of apoptosis by some of the flavonols in human promyelotic leukemia HL-60 cells. | 2005 | Int. J. Mol. Med. | pmid:15806302 |
| van Zanden JJ et al. | Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2. | 2005 | Biochem. Pharmacol. | pmid:15670588 |
| Oh HM et al. | Inhibitory activity of isorhamnetin from Persicaria thunbergii on Farnesyl Protein Transferase. | 2005 | Arch. Pharm. Res. | pmid:15789745 |
| Brusselmans K et al. | Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. | 2005 | J. Biol. Chem. | pmid:15533929 |
| Zhang Y and Zhao YM | [Studies on the chemical constituents in seeds of Atriplex centralasiatica]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16075733 |
| Zhang Q and Cui H | Simultaneous determination of quercetin, kaempferol, and isorhamnetin in phytopharmaceuticals of Hippophae rhamnoides L. by high-performance liquid chromatography with chemiluminescence detection. | 2005 | J Sep Sci | pmid:16116994 |
| Schulz HU et al. | Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. | 2005 | Arzneimittelforschung | pmid:15727160 |
| Lee YS et al. | Inhibitory effects of isorhamnetin-3-O-beta-D-glucoside from Salicornia herbacea on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. | 2005 | Biol. Pharm. Bull. | pmid:15863906 |
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| Olszewska M | High-performance liquid chromatographic identification of flavonoid monoglycosides from Prunus serotina ehrh. | 2005 Nov-Dec | Acta Pol Pharm | pmid:16583982 |
| Gray DE et al. | Simultaneous quantification of terpenelactones and flavonol aglycones in hydrolyzed ginkgo biloba extract by liquid chromatography with inline ultraviolet and evaporative light scattering detection. | 2005 Nov-Dec | J AOAC Int | pmid:16526440 |
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| Hubbard GP et al. | Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. | 2006 | Br. J. Nutr. | pmid:16925853 |
| Romani A et al. | HPLC-DAD/MS characterization of flavonoids and hydroxycinnamic derivatives in turnip tops (Brassica rapa L. Subsp. sylvestris L.). | 2006 | J. Agric. Food Chem. | pmid:16478258 |
| Dragoni S et al. | Red wine alcohol promotes quercetin absorption and directs its metabolism towards isorhamnetin and tamarixetin in rat intestine in vitro. | 2006 | Br. J. Pharmacol. | pmid:16444288 |
| Ding S et al. | Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry. | 2006 | Rapid Commun. Mass Spectrom. | pmid:16921563 |
| Shukla SK et al. | Protection from radiation-induced mitochondrial and genomic DNA damage by an extract of Hippophae rhamnoides. | 2006 | Environ. Mol. Mutagen. | pmid:16948057 |
| Bao M and Lou Y | Flavonoids from seabuckthorn protect endothelial cells (EA.hy926) from oxidized low-density lipoprotein induced injuries via regulation of LOX-1 and eNOS expression. | 2006 | J. Cardiovasc. Pharmacol. | pmid:16891912 |
| Zu Y et al. | Simultaneous determination of catechin, rutin, quercetin kaempferol and isorhamnetin in the extract of sea buckthorn (Hippophae rhamnoides L.) leaves by RP-HPLC with DAD. | 2006 | J Pharm Biomed Anal | pmid:16520013 |
| Mennen LI et al. | Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods. | 2006 | Br. J. Nutr. | pmid:16870009 |
| Milbury PE et al. | Determination of flavonoids and phenolics and their distribution in almonds. | 2006 | J. Agric. Food Chem. | pmid:16819912 |
| Lim SS et al. | Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera stamens. | 2006 | Phytother Res | pmid:16881021 |
| Innocenti G et al. | Cytotoxic constituents from Anagyris foetida leaves. | 2006 | Fitoterapia | pmid:16887297 |
| Dubber MJ and Kanfer I | Application of reverse-flow micellar electrokinetic chromatography for the simultaneous determination of flavonols and terpene trilactones in Ginkgo biloba dosage forms. | 2006 | J Chromatogr A | pmid:16720026 |
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| Saleem M et al. | Secondary metabolites from Opuntia ficus-indica var. saboten. | 2006 | Phytochemistry | pmid:16762382 |
| Tian X et al. | The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O-beta-D-xylopyranosyl-(1-6) -beta-D-glucopyranoside in the human intestinal cell line caco-2. | 2006 | Pharm. Res. | pmid:16832612 |