Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guo R et al. | Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophaë rhamnoides L.) berries. | 2017 | Food Chem | pmid:27979305 |
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| Mudrić SŽ et al. | The polyphenolics and carbohydrates as indicators of botanical and geographical origin of Serbian autochthonous clones of red spice paprika. | 2017 | Food Chem | pmid:27664689 |
| Ferreres F et al. | HPLC-DAD-ESI/MS(n) profiling of phenolic compounds from Lathyrus cicera L. seeds. | 2017 | Food Chem | pmid:27507525 |
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| Yang JH et al. | O-Methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-κB activation. | 2013 | Food Chem. Toxicol. | pmid:23774260 |
| Sabini MC et al. | Evaluation of the cytotoxicity, genotoxicity and apoptotic induction of an aqueous extract of Achyrocline satureioides (Lam.) DC. | 2013 | Food Chem. Toxicol. | pmid:23948353 |
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| Kong CS et al. | Protective effect of isorhamnetin 3-O-beta-D-glucopyranoside from Salicornia herbacea against oxidation-induced cell damage. | 2009 | Food Chem. Toxicol. | pmid:19445998 |
| Sarić A et al. | Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen. | 2009 | Food Chem. Toxicol. | pmid:19124059 |
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| Duan J et al. | Transport characteristics of isorhamnetin across intestinal Caco-2 cell monolayers and the effects of transporters on it. | 2014 | Food Chem. Toxicol. | pmid:24525098 |
| Lee-Hilz YY et al. | Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation. | 2008 | Food Chem. Toxicol. | pmid:18375031 |
| Jimenez R et al. | Quercetin and its metabolites inhibit the membrane NADPH oxidase activity in vascular smooth muscle cells from normotensive and spontaneously hypertensive rats. | 2015 | Food Funct | pmid:25562607 |
| RodrÃguez-RodrÃguez C et al. | The effect of isorhamnetin glycosides extracted from Opuntia ficus-indica in a mouse model of diet induced obesity. | 2015 | Food Funct | pmid:25588195 |
| Surco-Laos F et al. | Effects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans. | 2011 | Food Funct | pmid:21776484 |
| Spencer JP et al. | Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts. | 2001 | Free Radic. Biol. Med. | pmid:11677047 |
| Cornish KM et al. | Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. | 2002 | Free Radic. Biol. Med. | pmid:12086683 |
| Ader P et al. | Bioavailability and metabolism of the flavonol quercetin in the pig. | 2000 | Free Radic. Biol. Med. | pmid:10832067 |
| Lotito SB et al. | Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. | 2011 | Free Radic. Biol. Med. | pmid:21571063 |
| Sugihara N et al. | Synergistic effects of flavonoids and ascorbate on enhancement in DNA degradation induced by a bleomycin-Fe complex. | 2005 | Free Radic. Res. | pmid:15788228 |
| Young JM et al. | Comparative effects of enzogenol and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers. | 2006 | Free Radic. Res. | pmid:16298763 |
| Choi YH | The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation. | 2016 | Gen. Physiol. Biophys. | pmid:26830132 |
| Zhao TT et al. | Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes. | 2018 | Gene | pmid:29730426 |
| Khaleghi S et al. | Microarray analysis revealed different gene expression patterns in HepG2 cells treated with low and high concentrations of the extracts of Anacardium occidentale shoots. | 2011 | Genes Nutr | pmid:21484159 |
| Chen JH et al. | Estrogenic effects of flavonoid components in Xiaoyao powder. | 2016 | Genet. Mol. Res. | pmid:26909969 |
| Ren G et al. | Synthesis of flavonol 3-O-glycoside by UGT78D1. | 2012 | Glycoconj. J. | pmid:22767031 |
| Ye LM et al. | [Determination of isorhamnetin in Hippophae rhamnoides Linn from West Sichuan plateau using near infrared diffuse reflectance spectroscopy]. | 2008 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:18479014 |
| TAPPI G and KARRER P | [Not Available]. | 1949 | Helv. Chim. Acta | pmid:18115960 |
| Li B et al. | [The effects of quercetin and isorhamnetin on oxidative modification of VLDL induced by Cu2+]. | 2001 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:12600108 |
| Kong CS and Seo Y | Antiadipogenic activity of isohamnetin 3-O-β-D-glucopyranoside from Salicornia herbacea. | 2012 | Immunopharmacol Immunotoxicol | pmid:22978277 |
| Kandaswami C et al. | The antitumor activities of flavonoids. | 2005 Sep-Oct | In Vivo | pmid:16097445 |
| Vijayaraghavan R et al. | Comparative evaluation of some flavonoids and tocopherol acetate against the systemic toxicity induced by sulphur mustard. | 2008 | Indian J Pharmacol | pmid:20040938 |
| Bhagwat DP et al. | Immunosuppressive properties of Pluchea lanceolata leaves. | 2010 | Indian J Pharmacol | pmid:20606832 |
| Chi G et al. | Isorhamnetin protects mice from lipopolysaccharide-induced acute lung injury via the inhibition of inflammatory responses. | 2016 | Inflamm. Res. | pmid:26525359 |
| Seo K et al. | The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1. | 2014 | Inflammation | pmid:24337631 |
| Lindahl M and Tagesson C | Flavonoids as phospholipase A2 inhibitors: importance of their structure for selective inhibition of group II phospholipase A2. | 1997 | Inflammation | pmid:9246576 |
| Li Y et al. | Isorhamnetin ameliorates LPS-induced inflammatory response through downregulation of NF-κB signaling. | 2016 | Inflammation | pmid:27138362 |
| Yang B et al. | Protective Effect of Isorhamnetin on Lipopolysaccharide-Induced Acute Lung Injury in Mice. | 2016 | Inflammation | pmid:26276127 |
| Chen TL et al. | Protective effects of isorhamnetin on apoptosis and inflammation in TNF-α-induced HUVECs injury. | 2015 | Int J Clin Exp Pathol | pmid:26045738 |
| Zhang BY et al. | Isorhamnetin flavonoid synergistically enhances the anticancer activity and apoptosis induction by cis-platin and carboplatin in non-small cell lung carcinoma (NSCLC). | 2015 | Int J Clin Exp Pathol | pmid:25755690 |
| Arimboor R and Arumughan C | HPLC-DAD-MS/MS profiling of antioxidant flavonoid glycosides in sea buckthorn (Hippophae rhamnoides L.) seeds. | 2012 | Int J Food Sci Nutr | pmid:22264152 |
| Butryee C et al. | Effect of processing on the flavonoid content and antioxidant capacity of Citrus hystrix leaf. | 2009 | Int J Food Sci Nutr | pmid:19572229 |
| Bakır T et al. | Antioxidant/prooxidant effects of α-tocopherol, quercetin and isorhamnetin on linoleic acid peroxidation induced by Cu(II) and H2O2. | 2014 | Int J Food Sci Nutr | pmid:24152374 |
| Antunes-Ricardo M et al. | Bioaccessibility, Intestinal Permeability and Plasma Stability of Isorhamnetin Glycosides from Opuntia ficus-indica (L.). | 2017 | Int J Mol Sci | pmid:28829356 |