Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sundararajan R et al. | Cytisus scoparius link--a natural antioxidant. | 2006 | BMC Complement Altern Med | pmid:16542432 |
| Suomela JP et al. | Absorption of flavonols derived from sea buckthorn (Hippophaë rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans. | 2006 | J. Agric. Food Chem. | pmid:16968106 |
| Phadungkit M and Luanratana O | Anti-Salmonella activity of constituents of Ardisia elliptica Thunb. | 2006 | Nat. Prod. Res. | pmid:16901814 |
| Shin YM et al. | Transgenic rice lines expressing maize C1 and R-S regulatory genes produce various flavonoids in the endosperm. | 2006 | Plant Biotechnol. J. | pmid:17147636 |
| Bao M and Lou Y | Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK. | 2006 | Eur. J. Pharmacol. | pmid:16963021 |
| Grimm T et al. | Single and multiple dose pharmacokinetics of maritime pine bark extract (pycnogenol) after oral administration to healthy volunteers. | 2006 | BMC Clin Pharmacol | pmid:16887024 |
| Yue ME and Shi YP | Application of 1-alkyl-3-methylimidazolium-based ionic liquids in separation of bioactive flavonoids by capillary zone electrophoresis. | 2006 | J Sep Sci | pmid:16524102 |
| Lall N et al. | Antiviral and antituberculous activity of Helichrysum melanacme constituents. | 2006 | Fitoterapia | pmid:16529879 |
| Wang YJ et al. | [Quality standard for Xindi soft capsule]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16780155 |
| Rochfort SJ et al. | Characterization of flavonol conjugates in immature leaves of pak choi [Brassica rapa L. Ssp. chinensis L. (Hanelt.)] by HPLC-DAD and LC-MS/MS. | 2006 | J. Agric. Food Chem. | pmid:16787039 |
| Teng BS et al. | In vitro anti-tumor activity of isorhamnetin isolated from Hippophae rhamnoides L. against BEL-7402 cells. | 2006 | Pharmacol. Res. | pmid:16765054 |
| Hyun SK et al. | Isorhamnetin glycosides with free radical and ONOO-scavenging activities from the stamens of Nelumbo nucifera. | 2006 | Arch. Pharm. Res. | pmid:16681033 |
| Routaboul JM et al. | Flavonoid diversity and biosynthesis in seed of Arabidopsis thaliana. | 2006 | Planta | pmid:16395586 |
| Ma B et al. | Integrated isotachophoretic preconcentration with zone electrophoresis separation on a quartz microchip for UV detection of flavonoids. | 2006 | Electrophoresis | pmid:17117378 |
| Yeskaliyeva B et al. | Bioactive flavonoids and saponins from Climacoptera obtusifolia. | 2006 | Phytochemistry | pmid:16956629 |
| Bennett RN et al. | Ontogenic profiling of glucosinolates, flavonoids, and other secondary metabolites in Eruca sativa (salad rocket), Diplotaxis erucoides (wall rocket), Diplotaxis tenuifolia (wild rocket), and Bunias orientalis (Turkish rocket). | 2006 | J. Agric. Food Chem. | pmid:16719527 |
| de Beer D et al. | Unravelling the total antioxidant capacity of pinotage wines: contribution of phenolic compounds. | 2006 | J. Agric. Food Chem. | pmid:16608206 |
| Paulke A et al. | Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16434241 |
| Wijeratne SS et al. | Antioxidant polyphenols in almond and its coproducts. | 2006 | J. Agric. Food Chem. | pmid:16417285 |
| Shang XY et al. | Acetylated flavonol diglucosides from Meconopsis quintuplinervia. | 2006 | Phytochemistry | pmid:16412484 |
| Nikolova M and Asenov A | Surface flavonoid aglycones in newly studied plant species. | 2006 | Nat. Prod. Res. | pmid:16286319 |
| Chang TK et al. | Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes. | 2006 | Drug Metab. Dispos. | pmid:16258077 |
| Rajaraman G et al. | Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes. | 2006 | Toxicol. Appl. Pharmacol. | pmid:17045319 |
| Mattivi F et al. | Metabolite profiling of grape: Flavonols and anthocyanins. | 2006 | J. Agric. Food Chem. | pmid:17002441 |
| Sembries S et al. | Physiological effects of extraction juices from apple, grape, and red beet pomaces in rats. | 2006 | J. Agric. Food Chem. | pmid:17177570 |
| Mu LH and Zhang DM | [Studies on chemical constituents of Cercis chinensis]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17260796 |
| Chang TK et al. | Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16226778 |
| Jiang JS et al. | Mechanisms of suppression of nitric oxide production by 3-O-methylquercetin in RAW 264.7 cells. | 2006 | J Ethnopharmacol | pmid:16213685 |
| Küpeli E et al. | Effect of Cistus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice. | 2006 | J Ethnopharmacol | pmid:16216454 |
| Young JM et al. | Comparative effects of enzogenol and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers. | 2006 | Free Radic. Res. | pmid:16298763 |
| Lan K et al. | Quantitative determination of isorhamnetin, quercetin and kaempferol in rat plasma by liquid chromatography with electrospray ionization tandem mass spectrometry and its application to the pharmacokinetic study of isorhamnetin. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17154349 |
| Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
| Slimestad R et al. | Onions: a source of unique dietary flavonoids. | 2007 | J. Agric. Food Chem. | pmid:17997520 |
| Curir P et al. | Pavietin, a coumarin from Aesculus pavia with antifungal activity. | 2007 | J. Nat. Prod. | pmid:17914881 |
| Harbaum B et al. | Identification of flavonoids and hydroxycinnamic acids in pak choi varieties (Brassica campestris L. ssp. chinensis var. communis) by HPLC-ESI-MSn and NMR and their quantification by HPLC-DAD. | 2007 | J. Agric. Food Chem. | pmid:17848079 |
| Dongmo AB et al. | Flavonoids from Acacia pennata and their cyclooxygenase (COX-1 and COX-2) inhibitory activities. | 2007 | Planta Med. | pmid:17823873 |
| Fico G et al. | Comparative phytochemical and morphological analyses of three Italian Primula species. | 2007 | Phytochemistry | pmid:17544462 |
| Luo M et al. | Separation and determination of flavonoids in Lamiophlomis rotata by capillary electrophoresis using borate as electrolyte. | 2007 | J Pharm Biomed Anal | pmid:17512689 |
| Sayed HM et al. | A new steroid glycoside and furochromones from Cyperus rotundus L. | 2007 | Nat. Prod. Res. | pmid:17479423 |
| Chen C et al. | High-performance liquid chromatographic fingerprint analysis for different origins of sea buckthorn berries. | 2007 | J Chromatogr A | pmid:17449044 |
| Ninfali P et al. | Characterization and biological activity of the main flavonoids from Swiss Chard (Beta vulgaris subspecies cycla). | 2007 | Phytomedicine | pmid:16698256 |
| Numa AM et al. | Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype. | 2007 | Can. J. Physiol. Pharmacol. | pmid:18066130 |
| Yamaguchi M et al. | Effects of flavonoid on calcium content in femoral tissue culture and parathyroid hormone-stimulated osteoclastogenesis in bone marrow culture in vitro. | 2007 | Mol. Cell. Biochem. | pmid:17541507 |
| Nadova S et al. | Flavonoids potentiate the efficacy of cytarabine through modulation of drug-induced apoptosis. | 2007 | Neoplasma | pmid:17447850 |
| Liu R et al. | [Inhibitory effect of Isorhamnetin and Hesperidin on LDL oxidation induced by Cu2+]. | 2007 | Zhong Yao Cai | pmid:17918439 |
| Sanchez M et al. | Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta. | 2007 | J. Nutr. | pmid:17374653 |
| Ma G et al. | The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells. | 2007 | Chem. Biol. Interact. | pmid:17368593 |
| Küpeli E and Yesilada E | Flavonoids with anti-inflammatory and antinociceptive activity from Cistus laurifolius L. leaves through bioassay-guided procedures. | 2007 | J Ethnopharmacol | pmid:17540523 |
| Huang XA et al. | [Phytochemical investigation on Lysimachia fortunei]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583199 |
| Dufour C and Loonis M | Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. | 2007 | Biochim. Biophys. Acta | pmid:17428609 |