Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Azuma K et al. | Lowering effects of onion intake on oxidative stress biomarkers in streptozotocin-induced diabetic rats. | 2007 | J Clin Biochem Nutr | pmid:18188415 |
| Stracke R et al. | Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling. | 2007 | Plant J. | pmid:17419845 |
| Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
| Choi CW et al. | Antioxidant constituents and a new triterpenoid glycoside from Flos Lonicerae. | 2007 | Arch. Pharm. Res. | pmid:17328234 |
| Chen C et al. | High-performance liquid chromatographic fingerprint analysis for different origins of sea buckthorn berries. | 2007 | J Chromatogr A | pmid:17449044 |
| Flamini G | Flavonoids and other compounds from the aerial parts of Viola etrusca. | 2007 | Chem. Biodivers. | pmid:17311226 |
| Zhao Y et al. | A sensitive method for the detection and quantification of ginkgo flavonols from plasma. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17300134 |
| Kim JH and Mullin CA | An isorhamnetin rhamnoglycoside serves as a costimulant for sugars and amino acids in feeding responses of adult western corn rootworms (Diabrotica virgifera virgifera) to corn (Zea mays) pollen. | 2007 | J. Chem. Ecol. | pmid:17268822 |
| Rigano D et al. | Antibacterial activity of flavonoids and phenylpropanoids from Marrubium globosum ssp. libanoticum. | 2007 | Phytother Res | pmid:17186490 |
| Nadova S et al. | Flavonoids potentiate the efficacy of cytarabine through modulation of drug-induced apoptosis. | 2007 | Neoplasma | pmid:17447850 |
| Cannac M et al. | The influence of tissue handling on the flavonoid content of the aquatic plant Posidonia oceanica. | 2007 | J. Chem. Ecol. | pmid:17404815 |
| Castillo-Muñoz N et al. | Flavonol profiles of Vitis vinifera red grapes and their single-cultivar wines. | 2007 | J. Agric. Food Chem. | pmid:17263504 |
| Fiorentino A et al. | Reactive oxygen species scavenging activity of flavone glycosides from Melilotus neapolitana. | 2007 | Molecules | pmid:17846577 |
| Chawla R et al. | Radioprotective and antioxidant activity of fractionated extracts of berries of Hippophae rhamnoides. | 2007 | J Med Food | pmid:17472473 |
| Tundis R et al. | Inhibitory effects on the digestive enzyme alpha-amylase of three Salsola species (Chenopodiaceae) in vitro. | 2007 | Pharmazie | pmid:17663200 |
| Tamura M et al. | Effect of pectin enhancement on plasma quercetin and fecal flora in rutin-supplemented mice. | 2007 | J. Food Sci. | pmid:18034749 |
| Jiang JS et al. | Potent suppressive effects of 3-O-methylquercetin 5,7,3',4'-O-tetraacetate on ovalbumin-induced airway hyperresponsiveness. | 2007 | Planta Med. | pmid:17823872 |
| Dufour C and Loonis M | Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. | 2007 | Biochim. Biophys. Acta | pmid:17428609 |
| Gray D et al. | Evaluation of a method to determine flavonol aglycones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography: collaborative study. | 2007 Jan-Feb | J AOAC Int | pmid:17373435 |
| Wang D et al. | Preparation and characterization of solid lipid nanoparticles loaded with total flavones of Hippophae rhamnoides (TFH). | 2007 Mar-Apr | PDA J Pharm Sci Technol | pmid:17479719 |
| Vijayaraghavan R et al. | Comparative evaluation of some flavonoids and tocopherol acetate against the systemic toxicity induced by sulphur mustard. | 2008 | Indian J Pharmacol | pmid:20040938 |
| Yang RY et al. | Content and distribution of flavonoids among 91 edible plant species. | 2008 | Asia Pac J Clin Nutr | pmid:18296355 |
| Igarashi K et al. | Comparison of the preventive activity of isorhamnetin glycosides from atsumi-kabu (red turnip, Brassica, campestris L.) leaves on carbon tetrachloride-induced liver injury in mice. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18323640 |
| Babenko NA and Shakhova EG | Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells. | 2008 | Lipids Health Dis | pmid:18226198 |
| Nirmal J et al. | Evaluation of behavioural and antioxidant activity of Cytisus scoparius Link in rats exposed to chronic unpredictable mild stress. | 2008 | BMC Complement Altern Med | pmid:18435835 |
| Zhao Y et al. | Simultaneous determination of ginkgo flavonoids and terpenoids in plasma: ammonium formate in LC mobile phase enhancing electrospray ionization efficiency and capacity. | 2008 | J. Am. Soc. Mass Spectrom. | pmid:18155919 |
| Vukics V et al. | Analysis of heartsease (Viola tricolor L.) flavonoid glycosides by micro-liquid chromatography coupled to multistage mass spectrometry. | 2008 | J Chromatogr A | pmid:18514209 |
| Ye LM et al. | [Determination of isorhamnetin in Hippophae rhamnoides Linn from West Sichuan plateau using near infrared diffuse reflectance spectroscopy]. | 2008 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:18479014 |
| Lee SU et al. | Flavonoid content in fresh, home-processed, and light-exposed onions and in dehydrated commercial onion products. | 2008 | J. Agric. Food Chem. | pmid:18759442 |
| Moiteiro C et al. | HPLC quantification of dye flavonoids in Reseda luteola L. from Portugal. | 2008 | J Sep Sci | pmid:19003809 |
| Ferreres F et al. | New phenolic compounds and antioxidant potential of Catharanthus roseus. | 2008 | J. Agric. Food Chem. | pmid:18850714 |
| Lodi F et al. | Glucuronidated metabolites of the flavonoid quercetin do not auto-oxidise, do not generate free radicals and do not decrease nitric oxide bioavailability. | 2008 | Planta Med. | pmid:18484521 |
| Hanhineva K et al. | Non-targeted analysis of spatial metabolite composition in strawberry (Fragariaxananassa) flowers. | 2008 | Phytochemistry | pmid:18774147 |
| An RB et al. | In vitro hepatoprotective compounds from Suaeda glauca. | 2008 | Arch. Pharm. Res. | pmid:18481014 |
| Ameho CK et al. | Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats. | 2008 | J. Nutr. Biochem. | pmid:17904346 |
| Rao YK et al. | Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from Bauhinia variegata. | 2008 | Phytother Res | pmid:18384188 |
| Cao X et al. | Stationary phase retention and preliminary application of a spiral disk assembly designed for high-speed counter-current chromatography. | 2008 | J Chromatogr A | pmid:18339394 |
| MartÃnez-Sánchez A et al. | A comparative study of flavonoid compounds, vitamin C, and antioxidant properties of baby leaf Brassicaceae species. | 2008 | J. Agric. Food Chem. | pmid:18321050 |
| Winter TR and Rostás M | Ambient ultraviolet radiation induces protective responses in soybean but does not attenuate indirect defense. | 2008 | Environ. Pollut. | pmid:18166253 |
| Mennen LI et al. | Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects - variability and possible use as biomarkers of polyphenol intake. | 2008 | Eur J Clin Nutr | pmid:17426744 |
| Sharma UK et al. | Microwave-assisted efficient extraction of different parts of Hippophae rhamnoides for the comparative evaluation of antioxidant activity and quantification of its phenolic constituents by reverse-phase high-performance liquid chromatography (RP-HPLC). | 2008 | J. Agric. Food Chem. | pmid:18163559 |
| Liu AL et al. | Study of the electrochemical behavior of isorhamnetin on a glassy carbon electrode and its application. | 2008 | Talanta | pmid:18804639 |
| Lan K et al. | Intra-herb pharmacokinetics interaction between quercetin and isorhamentin. | 2008 | Acta Pharmacol. Sin. | pmid:18954533 |
| Griesser M et al. | Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle. | 2008 | J. Exp. Bot. | pmid:18487633 |
| Santos MR et al. | Influence of the metabolic profile on the in vivo antioxidant activity of quercetin under a low dosage oral regimen in rats. | 2008 | Br. J. Pharmacol. | pmid:18311191 |
| Silva BB et al. | Chemical composition and botanical origin of red propolis, a new type of brazilian propolis. | 2008 | Evid Based Complement Alternat Med | pmid:18830449 |
| Suzuki H et al. | Metabolic profiling of flavonoids in Lotus japonicus using liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry. | 2008 | Phytochemistry | pmid:17669449 |
| Steffen Y et al. | Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. | 2008 | Arch. Biochem. Biophys. | pmid:17996190 |
| Lee-Hilz YY et al. | Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation. | 2008 | Food Chem. Toxicol. | pmid:18375031 |
| Zeng Z et al. | Recent advances in the compound-oriented and pattern-oriented approaches to the quality control of herbal medicines. | 2008 | Chin Med | pmid:18680568 |