Isorhamnetin is a lipid of Polyketides (PK) class. Isorhamnetin is associated with abnormalities such as Facial Hemiatrophy, Colitis, endothelial dysfunction, Morphologically altered structure and Diabetes. The involved functions are known as enzyme activity, Methylation, Anabolism, Binding (Molecular Function) and Vmax. Isorhamnetin often locates in Body tissue, Cytoplasmic, Mucous Membrane, Cytoplasm and Human tissue. The associated genes with Isorhamnetin are CSK gene, RPS6KA3 gene, Mitogen-activated protein, NCF1 gene and Chromatin. The related lipids are Fatty Acids, Phosphatidylserines and Palmitates. The related experimental models are Mouse Model, Xenograft Model and Streptozotocin Diabetes.
To understand associated biological information of Isorhamnetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Isorhamnetin is suspected in Colitis, endothelial dysfunction, Morphologically altered structure, Facial Hemiatrophy, Diabetes, Hemorrhagic diarrhea and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Isorhamnetin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.' (Saud SM et al., 2013).
Xenograft Model are used in the study 'Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.' (Ramachandran L et al., 2012).
Streptozotocin Diabetes are used in the study 'Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.' (Dou W et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dai DZ and Dai Y | Role of endothelin receptor A and NADPH oxidase in vascular abnormalities. | 2010 | Vasc Health Risk Manag | pmid:20859547 |
| Ku SK et al. | Anticoagulant activities of persicarin and isorhamnetin. | 2013 | Vascul. Pharmacol. | pmid:23391847 |
| An D et al. | [HPLC-MS analysis of quercetin and its metabolites in portal vein after intragastrical administration of quercetin in rats]. | 2009 | Wei Sheng Yan Jiu | pmid:19689070 |
| Ding LL et al. | [Effects of isorhamnetin on CYP3A4 and herb-drug interaction]. | 2012 | Yao Xue Xue Bao | pmid:23162896 |
| Yang Y et al. | Studies on the chemical constituents of Anabasis aphylla L. | 2010 | Yao Xue Xue Bao | pmid:21348421 |
| Zhu M et al. | [Ginkgo flavones in in vitro metabolism and its clinical application]. | 2003 | Yao Xue Xue Bao | pmid:15040090 |
| Jiang LD et al. | [Study on determination and pharmacokinetics of metabolites from Folium Mori extract in rats]. | 2011 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:21845753 |
| Weng S and Lian J | [Determination of isorhamnetine and quercetin in flavone hippophaes tablets by HPLC method]. | 2001 | Zhong Yao Cai | pmid:11917852 |
| Song HJ et al. | [Studies on the chemical constituents from Rhododendron delavayi]. | 2009 | Zhong Yao Cai | pmid:20432898 |
| Liu R et al. | [Inhibitory effect of Isorhamnetin and Hesperidin on LDL oxidation induced by Cu2+]. | 2007 | Zhong Yao Cai | pmid:17918439 |