quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Neuroma D009463 1 associated lipids
Encephalitis, Arbovirus D004671 1 associated lipids
Neurofibromatoses D017253 1 associated lipids
Heat Stroke D018883 1 associated lipids
Post-Concussion Syndrome D038223 1 associated lipids
Prenatal Exposure Delayed Effects D011297 2 associated lipids
Enterovirus Infections D004769 2 associated lipids
Choroid Diseases D015862 2 associated lipids
CREST Syndrome D017675 2 associated lipids
Alcohol-Induced Disorders, Nervous System D020268 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Authors Title Published Journal PubMed Link
Walkowiak A et al. Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. 2019 Spectrochim Acta A Mol Biomol Spectrosc pmid:30321862
Maurya AK and Vinayak M Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. 2019 In Vitro Cell. Dev. Biol. Anim. pmid:30413935
Li J et al. Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. 2019 Chem. Biol. Interact. pmid:30365939
Mu Y et al. Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. 2019 Carbohydr Polym pmid:30318192
Li F et al. The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. 2019 Pest Manag. Sci. pmid:29797492
Schröder L et al. Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. 2019 Oncol. Rep. pmid:30320348
Bustos AS et al. Interaction Between Phenolic Compounds and Lipase: The Influence of Solubility and Presence of Particles in the IC Value. 2018 J. Food Sci. pmid:30020550
Liu Y et al. Light quality affects flavonoid production and related gene expression in Cyclocarya paliurus. 2018 J. Photochem. Photobiol. B, Biol. pmid:29334625
Wang D et al. Quercetin attenuates domoic acid-induced cognitive deficits in mice. 2018 Nutr Neurosci pmid:28277184
Kinger M et al. Some Important Dietary Polyphenolic Compounds: An Anti-inflammatory and Immunoregulatory Perspective. 2018 Mini Rev Med Chem pmid:28183265
Khlupova ME et al. Laccase-Catalyzed Heterocoupling of Dihydroquercetin and p-Aminobenzoic Acid: Effect of the Reaction Product on Cultured Cells. 2018 Biochemistry Mosc. pmid:30208835
Ashraf AHMZ et al. Differential Mechanism of Action of 3,4',7-O-trimethylquercetin in Three Types of Ovarian Cancer Cells. 2018 Anticancer Res. pmid:30194160
Rubio V et al. Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells. 2018 Chem. Biol. Interact. pmid:30171828
Huang ZQ et al. Antioxidant Activity and Hepatoprotective Potential of Quercetin 7-Rhamnoside In Vitro and In Vivo. 2018 Molecules pmid:29772655
Omar SH et al. Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.). 2018 Fitoterapia pmid:29772299
Qi F et al. Anti-inflammatory effects of isorhamnetin on LPS-stimulated human gingival fibroblasts by activating Nrf2 signaling pathway. 2018 Microb. Pathog. pmid:29704670
Pilařová V et al. Simultaneous determination of quercetin and its metabolites in rat plasma by using ultra-high performance liquid chromatography tandem mass spectrometry. 2018 Talanta pmid:29759252
Lu X et al. Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice. 2018 Biomed. Pharmacother. pmid:29684859
Liu FC et al. Arthroprotective Effects of Cf-02 Sharing Structural Similarity with Quercetin. 2018 Int J Mol Sci pmid:29757957
Kumar M et al. N-desmethyl tamoxifen and quercetin-loaded multiwalled CNTs: A synergistic approach to overcome MDR in cancer cells. 2018 Mater Sci Eng C Mater Biol Appl pmid:29752099
Niu X et al. Three-dimensional reduced graphene oxide aerogel modified electrode for the sensitive quercetin sensing and its application. 2018 Mater Sci Eng C Mater Biol Appl pmid:29752093
Chen Z et al. Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells. 2018 Phytomedicine pmid:29747752
Å ola I et al. Comparative Analysis of Native Crocus Taxa as a Great Source of Flavonoids with High Antioxidant Activity. 2018 Plant Foods Hum Nutr pmid:29860648
Negi S et al. Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. 2018 Toxicol In Vitro pmid:29933105
Jin UH et al. Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. 2018 Toxicol. Sci. pmid:29584932
Liu J et al. Preparation, characterization, digestibility and antioxidant activity of quercetin grafted Cynanchum auriculatum starch. 2018 Int. J. Biol. Macromol. pmid:29572138
Boadi WY and Lo A Effects of Quercetin, Kaempferol, and Exogenous Glutathione on Phospho- and Total-AKT in 3T3-L1 Preadipocytes. 2018 J Diet Suppl pmid:29345961
Ma YK et al. Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media. 2018 Int. J. Mol. Med. pmid:29568908
Donno D et al. New Findings in Prunus padus L. Fruits as a Source of Natural Compounds: Characterization of Metabolite Profiles and Preliminary Evaluation of Antioxidant Activity. 2018 Molecules pmid:29565317
Park DJ et al. Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model. 2018 J. Vet. Med. Sci. pmid:29563391
Tsunekawa R et al. Synthesis of fisetin and 2',4',6'-trihydroxydihyrochalcone 4'-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation. 2018 Biosci. Biotechnol. Biochem. pmid:29699439
Forney LA et al. Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner. 2018 Int J Mol Sci pmid:29562620
Hatahet T et al. Liposomes, lipid nanocapsules and smartCrystals®: A comparative study for an effective quercetin delivery to the skin. 2018 Int J Pharm pmid:29549014
Hwang DS et al. Effects of Rhei Undulati Rhizoma on lipopolysaccharide-induced neuroinflammation in vitro and in vivo. 2018 Environ. Toxicol. pmid:28984087
Li XM et al. Quercetin and aconitine synergistically induces the human cervical carcinoma HeLa cell apoptosis via endoplasmic reticulum (ER) stress pathway. 2018 PLoS ONE pmid:29324796
Hwang HV et al. Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. 2018 PLoS ONE pmid:29315311
Liaquat L et al. Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats. 2018 Life Sci. pmid:29287782
Ting Y et al. Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on Body Composition, Serum Lipid Profile, and Gene Expression. 2018 J. Agric. Food Chem. pmid:29249156
Sarangowa O et al. Botanical origin of Mei-gui Hua in Chinese markets. 2018 J Nat Med pmid:29188415
Liu Y et al. Geographic Variation in the Chemical Composition and Antioxidant Properties of Phenolic Compounds from (Batal) Iljinskaja Leaves. 2018 Molecules pmid:30249997
Naseer Z et al. Dietary quercetin maintains the semen quality in rabbits under summer heat stress. 2018 Theriogenology pmid:30243139
Fang J et al. Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy. 2018 Int J Nanomedicine pmid:30233175
Zhang M et al. Neurodevelopmental toxicity induced by maternal PM2.5 exposure and protective effects of quercetin and Vitamin C. 2018 Chemosphere pmid:30218877
Zhang C et al. Mechanistic insights into the inhibition of quercetin on xanthine oxidase. 2018 Int. J. Biol. Macromol. pmid:29410028
Kim YA et al. Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant in Human Keratinocytes. 2018 Molecules pmid:30216992
Ajaghaku DL et al. Upregulation of CD T-Lymphocytes by Isomeric Mixture of Quercetin-3-O-Rutinoside and Quercetin-3-O-Robinobioside Isolated from Millettia aboensis. 2018 Immunol. Invest. pmid:29405788
Giuliani C et al. Localization of phenolic compounds in the fruits of Silybum marianum characterized by different silymarin chemotype and altered colour. 2018 Fitoterapia pmid:30213759
Rahvar M et al. Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain. 2018 Bratisl Lek Listy pmid:29405727
Takabe W et al. Identification of Antiglycative Compounds in Japanese Red Water Pepper (Red Leaf Variant of the Sprout). 2018 Molecules pmid:30208642
Gao Q et al. A red-emitting indolium fluorescence probe for membranes - flavonoids interactions. 2018 Luminescence pmid:29405584
Wein S et al. Bioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows. 2018 J. Agric. Food Chem. pmid:30207714
Ge F et al. Taxifolin suppresses rat and human testicular androgen biosynthetic enzymes. 2018 Fitoterapia pmid:29402482
Li JP et al. Hyperoside and let-7a-5p synergistically inhibits lung cancer cell proliferation via inducing G1/S phase arrest. 2018 Gene pmid:30201337
Ding Y et al. Quercetin suppresses the chymotrypsin-like activity of proteasome via inhibition of MEK1/ERK1/2 signaling pathway in hepatocellular carcinoma HepG2 cells. 2018 Can. J. Physiol. Pharmacol. pmid:29394494
Liu T et al. Production of drug nanosuspensions: effect of drug physical properties on nanosizing efficiency. 2018 Drug Dev Ind Pharm pmid:28956456
Ginex T et al. Computational Study of the Aza-Michael Addition of the Flavonoid (+)-Taxifolin in the Inhibition of β-Amyloid Fibril Aggregation. 2018 Chemistry pmid:29384229
Kim Y and Chang KO Protein disulfide isomerases as potential therapeutic targets for influenza A and B viruses. 2018 Virus Res. pmid:29382552
Hamilton KE et al. Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1. 2018 Biochimie pmid:29857184
Sheth U and Bahadur A In-vitro evaluation of cytotoxic and antioxidant properties of drugs solubilized in EO-PO star block copolymer micelles. 2018 Colloids Surf B Biointerfaces pmid:30056295
Borse SP et al. Potential synergistic effects of quercetin with other phytoconstituents of Costus pictus (insulin plant) extract in the control of hyperglycemia and prevention of NSAID-induced gastroenteropathy in diabetic rats. 2018 Food Chem. Toxicol. pmid:30055312
Samad N et al. Quercetin protects against stress-induced anxiety- and depression-like behavior and improves memory in male mice. 2018 Physiol Res pmid:30044120
Rauf A et al. Anticancer potential of quercetin: A comprehensive review. 2018 Phytother Res pmid:30039547
North MK et al. The effects of quercetin supplementation on New Zealand White grower rabbit carcass and meat quality - A short communication. 2018 Meat Sci. pmid:30031202
Kruszewski M et al. The effect of quercetin on the electrical properties of model lipid membranes and human glioblastoma cells. 2018 Bioelectrochemistry pmid:30029034
Sharma A et al. Therapeutic charm of quercetin and its derivatives: a review of research and patents. 2018 Pharm Pat Anal pmid:29227203
Song JY et al. Quercetin Shows the Pharmacological Activity to Simultaneously Downregulate the Inflammatory and Fibrotic Responses to Tissue Injury in Association with its Ability to Target Multi-Kinases. 2018 Pharmacology pmid:30016781
Alugoju P et al. Quercetin Protects Yeast Saccharomyces cerevisiae pep4 Mutant from Oxidative and Apoptotic Stress and Extends Chronological Lifespan. 2018 Curr. Microbiol. pmid:29224051
Zhu Y et al. Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model. 2018 Food Funct pmid:29215110
Nambooppha B et al. Quercetin manipulates the expression of genes involved in the reactive oxygen species (ROS) process in chicken heterophils. 2018 J. Vet. Med. Sci. pmid:29877311
Lin J et al. Steamed bread enriched with quercetin as an antiglycative food product: its quality attributes and antioxidant properties. 2018 Food Funct pmid:29872802
Qiu L et al. Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats. 2018 Biomed. Pharmacother. pmid:29864946
Ventura-Martínez R et al. Spasmolytic effect of aqueous extract of Tagetes erecta L. flowers is mediated through calcium channel blockade on the guinea-pig ileum. 2018 Biomed. Pharmacother. pmid:29864942
Lee KM et al. Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed human keratinocytes. 2018 Biochem. Biophys. Res. Commun. pmid:29857000
Ramos-Pineda AM et al. Effect of the addition of mannoproteins on the interaction between wine flavonols and salivary proteins. 2018 Food Chem pmid:29853369
Selvarajan S et al. Fabrication of g-CN/NiO heterostructured nanocomposite modified glassy carbon electrode for quercetin biosensor. 2018 Ultrason Sonochem pmid:29137797
Singh A et al. Curcumin loaded chitin-glucan quercetin conjugate: Synthesis, characterization, antioxidant, in vitro release study, and anticancer activity. 2018 Int. J. Biol. Macromol. pmid:29128588
Lei CS et al. Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies. 2018 J. Nutr. Biochem. pmid:29125991
Yuan TY et al. Vasorelaxant effect of quercetin on cerebral basilar artery in vitro and the underlying mechanisms study. 2018 J Asian Nat Prod Res pmid:29693418
Kale A et al. Neuroprotective effects of Quercetin on radiation-induced brain injury in rats. 2018 J. Radiat. Res. pmid:29688418
Lin M et al. Quercetin improves postpartum hypogalactia in milk-deficient mice via stimulating prolactin production in pituitary gland. 2018 Phytother Res pmid:29671937
Seo S et al. Prediction of GPCR-Ligand Binding Using Machine Learning Algorithms. 2018 Comput Math Methods Med pmid:29666662
Jayachandran M et al. Isoquercetin ameliorates hyperglycemia and regulates key enzymes of glucose metabolism via insulin signaling pathway in streptozotocin-induced diabetic rats. 2018 Eur. J. Pharmacol. pmid:29665363
Hatware KV et al. Evidence for gastroprotective, anti-inflammatory and antioxidant potential of methanolic extract of Cordia dichotoma leaves on indomethacin and stress induced gastric lesions in Wistar rats. 2018 Biomed. Pharmacother. pmid:29660650
Li Y et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. 2018 Toxicol. Lett. pmid:29753067
Alves MC et al. Taxifolin: Evaluation Through Ex vivo Permeations on Human Skin and Porcine Vaginal Mucosa. 2018 Curr Drug Deliv pmid:29336264
Wei X et al. Quercetin exerts cardiovascular protective effects in LPS-induced dysfunction in vivo by regulating inflammatory cytokine expression, NF-κB phosphorylation, and caspase activity. 2018 Mol. Cell. Biochem. pmid:29322353
Lu Q et al. Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway. 2018 Acta Biochim. Pol. pmid:29281744
Dresch RR et al. Potential use of secondary products of the agri-food industry for topical formulations and comparative analysis of antioxidant activity of grape leaf polyphenols. 2018 Nat. Prod. Res. pmid:28403634
Seong JS et al. Surfactant-stable and pH-sensitive liposomes coated with N-succinyl-chitosan and chitooligosaccharide for delivery of quercetin. 2018 Carbohydr Polym pmid:29254020
de Lacerda Neto LJ et al. Modulation of antibiotic activity by the hydroalcoholic extract from leaves of Caryocar coriaceum WITTM. 2018 Nat. Prod. Res. pmid:28391717
Chatziathanasiadou MV et al. Amplifying and broadening the cytotoxic profile of quercetin in cancer cell lines through bioconjugation. 2018 Amino Acids pmid:29185031
Bonechi C et al. Protective effect of quercetin and rutin encapsulated liposomes on induced oxidative stress. 2018 Biophys. Chem. pmid:29174505
Shaalan YM et al. Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma. 2018 Nat. Prod. Res. pmid:28817968
de Oliveira Pedro R et al. Synergistic effect of quercetin and pH-responsive DEAE-chitosan carriers as drug delivery system for breast cancer treatment. 2018 Int. J. Biol. Macromol. pmid:28807690
Shalini D et al. Effect of size and shape on toxicity of zinc oxide (ZnO) nanomaterials in human peripheral blood lymphocytes. 2018 Toxicol. Mech. Methods pmid:28805101
Zhao TT et al. Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes. 2018 Gene pmid:29730426
Khaligh F et al. Effects of in ovo injection of chrysin, quercetin and ascorbic acid on hatchability, somatic attributes, hepatic oxidative status and early post-hatch performance of broiler chicks. 2018 J Anim Physiol Anim Nutr (Berl) pmid:28636279
Woźniak D et al. Comparison of Polyphenol Profile and Antimutagenic and Antioxidant Activities in Two Species Used as Source of Solidaginis herba - Goldenrod. 2018 Chem. Biodivers. pmid:29537689
Jiménez-López J et al. Phytochemical profile and antioxidant activity of caper berries (Capparis spinosa L.): Evaluation of the influence of the fermentation process. 2018 Food Chem pmid:29412927
Slámová K et al. "Sweet Flavonoids": Glycosidase-Catalyzed Modifications. 2018 Int J Mol Sci pmid:30037103