quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Neuroma D009463 1 associated lipids
Encephalitis, Arbovirus D004671 1 associated lipids
Neurofibromatoses D017253 1 associated lipids
Heat Stroke D018883 1 associated lipids
Post-Concussion Syndrome D038223 1 associated lipids
Prenatal Exposure Delayed Effects D011297 2 associated lipids
Enterovirus Infections D004769 2 associated lipids
Choroid Diseases D015862 2 associated lipids
CREST Syndrome D017675 2 associated lipids
Alcohol-Induced Disorders, Nervous System D020268 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Authors Title Published Journal PubMed Link
Yamashita K et al. Assessment of the skin sensitizing potential of chemicals, contained in foods and/or cosmetic ingredients, using a modified local lymph node assay with an elicitation phase (LLNA:DAE) method. 2018 J Toxicol Sci pmid:30078837
Abdelhalim MAK et al. Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo. 2018 Int J Nanomedicine pmid:30538457
Hyun HB et al. Quercetin Suppresses CYR61-Mediated Multidrug Resistance in Human Gastric Adenocarcinoma AGS Cells. 2018 Molecules pmid:29364834
Farrag Y et al. Starch films loaded with donut-shaped starch-quercetin microparticles: Characterization and release kinetics. 2018 Int. J. Biol. Macromol. pmid:30012488
Haque MW et al. Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway. 2018 Biomed. Pharmacother. pmid:29843042
Zhang Y et al. Anti-hypoglycemic and hepatocyte-protective effects of hyperoside from Zanthoxylum bungeanum leaves in mice with high-carbohydrate/high-fat diet and alloxan-induced diabetes. 2018 Int. J. Mol. Med. pmid:29115390
Xiao J Stability of dietary polyphenols: It's never too late to mend? 2018 Food Chem. Toxicol. pmid:29626578
Quintero-Soto MF et al. Phenolic profiles and their contribution to the antioxidant activity of selected chickpea genotypes from Mexico and ICRISAT collections. 2018 Plant Foods Hum Nutr pmid:29516285
Bondonno NP et al. Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial. 2018 Mol Nutr Food Res pmid:29086478
Deng M et al. Effect of Storage Conditions on Phenolic Profiles and Antioxidant Activity of Litchi Pericarp. 2018 Molecules pmid:30200581