quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Lead Poisoning D007855 4 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Per page 10 20 50 100 | Total 205

PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Authors Title Published Journal PubMed Link
Walkowiak A et al. Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. 2019 Spectrochim Acta A Mol Biomol Spectrosc pmid:30321862
Maurya AK and Vinayak M Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. 2019 In Vitro Cell. Dev. Biol. Anim. pmid:30413935
Li J et al. Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. 2019 Chem. Biol. Interact. pmid:30365939
Mu Y et al. Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. 2019 Carbohydr Polym pmid:30318192
Li F et al. The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. 2019 Pest Manag. Sci. pmid:29797492
Schröder L et al. Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. 2019 Oncol. Rep. pmid:30320348
Leng E et al. Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells. 2018 BMC Complement Altern Med pmid:29622007
Wu TC et al. Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. 2018 Chem. Biol. Interact. pmid:30016632
Lu N et al. Generation of a Diligand Complex of Bovine Serum Albumin with Quercetin and Carbon Nanotubes for the Protection of Bioactive Quercetin and Reduction of Cytotoxicity. 2018 J. Agric. Food Chem. pmid:30016096
Mohebali N et al. Effect of flavonoids rich extract of Capparis spinosa on inflammatory involved genes in amyloid-beta peptide injected rat model of Alzheimer's disease. 2018 Nutr Neurosci pmid:27778760
Arbain NH et al. Optimization of Quercetin loaded Palm Oil Ester Based Nanoemulsion Formulation for Pulmonary Delivery. 2018 J Oleo Sci pmid:30012897
Chirumbolo S and Bjørklund G Quercetin in collagen-induced arthritis. Some comments. 2018 Int. Immunopharmacol. pmid:29970297
Patel RV et al. Therapeutic potential of quercetin as a cardiovascular agent. 2018 Eur J Med Chem pmid:29966915
Riva A et al. Quercetin phytosome® in triathlon athletes: a pilot registry study. 2018 Minerva Med. pmid:29947492
Habtemariam S and Belai A Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin. 2018 Mini Rev Med Chem pmid:28117024
Asfaram A et al. Cu- and S- @SnO nanoparticles loaded on activated carbon for efficient ultrasound assisted dispersive µSPE-spectrophotometric detection of quercetin in Nasturtium officinale extract and fruit juice samples: CCD-RSM design. 2018 Ultrason Sonochem pmid:29908597
Mehrbod P et al. Immunomodulatory properties of quercetin-3-O-α-L-rhamnopyranoside from Rapanea melanophloeos against influenza a virus. 2018 BMC Complement Altern Med pmid:29903008
Kapur B et al. Health and taste related compounds in strawberries under various irrigation regimes and bio-stimulant application. 2018 Food Chem pmid:29784329
Váradyová Z et al. Ovicidal and larvicidal activity of extracts from medicinal-plants against Haemonchus contortus. 2018 Exp. Parasitol. pmid:30389531
Aghapour F et al. Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines. 2018 Biochem. Biophys. Res. Commun. pmid:29698680
Sun S et al. Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway. 2018 Gene pmid:29678660
Suke SG et al. Ameliorative effect of nanoencapsulated flavonoid against chlorpyrifos-induced hepatic oxidative damage and immunotoxicity in Wistar rats. 2018 J. Biochem. Mol. Toxicol. pmid:29667781
Zhu Y et al. Molecular Cloning and Functional Characterization of a Dihydroflavonol 4-Reductase from Vitis bellula. 2018 Molecules pmid:29642567
Dresler S et al. Methodological aspects of biologically active compounds quantification in the genus Hypericum. 2018 J Pharm Biomed Anal pmid:29621655
Jeong DW et al. Deastringent Peel Extracts of Persimmon ( Thunb. cv. Cheongdo-Bansi) Protect Neuronal PC-12 and SH-SY5Y Cells against Oxidative Stress. 2018 J. Microbiol. Biotechnol. pmid:29975999
Gaudry A et al. The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells. 2018 Int J Mol Sci pmid:29621184
Du G et al. Quercetin protects rat cortical neurons against traumatic brain injury. 2018 Mol Med Rep pmid:29620218
Jahan S et al. Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study. 2018 J Ovarian Res pmid:29615083
Sung YY et al. Aqueous and ethanolic extracts of welsh onion, Allium fistulosum, attenuate high-fat diet-induced obesity. 2018 BMC Complement Altern Med pmid:29558911
Rishitha N and Muthuraman A Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish. 2018 Life Sci. pmid:29522770
Murota K et al. Flavonoid metabolism: the interaction of metabolites and gut microbiota. 2018 Biosci. Biotechnol. Biochem. pmid:29504827
Kim MK et al. In Vitro Synergism and Anti-biofilm Activity of Quercetin-Pivaloxymethyl Conjugate against Staphylococcus aureus and Enterococcus Species. 2018 Chem. Pharm. Bull. pmid:30381653
Silva W et al. Double emulsions as potential fat replacers with gallic acid and quercetin nanoemulsions in the aqueous phases. 2018 Food Chem pmid:29502846
Naeimi R et al. Querectin improves myelin repair of optic chiasm in lyolecithin-induced focal demyelination model. 2018 Biomed. Pharmacother. pmid:29501770
Foti MC et al. Singlet oxygen quenching- and chain-breaking antioxidant-properties of a quercetin dimer able to prevent age-related macular degeneration. 2018 Biophys. Chem. pmid:30352336
Ozdemir Olgun FA et al. A novel cerium oxide nanoparticles-based colorimetric sensor using tetramethyl benzidine reagent for antioxidant activity assay. 2018 Talanta pmid:29501192
Ebrahimpour S et al. Effect of quercetin-conjugated superparamagnetic iron oxide nanoparticles on diabetes-induced learning and memory impairment in rats. 2018 Int J Nanomedicine pmid:30349252
Xia F et al. Rapid Determination of Active Compounds and Antioxidant Activity of Okra Seeds Using Fourier Transform Near Infrared (FT-NIR) Spectroscopy. 2018 Molecules pmid:29498632
Donno D et al. Assessing Nutritional Traits and Phytochemical Composition of Artisan Jams Produced in Comoros Islands: Using Indigenous Fruits with High Health-Impact as an Example of Biodiversity Integration and Food Security in Rural Development. 2018 Molecules pmid:30347846
Wu Q et al. Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells. 2018 Food Funct pmid:29497723
Ahmed OM et al. Quercetin and low level laser therapy promote wound healing process in diabetic rats via structural reorganization and modulatory effects on inflammation and oxidative stress. 2018 Biomed. Pharmacother. pmid:29477473
Pradhan AB et al. Role of hydroxyl groups in the B-ring of flavonoids in stabilization of the Hoogsteen paired third strand of Poly(U).Poly(A)*Poly(U) triplex. 2018 Arch. Biochem. Biophys. pmid:29162368
Zhou J et al. Determination of isoquercitrin in rat plasma by high performance liquid chromatography coupled with a novel synergistic cloud point extraction. 2018 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29153998
Wen P et al. Preparation and Characterization of Electrospun Colon-Specific Delivery System for Quercetin and Its Antiproliferative Effect on Cancer Cells. 2018 J. Agric. Food Chem. pmid:30148954
Erdogan S et al. Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway. 2018 Biomed. Pharmacother. pmid:30142541
Sunoqrot S et al. Facile synthesis and surface modification of bioinspired nanoparticles from quercetin for drug delivery. 2018 Biomater Sci pmid:30140818
Hussain J et al. New robust sensitive fluorescence spectroscopy coupled with PLSR for estimation of quercetin in Ziziphus mucronata and Ziziphus sativa. 2018 Spectrochim Acta A Mol Biomol Spectrosc pmid:29331816
Zhao QY et al. Selective recognition and fast enrichment of anthocyanins by dummy molecularly imprinted magnetic nanoparticles. 2018 J Chromatogr A pmid:30139620
Jadán-Piedra C et al. In vitro evaluation of dietary compounds to reduce mercury bioavailability. 2018 Food Chem pmid:29329865
Baksi R et al. In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles. 2018 Biomed. Pharmacother. pmid:30119227
Lu Z et al. Preparation and in vitro and in vivo evaluation of quercetin-loaded mixed micelles for oral delivery. 2018 Biosci. Biotechnol. Biochem. pmid:29327653
Junyuan Z et al. Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition. 2018 Pancreatology pmid:30115563
Hobbs CA et al. Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential. 2018 Food Chem. Toxicol. pmid:29317330
Chen Z et al. Effects of Quercetin on Proliferation and Hâ‚‚Oâ‚‚-Induced Apoptosis of Intestinal Porcine Enterocyte Cells. 2018 Molecules pmid:30103566
Xiao Y and Lee IS Microbial transformation of quercetin and its prenylated derivatives. 2018 Nat. Prod. Res. pmid:28826260
Babaei F et al. Quercetin in Food: Possible Mechanisms of Its Effect on Memory. 2018 J. Food Sci. pmid:30103275
Ren K et al. Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARγ/LXRα pathway. 2018 Food Funct pmid:29292466
Chan ST et al. Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice. 2018 Food Funct pmid:29292417
Guimarães GC et al. Binding investigation between M2-1protein from hRSV and acetylated quercetin derivatives: H NMR, fluorescence spectroscopy, and molecular docking. 2018 Int. J. Biol. Macromol. pmid:29292149
Verjee S et al. Hyperforin and Miquelianin from St. John's Wort Attenuate Gene Expression in Neuronal Cells After Dexamethasone-Induced Stress. 2018 Planta Med. pmid:29499586
Yang H et al. Quercetin Treatment Improves Renal Function and Protects the Kidney in a Rat Model of Adenine-Induced Chronic Kidney Disease. 2018 Med. Sci. Monit. pmid:29987270
Farazuddin M et al. Quercetin prevents rhinovirus-induced progression of lung disease in mice with COPD phenotype. 2018 PLoS ONE pmid:29975735
Rastogi S and Haldar C Comparative effect of melatonin and quercetin in counteracting LPS induced oxidative stress in bone marrow mononuclear cells and spleen of Funambulus pennanti. 2018 Food Chem. Toxicol. pmid:29964085
Li ZP et al. Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation. 2018 Molecules pmid:29958399
Cao L et al. Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways. 2018 Int. J. Mol. Med. pmid:29956731
Steinborn C et al. In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica. 2018 Planta Med. pmid:29202511
Fan D et al. A comparison of mutagenic PhIP and beneficial 8-C-(E-phenylethenyl)quercetin and 6-C-(E-phenylethenyl)quercetin formation under microwave and conventional heating. 2018 Food Funct pmid:29953158
Braun JBS et al. Pretreatment with quercetin prevents changes in lymphocytes E-NTPDase/E-ADA activities and cytokines secretion in hyperlipidemic rats. 2018 Mol. Cell. Biochem. pmid:29188537
Kim JE et al. Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal. 2018 Pharm Biol pmid:29952685
K N L et al. Augmentation of antioxidant and iron(III) chelation properties of tertiary mixture of bioactive ligands. 2018 J Trace Elem Med Biol pmid:29173467
Suganya N et al. Quercetin improves endothelial function in diabetic rats through inhibition of endoplasmic reticulum stress-mediated oxidative stress. 2018 Eur. J. Pharmacol. pmid:29169872
Mandrone M et al. Identification of a Collagenase-Inhibiting Flavonoid from Alchemilla vulgaris Using NMR-Based Metabolomics. 2018 Planta Med. pmid:29797306
Escher GB et al. Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract. 2018 Food Chem. Toxicol. pmid:29787846
Crascì L et al. Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation. 2018 Drug Res (Stuttg) pmid:29108086
Zhang L et al. UV-Vis spectroscopy combined with chemometric study on the interactions of three dietary flavonoids with copper ions. 2018 Food Chem pmid:29784309
Pawlikowska-Pawlega B et al. Interaction of a quercetin derivative - lensoside Aβ with liposomal membranes. 2018 Biochim Biophys Acta Biomembr pmid:29106971
Tsukamoto Y et al. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. 2018 PLoS ONE pmid:29782545
Chalet C et al. Intestinal disposition of quercetin and its phase-II metabolites after oral administration in healthy volunteers. 2018 J. Pharm. Pharmacol. pmid:29761870
Shu B et al. Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-κB signaling suppression. 2018 Cell. Signal. pmid:29080804
Li S et al. A novel electrochemical sensor for detecting hyperin with a nanocomposite of ZrO-SDS-SWCNTs as decoration. 2018 Talanta pmid:29759227
Trinh PTN et al. A new benzofuran derivative from the leaves of Ficus pumila L. 2018 Nat. Prod. Res. pmid:29072969
Ding M et al. A network pharmacology-integrated metabolomics strategy for clarifying the difference between effective compounds of raw and processed Farfarae flos by ultra high-performance liquid chromatography-quadrupole-time of flight mass spectrometry. 2018 J Pharm Biomed Anal pmid:29753281
Wang XF et al. Protective Effect of Quercetin in LPS-Induced Murine Acute Lung Injury Mediated by cAMP-Epac Pathway. 2018 Inflammation pmid:29569077
Guazelli CFS et al. Quercetin attenuates zymosan-induced arthritis in mice. 2018 Biomed. Pharmacother. pmid:29554596
Kim J et al. Quercetin-3-O-α-l-arabinopyranoside protects against retinal cell death via blue light-induced damage in human RPE cells and Balb-c mice. 2018 Food Funct pmid:29541735
Safwat NA et al. Quercetin 3-O-glucoside recovered from the wild Egyptian Sahara plant, Euphorbia paralias L., inhibits glutamine synthetase and has antimycobacterial activity. 2018 Tuberculosis (Edinb) pmid:29523309
Osawe SO and Farombi EO Quercetin and rutin ameliorates sulphasalazine-induced spermiotoxicity, alterations in reproductive hormones and steroidogenic enzyme imbalance in rats. 2018 Andrologia pmid:29512831
Nile A et al. Valorization of onion solid waste and their flavonols for assessment of cytotoxicity, enzyme inhibitory and antioxidant activities. 2018 Food Chem. Toxicol. pmid:29496529
Mendel M et al. Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility-in vitro study. 2018 J. Vet. Pharmacol. Ther. pmid:28913883
Pham-Hoang BN et al. Fluorescence Lifetime and UV-Vis Spectroscopy to Evaluate the Interactions Between Quercetin and Its Yeast Microcapsule. 2018 Biotechnol J pmid:28887909
Larit F et al. Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants. 2018 Phytomedicine pmid:29496172
Wang Y et al. Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats. 2018 J. Cell. Biochem. pmid:28865131
Wu Q et al. Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. 2018 J. Agric. Food Chem. pmid:29905475
Jan S et al. Effect of environmental variables on phytonutrients of Origanum vulgare L. in the sub-humid region of the northwestern Himalayas. 2018 Environ Monit Assess pmid:30187208
Bouratoua A et al. Chemical composition and antioxidant activity of aerial parts of Ferula longipes Coss. ex Bonnier and Maury. 2018 Nat. Prod. Res. pmid:28714345
Cerulli A et al. Phenolics from Castanea sativa leaves and their effects on UVB-induced damage. 2018 Nat. Prod. Res. pmid:28539059
Zhang XF et al. UPLC-MS/MS analysis for antioxidant components of Lycii Fructus based on spectrum-effect relationship. 2018 Talanta pmid:29332828
Zahid K et al. Phytochemical screening, antioxidant activity, total phenolic and total flavonoid contents of seven local varieties of Rosa indica L. 2018 Nat. Prod. Res. pmid:28539055
Bhattacharya D et al. Antibacterial activity of polyphenolic fraction of Kombucha against Vibrio cholerae: targeting cell membrane. 2018 Lett. Appl. Microbiol. pmid:29193174
Chung JO et al. Quercetin and fisetin enhanced the small intestine cellular uptake and plasma levels of epi-catechins in in vitro and in vivo models. 2018 Food Funct pmid:29168878