| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with quercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with quercetin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with quercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Walkowiak A et al. | Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. | 2019 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:30321862 |
| Maurya AK and Vinayak M | Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. | 2019 | In Vitro Cell. Dev. Biol. Anim. | pmid:30413935 |
| Li J et al. | Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. | 2019 | Chem. Biol. Interact. | pmid:30365939 |
| Mu Y et al. | Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. | 2019 | Carbohydr Polym | pmid:30318192 |
| Li F et al. | The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. | 2019 | Pest Manag. Sci. | pmid:29797492 |
| Schröder L et al. | Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. | 2019 | Oncol. Rep. | pmid:30320348 |
| Mehrbod P et al. | Immunomodulatory properties of quercetin-3-O-α-L-rhamnopyranoside from Rapanea melanophloeos against influenza a virus. | 2018 | BMC Complement Altern Med | pmid:29903008 |
| Laczkó-Zöld E et al. | Extractability of polyphenols from black currant, red currant and gooseberry and their antioxidant activity. | 2018 | Acta. Biol. Hung. | pmid:29888668 |
| Wang WJ et al. | Deciphering the chemoselectivity of nickel-dependent quercetin 2,4-dioxygenase. | 2018 | Phys Chem Chem Phys | pmid:29869653 |
| Zhou W et al. | A two-step ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry with mass defect filtering method for rapid identification of analogues from known components of different chemical structure types in Fructus Gardeniae-Fructus Forsythiae herb pair extract and in rat's blood. | 2018 | J Chromatogr A | pmid:29861306 |
| Jahan S et al. | Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study. | 2018 | J Ovarian Res | pmid:29615083 |
| Qureshi AA et al. | Proteasome inhibitors modulate anticancer and anti-proliferative properties via NF-kB signaling, and ubiquitin-proteasome pathways in cancer cell lines of different organs. | 2018 | Lipids Health Dis | pmid:29606130 |
| Ge L et al. | B-factor-saturation mutagenesis as a strategy to increase the thermostability of α-L-rhamnosidase from Aspergillus terreus. | 2018 | J. Biotechnol. | pmid:29605638 |
| Chen J et al. | Pretreatment with dihydroquercetin, a dietary flavonoid, protected against concanavalin A-induced immunological hepatic injury in mice and TNF-α/ActD-induced apoptosis in HepG2 cells. | 2018 | Food Funct | pmid:29589006 |
| Zhu Q et al. | Comparison of flavonoids and isoflavonoids to inhibit rat and human 11β-hydroxysteroid dehydrogenase 1 and 2. | 2018 | Steroids | pmid:29425740 |
| Rishitha N and Muthuraman A | Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish. | 2018 | Life Sci. | pmid:29522770 |
| Khalil SR et al. | Intermediate filament protein expression pattern and inflammatory response changes in kidneys of rats receiving doxorubicin chemotherapy and quercetin. | 2018 | Toxicol. Lett. | pmid:29474904 |
| Dai Y et al. | Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway. | 2018 | Chem. Biol. Interact. | pmid:29454613 |
| Feng J et al. | Quercetin restrains TGF-β1-induced epithelial-mesenchymal transition by inhibiting Twist1 and regulating E-cadherin expression. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29425820 |
| Islami M et al. | Controlled quercetin release from high-capacity-loading hyperbranched polyglycerol-functionalized graphene oxide. | 2018 | Int J Nanomedicine | pmid:30323593 |
| Li S et al. | Quercetin enhances chemotherapeutic effect of doxorubicin against human breast cancer cells while reducing toxic side effects of it. | 2018 | Biomed. Pharmacother. | pmid:29475141 |
| Porcu EP et al. | Aqueous injection of quercetin: An approach for confirmation of its direct in vivo cardiovascular effects. | 2018 | Int J Pharm | pmid:29474897 |
| Ray S et al. | Modulation in phenolic root exudate profile of Abelmoschus esculentus expressing activation of defense pathway. | 2018 | Microbiol. Res. | pmid:29458844 |
| Sakalli S et al. | In vitro effects of diosmin, naringenin, quercetin and indole-3-carbinol on fish hepatic CYP1A1 in the presence of clotrimazole and dexamethasone. | 2018 | Chemosphere | pmid:29100118 |
| Babaei F et al. | Quercetin in Food: Possible Mechanisms of Its Effect on Memory. | 2018 | J. Food Sci. | pmid:30103275 |
| Wang R et al. | A strategy for absolute quantitation of isomers using high performance liquid chromatography-ion mobility mass spectrometry and material balance principle. | 2018 | J Chromatogr A | pmid:30097341 |
| Ma Y et al. | Quercetin potentiates the concurrent hyper-accumulation of cellular biomass and lipids in Chlorella vulgaris. | 2018 | Bioresour. Technol. | pmid:30093226 |
| Guimarães GC et al. | Binding investigation between M2-1protein from hRSV and acetylated quercetin derivatives: H NMR, fluorescence spectroscopy, and molecular docking. | 2018 | Int. J. Biol. Macromol. | pmid:29292149 |
| Wu Z et al. | Simultaneous Enrichment and Separation of Four Flavonoids from Zanthoxylum bungeanum Leaves by Ultrasound-Assisted Extraction and Macroporous Resins with Evaluation of Antioxidant Activities. | 2018 | J. Food Sci. | pmid:30080245 |
| Chirumbolo S and Bjørklund G | Quercetin in the experimental liver fibrosis induced by carbon tetrachloride (CCl). | 2018 | Int. Immunopharmacol. | pmid:29287251 |
| Sommella E et al. | Chemical profiling of bioactive constituents in hop cones and pellets extracts by online comprehensive two-dimensional liquid chromatography with tandem mass spectrometry and direct infusion Fourier transform ion cyclotron resonance mass spectrometry. | 2018 | J Sep Sci | pmid:29282870 |
| Mukhopadhyay P et al. | Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment. | 2018 | Carbohydr Polym | pmid:29279124 |
| Zahoor M et al. | Isolation of quercetin and mandelic acid from Aesculus indica fruit and their biological activities. | 2018 | BMC Biochem. | pmid:29940844 |
| Yamina AM et al. | Preparation of multifunctional PEG-graft-Halloysite Nanotubes for Controlled Drug Release, Tumor Cell Targeting, and Bio-imaging. | 2018 | Colloids Surf B Biointerfaces | pmid:29936385 |
| Wang J et al. | Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro. | 2018 | J Ovarian Res | pmid:29929541 |
| Özbilgin S et al. | In vivo wound-healing activity of Euphorbia characias subsp. wulfenii: Isolation and quantification of quercetin glycosides as bioactive compounds. | 2018 | J Ethnopharmacol | pmid:29920357 |
| Bedada SK and Neerati P | Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers. | 2018 | Phytother Res | pmid:29168292 |
| Kawabata K et al. | Functional properties of anti-inflammatory substances from quercetin-treated Bifidobacterium adolescentis. | 2018 | Biosci. Biotechnol. Biochem. | pmid:29165050 |
| Ding M et al. | A network pharmacology-integrated metabolomics strategy for clarifying the difference between effective compounds of raw and processed Farfarae flos by ultra high-performance liquid chromatography-quadrupole-time of flight mass spectrometry. | 2018 | J Pharm Biomed Anal | pmid:29753281 |
| Al-Asmari AK et al. | Protective effects of a natural herbal compound quercetin against snake venom-induced hepatic and renal toxicities in rats. | 2018 | Food Chem. Toxicol. | pmid:29751071 |
| Chen Y et al. | Hyperoside protects human kidney‑2 cells against oxidative damage induced by oxalic acid. | 2018 | Mol Med Rep | pmid:29750296 |
| Wang D et al. | Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression. | 2018 | Mol Med Rep | pmid:29749525 |
| Wang Y et al. | Development of a LC-MS/MS method to investigate the interference of pharmacokinetics of the main constituents in Saxifraga stolonifera: Involvement of drug metabolism enzymes. | 2018 | J Pharm Biomed Anal | pmid:29017109 |
| Nile A et al. | Valorization of onion solid waste and their flavonols for assessment of cytotoxicity, enzyme inhibitory and antioxidant activities. | 2018 | Food Chem. Toxicol. | pmid:29496529 |
| Vanden Braber NL et al. | Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin. | 2018 | Int. J. Biol. Macromol. | pmid:29421395 |
| Kajbafvala A et al. | Formulation, characterization, and in vitro/ex vivo evaluation of quercetin-loaded microemulsion for topical application. | 2018 | Pharm Dev Technol | pmid:27871215 |
| Yamauchi K and Mitsunaga T | Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model. | 2018 | J Nat Med | pmid:29442220 |
| Ujah GA et al. | Effect of quercetin on cadmium chloride-induced impairments in sexual behaviour and steroidogenesis in male Wistar rats. | 2018 | Andrologia | pmid:28703286 |
| Silinsin M and Bursal E | UHPLC-MS/MS phenolic profiling and in vitro antioxidant activities of Inula graveolens (L.) Desf. | 2018 | Nat. Prod. Res. | pmid:28697630 |
| Chung JO et al. | Quercetin and fisetin enhanced the small intestine cellular uptake and plasma levels of epi-catechins in in vitro and in vivo models. | 2018 | Food Funct | pmid:29168878 |