quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
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Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with quercetin?
Related references are published most in these journals:
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What lipids are associated with quercetin?
Related references are published most in these journals:
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What genes are associated with quercetin?
Related references are published most in these journals:
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Bernd A et al. | Phototoxic effects of Hypericum extract in cultures of human keratinocytes compared with those of psoralen. | 1999 | Photochem. Photobiol. | pmid:10048312 |
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| Tribrat TA et al. | [The correction of hemorheological disorders in patients with ischemic heart disease and concomitant chronic cholecystitis]. | 1998 Oct-Nov | Lik. Sprava | pmid:10050457 |
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| Xiao D et al. | Quercetin induced apoptosis in human leukemia HL-60 cells. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072952 |
| Matsuse IT et al. | A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes. | 1999 | J Ethnopharmacol | pmid:10075118 |
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| Shen F et al. | Synergistic down-regulation of signal transduction and cytotoxicity by tiazofurin and quercetin in human ovarian carcinoma cells. | 1999 | Life Sci. | pmid:10353585 |
| Ciolino HP et al. | Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. | 1999 | Biochem. J. | pmid:10359656 |
| Erlund I et al. | Validated method for the quantitation of quercetin from human plasma using high-performance liquid chromatography with electrochemical detection. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10360437 |
| Graefe EU et al. | Pharmacokinetics and bioavailability of the flavonol quercetin in humans. | 1999 | Int J Clin Pharmacol Ther | pmid:10363620 |
| Izzard RA et al. | Competitive and noncompetitive inhibition of the DNA-dependent protein kinase. | 1999 | Cancer Res. | pmid:10363977 |
| Safety assessment and potential health benefits of food components based on selected scientific criteria. ILSI North America Technical Committee on Food Components for Health Promotion. | 1999 | Crit Rev Food Sci Nutr | pmid:10367185 | |
| Blardi P et al. | Stimulation of endogenous adenosine release by oral administration of quercetin and resveratrol in man. | 1999 | Drugs Exp Clin Res | pmid:10370871 |
| Miodini P et al. | The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function. | 1999 | Br. J. Cancer | pmid:10376965 |
| Pelletier MK et al. | Disruption of specific flavonoid genes enhances the accumulation of flavonoid enzymes and end-products in Arabidopsis seedlings. | 1999 | Plant Mol. Biol. | pmid:10394944 |
| Lee E et al. | Anti-allergic actions of the leaves of Castanea crenata and isolation of an active component responsible for the inhibition of mast cell degranulation. | 1999 | Arch. Pharm. Res. | pmid:10403140 |
| Alexandrakis M et al. | Differential effect of flavonoids on inhibition of secretion and accumulation of secretory granules in rat basophilic leukemia cells. | 1999 | Int. J. Immunopharmacol. | pmid:10405873 |
| Ghosh JC et al. | Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation. | 1999 | J. Radiat. Res. | pmid:10408175 |
| Crespy V et al. | Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen. | 1999 | Am. J. Physiol. | pmid:10409158 |
| Roth A et al. | Phytoestrogen kaempferol (3,4',5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity. | 1999 | J. Neurosci. Res. | pmid:10412031 |
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| Johnson ET et al. | Cymbidium hybrida dihydroflavonol 4-reductase does not efficiently reduce dihydrokaempferol to produce orange pelargonidin-type anthocyanins. | 1999 | Plant J. | pmid:10417729 |
| Khanduja KL et al. | Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin in mice. | 1999 | Food Chem. Toxicol. | pmid:10418948 |
| Shimura M et al. | Inhibition of Vpr-induced cell cycle abnormality by quercetin: a novel strategy for searching compounds targeting Vpr. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425183 |
| Rossi G | [Trends in the treatment of cystic fibrosis]. | 1999 Jul-Aug | Recenti Prog Med | pmid:10429516 |
| Chen ZW and Ma CG | Effects of hyperin on free intracellular calcium in dissociated neonatal rat brain cells. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10437120 |
| Xiao D et al. | Quercetin down-regulated bcl-2 gene expression in human leukemia HL-60 cells. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10437144 |
| Viturro C et al. | Free radical scavengers from Mutisia friesiana (Asteraceae) and Sanicula graveolens (Apiaceae). | 1999 | Phytother Res | pmid:10441784 |
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| Kim DH et al. | Metabolism of quercitrin by human intestinal bacteria and its relation to some biological activities. | 1999 | Biol. Pharm. Bull. | pmid:10443478 |
| Richter M et al. | Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling. | 1999 | Nutr Cancer | pmid:10453447 |
| Manjeet K R and Ghosh B | Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages. | 1999 | Int. J. Immunopharmacol. | pmid:10454017 |
| Dunlap DY et al. | Differential toxicities of TCDD in vivo among normal, c-src knockout, geldanamycin- and quercetin-treated mice. | 1999 | Toxicology | pmid:10463766 |
| Kaltenbach RF et al. | Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1' substituents. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10465557 |
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| Spencer JP et al. | The small intestine can both absorb and glucuronidate luminal flavonoids. | 1999 | FEBS Lett. | pmid:10481070 |
| Kobuchi H et al. | Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway. | 1999 | Am. J. Physiol. | pmid:10484327 |
| Wang H and Joseph JA | Structure-activity relationships of quercetin in antagonizing hydrogen peroxide-induced calcium dysregulation in PC12 cells. | 1999 | Free Radic. Biol. Med. | pmid:10490289 |
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| Halonen SK et al. | Effect of cytokines and quercetin on Toxoplasma gondii cyst induction in murine astrocytes. | 1999 Sep-Oct | J. Eukaryot. Microbiol. | pmid:10519260 |
| Tanaka T et al. | Inhibition of azoxymethane-induced aberrant crypt foci in rats by natural compounds, caffeine, quercetin and morin. | 1999 Nov-Dec | Oncol. Rep. | pmid:10523707 |
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| Nagata H et al. | Antioxidative action of flavonoids, quercetin and catechin, mediated by the activation of glutathione peroxidase. | 1999 | Tokai J. Exp. Clin. Med. | pmid:10530620 |
| Ishikawa Y et al. | Bioflavonoid quercetin inhibits interleukin-1-induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB. | 1999 | J. Am. Soc. Nephrol. | pmid:10541287 |
| Yamano S et al. | Purification and characterization of rat liver naloxone reductase that is identical to 3alpha-hydroxysteroid dehydrogenase. | 1999 | Xenobiotica | pmid:10548452 |
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| Aherne SA and O'Brien NM | Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells. | 1999 | Nutr Cancer | pmid:10578483 |
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| Li DP et al. | Inhibition of heat shock factor activity prevents heat shock potentiation of glucocorticoid receptor-mediated gene expression. | 1999 | Cell Stress Chaperones | pmid:10590836 |
| Yamamoto N et al. | Inhibitory effect of quercetin metabolites and their related derivatives on copper ion-induced lipid peroxidation in human low-density lipoprotein. | 1999 | Arch. Biochem. Biophys. | pmid:10600174 |
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