quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with quercetin?
Related references are published most in these journals:
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What lipids are associated with quercetin?
Related references are published most in these journals:
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What genes are associated with quercetin?
Related references are published most in these journals:
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:5155019 | ||||
| Bayes M et al. | Gateways to clinical trials. | Methods Find Exp Clin Pharmacol | pmid:16179960 | |
| Koru O et al. | In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens. | Anaerobe | pmid:17475517 | |
| Tomillero A and Moral MA | Gateways to clinical trials. July-August 2008. | Methods Find Exp Clin Pharmacol | pmid:18850047 | |
| Kalveniene Z et al. | The qualitative analysis of ethanol extracts of herbal raw materials by method of high pressure liquid chromatography. | Acta Pol Pharm | pmid:18536158 | |
| Pi J et al. | Investigation of quercetin-induced HepG2 cell apoptosis-associated cellular biophysical alterations by atomic force microscopy. | Scanning | pmid:26179807 | |
| Mozzicafreddo M et al. | Antiplasmin activity of natural occurring polyphenols. | Biochim. Biophys. Acta | pmid:18456009 | |
| Patil SL et al. | Antigenotoxic potential of rutin and quercetin in Swiss mice exposed to gamma radiation. | Biomed J | pmid:25179701 | |
| Jhong CH et al. | Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico. | Biofactors | pmid:26154585 | |
| Kovácik J et al. | Physiological responses of Scenedesmus quadricauda (Chlorophyceae) to UV-A and UV-C light. | Photochem. Photobiol. | pmid:20202162 | |
| Li QC et al. | Enhanced therapeutic efficacy and amelioration of cisplatin-induced nephrotoxicity by quercetin in 1,2-dimethyl hydrazine-induced colon cancer in rats. | Indian J Pharmacol | pmid:27127319 | |
| Francik R et al. | Antioxidant activity of beta-carboline derivatives. | Acta Pol Pharm | pmid:21485291 | |
| Harput US et al. | Antinociceptive, free radical-scavenging, and cytotoxic activities of Acanthus hirsutus Boiss. | J Med Food | pmid:21480807 | |
| Liu D et al. | Determination of rutin and isoquercetin contents in Hibisci mutabilis Folium in different collection periods by HPLC. | J Chromatogr Sci | pmid:26089170 | |
| Viswanatha GL et al. | LC-MS/MS profiling and neuroprotective effects of Mentat® against transient global ischemia and reperfusion-induced brain injury in rats. | Nutrition | pmid:26059376 | |
| Bayés M et al. | Gateways to clinical trials. | Methods Find Exp Clin Pharmacol | pmid:17922073 | |
| pmid:12214854 | ||||
| Hu J et al. | The effects of natural flavonoids on lipoxygenase-mediated oxidation of compounds with a benzene ring structure--a new possible mechanism of flavonoid anti-chemical carcinogenesis and other toxicities. | Int. J. Toxicol. | pmid:16815818 | |
| Qi J et al. | Screening of peroxynitrite scavengers in Flos Lonicerae by using two new methods, an HPLC-DAD-CL technique and a peroxynitrite spiking test followed by HPLC-DAD analysis. | Phytochem Anal | pmid:26567775 | |
| Gerhardt KE et al. | The effects of far-red light on plant growth and flavonoid accumulation in Brassica napus in the presence of ultraviolet B radiation. | Photochem. Photobiol. | pmid:18466203 | |
| Lahaie-Collins V et al. | Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP+-induced oxidative stress. | Oxid Med Cell Longev | pmid:19794909 | |
| Verma S et al. | Modulation of ionizing radiation induced oxidative imbalance by semi-fractionated extract of Piper betle: an in vitro and in vivo assessment. | Oxid Med Cell Longev | pmid:20716927 | |
| Arikan S et al. | Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model. | Arq Bras Oftalmol | pmid:25945531 | |
| Owens DK and McIntosh CA | Identification, recombinant expression, and biochemical characterization of a flavonol 3-O-glucosyltransferase clone from Citrus paradisi. | Phytochemistry | pmid:19733370 | |
| Haghighi M et al. | On the formulation design and rheological evaluations of pectin-based functional gels. | J. Food Sci. | pmid:21535667 | |
| Chan PC et al. | Ginkgo biloba leave extract: biological, medicinal, and toxicological effects. | J Environ Sci Health C Environ Carcinog Ecotoxicol Rev | pmid:17763047 | |
| Gaboriau F et al. | A simple assay for the measurement of plasma antioxidant status using spontaneous autoxidation of homovanillic acid. | J Pharmacol Toxicol Methods | pmid:12387937 | |
| Chi KK et al. | Comparison of quercetin and resveratrol in the prevention of injury due to testicular torsion/detorsion in rats. | Asian J. Androl. | pmid:26620457 | |
| Mitani A et al. | Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease. | Exp. Lung Res. | pmid:29227717 | |
| Thomsen H et al. | Characterization of Constituents and Anthelmintic Properties of Hagenia abyssinica. | Sci Pharm | pmid:22896828 | |
| de Oliveira MR et al. | Quercetin and the mitochondria: A mechanistic view. | Biotechnol. Adv. | pmid:26740171 | |
| Abo-Youssef AM | Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats. | Indian J Pharmacol | pmid:26729953 | |
| Lorenz P et al. | Investigations into the phenolic constituents of dog's mercury (Mercurialis perennis L.) by LC-MS/MS and GC-MS analyses. | Phytochem Anal | pmid:21692118 | |
| Sapir M et al. | Molecular aspects of Anthocyanin fruit tomato in relation to high pigment-1. | J. Hered. | pmid:18344529 | |
| Bae DS et al. | Importance of NKG2D-NKG2D ligands interaction for cytolytic activity of natural killer cell. | Cell. Immunol. | pmid:22613008 | |
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| Taamalli A et al. | LC-MS-based metabolite profiling of methanolic extracts from the medicinal and aromatic species Mentha pulegium and Origanum majorana. | Phytochem Anal | pmid:25982347 | |
| Jani N et al. | Exogenous glutathione is essential in the testing of antioxidant capacity using radical-induced haemolysis. | J Pharmacol Toxicol Methods | pmid:22507255 | |
| Murakami Y et al. | Radical-scavenging and Anti-inflammatory Activity of Quercetin and Related Compounds and Their Combinations Against RAW264.7 Cells Stimulated with Porphyromonas gingivalis Fimbriae. Relationships between Anti-inflammatory Activity and Quantum Chemical Parameters. | In Vivo | pmid:26546527 | |
| Selloum L et al. | Scavenger effect of flavonols on HOCl-induced luminol chemiluminescence. | Luminescence | pmid:15287004 | |
| Guo Y et al. | Quercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults. | Nutrition | pmid:25280405 | |
| Oliveira DR et al. | Special metabolites isolated from Urochloa humidicola (Poaceae). | An. Acad. Bras. Cienc. | pmid:28640339 | |
| Boumaza S et al. | Therapeutic Role of Resveratrol and Quercetin on Aortic Fibroblasts of Psammomys obesus After Oxidative Stress by Hydrogen Peroxide. | Am J Ther | pmid:26766292 | |
| pmid:15113146 | ||||
| Kawakami K et al. | Identification of 2″-galloylated flavonol 3-o-glycosides accumulating in developing leaves of persimmon. | Phytochem Anal | pmid:21413094 | |
| Forman V et al. | [Constituents of the leaves of Cornus officinalis Sieb. et Zucc.] | Ceska Slov Farm | pmid:27860471 | |
| Mandic P et al. | The effects of quercetin on liver regeneration after liver resection in rats. | Folia Morphol. (Warsz) | pmid:26711645 | |
| Guo X et al. | Synergistic interactions of apigenin, naringin, quercetin and emodin on inhibition of 3T3-L1 preadipocyte differentiation and pancreas lipase activity. | Obes Res Clin Pract | pmid:26314502 | |
| Zheng J et al. | Therapeutic effects of quercetin on early inflammation in hypertriglyceridemia-related acute pancreatitis and its mechanism. | Pancreatology | pmid:26873426 | |
| GarcÃa MT and González EL | Natural antioxidants protect against cadmium-induced damage during pregnancy and lactation in rats' pups. | J. Food Sci. | pmid:20492210 |