quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with quercetin?
Related references are published most in these journals:
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What lipids are associated with quercetin?
Related references are published most in these journals:
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What genes are associated with quercetin?
Related references are published most in these journals:
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Walkowiak A et al. | Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. | 2019 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:30321862 |
| Maurya AK and Vinayak M | Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. | 2019 | In Vitro Cell. Dev. Biol. Anim. | pmid:30413935 |
| Li J et al. | Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. | 2019 | Chem. Biol. Interact. | pmid:30365939 |
| Mu Y et al. | Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. | 2019 | Carbohydr Polym | pmid:30318192 |
| Li F et al. | The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. | 2019 | Pest Manag. Sci. | pmid:29797492 |
| Schröder L et al. | Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. | 2019 | Oncol. Rep. | pmid:30320348 |
| Leng E et al. | Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells. | 2018 | BMC Complement Altern Med | pmid:29622007 |
| Mohebali N et al. | Effect of flavonoids rich extract of Capparis spinosa on inflammatory involved genes in amyloid-beta peptide injected rat model of Alzheimer's disease. | 2018 | Nutr Neurosci | pmid:27778760 |
| Patel RV et al. | Therapeutic potential of quercetin as a cardiovascular agent. | 2018 | Eur J Med Chem | pmid:29966915 |
| Riva A et al. | Quercetin phytosome® in triathlon athletes: a pilot registry study. | 2018 | Minerva Med. | pmid:29947492 |
| Asfaram A et al. | Cu- and S- @SnO nanoparticles loaded on activated carbon for efficient ultrasound assisted dispersive µSPE-spectrophotometric detection of quercetin in Nasturtium officinale extract and fruit juice samples: CCD-RSM design. | 2018 | Ultrason Sonochem | pmid:29908597 |
| Mehrbod P et al. | Immunomodulatory properties of quercetin-3-O-α-L-rhamnopyranoside from Rapanea melanophloeos against influenza a virus. | 2018 | BMC Complement Altern Med | pmid:29903008 |
| Dresler S et al. | Methodological aspects of biologically active compounds quantification in the genus Hypericum. | 2018 | J Pharm Biomed Anal | pmid:29621655 |
| Gaudry A et al. | The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells. | 2018 | Int J Mol Sci | pmid:29621184 |
| Du G et al. | Quercetin protects rat cortical neurons against traumatic brain injury. | 2018 | Mol Med Rep | pmid:29620218 |
| Sung YY et al. | Aqueous and ethanolic extracts of welsh onion, Allium fistulosum, attenuate high-fat diet-induced obesity. | 2018 | BMC Complement Altern Med | pmid:29558911 |
| Foti MC et al. | Singlet oxygen quenching- and chain-breaking antioxidant-properties of a quercetin dimer able to prevent age-related macular degeneration. | 2018 | Biophys. Chem. | pmid:30352336 |
| Ebrahimpour S et al. | Effect of quercetin-conjugated superparamagnetic iron oxide nanoparticles on diabetes-induced learning and memory impairment in rats. | 2018 | Int J Nanomedicine | pmid:30349252 |
| Xia F et al. | Rapid Determination of Active Compounds and Antioxidant Activity of Okra Seeds Using Fourier Transform Near Infrared (FT-NIR) Spectroscopy. | 2018 | Molecules | pmid:29498632 |
| Donno D et al. | Assessing Nutritional Traits and Phytochemical Composition of Artisan Jams Produced in Comoros Islands: Using Indigenous Fruits with High Health-Impact as an Example of Biodiversity Integration and Food Security in Rural Development. | 2018 | Molecules | pmid:30347846 |
| Wu Q et al. | Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells. | 2018 | Food Funct | pmid:29497723 |
| Ahmed OM et al. | Quercetin and low level laser therapy promote wound healing process in diabetic rats via structural reorganization and modulatory effects on inflammation and oxidative stress. | 2018 | Biomed. Pharmacother. | pmid:29477473 |
| Zhao QY et al. | Selective recognition and fast enrichment of anthocyanins by dummy molecularly imprinted magnetic nanoparticles. | 2018 | J Chromatogr A | pmid:30139620 |
| Baksi R et al. | In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles. | 2018 | Biomed. Pharmacother. | pmid:30119227 |
| Junyuan Z et al. | Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition. | 2018 | Pancreatology | pmid:30115563 |
| Hobbs CA et al. | Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential. | 2018 | Food Chem. Toxicol. | pmid:29317330 |
| Chen Z et al. | Effects of Quercetin on Proliferation and Hâ‚‚Oâ‚‚-Induced Apoptosis of Intestinal Porcine Enterocyte Cells. | 2018 | Molecules | pmid:30103566 |
| Babaei F et al. | Quercetin in Food: Possible Mechanisms of Its Effect on Memory. | 2018 | J. Food Sci. | pmid:30103275 |
| Ren K et al. | Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARγ/LXRα pathway. | 2018 | Food Funct | pmid:29292466 |
| Chan ST et al. | Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice. | 2018 | Food Funct | pmid:29292417 |
| Guimarães GC et al. | Binding investigation between M2-1protein from hRSV and acetylated quercetin derivatives: H NMR, fluorescence spectroscopy, and molecular docking. | 2018 | Int. J. Biol. Macromol. | pmid:29292149 |
| Verjee S et al. | Hyperforin and Miquelianin from St. John's Wort Attenuate Gene Expression in Neuronal Cells After Dexamethasone-Induced Stress. | 2018 | Planta Med. | pmid:29499586 |
| Li ZP et al. | Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation. | 2018 | Molecules | pmid:29958399 |
| Cao L et al. | Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways. | 2018 | Int. J. Mol. Med. | pmid:29956731 |
| Fan D et al. | A comparison of mutagenic PhIP and beneficial 8-C-(E-phenylethenyl)quercetin and 6-C-(E-phenylethenyl)quercetin formation under microwave and conventional heating. | 2018 | Food Funct | pmid:29953158 |
| Kim JE et al. | Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal. | 2018 | Pharm Biol | pmid:29952685 |
| K N L et al. | Augmentation of antioxidant and iron(III) chelation properties of tertiary mixture of bioactive ligands. | 2018 | J Trace Elem Med Biol | pmid:29173467 |
| Suganya N et al. | Quercetin improves endothelial function in diabetic rats through inhibition of endoplasmic reticulum stress-mediated oxidative stress. | 2018 | Eur. J. Pharmacol. | pmid:29169872 |
| Zhang L et al. | UV-Vis spectroscopy combined with chemometric study on the interactions of three dietary flavonoids with copper ions. | 2018 | Food Chem | pmid:29784309 |
| Tsukamoto Y et al. | Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. | 2018 | PLoS ONE | pmid:29782545 |
| Chalet C et al. | Intestinal disposition of quercetin and its phase-II metabolites after oral administration in healthy volunteers. | 2018 | J. Pharm. Pharmacol. | pmid:29761870 |
| Li S et al. | A novel electrochemical sensor for detecting hyperin with a nanocomposite of ZrO-SDS-SWCNTs as decoration. | 2018 | Talanta | pmid:29759227 |
| Trinh PTN et al. | A new benzofuran derivative from the leaves of Ficus pumila L. | 2018 | Nat. Prod. Res. | pmid:29072969 |
| Kim J et al. | Quercetin-3-O-α-l-arabinopyranoside protects against retinal cell death via blue light-induced damage in human RPE cells and Balb-c mice. | 2018 | Food Funct | pmid:29541735 |
| Safwat NA et al. | Quercetin 3-O-glucoside recovered from the wild Egyptian Sahara plant, Euphorbia paralias L., inhibits glutamine synthetase and has antimycobacterial activity. | 2018 | Tuberculosis (Edinb) | pmid:29523309 |
| Osawe SO and Farombi EO | Quercetin and rutin ameliorates sulphasalazine-induced spermiotoxicity, alterations in reproductive hormones and steroidogenic enzyme imbalance in rats. | 2018 | Andrologia | pmid:29512831 |
| Pham-Hoang BN et al. | Fluorescence Lifetime and UV-Vis Spectroscopy to Evaluate the Interactions Between Quercetin and Its Yeast Microcapsule. | 2018 | Biotechnol J | pmid:28887909 |
| Larit F et al. | Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants. | 2018 | Phytomedicine | pmid:29496172 |
| Wu Q et al. | Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. | 2018 | J. Agric. Food Chem. | pmid:29905475 |
| Bouratoua A et al. | Chemical composition and antioxidant activity of aerial parts of Ferula longipes Coss. ex Bonnier and Maury. | 2018 | Nat. Prod. Res. | pmid:28714345 |