quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with quercetin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Leng E et al. | Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells. | 2018 | BMC Complement Altern Med | pmid:29622007 |
Mohebali N et al. | Effect of flavonoids rich extract of Capparis spinosa on inflammatory involved genes in amyloid-beta peptide injected rat model of Alzheimer's disease. | 2018 | Nutr Neurosci | pmid:27778760 |
Arbain NH et al. | Optimization of Quercetin loaded Palm Oil Ester Based Nanoemulsion Formulation for Pulmonary Delivery. | 2018 | J Oleo Sci | pmid:30012897 |
Chirumbolo S and Bjørklund G | Quercetin in collagen-induced arthritis. Some comments. | 2018 | Int. Immunopharmacol. | pmid:29970297 |
Patel RV et al. | Therapeutic potential of quercetin as a cardiovascular agent. | 2018 | Eur J Med Chem | pmid:29966915 |
Riva A et al. | Quercetin phytosome® in triathlon athletes: a pilot registry study. | 2018 | Minerva Med. | pmid:29947492 |
Habtemariam S and Belai A | Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin. | 2018 | Mini Rev Med Chem | pmid:28117024 |
Asfaram A et al. | Cu- and S- @SnO nanoparticles loaded on activated carbon for efficient ultrasound assisted dispersive µSPE-spectrophotometric detection of quercetin in Nasturtium officinale extract and fruit juice samples: CCD-RSM design. | 2018 | Ultrason Sonochem | pmid:29908597 |
Kapur B et al. | Health and taste related compounds in strawberries under various irrigation regimes and bio-stimulant application. | 2018 | Food Chem | pmid:29784329 |
Váradyová Z et al. | Ovicidal and larvicidal activity of extracts from medicinal-plants against Haemonchus contortus. | 2018 | Exp. Parasitol. | pmid:30389531 |
Suke SG et al. | Ameliorative effect of nanoencapsulated flavonoid against chlorpyrifos-induced hepatic oxidative damage and immunotoxicity in Wistar rats. | 2018 | J. Biochem. Mol. Toxicol. | pmid:29667781 |
Zhu Y et al. | Molecular Cloning and Functional Characterization of a Dihydroflavonol 4-Reductase from Vitis bellula. | 2018 | Molecules | pmid:29642567 |
Dresler S et al. | Methodological aspects of biologically active compounds quantification in the genus Hypericum. | 2018 | J Pharm Biomed Anal | pmid:29621655 |
Kim MK et al. | In Vitro Synergism and Anti-biofilm Activity of Quercetin-Pivaloxymethyl Conjugate against Staphylococcus aureus and Enterococcus Species. | 2018 | Chem. Pharm. Bull. | pmid:30381653 |
Naeimi R et al. | Querectin improves myelin repair of optic chiasm in lyolecithin-induced focal demyelination model. | 2018 | Biomed. Pharmacother. | pmid:29501770 |
Foti MC et al. | Singlet oxygen quenching- and chain-breaking antioxidant-properties of a quercetin dimer able to prevent age-related macular degeneration. | 2018 | Biophys. Chem. | pmid:30352336 |
Ozdemir Olgun FA et al. | A novel cerium oxide nanoparticles-based colorimetric sensor using tetramethyl benzidine reagent for antioxidant activity assay. | 2018 | Talanta | pmid:29501192 |
Ebrahimpour S et al. | Effect of quercetin-conjugated superparamagnetic iron oxide nanoparticles on diabetes-induced learning and memory impairment in rats. | 2018 | Int J Nanomedicine | pmid:30349252 |
Xia F et al. | Rapid Determination of Active Compounds and Antioxidant Activity of Okra Seeds Using Fourier Transform Near Infrared (FT-NIR) Spectroscopy. | 2018 | Molecules | pmid:29498632 |
Wu Q et al. | Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells. | 2018 | Food Funct | pmid:29497723 |
Zhou J et al. | Determination of isoquercitrin in rat plasma by high performance liquid chromatography coupled with a novel synergistic cloud point extraction. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29153998 |
Erdogan S et al. | Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway. | 2018 | Biomed. Pharmacother. | pmid:30142541 |
Sunoqrot S et al. | Facile synthesis and surface modification of bioinspired nanoparticles from quercetin for drug delivery. | 2018 | Biomater Sci | pmid:30140818 |
Zhao QY et al. | Selective recognition and fast enrichment of anthocyanins by dummy molecularly imprinted magnetic nanoparticles. | 2018 | J Chromatogr A | pmid:30139620 |
Jadán-Piedra C et al. | In vitro evaluation of dietary compounds to reduce mercury bioavailability. | 2018 | Food Chem | pmid:29329865 |
Baksi R et al. | In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles. | 2018 | Biomed. Pharmacother. | pmid:30119227 |
Lu Z et al. | Preparation and in vitro and in vivo evaluation of quercetin-loaded mixed micelles for oral delivery. | 2018 | Biosci. Biotechnol. Biochem. | pmid:29327653 |
Junyuan Z et al. | Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition. | 2018 | Pancreatology | pmid:30115563 |
Hobbs CA et al. | Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential. | 2018 | Food Chem. Toxicol. | pmid:29317330 |
Ren K et al. | Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARγ/LXRα pathway. | 2018 | Food Funct | pmid:29292466 |
Farazuddin M et al. | Quercetin prevents rhinovirus-induced progression of lung disease in mice with COPD phenotype. | 2018 | PLoS ONE | pmid:29975735 |
Rastogi S and Haldar C | Comparative effect of melatonin and quercetin in counteracting LPS induced oxidative stress in bone marrow mononuclear cells and spleen of Funambulus pennanti. | 2018 | Food Chem. Toxicol. | pmid:29964085 |
Li ZP et al. | Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation. | 2018 | Molecules | pmid:29958399 |
Cao L et al. | Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways. | 2018 | Int. J. Mol. Med. | pmid:29956731 |
Steinborn C et al. | In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica. | 2018 | Planta Med. | pmid:29202511 |
Fan D et al. | A comparison of mutagenic PhIP and beneficial 8-C-(E-phenylethenyl)quercetin and 6-C-(E-phenylethenyl)quercetin formation under microwave and conventional heating. | 2018 | Food Funct | pmid:29953158 |
Braun JBS et al. | Pretreatment with quercetin prevents changes in lymphocytes E-NTPDase/E-ADA activities and cytokines secretion in hyperlipidemic rats. | 2018 | Mol. Cell. Biochem. | pmid:29188537 |
K N L et al. | Augmentation of antioxidant and iron(III) chelation properties of tertiary mixture of bioactive ligands. | 2018 | J Trace Elem Med Biol | pmid:29173467 |
Escher GB et al. | Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract. | 2018 | Food Chem. Toxicol. | pmid:29787846 |
Zhang L et al. | UV-Vis spectroscopy combined with chemometric study on the interactions of three dietary flavonoids with copper ions. | 2018 | Food Chem | pmid:29784309 |
Tsukamoto Y et al. | Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. | 2018 | PLoS ONE | pmid:29782545 |
Chalet C et al. | Intestinal disposition of quercetin and its phase-II metabolites after oral administration in healthy volunteers. | 2018 | J. Pharm. Pharmacol. | pmid:29761870 |
Shu B et al. | Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-κB signaling suppression. | 2018 | Cell. Signal. | pmid:29080804 |
Trinh PTN et al. | A new benzofuran derivative from the leaves of Ficus pumila L. | 2018 | Nat. Prod. Res. | pmid:29072969 |
Kim J et al. | Quercetin-3-O-α-l-arabinopyranoside protects against retinal cell death via blue light-induced damage in human RPE cells and Balb-c mice. | 2018 | Food Funct | pmid:29541735 |
Safwat NA et al. | Quercetin 3-O-glucoside recovered from the wild Egyptian Sahara plant, Euphorbia paralias L., inhibits glutamine synthetase and has antimycobacterial activity. | 2018 | Tuberculosis (Edinb) | pmid:29523309 |
Pham-Hoang BN et al. | Fluorescence Lifetime and UV-Vis Spectroscopy to Evaluate the Interactions Between Quercetin and Its Yeast Microcapsule. | 2018 | Biotechnol J | pmid:28887909 |
Larit F et al. | Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants. | 2018 | Phytomedicine | pmid:29496172 |
Bouratoua A et al. | Chemical composition and antioxidant activity of aerial parts of Ferula longipes Coss. ex Bonnier and Maury. | 2018 | Nat. Prod. Res. | pmid:28714345 |
Bhattacharya D et al. | Antibacterial activity of polyphenolic fraction of Kombucha against Vibrio cholerae: targeting cell membrane. | 2018 | Lett. Appl. Microbiol. | pmid:29193174 |