quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with quercetin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bustos AS et al. | Interaction Between Phenolic Compounds and Lipase: The Influence of Solubility and Presence of Particles in the IC Value. | 2018 | J. Food Sci. | pmid:30020550 |
Ashraf AHMZ et al. | Differential Mechanism of Action of 3,4',7-O-trimethylquercetin in Three Types of Ovarian Cancer Cells. | 2018 | Anticancer Res. | pmid:30194160 |
Rubio V et al. | Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells. | 2018 | Chem. Biol. Interact. | pmid:30171828 |
Jang SA et al. | Hyperoside suppresses tumor necrosis factor α-mediated vascular inflammatory responses by downregulating mitogen-activated protein kinases and nuclear factor-κB signaling. | 2018 | Chem. Biol. Interact. | pmid:30125551 |
Chen X et al. | Gastrointestinal Fate of Fluid and Gelled Nutraceutical Emulsions: Impact on Proteolysis, Lipolysis, and Quercetin Bioaccessibility. | 2018 | J. Agric. Food Chem. | pmid:30102529 |
Das S et al. | Molecular recognition of bio-active flavonoids quercetin and rutin by bovine hemoglobin: an overview of the binding mechanism, thermodynamics and structural aspects through multi-spectroscopic and molecular dynamics simulation studies. | 2018 | Phys Chem Chem Phys | pmid:30101248 |
Yamashita K et al. | Assessment of the skin sensitizing potential of chemicals, contained in foods and/or cosmetic ingredients, using a modified local lymph node assay with an elicitation phase (LLNA:DAE) method. | 2018 | J Toxicol Sci | pmid:30078837 |
Liu Y et al. | Antidiabetic Effect of Leaves Depends on the Contents of Antihyperglycemic Flavonoids and Antihyperlipidemic Triterpenoids. | 2018 | Molecules | pmid:29710841 |
Xia J et al. | Shufeng Jiedu Capsule and its active ingredients induce apoptosis, inhibit migration and invasion, and enhances doxorubicin therapeutic efficacy in hepatocellular carcinoma. | 2018 | Biomed. Pharmacother. | pmid:29710492 |
Lu N et al. | Inhibitive Effects of Quercetin on Myeloperoxidase-Dependent Hypochlorous Acid Formation and Vascular Endothelial Injury. | 2018 | J. Agric. Food Chem. | pmid:29708335 |
Jin UH et al. | Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. | 2018 | Toxicol. Sci. | pmid:29584932 |
Hwang DS et al. | Effects of Rhei Undulati Rhizoma on lipopolysaccharide-induced neuroinflammation in vitro and in vivo. | 2018 | Environ. Toxicol. | pmid:28984087 |
Ma C et al. | Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway. | 2018 | Mol Med Rep | pmid:29532872 |
Fusi J et al. | An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds. | 2018 | Biomed. Pharmacother. | pmid:29525677 |
Abdelhalim MAK et al. | Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo. | 2018 | Int J Nanomedicine | pmid:30538457 |
Ding T et al. | Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome. | 2018 | Phytomedicine | pmid:29519318 |
Sarangowa O et al. | Botanical origin of Mei-gui Hua in Chinese markets. | 2018 | J Nat Med | pmid:29188415 |
Takabe W et al. | Identification of Antiglycative Compounds in Japanese Red Water Pepper (Red Leaf Variant of the Sprout). | 2018 | Molecules | pmid:30208642 |
Wein S et al. | Bioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows. | 2018 | J. Agric. Food Chem. | pmid:30207714 |
Li JP et al. | Hyperoside and let-7a-5p synergistically inhibits lung cancer cell proliferation via inducing G1/S phase arrest. | 2018 | Gene | pmid:30201337 |
Ding Y et al. | Quercetin suppresses the chymotrypsin-like activity of proteasome via inhibition of MEK1/ERK1/2 signaling pathway in hepatocellular carcinoma HepG2 cells. | 2018 | Can. J. Physiol. Pharmacol. | pmid:29394494 |
Tanaka S et al. | Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin. | 2018 | Biosci. Biotechnol. Biochem. | pmid:30200823 |
Ginex T et al. | Computational Study of the Aza-Michael Addition of the Flavonoid (+)-Taxifolin in the Inhibition of β-Amyloid Fibril Aggregation. | 2018 | Chemistry | pmid:29384229 |
Carbone ML et al. | Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. | 2018 | Int J Mol Sci | pmid:30200670 |
Kim Y and Chang KO | Protein disulfide isomerases as potential therapeutic targets for influenza A and B viruses. | 2018 | Virus Res. | pmid:29382552 |
Hyun HB et al. | Quercetin Suppresses CYR61-Mediated Multidrug Resistance in Human Gastric Adenocarcinoma AGS Cells. | 2018 | Molecules | pmid:29364834 |
Song JY et al. | Quercetin Shows the Pharmacological Activity to Simultaneously Downregulate the Inflammatory and Fibrotic Responses to Tissue Injury in Association with its Ability to Target Multi-Kinases. | 2018 | Pharmacology | pmid:30016781 |
Farrag Y et al. | Starch films loaded with donut-shaped starch-quercetin microparticles: Characterization and release kinetics. | 2018 | Int. J. Biol. Macromol. | pmid:30012488 |
Li JJ et al. | Fast dissolving drug delivery membrane based on the ultra-thin shell of electrospun core-shell nanofibers. | 2018 | Eur J Pharm Sci | pmid:30008429 |
Zhu Y et al. | Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model. | 2018 | Food Funct | pmid:29215110 |
Vimalraj S et al. | Mixed-ligand copper(II) complex of quercetin regulate osteogenesis and angiogenesis. | 2018 | Mater Sci Eng C Mater Biol Appl | pmid:29208278 |
Yang X et al. | Quercetin synergistically reactivates human immunodeficiency virus type 1 latency by activating nuclear factor‑κB. | 2018 | Mol Med Rep | pmid:29207194 |
Kalinová JP et al. | Contribution to the study of rutin stability in the achenes of Tartary buckwheat (Fagopyrum tataricum). | 2018 | Food Chem | pmid:29655739 |
Lee KM et al. | Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed human keratinocytes. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29857000 |
Ramos-Pineda AM et al. | Effect of the addition of mannoproteins on the interaction between wine flavonols and salivary proteins. | 2018 | Food Chem | pmid:29853369 |
Wang L et al. | Fermentation and complex enzyme hydrolysis for improving the total soluble phenolic contents, flavonoid aglycones contents and bio-activities of guava leaves tea. | 2018 | Food Chem | pmid:29853365 |
Abdullah AA et al. | The performance of cathodically pretreated boron-doped diamond electrode in cationic surfactant media for enhancing the adsorptive stripping voltammetric determination of catechol-containing flavonoid quercetin in apple juice. | 2018 | Talanta | pmid:29853029 |
Singh A et al. | Curcumin loaded chitin-glucan quercetin conjugate: Synthesis, characterization, antioxidant, in vitro release study, and anticancer activity. | 2018 | Int. J. Biol. Macromol. | pmid:29128588 |
Li S et al. | Quercetin protects against ox‑LDL‑induced injury via regulation of ABCAl, LXR‑α and PCSK9 in RAW264.7 macrophages. | 2018 | Mol Med Rep | pmid:29845234 |
Lei CS et al. | Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies. | 2018 | J. Nutr. Biochem. | pmid:29125991 |
Haque MW et al. | Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway. | 2018 | Biomed. Pharmacother. | pmid:29843042 |
He K et al. | LPS ameliorates renal ischemia/reperfusion injury via Hsp27 up-regulation. | 2018 | Int Urol Nephrol | pmid:29124510 |
Kellett ME et al. | Modification of the cellular antioxidant activity (CAA) assay to study phenolic antioxidants in a Caco-2 cell line. | 2018 | Food Chem | pmid:29120793 |
Zhang Y et al. | Anti-hypoglycemic and hepatocyte-protective effects of hyperoside from Zanthoxylum bungeanum leaves in mice with high-carbohydrate/high-fat diet and alloxan-induced diabetes. | 2018 | Int. J. Mol. Med. | pmid:29115390 |
Jayachandran M et al. | Isoquercetin ameliorates hyperglycemia and regulates key enzymes of glucose metabolism via insulin signaling pathway in streptozotocin-induced diabetic rats. | 2018 | Eur. J. Pharmacol. | pmid:29665363 |
Hatware KV et al. | Evidence for gastroprotective, anti-inflammatory and antioxidant potential of methanolic extract of Cordia dichotoma leaves on indomethacin and stress induced gastric lesions in Wistar rats. | 2018 | Biomed. Pharmacother. | pmid:29660650 |
Li S et al. | Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation. | 2018 | Phytother Res | pmid:29635751 |
Xiao J | Stability of dietary polyphenols: It's never too late to mend? | 2018 | Food Chem. Toxicol. | pmid:29626578 |
Quintero-Soto MF et al. | Phenolic profiles and their contribution to the antioxidant activity of selected chickpea genotypes from Mexico and ICRISAT collections. | 2018 | Plant Foods Hum Nutr | pmid:29516285 |
de Lacerda Neto LJ et al. | Modulation of antibiotic activity by the hydroalcoholic extract from leaves of Caryocar coriaceum WITTM. | 2018 | Nat. Prod. Res. | pmid:28391717 |
Chatziathanasiadou MV et al. | Amplifying and broadening the cytotoxic profile of quercetin in cancer cell lines through bioconjugation. | 2018 | Amino Acids | pmid:29185031 |
Bonechi C et al. | Protective effect of quercetin and rutin encapsulated liposomes on induced oxidative stress. | 2018 | Biophys. Chem. | pmid:29174505 |
Curgali K et al. | Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells. | 2018 | Acta Histochem. | pmid:29129327 |
Andres S et al. | Safety Aspects of the Use of Quercetin as a Dietary Supplement. | 2018 | Mol Nutr Food Res | pmid:29127724 |
Bondonno NP et al. | Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial. | 2018 | Mol Nutr Food Res | pmid:29086478 |
Zhao TT et al. | Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes. | 2018 | Gene | pmid:29730426 |
Deng M et al. | Effect of Storage Conditions on Phenolic Profiles and Antioxidant Activity of Litchi Pericarp. | 2018 | Molecules | pmid:30200581 |
Wang J et al. | Isorhamnetin prevents H2O2‑induced oxidative stress in human retinal pigment epithelial cells. | 2018 | Mol Med Rep | pmid:29115489 |
Ahmad N et al. | Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia. | 2018 | Artif Cells Nanomed Biotechnol | pmid:28604104 |
Woźniak D et al. | Comparison of Polyphenol Profile and Antimutagenic and Antioxidant Activities in Two Species Used as Source of Solidaginis herba - Goldenrod. | 2018 | Chem. Biodivers. | pmid:29537689 |
Liu ZH et al. | Synergistic effects and related bioactive mechanisms of Potentilla fruticosa Linn. leaves combined with green tea polyphenols studied with microbial test system (MTS). | 2018 | Nat. Prod. Res. | pmid:28602107 |
Yang T et al. | Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats. | 2018 | Mol Med Rep | pmid:30015887 |
Ojo OA et al. | Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill bark. | 2018 | J Basic Clin Physiol Pharmacol | pmid:29381472 |
Braun JBS et al. | Neuroprotective effects of pretreatment with quercetin as assessed by acetylcholinesterase assay and behavioral testing in poloxamer-407 induced hyperlipidemic rats. | 2017 | Biomed. Pharmacother. | pmid:28192878 |
Ballmann C et al. | Long-term dietary quercetin enrichment as a cardioprotective countermeasure in mdx mice. | 2017 | Exp. Physiol. | pmid:28192862 |
Gilley AD et al. | Novel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations in vitro. | 2017 | Carbohydr Polym | pmid:27988001 |
Caddeo C et al. | Physico-chemical characterization of succinyl chitosan-stabilized liposomes for the oral co-delivery of quercetin and resveratrol. | 2017 | Carbohydr Polym | pmid:27987905 |
Adomako-Bonsu AG et al. | Antioxidant activity of rosmarinic acid and its principal metabolites in chemical and cellular systems: Importance of physico-chemical characteristics. | 2017 | Toxicol In Vitro | pmid:28122265 |
Abdel-Wahhab MA et al. | Chitosan nanoparticles plus quercetin suppress the oxidative stress, modulate DNA fragmentation and gene expression in the kidney of rats fed ochratoxin A-contaminated diet. | 2017 | Food Chem. Toxicol. | pmid:27923682 |
Silva FC et al. | Antihyperglycemic Effect of Quercetin in Ovariectomized Rats Treated with Tamoxifen. | 2017 | J Med Food | pmid:28121480 |
Kim MK et al. | Quercetin-glutamic acid conjugate with a non-hydrolysable linker; a novel scaffold for multidrug resistance reversal agents through inhibition of P-glycoprotein. | 2017 | Bioorg. Med. Chem. | pmid:28043777 |
Peron G et al. | The antiadhesive activity of cranberry phytocomplex studied by metabolomics: Intestinal PAC-A metabolites but not intact PAC-A are identified as markers in active urines against uropathogenic Escherichia coli. | 2017 | Fitoterapia | pmid:28844930 |
Cialdella-Kam L et al. | Quercetin and Green Tea Extract Supplementation Downregulates Genes Related to Tissue Inflammatory Responses to a 12-Week High Fat-Diet in Mice. | 2017 | Nutrients | pmid:28753942 |
He Y et al. | Quercetin induces autophagy via FOXO1-dependent pathways and autophagy suppression enhances quercetin-induced apoptosis in PASMCs in hypoxia. | 2017 | Free Radic. Biol. Med. | pmid:27979659 |
Chen H and Yao Y | Phytoglycogen improves the water solubility and Caco-2 monolayer permeation of quercetin. | 2017 | Food Chem | pmid:27979200 |
Rybakovsky E et al. | Improvement of Human-Oral-Epithelial-Barrier Function and of Tight Junctions by Micronutrients. | 2017 | J. Agric. Food Chem. | pmid:29172516 |
Chen TY et al. | Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat. | 2017 | Mol Nutr Food Res | pmid:28568316 |
Lagunes I et al. | Singlet Oxygen Detection Using Red Wine Extracts as Photosensitizers. | 2017 | J. Food Sci. | pmid:28841237 |
Hashemzaei M et al. | Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo. | 2017 | Oncol. Rep. | pmid:28677813 |
Sánchez-González PD et al. | Differential effect of quercetin on cisplatin-induced toxicity in kidney and tumor tissues. | 2017 | Food Chem. Toxicol. | pmid:28669851 |
Esrefoglu M et al. | Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage. | 2017 | Bratisl Lek Listy | pmid:28664744 |
Tressera-Rimbau A et al. | Dietary Polyphenols in the Prevention of Stroke. | 2017 | Oxid Med Cell Longev | pmid:29204249 |
Guo R et al. | Comparative assessment of phytochemical profiles, antioxidant and antiproliferative activities of Sea buckthorn (Hippophaë rhamnoides L.) berries. | 2017 | Food Chem | pmid:27979305 |
Nagpal I and Abraham SK | Ameliorative effects of gallic acid, quercetin and limonene on urethane-induced genotoxicity and oxidative stress in Drosophila melanogaster. | 2017 | Toxicol. Mech. Methods | pmid:28043195 |
Gasmi S et al. | Effects of Deltamethrin on striatum and hippocampus mitochondrial integrity and the protective role of Quercetin in rats. | 2017 | Environ Sci Pollut Res Int | pmid:28551743 |
Yamauchi K et al. | 3,4',7-O-trimethylquercetin Inhibits Invasion and Migration of Ovarian Cancer Cells. | 2017 | Anticancer Res. | pmid:28551617 |
Omar SH et al. | Olive (Olea europaea L.) Biophenols: A Nutriceutical against Oxidative Stress in SH-SY5Y Cells. | 2017 | Molecules | pmid:29109370 |
Arias N et al. | A combination of resveratrol and quercetin induces browning in white adipose tissue of rats fed an obesogenic diet. | 2017 | Obesity (Silver Spring) | pmid:27874268 |
Foster CK and Thorpe C | Challenges in the evaluation of thiol-reactive inhibitors of human protein disulfide Isomerase. | 2017 | Free Radic. Biol. Med. | pmid:28465261 |
Zhu B et al. | Co-delivery of vincristine and quercetin by nanocarriers for lymphoma combination chemotherapy. | 2017 | Biomed. Pharmacother. | pmid:28463792 |
Oliveira CD et al. | Peltatoside Isolated from Annona crassiflora Induces Peripheral Antinociception by Activation of the Cannabinoid System. | 2017 | Planta Med. | pmid:27574895 |
Alrushaid S et al. | Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative. | 2017 | Drug Deliv Transl Res | pmid:28462502 |
Cao H et al. | Isoquercetin ameliorated hypoxia/reoxygenation-induced H9C2 cardiomyocyte apoptosis via a mitochondrial-dependent pathway. | 2017 | Biomed. Pharmacother. | pmid:28915535 |
Bahar E et al. | Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-κB and HO-1/Nrf2 Pathways. | 2017 | Int J Mol Sci | pmid:28914791 |
Singh D et al. | Quercetin exhibits adjuvant activity by enhancing Th2 immune response in ovalbumin immunized mice. | 2017 | Biomed. Pharmacother. | pmid:28380410 |
Terao J | Factors modulating bioavailability of quercetin-related flavonoids and the consequences of their vascular function. | 2017 | Biochem. Pharmacol. | pmid:28377278 |
Nna VU et al. | Cadmium chloride-induced testicular toxicity in male wistar rats; prophylactic effect of quercetin, and assessment of testicular recovery following cadmium chloride withdrawal. | 2017 | Biomed. Pharmacother. | pmid:28756368 |
Seifi-Jamadi A et al. | Antioxidant effect of quercetin in an extender containing DMA or glycerol on freezing capacity of goat semen. | 2017 | Cryobiology | pmid:28279680 |
Yildiz I et al. | Bioactivity-guided isolation of flavonoids from Cynanchum acutum L. subsp. sibiricum (willd.) Rech. f. and investigation of their antiproliferative activity. | 2017 | Nat. Prod. Res. | pmid:28278670 |
Ahmad N et al. | Enhancement of Quercetin Oral Bioavailability by Self-Nanoemulsifying Drug Delivery System and their Quantification Through Ultra High Performance Liquid Chromatography and Mass Spectrometry in Cerebral Ischemia. | 2017 | Drug Res (Stuttg) | pmid:28561230 |