quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
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Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with quercetin?
Related references are published most in these journals:
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What lipids are associated with quercetin?
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What genes are associated with quercetin?
Related references are published most in these journals:
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Walkowiak A et al. | Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. | 2019 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:30321862 |
| Maurya AK and Vinayak M | Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. | 2019 | In Vitro Cell. Dev. Biol. Anim. | pmid:30413935 |
| Li J et al. | Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. | 2019 | Chem. Biol. Interact. | pmid:30365939 |
| Mu Y et al. | Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. | 2019 | Carbohydr Polym | pmid:30318192 |
| Li F et al. | The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. | 2019 | Pest Manag. Sci. | pmid:29797492 |
| Schröder L et al. | Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. | 2019 | Oncol. Rep. | pmid:30320348 |
| Maturu P et al. | Quercetin attenuates the hyperoxic lung injury in neonatal mice: Implications for Bronchopulmonary dysplasia (BPD). | 2018 | Food Chem. Toxicol. | pmid:29432836 |
| Wang D et al. | Quercetin attenuates domoic acid-induced cognitive deficits in mice. | 2018 | Nutr Neurosci | pmid:28277184 |
| Kinger M et al. | Some Important Dietary Polyphenolic Compounds: An Anti-inflammatory and Immunoregulatory Perspective. | 2018 | Mini Rev Med Chem | pmid:28183265 |
| Khlupova ME et al. | Laccase-Catalyzed Heterocoupling of Dihydroquercetin and p-Aminobenzoic Acid: Effect of the Reaction Product on Cultured Cells. | 2018 | Biochemistry Mosc. | pmid:30208835 |
| Ashraf AHMZ et al. | Differential Mechanism of Action of 3,4',7-O-trimethylquercetin in Three Types of Ovarian Cancer Cells. | 2018 | Anticancer Res. | pmid:30194160 |
| Habtemariam S and Belai A | Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin. | 2018 | Mini Rev Med Chem | pmid:28117024 |
| Liu L et al. | One-step synthesis of fluorescent carbon dots for sensitive and selective detection of hyperin. | 2018 | Talanta | pmid:29784367 |
| Singh A et al. | Synthesis of chitin-glucan-aldehyde-quercetin conjugate and evaluation of anticancer and antioxidant activities. | 2018 | Carbohydr Polym | pmid:29773403 |
| Huang ZQ et al. | Antioxidant Activity and Hepatoprotective Potential of Quercetin 7-Rhamnoside In Vitro and In Vivo. | 2018 | Molecules | pmid:29772655 |
| Omar SH et al. | Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.). | 2018 | Fitoterapia | pmid:29772299 |
| Qi F et al. | Anti-inflammatory effects of isorhamnetin on LPS-stimulated human gingival fibroblasts by activating Nrf2 signaling pathway. | 2018 | Microb. Pathog. | pmid:29704670 |
| Pilařová V et al. | Simultaneous determination of quercetin and its metabolites in rat plasma by using ultra-high performance liquid chromatography tandem mass spectrometry. | 2018 | Talanta | pmid:29759252 |
| Lu X et al. | Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice. | 2018 | Biomed. Pharmacother. | pmid:29684859 |
| Liu FC et al. | Arthroprotective Effects of Cf-02 Sharing Structural Similarity with Quercetin. | 2018 | Int J Mol Sci | pmid:29757957 |
| Kumar M et al. | N-desmethyl tamoxifen and quercetin-loaded multiwalled CNTs: A synergistic approach to overcome MDR in cancer cells. | 2018 | Mater Sci Eng C Mater Biol Appl | pmid:29752099 |
| Niu X et al. | Three-dimensional reduced graphene oxide aerogel modified electrode for the sensitive quercetin sensing and its application. | 2018 | Mater Sci Eng C Mater Biol Appl | pmid:29752093 |
| Chen Z et al. | Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells. | 2018 | Phytomedicine | pmid:29747752 |
| Å ola I et al. | Comparative Analysis of Native Crocus Taxa as a Great Source of Flavonoids with High Antioxidant Activity. | 2018 | Plant Foods Hum Nutr | pmid:29860648 |
| Negi S et al. | Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. | 2018 | Toxicol In Vitro | pmid:29933105 |
| Jin UH et al. | Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. | 2018 | Toxicol. Sci. | pmid:29584932 |
| Sung YY et al. | Aqueous and ethanolic extracts of welsh onion, Allium fistulosum, attenuate high-fat diet-induced obesity. | 2018 | BMC Complement Altern Med | pmid:29558911 |
| Borovskaya TG et al. | Experimental Analysis of the Efficacy of Dihydroquercetin on the Model of Chronic Nonbacterial Inflammation of the Prostatic Gland. | 2018 | Bull. Exp. Biol. Med. | pmid:29577199 |
| Rishitha N and Muthuraman A | Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish. | 2018 | Life Sci. | pmid:29522770 |
| Castillo RL et al. | Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats. | 2018 | Oxid Med Cell Longev | pmid:29576853 |
| Khalil SR et al. | Intermediate filament protein expression pattern and inflammatory response changes in kidneys of rats receiving doxorubicin chemotherapy and quercetin. | 2018 | Toxicol. Lett. | pmid:29474904 |
| Liu J et al. | Preparation, characterization, digestibility and antioxidant activity of quercetin grafted Cynanchum auriculatum starch. | 2018 | Int. J. Biol. Macromol. | pmid:29572138 |
| Boadi WY and Lo A | Effects of Quercetin, Kaempferol, and Exogenous Glutathione on Phospho- and Total-AKT in 3T3-L1 Preadipocytes. | 2018 | J Diet Suppl | pmid:29345961 |
| Dai Y et al. | Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway. | 2018 | Chem. Biol. Interact. | pmid:29454613 |
| Ma YK et al. | Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media. | 2018 | Int. J. Mol. Med. | pmid:29568908 |
| Donno D et al. | New Findings in Prunus padus L. Fruits as a Source of Natural Compounds: Characterization of Metabolite Profiles and Preliminary Evaluation of Antioxidant Activity. | 2018 | Molecules | pmid:29565317 |
| Park DJ et al. | Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model. | 2018 | J. Vet. Med. Sci. | pmid:29563391 |
| Tsunekawa R et al. | Synthesis of fisetin and 2',4',6'-trihydroxydihyrochalcone 4'-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation. | 2018 | Biosci. Biotechnol. Biochem. | pmid:29699439 |
| Forney LA et al. | Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner. | 2018 | Int J Mol Sci | pmid:29562620 |
| Hatahet T et al. | Liposomes, lipid nanocapsules and smartCrystals®: A comparative study for an effective quercetin delivery to the skin. | 2018 | Int J Pharm | pmid:29549014 |
| Zhou J et al. | Determination of isoquercitrin in rat plasma by high performance liquid chromatography coupled with a novel synergistic cloud point extraction. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29153998 |
| Chen Y et al. | Beneficial effects of hyperoside on bone metabolism in ovariectomized mice. | 2018 | Biomed. Pharmacother. | pmid:30257331 |
| Rjeibi I et al. | Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice. | 2018 | Oxid Med Cell Longev | pmid:30254713 |
| Liu Y et al. | Geographic Variation in the Chemical Composition and Antioxidant Properties of Phenolic Compounds from (Batal) Iljinskaja Leaves. | 2018 | Molecules | pmid:30249997 |
| Naseer Z et al. | Dietary quercetin maintains the semen quality in rabbits under summer heat stress. | 2018 | Theriogenology | pmid:30243139 |
| Sakalli S et al. | In vitro effects of diosmin, naringenin, quercetin and indole-3-carbinol on fish hepatic CYP1A1 in the presence of clotrimazole and dexamethasone. | 2018 | Chemosphere | pmid:29100118 |
| Nakhlband A et al. | Marrubiin-loaded solid lipid nanoparticles' impact on TNF-α treated umbilical vein endothelial cells: A study for cardioprotective effect. | 2018 | Colloids Surf B Biointerfaces | pmid:29413609 |
| Fang J et al. | Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy. | 2018 | Int J Nanomedicine | pmid:30233175 |
| Omwenga EO et al. | Chitosan nanoencapsulation of flavonoids enhances their quorum sensing and biofilm formation inhibitory activities against an E.coli Top 10 biosensor. | 2018 | Colloids Surf B Biointerfaces | pmid:29413589 |
| Zhang M et al. | Neurodevelopmental toxicity induced by maternal PM2.5 exposure and protective effects of quercetin and Vitamin C. | 2018 | Chemosphere | pmid:30218877 |
| Zhang C et al. | Mechanistic insights into the inhibition of quercetin on xanthine oxidase. | 2018 | Int. J. Biol. Macromol. | pmid:29410028 |
| Kim YA et al. | Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant in Human Keratinocytes. | 2018 | Molecules | pmid:30216992 |
| Ajaghaku DL et al. | Upregulation of CD T-Lymphocytes by Isomeric Mixture of Quercetin-3-O-Rutinoside and Quercetin-3-O-Robinobioside Isolated from Millettia aboensis. | 2018 | Immunol. Invest. | pmid:29405788 |
| Giuliani C et al. | Localization of phenolic compounds in the fruits of Silybum marianum characterized by different silymarin chemotype and altered colour. | 2018 | Fitoterapia | pmid:30213759 |
| Rahvar M et al. | Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain. | 2018 | Bratisl Lek Listy | pmid:29405727 |
| Gao Q et al. | A red-emitting indolium fluorescence probe for membranes - flavonoids interactions. | 2018 | Luminescence | pmid:29405584 |
| Ge F et al. | Taxifolin suppresses rat and human testicular androgen biosynthetic enzymes. | 2018 | Fitoterapia | pmid:29402482 |
| Ding Y et al. | Quercetin suppresses the chymotrypsin-like activity of proteasome via inhibition of MEK1/ERK1/2 signaling pathway in hepatocellular carcinoma HepG2 cells. | 2018 | Can. J. Physiol. Pharmacol. | pmid:29394494 |
| Wu D et al. | Metabolite Profiles, Bioactivity, and HPLC Fingerprint of Different Varieties of Oliv.: Towards the Utilization of Medicinal and Commercial Chinese Endemic Tree. | 2018 | Molecules | pmid:30061494 |
| Hamilton KE et al. | Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1. | 2018 | Biochimie | pmid:29857184 |
| Fan HR et al. | Quercetin Reduces Cortical GABAergic Transmission and Alleviates MK-801-Induced Hyperactivity. | 2018 | EBioMedicine | pmid:30057312 |
| Sheth U and Bahadur A | In-vitro evaluation of cytotoxic and antioxidant properties of drugs solubilized in EO-PO star block copolymer micelles. | 2018 | Colloids Surf B Biointerfaces | pmid:30056295 |
| Chen X et al. | Plant flavonoid taxifolin inhibits the growth, migration and invasion of human osteosarcoma cells. | 2018 | Mol Med Rep | pmid:29257319 |
| Borse SP et al. | Potential synergistic effects of quercetin with other phytoconstituents of Costus pictus (insulin plant) extract in the control of hyperglycemia and prevention of NSAID-induced gastroenteropathy in diabetic rats. | 2018 | Food Chem. Toxicol. | pmid:30055312 |
| Samad N et al. | Quercetin protects against stress-induced anxiety- and depression-like behavior and improves memory in male mice. | 2018 | Physiol Res | pmid:30044120 |
| Rauf A et al. | Anticancer potential of quercetin: A comprehensive review. | 2018 | Phytother Res | pmid:30039547 |
| North MK et al. | The effects of quercetin supplementation on New Zealand White grower rabbit carcass and meat quality - A short communication. | 2018 | Meat Sci. | pmid:30031202 |
| Kruszewski M et al. | The effect of quercetin on the electrical properties of model lipid membranes and human glioblastoma cells. | 2018 | Bioelectrochemistry | pmid:30029034 |
| Sharma A et al. | Therapeutic charm of quercetin and its derivatives: a review of research and patents. | 2018 | Pharm Pat Anal | pmid:29227203 |
| Alugoju P et al. | Quercetin Protects Yeast Saccharomyces cerevisiae pep4 Mutant from Oxidative and Apoptotic Stress and Extends Chronological Lifespan. | 2018 | Curr. Microbiol. | pmid:29224051 |
| Aithal GC et al. | Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations. | 2018 | Molecules | pmid:29882751 |
| Park J et al. | Systematic metabolic profiling and bioactivity assays for bioconversion of Aceraceae family. | 2018 | PLoS ONE | pmid:29879203 |
| Nambooppha B et al. | Quercetin manipulates the expression of genes involved in the reactive oxygen species (ROS) process in chicken heterophils. | 2018 | J. Vet. Med. Sci. | pmid:29877311 |
| Lin J et al. | Steamed bread enriched with quercetin as an antiglycative food product: its quality attributes and antioxidant properties. | 2018 | Food Funct | pmid:29872802 |
| Yang Y et al. | Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect. | 2018 | Int. Immunopharmacol. | pmid:29149703 |
| Qiu L et al. | Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats. | 2018 | Biomed. Pharmacother. | pmid:29864946 |
| Ventura-MartÃnez R et al. | Spasmolytic effect of aqueous extract of Tagetes erecta L. flowers is mediated through calcium channel blockade on the guinea-pig ileum. | 2018 | Biomed. Pharmacother. | pmid:29864942 |
| Lee KM et al. | Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed human keratinocytes. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29857000 |
| Selvarajan S et al. | Fabrication of g-CN/NiO heterostructured nanocomposite modified glassy carbon electrode for quercetin biosensor. | 2018 | Ultrason Sonochem | pmid:29137797 |
| Singh A et al. | Curcumin loaded chitin-glucan quercetin conjugate: Synthesis, characterization, antioxidant, in vitro release study, and anticancer activity. | 2018 | Int. J. Biol. Macromol. | pmid:29128588 |
| Lotha R et al. | Plant nutraceuticals (Quercetrin and Afzelin) capped silver nanoparticles exert potent antibiofilm effect against food borne pathogen Salmonella enterica serovar Typhi and curtail planktonic growth in zebrafish infection model. | 2018 | Microb. Pathog. | pmid:29715535 |
| Abdel Aziz RL et al. | Dose- dependent ameliorative effects of quercetin and l-Carnitine against atrazine- induced reproductive toxicity in adult male Albino rats. | 2018 | Biomed. Pharmacother. | pmid:29710542 |
| Yuan TY et al. | Vasorelaxant effect of quercetin on cerebral basilar artery in vitro and the underlying mechanisms study. | 2018 | J Asian Nat Prod Res | pmid:29693418 |
| Kale A et al. | Neuroprotective effects of Quercetin on radiation-induced brain injury in rats. | 2018 | J. Radiat. Res. | pmid:29688418 |
| Lin M et al. | Quercetin improves postpartum hypogalactia in milk-deficient mice via stimulating prolactin production in pituitary gland. | 2018 | Phytother Res | pmid:29671937 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| Sturza A et al. | Quercetin exerts an inhibitory effect on cellular bioenergetics of the B164A5 murine melanoma cell line. | 2018 | Mol. Cell. Biochem. | pmid:29380243 |
| Cornara L et al. | Zornia latifolia: a smart drug being adulterated by Stylosanthes guianensis. | 2018 | Int. J. Legal Med. | pmid:29362872 |
| Alves MC et al. | Taxifolin: Evaluation Through Ex vivo Permeations on Human Skin and Porcine Vaginal Mucosa. | 2018 | Curr Drug Deliv | pmid:29336264 |
| Wei X et al. | Quercetin exerts cardiovascular protective effects in LPS-induced dysfunction in vivo by regulating inflammatory cytokine expression, NF-κB phosphorylation, and caspase activity. | 2018 | Mol. Cell. Biochem. | pmid:29322353 |
| Lu Q et al. | Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway. | 2018 | Acta Biochim. Pol. | pmid:29281744 |
| Seong JS et al. | Surfactant-stable and pH-sensitive liposomes coated with N-succinyl-chitosan and chitooligosaccharide for delivery of quercetin. | 2018 | Carbohydr Polym | pmid:29254020 |
| Adhikary R et al. | Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases. | 2018 | J Ethnopharmacol | pmid:28826781 |
| Shaalan YM et al. | Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma. | 2018 | Nat. Prod. Res. | pmid:28817968 |
| de Oliveira Pedro R et al. | Synergistic effect of quercetin and pH-responsive DEAE-chitosan carriers as drug delivery system for breast cancer treatment. | 2018 | Int. J. Biol. Macromol. | pmid:28807690 |
| Shalini D et al. | Effect of size and shape on toxicity of zinc oxide (ZnO) nanomaterials in human peripheral blood lymphocytes. | 2018 | Toxicol. Mech. Methods | pmid:28805101 |
| Eren-Guzelgun B et al. | In vitro antioxidant/prooxidant effects of combined use of flavonoids. | 2018 | Nat. Prod. Res. | pmid:28669231 |
| Khaligh F et al. | Effects of in ovo injection of chrysin, quercetin and ascorbic acid on hatchability, somatic attributes, hepatic oxidative status and early post-hatch performance of broiler chicks. | 2018 | J Anim Physiol Anim Nutr (Berl) | pmid:28636279 |
| Jiménez-López J et al. | Phytochemical profile and antioxidant activity of caper berries (Capparis spinosa L.): Evaluation of the influence of the fermentation process. | 2018 | Food Chem | pmid:29412927 |
| Slámová K et al. | "Sweet Flavonoids": Glycosidase-Catalyzed Modifications. | 2018 | Int J Mol Sci | pmid:30037103 |