| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Contusions | D003288 | 3 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with quercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with quercetin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with quercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Walkowiak A et al. | Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. | 2019 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:30321862 |
| Maurya AK and Vinayak M | Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. | 2019 | In Vitro Cell. Dev. Biol. Anim. | pmid:30413935 |
| Li J et al. | Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. | 2019 | Chem. Biol. Interact. | pmid:30365939 |
| Mu Y et al. | Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. | 2019 | Carbohydr Polym | pmid:30318192 |
| Li F et al. | The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. | 2019 | Pest Manag. Sci. | pmid:29797492 |
| Schröder L et al. | Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. | 2019 | Oncol. Rep. | pmid:30320348 |
| Tutino V et al. | Cannabinoid Receptor-1 Up-regulation in Azoxymethane (AOM)-treated Mice After Dietary Treatment with Quercetin. | 2018 | Anticancer Res. | pmid:30061214 |
| Jia L et al. | Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction. | 2018 | Life Sci. | pmid:30025823 |
| Wu TC et al. | Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. | 2018 | Chem. Biol. Interact. | pmid:30016632 |
| Zhang Y et al. | Amelioration of Alcoholic Liver Steatosis by Dihydroquercetin through the Modulation of AMPK-Dependent Lipogenesis Mediated by P2X7R-NLRP3-Inflammasome Activation. | 2018 | J. Agric. Food Chem. | pmid:29706079 |
| Lu J et al. | Quercetin Inhibits the Migration and Invasion of HCCLM3 Cells by Suppressing the Expression of p-Akt1, Matrix Metalloproteinase (MMP) MMP-2, and MMP-9. | 2018 | Med. Sci. Monit. | pmid:29701200 |
| Aghapour F et al. | Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29698680 |
| Sun S et al. | Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway. | 2018 | Gene | pmid:29678660 |
| Jeong DW et al. | Deastringent Peel Extracts of Persimmon ( Thunb. cv. Cheongdo-Bansi) Protect Neuronal PC-12 and SH-SY5Y Cells against Oxidative Stress. | 2018 | J. Microbiol. Biotechnol. | pmid:29975999 |
| de Oliveira TS et al. | Neuroprotective Effect of Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties. | 2018 | Oxid Med Cell Longev | pmid:30420910 |
| Patrizio F et al. | The acute effect of Quercetin on muscle performance following a single resistance training session. | 2018 | Eur. J. Appl. Physiol. | pmid:29511920 |
| Song YY et al. | Phenolic Compounds from Belamcanda chinensis Seeds. | 2018 | Molecules | pmid:29510567 |
| Murota K et al. | Flavonoid metabolism: the interaction of metabolites and gut microbiota. | 2018 | Biosci. Biotechnol. Biochem. | pmid:29504827 |
| Silva W et al. | Double emulsions as potential fat replacers with gallic acid and quercetin nanoemulsions in the aqueous phases. | 2018 | Food Chem | pmid:29502846 |
| Hidaka M et al. | Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29608894 |
| Wang X et al. | Hyperoside Protects Against Pressure Overload-Induced Cardiac Remodeling via the AKT Signaling Pathway. | 2018 | Cell. Physiol. Biochem. | pmid:30466089 |
| Hayamizu K et al. | Cardiotonic actions of quercetin and its metabolite tamarixetin through a digitalis-like enhancement of Ca transients. | 2018 | Arch. Biochem. Biophys. | pmid:29169900 |
| Pradhan AB et al. | Role of hydroxyl groups in the B-ring of flavonoids in stabilization of the Hoogsteen paired third strand of Poly(U).Poly(A)*Poly(U) triplex. | 2018 | Arch. Biochem. Biophys. | pmid:29162368 |
| Mazhar M et al. | Quercetin modulates iron homeostasis and iNOS expression of splenic macrophages in a rat model of iron deficiency anemia. | 2018 | Chin J Nat Med | pmid:30197123 |
| Song JE et al. | Quercetin Inlaid Silk Fibroin/Hydroxyapatite Scaffold Promotes Enhanced Osteogenesis. | 2018 | ACS Appl Mater Interfaces | pmid:30188112 |
| Akintunde JK et al. | Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey inhibits oxidative damage and econucleotidase followed by increased cellular ATP in testicular cells of rats exposed to metropolitan polluted river water. | 2018 | J Basic Clin Physiol Pharmacol | pmid:29360627 |
| Wang R et al. | Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM). | 2018 | Med. Sci. Monit. | pmid:29353288 |
| Xiao Y and Lee IS | Microbial transformation of quercetin and its prenylated derivatives. | 2018 | Nat. Prod. Res. | pmid:28826260 |
| Teppabut Y et al. | Change of Petals' Color and Chemical Components in Flowers during Senescence. | 2018 | Molecules | pmid:30002287 |
| Liu S et al. | Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation. | 2018 | Food Funct | pmid:29993075 |
| Yang H et al. | Quercetin Treatment Improves Renal Function and Protects the Kidney in a Rat Model of Adenine-Induced Chronic Kidney Disease. | 2018 | Med. Sci. Monit. | pmid:29987270 |
| Lee HN et al. | Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models. | 2018 | Int. J. Mol. Med. | pmid:29207037 |
| Shen XY et al. | Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells. | 2018 | Int. J. Mol. Med. | pmid:29207020 |
| Steinborn C et al. | In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica. | 2018 | Planta Med. | pmid:29202511 |
| Younas M et al. | Differential accumulation of silymarin induced by exposure of Silybum marianum L. callus cultures to several spectres of monochromatic lights. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29803074 |
| Sherif IO | The effect of natural antioxidants in cyclophosphamide-induced hepatotoxicity: Role of Nrf2/HO-1 pathway. | 2018 | Int. Immunopharmacol. | pmid:29800788 |
| Yin C et al. | Phytochemical analysis and antibacterial activity of Gentiana macrophylla extract against bacteria isolated from burn wound infections. | 2018 | Microb. Pathog. | pmid:29111322 |
| Mandrone M et al. | Identification of a Collagenase-Inhibiting Flavonoid from Alchemilla vulgaris Using NMR-Based Metabolomics. | 2018 | Planta Med. | pmid:29797306 |
| Crascì L et al. | Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation. | 2018 | Drug Res (Stuttg) | pmid:29108086 |
| Pawlikowska-Pawlega B et al. | Interaction of a quercetin derivative - lensoside Aβ with liposomal membranes. | 2018 | Biochim Biophys Acta Biomembr | pmid:29106971 |
| Wang XF et al. | Protective Effect of Quercetin in LPS-Induced Murine Acute Lung Injury Mediated by cAMP-Epac Pathway. | 2018 | Inflammation | pmid:29569077 |
| Wang L et al. | Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers. | 2018 | J Microencapsul | pmid:29624090 |
| Guazelli CFS et al. | Quercetin attenuates zymosan-induced arthritis in mice. | 2018 | Biomed. Pharmacother. | pmid:29554596 |
| Mendel M et al. | Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility-in vitro study. | 2018 | J. Vet. Pharmacol. Ther. | pmid:28913883 |
| Singh S and Kumar P | Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration in experimental rats: Biochemical and neurochemical evidences. | 2018 | Neurosci. Res. | pmid:29056550 |
| Palle S and Neerati P | Quercetin nanoparticles alter pharmacokinetics of bromocriptine, reflecting its enhanced inhibitory action on liver and intestinal CYP 3A enzymes in rats. | 2018 | Xenobiotica | pmid:28990837 |
| Wang Y et al. | Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats. | 2018 | J. Cell. Biochem. | pmid:28865131 |
| Jan S et al. | Effect of environmental variables on phytonutrients of Origanum vulgare L. in the sub-humid region of the northwestern Himalayas. | 2018 | Environ Monit Assess | pmid:30187208 |
| Cerulli A et al. | Phenolics from Castanea sativa leaves and their effects on UVB-induced damage. | 2018 | Nat. Prod. Res. | pmid:28539059 |
| Zhang XF et al. | UPLC-MS/MS analysis for antioxidant components of Lycii Fructus based on spectrum-effect relationship. | 2018 | Talanta | pmid:29332828 |