quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with quercetin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Walkowiak A et al. | Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. | 2019 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:30321862 |
Maurya AK and Vinayak M | Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. | 2019 | In Vitro Cell. Dev. Biol. Anim. | pmid:30413935 |
Li J et al. | Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. | 2019 | Chem. Biol. Interact. | pmid:30365939 |
Mu Y et al. | Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. | 2019 | Carbohydr Polym | pmid:30318192 |
Li F et al. | The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. | 2019 | Pest Manag. Sci. | pmid:29797492 |
Schröder L et al. | Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. | 2019 | Oncol. Rep. | pmid:30320348 |
Liu Y et al. | Light quality affects flavonoid production and related gene expression in Cyclocarya paliurus. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29334625 |
Eftekhari A et al. | Hepatoprotective and free radical scavenging actions of quercetin nanoparticles on aflatoxin B1-induced liver damage: in vitro/in vivo studies. | 2018 | Artif Cells Nanomed Biotechnol | pmid:28423950 |
Xu MJ et al. | Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2. | 2018 | Chem. Biol. Interact. | pmid:29689254 |
Maturu P et al. | Quercetin attenuates the hyperoxic lung injury in neonatal mice: Implications for Bronchopulmonary dysplasia (BPD). | 2018 | Food Chem. Toxicol. | pmid:29432836 |
Wang D et al. | Quercetin attenuates domoic acid-induced cognitive deficits in mice. | 2018 | Nutr Neurosci | pmid:28277184 |
Zhou JL et al. | Structures and bioactivities of seven flavonoids from Osmanthus fragrans 'Jinqiu' essential oil extraction residues. | 2018 | Nat. Prod. Res. | pmid:28431473 |
Yang T et al. | Interactions of quercetin, curcumin, epigallocatechin gallate and folic acid with gelatin. | 2018 | Int. J. Biol. Macromol. | pmid:29908276 |
Patra A et al. | Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers. | 2018 | Int J Nanomedicine | pmid:29844670 |
Zhang X et al. | Chemical Fingerprint and Quantitative Analysis for the Quality Evaluation of Docynia dcne Leaves by High-Performance Liquid Chromatography Coupled with Chemometrics Analysis. | 2018 | J Chromatogr Sci | pmid:29800095 |
Abdelhalim MAK et al. | The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats. | 2018 | Int J Nanomedicine | pmid:29785108 |
Liu L et al. | One-step synthesis of fluorescent carbon dots for sensitive and selective detection of hyperin. | 2018 | Talanta | pmid:29784367 |
Singh A et al. | Synthesis of chitin-glucan-aldehyde-quercetin conjugate and evaluation of anticancer and antioxidant activities. | 2018 | Carbohydr Polym | pmid:29773403 |
Huang ZQ et al. | Antioxidant Activity and Hepatoprotective Potential of Quercetin 7-Rhamnoside In Vitro and In Vivo. | 2018 | Molecules | pmid:29772655 |
Šarić Mustapić D et al. | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. | 2018 | Molecules | pmid:30301254 |
Omar SH et al. | Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.). | 2018 | Fitoterapia | pmid:29772299 |
Qi F et al. | Anti-inflammatory effects of isorhamnetin on LPS-stimulated human gingival fibroblasts by activating Nrf2 signaling pathway. | 2018 | Microb. Pathog. | pmid:29704670 |
Farrag Y et al. | Preparation of starch nanoparticles loaded with quercetin using nanoprecipitation technique. | 2018 | Int. J. Biol. Macromol. | pmid:29580996 |
UylaÅŸ MU et al. | Quercetin dose affects the fate of hepatic ischemia and reperfusion injury in rats: An experimental research. | 2018 | Int J Surg | pmid:29578092 |
Yu Y et al. | Nanostructured lipid carrier-based pH and temperature dual-responsive hydrogel composed of carboxymethyl chitosan and poloxamer for drug delivery. | 2018 | Int. J. Biol. Macromol. | pmid:29578017 |
Borovskaya TG et al. | Experimental Analysis of the Efficacy of Dihydroquercetin on the Model of Chronic Nonbacterial Inflammation of the Prostatic Gland. | 2018 | Bull. Exp. Biol. Med. | pmid:29577199 |
Castillo RL et al. | Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats. | 2018 | Oxid Med Cell Longev | pmid:29576853 |
Liu J et al. | Preparation, characterization, digestibility and antioxidant activity of quercetin grafted Cynanchum auriculatum starch. | 2018 | Int. J. Biol. Macromol. | pmid:29572138 |
Boadi WY and Lo A | Effects of Quercetin, Kaempferol, and Exogenous Glutathione on Phospho- and Total-AKT in 3T3-L1 Preadipocytes. | 2018 | J Diet Suppl | pmid:29345961 |
Ma YK et al. | Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media. | 2018 | Int. J. Mol. Med. | pmid:29568908 |
Vovkun T et al. | Water-soluble quercetin modulates the choleresis and bile lipid ratio in rats. | 2018 | Gen. Physiol. Biophys. | pmid:29424356 |
Tsunekawa R et al. | Synthesis of fisetin and 2',4',6'-trihydroxydihyrochalcone 4'-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation. | 2018 | Biosci. Biotechnol. Biochem. | pmid:29699439 |
Zhang L et al. | Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats. | 2018 | J. Agric. Food Chem. | pmid:29359554 |
Li X et al. | Quercetin suppresses breast cancer stem cells (CD44/CD24) by inhibiting the PI3K/Akt/mTOR-signaling pathway. | 2018 | Life Sci. | pmid:29355544 |
Szopa A et al. | The importance of monochromatic lights in the production of phenolic acids and flavonoids in shoot cultures of Aronia melanocarpa, Aronia arbutifolia and Aronia × prunifolia. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29351879 |
Suvarna VM and Sangave PC | HPLC Estimation, Ex vivo Everted Sac Permeability and In Vivo Pharmacokinetic Studies of Darunavir. | 2018 | J Chromatogr Sci | pmid:29342239 |
Li XM et al. | Quercetin and aconitine synergistically induces the human cervical carcinoma HeLa cell apoptosis via endoplasmic reticulum (ER) stress pathway. | 2018 | PLoS ONE | pmid:29324796 |
Nakamura M et al. | Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. | 2018 | J Toxicol Sci | pmid:30298849 |
Zeng Y et al. | Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin. | 2018 | Pharm Biol | pmid:30266078 |
Dymarska M et al. | Glycosylation of 3-Hydroxyflavone, 3-Methoxyflavone, Quercetin and Baicalein in Fungal Cultures of the Genus . | 2018 | Molecules | pmid:30262733 |
Chen Y et al. | Beneficial effects of hyperoside on bone metabolism in ovariectomized mice. | 2018 | Biomed. Pharmacother. | pmid:30257331 |
Zhu X et al. | Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway. | 2018 | Food Chem. Toxicol. | pmid:29438776 |
Rjeibi I et al. | Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice. | 2018 | Oxid Med Cell Longev | pmid:30254713 |
Babotă M et al. | Phytochemical Analysis, Antioxidant and Antimicrobial Activities of Helichrysum arenarium (L.) Moench. and Antennaria dioica (L.) Gaertn. Flowers. | 2018 | Molecules | pmid:29438342 |
Liu Y et al. | Geographic Variation in the Chemical Composition and Antioxidant Properties of Phenolic Compounds from (Batal) Iljinskaja Leaves. | 2018 | Molecules | pmid:30249997 |
Xiao L et al. | Quercetin and iron metabolism: What we know and what we need to know. | 2018 | Food Chem. Toxicol. | pmid:29432835 |
Naseer Z et al. | Dietary quercetin maintains the semen quality in rabbits under summer heat stress. | 2018 | Theriogenology | pmid:30243139 |
Nakhlband A et al. | Marrubiin-loaded solid lipid nanoparticles' impact on TNF-α treated umbilical vein endothelial cells: A study for cardioprotective effect. | 2018 | Colloids Surf B Biointerfaces | pmid:29413609 |
Omwenga EO et al. | Chitosan nanoencapsulation of flavonoids enhances their quorum sensing and biofilm formation inhibitory activities against an E.coli Top 10 biosensor. | 2018 | Colloids Surf B Biointerfaces | pmid:29413589 |
Zhang C et al. | Mechanistic insights into the inhibition of quercetin on xanthine oxidase. | 2018 | Int. J. Biol. Macromol. | pmid:29410028 |
Ajaghaku DL et al. | Upregulation of CD T-Lymphocytes by Isomeric Mixture of Quercetin-3-O-Rutinoside and Quercetin-3-O-Robinobioside Isolated from Millettia aboensis. | 2018 | Immunol. Invest. | pmid:29405788 |
Chatzikonstantinou AV et al. | Enriching the biological space of natural products and charting drug metabolites, through real time biotransformation monitoring: The NMR tube bioreactor. | 2018 | Biochim Biophys Acta Gen Subj | pmid:28974426 |
Liu T et al. | Production of drug nanosuspensions: effect of drug physical properties on nanosizing efficiency. | 2018 | Drug Dev Ind Pharm | pmid:28956456 |
Zhou YQ et al. | Hyperoside Suppresses Lipopolysaccharide-induced Inflammation and Apoptosis in Human Umbilical Vein Endothelial Cells. | 2018 | Curr Med Sci | pmid:30074179 |
Yao C et al. | Inhibition of enterovirus 71 replication and viral 3C protease by quercetin. | 2018 | Virol. J. | pmid:30064445 |
Khorshidi M et al. | The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome. | 2018 | Phytother Res | pmid:30062709 |
Rácz A et al. | Selective responses of class III plant peroxidase isoforms to environmentally relevant UV-B doses. | 2018 | J. Plant Physiol. | pmid:29272746 |
Wu D et al. | Metabolite Profiles, Bioactivity, and HPLC Fingerprint of Different Varieties of Oliv.: Towards the Utilization of Medicinal and Commercial Chinese Endemic Tree. | 2018 | Molecules | pmid:30061494 |
Fan HR et al. | Quercetin Reduces Cortical GABAergic Transmission and Alleviates MK-801-Induced Hyperactivity. | 2018 | EBioMedicine | pmid:30057312 |
Yan S et al. | Silk fabric dyed with extract of sophora flower bud. | 2018 | Nat. Prod. Res. | pmid:28748727 |
Sheth U and Bahadur A | In-vitro evaluation of cytotoxic and antioxidant properties of drugs solubilized in EO-PO star block copolymer micelles. | 2018 | Colloids Surf B Biointerfaces | pmid:30056295 |
Chen X et al. | Plant flavonoid taxifolin inhibits the growth, migration and invasion of human osteosarcoma cells. | 2018 | Mol Med Rep | pmid:29257319 |
Borse SP et al. | Potential synergistic effects of quercetin with other phytoconstituents of Costus pictus (insulin plant) extract in the control of hyperglycemia and prevention of NSAID-induced gastroenteropathy in diabetic rats. | 2018 | Food Chem. Toxicol. | pmid:30055312 |
Kuipers EN et al. | Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice. | 2018 | Int J Mol Sci | pmid:29914151 |
Pathak RK et al. | Identification of new drug-like compounds from millets as Xanthine oxidoreductase inhibitors for treatment of Hyperuricemia: A molecular docking and simulation study. | 2018 | Comput Biol Chem | pmid:29906649 |
Diamantis DA et al. | Exploring the oxidation and iron binding profile of a cyclodextrin encapsulated quercetin complex unveiled a controlled complex dissociation through a chemical stimulus. | 2018 | Biochim Biophys Acta Gen Subj | pmid:29886278 |
Aithal GC et al. | Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations. | 2018 | Molecules | pmid:29882751 |
Yun J et al. | Effect of isoquercitrin on membrane dynamics and apoptosis-like death in Escherichia coli. | 2018 | Biochim Biophys Acta Biomembr | pmid:29155212 |
Park J et al. | Systematic metabolic profiling and bioactivity assays for bioconversion of Aceraceae family. | 2018 | PLoS ONE | pmid:29879203 |
Nambooppha B et al. | Quercetin manipulates the expression of genes involved in the reactive oxygen species (ROS) process in chicken heterophils. | 2018 | J. Vet. Med. Sci. | pmid:29877311 |
Lin J et al. | Steamed bread enriched with quercetin as an antiglycative food product: its quality attributes and antioxidant properties. | 2018 | Food Funct | pmid:29872802 |
Yang Y et al. | Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect. | 2018 | Int. Immunopharmacol. | pmid:29149703 |
Qiu L et al. | Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats. | 2018 | Biomed. Pharmacother. | pmid:29864946 |
Sohn EJ et al. | Restoring Effects of Natural Anti-Oxidant Quercetin on Cellular Senescent Human Dermal Fibroblasts. | 2018 | Am. J. Chin. Med. | pmid:29737207 |
Pang XG et al. | Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway. | 2018 | Biomed Res Int | pmid:29736392 |
Jangde R et al. | In vitro and In vivo characterization of quercetin loaded multiphase hydrogel for wound healing application. | 2018 | Int. J. Biol. Macromol. | pmid:29730004 |
Zhuang M et al. | Islet protection and amelioration of type 2 diabetes mellitus by treatment with quercetin from the flowers of . | 2018 | Drug Des Devel Ther | pmid:29720871 |
Lotha R et al. | Plant nutraceuticals (Quercetrin and Afzelin) capped silver nanoparticles exert potent antibiofilm effect against food borne pathogen Salmonella enterica serovar Typhi and curtail planktonic growth in zebrafish infection model. | 2018 | Microb. Pathog. | pmid:29715535 |
Yang JX et al. | Effects of phyto-oestrogen quercetin on productive performance, hormones, reproductive organs and apoptotic genes in laying hens. | 2018 | J Anim Physiol Anim Nutr (Berl) | pmid:28986927 |
Abdel Aziz RL et al. | Dose- dependent ameliorative effects of quercetin and l-Carnitine against atrazine- induced reproductive toxicity in adult male Albino rats. | 2018 | Biomed. Pharmacother. | pmid:29710542 |
Bedada SK and Neerati P | The effect of quercetin on the pharmacokinetics of chlorzoxazone, a CYP2E1 substrate, in healthy subjects. | 2018 | Eur. J. Clin. Pharmacol. | pmid:28983678 |
Afifi NA et al. | Hepatoprotective influence of quercetin and ellagic acid on thioacetamide-induced hepatotoxicity in rats. | 2018 | Can. J. Physiol. Pharmacol. | pmid:29414242 |
Mao T et al. | Protective Effects of Quercetin Against Cadmium Chloride-Induced Oxidative Injury in Goat Sperm and Zygotes. | 2018 | Biol Trace Elem Res | pmid:29397540 |
Mbikay M et al. | Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas. | 2018 | Mol Nutr Food Res | pmid:29396908 |
Zou H et al. | Synergistic Anti-tumour Effects of Quercetin and Oncolytic Adenovirus expressing TRAIL in Human Hepatocellular Carcinoma. | 2018 | Sci Rep | pmid:29391509 |
Sturza A et al. | Quercetin exerts an inhibitory effect on cellular bioenergetics of the B164A5 murine melanoma cell line. | 2018 | Mol. Cell. Biochem. | pmid:29380243 |
Cornara L et al. | Zornia latifolia: a smart drug being adulterated by Stylosanthes guianensis. | 2018 | Int. J. Legal Med. | pmid:29362872 |
Alves MC et al. | Taxifolin: Evaluation Through Ex vivo Permeations on Human Skin and Porcine Vaginal Mucosa. | 2018 | Curr Drug Deliv | pmid:29336264 |
Suzen A et al. | Protective Effects of Hypericum perforatum and Quercetin in a Rat Model of Ischemia/Reperfusion Injury of Testes. | 2018 | Eur J Pediatr Surg | pmid:28837999 |
Adhikary R et al. | Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases. | 2018 | J Ethnopharmacol | pmid:28826781 |
Chen X et al. | Coencapsulation of (-)-Epigallocatechin-3-gallate and Quercetin in Particle-Stabilized W/O/W Emulsion Gels: Controlled Release and Bioaccessibility. | 2018 | J. Agric. Food Chem. | pmid:29578697 |
Arif H et al. | Flavonoids-induced redox cycling of copper ions leads to generation of reactive oxygen species: A potential role in cancer chemoprevention. | 2018 | Int. J. Biol. Macromol. | pmid:28834706 |
Zhu JX et al. | Quercetin, Kaempferol and Isorhamnetin in Elaeagnus pungens Thunb. Leaf: Pharmacological Activities and Quantitative Determination Studies. | 2018 | Chem. Biodivers. | pmid:29802806 |
Shi H et al. | Isorhamnetin, the active constituent of a Chinese herb Hippophae rhamnoides L, is a potent suppressor of dendritic-cell maturation and trafficking. | 2018 | Int. Immunopharmacol. | pmid:29272818 |
Eren-Guzelgun B et al. | In vitro antioxidant/prooxidant effects of combined use of flavonoids. | 2018 | Nat. Prod. Res. | pmid:28669231 |
Zhang P and Zhang X | Stimulatory effects of curcumin and quercetin on posttranslational modifications of p53 during lung carcinogenesis. | 2018 | Hum Exp Toxicol | pmid:28681665 |
Kasmi S et al. | Modulatory effects of quercetin on liver histopathological, biochemical, hematological, oxidative stress and DNA alterations in rats exposed to graded doses of score 250. | 2018 | Toxicol. Mech. Methods | pmid:28679351 |
Khaligh F et al. | Effects of in ovo injection of chrysin, quercetin and ascorbic acid on hatchability, somatic attributes, hepatic oxidative status and early post-hatch performance of broiler chicks. | 2018 | J Anim Physiol Anim Nutr (Berl) | pmid:28636279 |
Shi Q et al. | Comparative Analysis of Pigments, Phenolics, and Antioxidant Activity of Chinese Jujube ( Mill.) during Fruit Development. | 2018 | Molecules | pmid:30071615 |
Jiménez-López J et al. | Phytochemical profile and antioxidant activity of caper berries (Capparis spinosa L.): Evaluation of the influence of the fermentation process. | 2018 | Food Chem | pmid:29412927 |