quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with quercetin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid:5155019 | ||||
Bayes M et al. | Gateways to clinical trials. | Methods Find Exp Clin Pharmacol | pmid:16179960 | |
Tomillero A and Moral MA | Gateways to clinical trials. July-August 2008. | Methods Find Exp Clin Pharmacol | pmid:18850047 | |
Rosenblat M et al. | HDL3 stimulates paraoxonase 1 antiatherogenic catalytic and biological activities in a macrophage model system: in vivo and in vitro studies. | Biofactors | pmid:25230879 | |
Kalveniene Z et al. | The qualitative analysis of ethanol extracts of herbal raw materials by method of high pressure liquid chromatography. | Acta Pol Pharm | pmid:18536158 | |
Pi J et al. | Investigation of quercetin-induced HepG2 cell apoptosis-associated cellular biophysical alterations by atomic force microscopy. | Scanning | pmid:26179807 | |
Patil SL et al. | Antigenotoxic potential of rutin and quercetin in Swiss mice exposed to gamma radiation. | Biomed J | pmid:25179701 | |
Jhong CH et al. | Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico. | Biofactors | pmid:26154585 | |
Kovácik J et al. | Physiological responses of Scenedesmus quadricauda (Chlorophyceae) to UV-A and UV-C light. | Photochem. Photobiol. | pmid:20202162 | |
Li QC et al. | Enhanced therapeutic efficacy and amelioration of cisplatin-induced nephrotoxicity by quercetin in 1,2-dimethyl hydrazine-induced colon cancer in rats. | Indian J Pharmacol | pmid:27127319 | |
Francik R et al. | Antioxidant activity of beta-carboline derivatives. | Acta Pol Pharm | pmid:21485291 | |
Harput US et al. | Antinociceptive, free radical-scavenging, and cytotoxic activities of Acanthus hirsutus Boiss. | J Med Food | pmid:21480807 | |
Liu D et al. | Determination of rutin and isoquercetin contents in Hibisci mutabilis Folium in different collection periods by HPLC. | J Chromatogr Sci | pmid:26089170 | |
Filho JS et al. | Quercetin in equine frozen semen. | Cryo Letters | pmid:29734431 | |
Bayés M et al. | Gateways to clinical trials. | Methods Find Exp Clin Pharmacol | pmid:17922073 | |
pmid:12214854 | ||||
Qi J et al. | Screening of peroxynitrite scavengers in Flos Lonicerae by using two new methods, an HPLC-DAD-CL technique and a peroxynitrite spiking test followed by HPLC-DAD analysis. | Phytochem Anal | pmid:26567775 | |
Dodda D et al. | Targeting oxidative stress attenuates trinitrobenzene sulphonic acid induced inflammatory bowel disease like symptoms in rats: role of quercetin. | Indian J Pharmacol | pmid:24987175 | |
Sakai-Kashiwabara M et al. | Suppressive activity of quercetin on the production of eosinophil chemoattractants from eosinophils in vitro. | In Vivo | pmid:24982217 | |
Gerhardt KE et al. | The effects of far-red light on plant growth and flavonoid accumulation in Brassica napus in the presence of ultraviolet B radiation. | Photochem. Photobiol. | pmid:18466203 | |
Lahaie-Collins V et al. | Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP+-induced oxidative stress. | Oxid Med Cell Longev | pmid:19794909 | |
Verma S et al. | Modulation of ionizing radiation induced oxidative imbalance by semi-fractionated extract of Piper betle: an in vitro and in vivo assessment. | Oxid Med Cell Longev | pmid:20716927 | |
Arikan S et al. | Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model. | Arq Bras Oftalmol | pmid:25945531 | |
Owens DK and McIntosh CA | Identification, recombinant expression, and biochemical characterization of a flavonol 3-O-glucosyltransferase clone from Citrus paradisi. | Phytochemistry | pmid:19733370 | |
Haghighi M et al. | On the formulation design and rheological evaluations of pectin-based functional gels. | J. Food Sci. | pmid:21535667 | |
Chan PC et al. | Ginkgo biloba leave extract: biological, medicinal, and toxicological effects. | J Environ Sci Health C Environ Carcinog Ecotoxicol Rev | pmid:17763047 | |
Khorsandi L et al. | Quercetin induces apoptosis and necroptosis in MCF-7 breast cancer cells. | Bratisl Lek Listy | pmid:28814095 | |
Chi KK et al. | Comparison of quercetin and resveratrol in the prevention of injury due to testicular torsion/detorsion in rats. | Asian J. Androl. | pmid:26620457 | |
Mitani A et al. | Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease. | Exp. Lung Res. | pmid:29227717 | |
Thomsen H et al. | Characterization of Constituents and Anthelmintic Properties of Hagenia abyssinica. | Sci Pharm | pmid:22896828 | |
de Oliveira MR et al. | Quercetin and the mitochondria: A mechanistic view. | Biotechnol. Adv. | pmid:26740171 | |
Lorenz P et al. | Investigations into the phenolic constituents of dog's mercury (Mercurialis perennis L.) by LC-MS/MS and GC-MS analyses. | Phytochem Anal | pmid:21692118 | |
Sapir M et al. | Molecular aspects of Anthocyanin fruit tomato in relation to high pigment-1. | J. Hered. | pmid:18344529 | |
Bae DS et al. | Importance of NKG2D-NKG2D ligands interaction for cytolytic activity of natural killer cell. | Cell. Immunol. | pmid:22613008 | |
Mesbah MK et al. | HPLC determination of certain flavonoids and terpene lactones in selected Ginkgo biloba L. phytopharmaceuticals. | Farmaco | pmid:15936022 | |
Murakami Y et al. | Radical-scavenging and Anti-inflammatory Activity of Quercetin and Related Compounds and Their Combinations Against RAW264.7 Cells Stimulated with Porphyromonas gingivalis Fimbriae. Relationships between Anti-inflammatory Activity and Quantum Chemical Parameters. | In Vivo | pmid:26546527 | |
Selloum L et al. | Scavenger effect of flavonols on HOCl-induced luminol chemiluminescence. | Luminescence | pmid:15287004 | |
Guo Y et al. | Quercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults. | Nutrition | pmid:25280405 | |
Oliveira DR et al. | Special metabolites isolated from Urochloa humidicola (Poaceae). | An. Acad. Bras. Cienc. | pmid:28640339 | |
Pattanashetti LA et al. | Evaluation of neuroprotective effect of quercetin with donepezil in scopolamine-induced amnesia in rats. | Indian J Pharmacol | pmid:28458424 | |
pmid:15113146 | ||||
Tang YP et al. | Two new isoflavone triglycosides from the small branches of Sophora japonica. | J Asian Nat Prod Res | pmid:18058382 | |
Azadi L et al. | Effects of Tempol and Quercetin on Human Sperm Function after Cryopreservation. | Cryo Letters | pmid:28376137 | |
Ramezani F et al. | Sequential Therapy of Breast Cancer Cell Lines with Vitamin C and Quercetin Improves the Efficacy of Chemotherapeutic Drugs. | Nutr Cancer | pmid:28742385 | |
Mandic P et al. | The effects of quercetin on liver regeneration after liver resection in rats. | Folia Morphol. (Warsz) | pmid:26711645 | |
Kanter M et al. | The effects of quercetin on liver regeneration after liver resection in rats. | Folia Morphol. (Warsz) | pmid:26431047 | |
pmid:23856528 | ||||
pmid:14646188 | ||||
Zheng J et al. | Therapeutic effects of quercetin on early inflammation in hypertriglyceridemia-related acute pancreatitis and its mechanism. | Pancreatology | pmid:26873426 | |
GarcÃa MT and González EL | Natural antioxidants protect against cadmium-induced damage during pregnancy and lactation in rats' pups. | J. Food Sci. | pmid:20492210 |