quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with quercetin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Xu MJ et al. | Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2. | 2018 | Chem. Biol. Interact. | pmid:29689254 |
Abdelhalim MAK et al. | The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats. | 2018 | Int J Nanomedicine | pmid:29785108 |
Dymarska M et al. | Glycosylation of 3-Hydroxyflavone, 3-Methoxyflavone, Quercetin and Baicalein in Fungal Cultures of the Genus . | 2018 | Molecules | pmid:30262733 |
Xiao L et al. | Quercetin and iron metabolism: What we know and what we need to know. | 2018 | Food Chem. Toxicol. | pmid:29432835 |
Khorshidi M et al. | The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome. | 2018 | Phytother Res | pmid:30062709 |
Diamantis DA et al. | Exploring the oxidation and iron binding profile of a cyclodextrin encapsulated quercetin complex unveiled a controlled complex dissociation through a chemical stimulus. | 2018 | Biochim Biophys Acta Gen Subj | pmid:29886278 |
Zhuang M et al. | Islet protection and amelioration of type 2 diabetes mellitus by treatment with quercetin from the flowers of . | 2018 | Drug Des Devel Ther | pmid:29720871 |
Zou H et al. | Synergistic Anti-tumour Effects of Quercetin and Oncolytic Adenovirus expressing TRAIL in Human Hepatocellular Carcinoma. | 2018 | Sci Rep | pmid:29391509 |
Arif H et al. | Flavonoids-induced redox cycling of copper ions leads to generation of reactive oxygen species: A potential role in cancer chemoprevention. | 2018 | Int. J. Biol. Macromol. | pmid:28834706 |
Kasmi S et al. | Modulatory effects of quercetin on liver histopathological, biochemical, hematological, oxidative stress and DNA alterations in rats exposed to graded doses of score 250. | 2018 | Toxicol. Mech. Methods | pmid:28679351 |