quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with quercetin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Walkowiak A et al. | Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. | 2019 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:30321862 |
Maurya AK and Vinayak M | Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. | 2019 | In Vitro Cell. Dev. Biol. Anim. | pmid:30413935 |
Li J et al. | Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. | 2019 | Chem. Biol. Interact. | pmid:30365939 |
Mu Y et al. | Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. | 2019 | Carbohydr Polym | pmid:30318192 |
Li F et al. | The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. | 2019 | Pest Manag. Sci. | pmid:29797492 |
Schröder L et al. | Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. | 2019 | Oncol. Rep. | pmid:30320348 |
Eftekhari A et al. | Hepatoprotective and free radical scavenging actions of quercetin nanoparticles on aflatoxin B1-induced liver damage: in vitro/in vivo studies. | 2018 | Artif Cells Nanomed Biotechnol | pmid:28423950 |
Yang T et al. | Interactions of quercetin, curcumin, epigallocatechin gallate and folic acid with gelatin. | 2018 | Int. J. Biol. Macromol. | pmid:29908276 |
Asfaram A et al. | Cu- and S- @SnO nanoparticles loaded on activated carbon for efficient ultrasound assisted dispersive µSPE-spectrophotometric detection of quercetin in Nasturtium officinale extract and fruit juice samples: CCD-RSM design. | 2018 | Ultrason Sonochem | pmid:29908597 |
Mehrbod P et al. | Immunomodulatory properties of quercetin-3-O-α-L-rhamnopyranoside from Rapanea melanophloeos against influenza a virus. | 2018 | BMC Complement Altern Med | pmid:29903008 |
Laczkó-Zöld E et al. | Extractability of polyphenols from black currant, red currant and gooseberry and their antioxidant activity. | 2018 | Acta. Biol. Hung. | pmid:29888668 |
Wang WJ et al. | Deciphering the chemoselectivity of nickel-dependent quercetin 2,4-dioxygenase. | 2018 | Phys Chem Chem Phys | pmid:29869653 |
Zhou W et al. | A two-step ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry with mass defect filtering method for rapid identification of analogues from known components of different chemical structure types in Fructus Gardeniae-Fructus Forsythiae herb pair extract and in rat's blood. | 2018 | J Chromatogr A | pmid:29861306 |
Patra A et al. | Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers. | 2018 | Int J Nanomedicine | pmid:29844670 |
Zhang X et al. | Chemical Fingerprint and Quantitative Analysis for the Quality Evaluation of Docynia dcne Leaves by High-Performance Liquid Chromatography Coupled with Chemometrics Analysis. | 2018 | J Chromatogr Sci | pmid:29800095 |
Šarić Mustapić D et al. | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. | 2018 | Molecules | pmid:30301254 |
Gaudry A et al. | The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells. | 2018 | Int J Mol Sci | pmid:29621184 |
Du G et al. | Quercetin protects rat cortical neurons against traumatic brain injury. | 2018 | Mol Med Rep | pmid:29620218 |
Jahan S et al. | Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study. | 2018 | J Ovarian Res | pmid:29615083 |
Qureshi AA et al. | Proteasome inhibitors modulate anticancer and anti-proliferative properties via NF-kB signaling, and ubiquitin-proteasome pathways in cancer cell lines of different organs. | 2018 | Lipids Health Dis | pmid:29606130 |
Ge L et al. | B-factor-saturation mutagenesis as a strategy to increase the thermostability of α-L-rhamnosidase from Aspergillus terreus. | 2018 | J. Biotechnol. | pmid:29605638 |
Chen J et al. | Pretreatment with dihydroquercetin, a dietary flavonoid, protected against concanavalin A-induced immunological hepatic injury in mice and TNF-α/ActD-induced apoptosis in HepG2 cells. | 2018 | Food Funct | pmid:29589006 |
Zhu Q et al. | Comparison of flavonoids and isoflavonoids to inhibit rat and human 11β-hydroxysteroid dehydrogenase 1 and 2. | 2018 | Steroids | pmid:29425740 |
Farrag Y et al. | Preparation of starch nanoparticles loaded with quercetin using nanoprecipitation technique. | 2018 | Int. J. Biol. Macromol. | pmid:29580996 |
Sung YY et al. | Aqueous and ethanolic extracts of welsh onion, Allium fistulosum, attenuate high-fat diet-induced obesity. | 2018 | BMC Complement Altern Med | pmid:29558911 |
Rishitha N and Muthuraman A | Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish. | 2018 | Life Sci. | pmid:29522770 |
Khalil SR et al. | Intermediate filament protein expression pattern and inflammatory response changes in kidneys of rats receiving doxorubicin chemotherapy and quercetin. | 2018 | Toxicol. Lett. | pmid:29474904 |
Dai Y et al. | Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway. | 2018 | Chem. Biol. Interact. | pmid:29454613 |
Feng J et al. | Quercetin restrains TGF-β1-induced epithelial-mesenchymal transition by inhibiting Twist1 and regulating E-cadherin expression. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29425820 |
Vovkun T et al. | Water-soluble quercetin modulates the choleresis and bile lipid ratio in rats. | 2018 | Gen. Physiol. Biophys. | pmid:29424356 |
Zhang L et al. | Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats. | 2018 | J. Agric. Food Chem. | pmid:29359554 |
Ebrahimpour S et al. | Effect of quercetin-conjugated superparamagnetic iron oxide nanoparticles on diabetes-induced learning and memory impairment in rats. | 2018 | Int J Nanomedicine | pmid:30349252 |
Donno D et al. | Assessing Nutritional Traits and Phytochemical Composition of Artisan Jams Produced in Comoros Islands: Using Indigenous Fruits with High Health-Impact as an Example of Biodiversity Integration and Food Security in Rural Development. | 2018 | Molecules | pmid:30347846 |
Islami M et al. | Controlled quercetin release from high-capacity-loading hyperbranched polyglycerol-functionalized graphene oxide. | 2018 | Int J Nanomedicine | pmid:30323593 |
Ahmed OM et al. | Quercetin and low level laser therapy promote wound healing process in diabetic rats via structural reorganization and modulatory effects on inflammation and oxidative stress. | 2018 | Biomed. Pharmacother. | pmid:29477473 |
Li S et al. | Quercetin enhances chemotherapeutic effect of doxorubicin against human breast cancer cells while reducing toxic side effects of it. | 2018 | Biomed. Pharmacother. | pmid:29475141 |
Nakamura M et al. | Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. | 2018 | J Toxicol Sci | pmid:30298849 |
Porcu EP et al. | Aqueous injection of quercetin: An approach for confirmation of its direct in vivo cardiovascular effects. | 2018 | Int J Pharm | pmid:29474897 |
Ray S et al. | Modulation in phenolic root exudate profile of Abelmoschus esculentus expressing activation of defense pathway. | 2018 | Microbiol. Res. | pmid:29458844 |
Zhu X et al. | Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway. | 2018 | Food Chem. Toxicol. | pmid:29438776 |
Sakalli S et al. | In vitro effects of diosmin, naringenin, quercetin and indole-3-carbinol on fish hepatic CYP1A1 in the presence of clotrimazole and dexamethasone. | 2018 | Chemosphere | pmid:29100118 |
Junyuan Z et al. | Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition. | 2018 | Pancreatology | pmid:30115563 |
Chen Z et al. | Effects of Quercetin on Proliferation and Hâ‚‚Oâ‚‚-Induced Apoptosis of Intestinal Porcine Enterocyte Cells. | 2018 | Molecules | pmid:30103566 |
Babaei F et al. | Quercetin in Food: Possible Mechanisms of Its Effect on Memory. | 2018 | J. Food Sci. | pmid:30103275 |
Ren K et al. | Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARγ/LXRα pathway. | 2018 | Food Funct | pmid:29292466 |
Wang R et al. | A strategy for absolute quantitation of isomers using high performance liquid chromatography-ion mobility mass spectrometry and material balance principle. | 2018 | J Chromatogr A | pmid:30097341 |
Chan ST et al. | Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice. | 2018 | Food Funct | pmid:29292417 |
Ma Y et al. | Quercetin potentiates the concurrent hyper-accumulation of cellular biomass and lipids in Chlorella vulgaris. | 2018 | Bioresour. Technol. | pmid:30093226 |
Guimarães GC et al. | Binding investigation between M2-1protein from hRSV and acetylated quercetin derivatives: H NMR, fluorescence spectroscopy, and molecular docking. | 2018 | Int. J. Biol. Macromol. | pmid:29292149 |
Wu Z et al. | Simultaneous Enrichment and Separation of Four Flavonoids from Zanthoxylum bungeanum Leaves by Ultrasound-Assisted Extraction and Macroporous Resins with Evaluation of Antioxidant Activities. | 2018 | J. Food Sci. | pmid:30080245 |
Chirumbolo S and Bjørklund G | Quercetin in the experimental liver fibrosis induced by carbon tetrachloride (CCl). | 2018 | Int. Immunopharmacol. | pmid:29287251 |
Verjee S et al. | Hyperforin and Miquelianin from St. John's Wort Attenuate Gene Expression in Neuronal Cells After Dexamethasone-Induced Stress. | 2018 | Planta Med. | pmid:29499586 |
Zhou YQ et al. | Hyperoside Suppresses Lipopolysaccharide-induced Inflammation and Apoptosis in Human Umbilical Vein Endothelial Cells. | 2018 | Curr Med Sci | pmid:30074179 |
Sommella E et al. | Chemical profiling of bioactive constituents in hop cones and pellets extracts by online comprehensive two-dimensional liquid chromatography with tandem mass spectrometry and direct infusion Fourier transform ion cyclotron resonance mass spectrometry. | 2018 | J Sep Sci | pmid:29282870 |
Mukhopadhyay P et al. | Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment. | 2018 | Carbohydr Polym | pmid:29279124 |
Rácz A et al. | Selective responses of class III plant peroxidase isoforms to environmentally relevant UV-B doses. | 2018 | J. Plant Physiol. | pmid:29272746 |
Yan S et al. | Silk fabric dyed with extract of sophora flower bud. | 2018 | Nat. Prod. Res. | pmid:28748727 |
Fan D et al. | A comparison of mutagenic PhIP and beneficial 8-C-(E-phenylethenyl)quercetin and 6-C-(E-phenylethenyl)quercetin formation under microwave and conventional heating. | 2018 | Food Funct | pmid:29953158 |
Kim JE et al. | Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal. | 2018 | Pharm Biol | pmid:29952685 |
Zahoor M et al. | Isolation of quercetin and mandelic acid from Aesculus indica fruit and their biological activities. | 2018 | BMC Biochem. | pmid:29940844 |
Yamina AM et al. | Preparation of multifunctional PEG-graft-Halloysite Nanotubes for Controlled Drug Release, Tumor Cell Targeting, and Bio-imaging. | 2018 | Colloids Surf B Biointerfaces | pmid:29936385 |
K N L et al. | Augmentation of antioxidant and iron(III) chelation properties of tertiary mixture of bioactive ligands. | 2018 | J Trace Elem Med Biol | pmid:29173467 |
Wang J et al. | Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro. | 2018 | J Ovarian Res | pmid:29929541 |
Suganya N et al. | Quercetin improves endothelial function in diabetic rats through inhibition of endoplasmic reticulum stress-mediated oxidative stress. | 2018 | Eur. J. Pharmacol. | pmid:29169872 |
Özbilgin S et al. | In vivo wound-healing activity of Euphorbia characias subsp. wulfenii: Isolation and quantification of quercetin glycosides as bioactive compounds. | 2018 | J Ethnopharmacol | pmid:29920357 |
Bedada SK and Neerati P | Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers. | 2018 | Phytother Res | pmid:29168292 |
Kuipers EN et al. | Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice. | 2018 | Int J Mol Sci | pmid:29914151 |
Kawabata K et al. | Functional properties of anti-inflammatory substances from quercetin-treated Bifidobacterium adolescentis. | 2018 | Biosci. Biotechnol. Biochem. | pmid:29165050 |
Yun J et al. | Effect of isoquercitrin on membrane dynamics and apoptosis-like death in Escherichia coli. | 2018 | Biochim Biophys Acta Biomembr | pmid:29155212 |
Chalet C et al. | Intestinal disposition of quercetin and its phase-II metabolites after oral administration in healthy volunteers. | 2018 | J. Pharm. Pharmacol. | pmid:29761870 |
Li S et al. | A novel electrochemical sensor for detecting hyperin with a nanocomposite of ZrO-SDS-SWCNTs as decoration. | 2018 | Talanta | pmid:29759227 |
Ding M et al. | A network pharmacology-integrated metabolomics strategy for clarifying the difference between effective compounds of raw and processed Farfarae flos by ultra high-performance liquid chromatography-quadrupole-time of flight mass spectrometry. | 2018 | J Pharm Biomed Anal | pmid:29753281 |
Al-Asmari AK et al. | Protective effects of a natural herbal compound quercetin against snake venom-induced hepatic and renal toxicities in rats. | 2018 | Food Chem. Toxicol. | pmid:29751071 |
Chen Y et al. | Hyperoside protects human kidney‑2 cells against oxidative damage induced by oxalic acid. | 2018 | Mol Med Rep | pmid:29750296 |
Wang D et al. | Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression. | 2018 | Mol Med Rep | pmid:29749525 |
Sohn EJ et al. | Restoring Effects of Natural Anti-Oxidant Quercetin on Cellular Senescent Human Dermal Fibroblasts. | 2018 | Am. J. Chin. Med. | pmid:29737207 |
Pang XG et al. | Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway. | 2018 | Biomed Res Int | pmid:29736392 |
Jangde R et al. | In vitro and In vivo characterization of quercetin loaded multiphase hydrogel for wound healing application. | 2018 | Int. J. Biol. Macromol. | pmid:29730004 |
Wang Y et al. | Development of a LC-MS/MS method to investigate the interference of pharmacokinetics of the main constituents in Saxifraga stolonifera: Involvement of drug metabolism enzymes. | 2018 | J Pharm Biomed Anal | pmid:29017109 |
Yang JX et al. | Effects of phyto-oestrogen quercetin on productive performance, hormones, reproductive organs and apoptotic genes in laying hens. | 2018 | J Anim Physiol Anim Nutr (Berl) | pmid:28986927 |
Bedada SK and Neerati P | The effect of quercetin on the pharmacokinetics of chlorzoxazone, a CYP2E1 substrate, in healthy subjects. | 2018 | Eur. J. Clin. Pharmacol. | pmid:28983678 |
Osawe SO and Farombi EO | Quercetin and rutin ameliorates sulphasalazine-induced spermiotoxicity, alterations in reproductive hormones and steroidogenic enzyme imbalance in rats. | 2018 | Andrologia | pmid:29512831 |
Nile A et al. | Valorization of onion solid waste and their flavonols for assessment of cytotoxicity, enzyme inhibitory and antioxidant activities. | 2018 | Food Chem. Toxicol. | pmid:29496529 |
Vanden Braber NL et al. | Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin. | 2018 | Int. J. Biol. Macromol. | pmid:29421395 |
Afifi NA et al. | Hepatoprotective influence of quercetin and ellagic acid on thioacetamide-induced hepatotoxicity in rats. | 2018 | Can. J. Physiol. Pharmacol. | pmid:29414242 |
Mao T et al. | Protective Effects of Quercetin Against Cadmium Chloride-Induced Oxidative Injury in Goat Sperm and Zygotes. | 2018 | Biol Trace Elem Res | pmid:29397540 |
Pham-Hoang BN et al. | Fluorescence Lifetime and UV-Vis Spectroscopy to Evaluate the Interactions Between Quercetin and Its Yeast Microcapsule. | 2018 | Biotechnol J | pmid:28887909 |
Larit F et al. | Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants. | 2018 | Phytomedicine | pmid:29496172 |
Chen X et al. | Coencapsulation of (-)-Epigallocatechin-3-gallate and Quercetin in Particle-Stabilized W/O/W Emulsion Gels: Controlled Release and Bioaccessibility. | 2018 | J. Agric. Food Chem. | pmid:29578697 |
Wu Q et al. | Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. | 2018 | J. Agric. Food Chem. | pmid:29905475 |
Kajbafvala A et al. | Formulation, characterization, and in vitro/ex vivo evaluation of quercetin-loaded microemulsion for topical application. | 2018 | Pharm Dev Technol | pmid:27871215 |
Zhu JX et al. | Quercetin, Kaempferol and Isorhamnetin in Elaeagnus pungens Thunb. Leaf: Pharmacological Activities and Quantitative Determination Studies. | 2018 | Chem. Biodivers. | pmid:29802806 |
Yamauchi K and Mitsunaga T | Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model. | 2018 | J Nat Med | pmid:29442220 |
Ujah GA et al. | Effect of quercetin on cadmium chloride-induced impairments in sexual behaviour and steroidogenesis in male Wistar rats. | 2018 | Andrologia | pmid:28703286 |
Shi H et al. | Isorhamnetin, the active constituent of a Chinese herb Hippophae rhamnoides L, is a potent suppressor of dendritic-cell maturation and trafficking. | 2018 | Int. Immunopharmacol. | pmid:29272818 |
Silinsin M and Bursal E | UHPLC-MS/MS phenolic profiling and in vitro antioxidant activities of Inula graveolens (L.) Desf. | 2018 | Nat. Prod. Res. | pmid:28697630 |
Zhang P and Zhang X | Stimulatory effects of curcumin and quercetin on posttranslational modifications of p53 during lung carcinogenesis. | 2018 | Hum Exp Toxicol | pmid:28681665 |
Bouratoua A et al. | Chemical composition and antioxidant activity of aerial parts of Ferula longipes Coss. ex Bonnier and Maury. | 2018 | Nat. Prod. Res. | pmid:28714345 |
Shi Q et al. | Comparative Analysis of Pigments, Phenolics, and Antioxidant Activity of Chinese Jujube ( Mill.) during Fruit Development. | 2018 | Molecules | pmid:30071615 |
Chung JO et al. | Quercetin and fisetin enhanced the small intestine cellular uptake and plasma levels of epi-catechins in in vitro and in vivo models. | 2018 | Food Funct | pmid:29168878 |