| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Contusions | D003288 | 3 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with quercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with quercetin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with quercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Walkowiak A et al. | Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. | 2019 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:30321862 |
| Maurya AK and Vinayak M | Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. | 2019 | In Vitro Cell. Dev. Biol. Anim. | pmid:30413935 |
| Li J et al. | Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. | 2019 | Chem. Biol. Interact. | pmid:30365939 |
| Mu Y et al. | Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. | 2019 | Carbohydr Polym | pmid:30318192 |
| Li F et al. | The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. | 2019 | Pest Manag. Sci. | pmid:29797492 |
| Schröder L et al. | Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. | 2019 | Oncol. Rep. | pmid:30320348 |
| Bustos AS et al. | Interaction Between Phenolic Compounds and Lipase: The Influence of Solubility and Presence of Particles in the IC Value. | 2018 | J. Food Sci. | pmid:30020550 |
| Kinger M et al. | Some Important Dietary Polyphenolic Compounds: An Anti-inflammatory and Immunoregulatory Perspective. | 2018 | Mini Rev Med Chem | pmid:28183265 |
| Khlupova ME et al. | Laccase-Catalyzed Heterocoupling of Dihydroquercetin and p-Aminobenzoic Acid: Effect of the Reaction Product on Cultured Cells. | 2018 | Biochemistry Mosc. | pmid:30208835 |
| Ashraf AHMZ et al. | Differential Mechanism of Action of 3,4',7-O-trimethylquercetin in Three Types of Ovarian Cancer Cells. | 2018 | Anticancer Res. | pmid:30194160 |
| Rubio V et al. | Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells. | 2018 | Chem. Biol. Interact. | pmid:30171828 |
| Lu X et al. | Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice. | 2018 | Biomed. Pharmacother. | pmid:29684859 |
| Kumar M et al. | N-desmethyl tamoxifen and quercetin-loaded multiwalled CNTs: A synergistic approach to overcome MDR in cancer cells. | 2018 | Mater Sci Eng C Mater Biol Appl | pmid:29752099 |
| Niu X et al. | Three-dimensional reduced graphene oxide aerogel modified electrode for the sensitive quercetin sensing and its application. | 2018 | Mater Sci Eng C Mater Biol Appl | pmid:29752093 |
| Chen Z et al. | Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells. | 2018 | Phytomedicine | pmid:29747752 |
| Å ola I et al. | Comparative Analysis of Native Crocus Taxa as a Great Source of Flavonoids with High Antioxidant Activity. | 2018 | Plant Foods Hum Nutr | pmid:29860648 |
| Negi S et al. | Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. | 2018 | Toxicol In Vitro | pmid:29933105 |
| Jin UH et al. | Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. | 2018 | Toxicol. Sci. | pmid:29584932 |
| Forney LA et al. | Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner. | 2018 | Int J Mol Sci | pmid:29562620 |
| Hatahet T et al. | Liposomes, lipid nanocapsules and smartCrystals®: A comparative study for an effective quercetin delivery to the skin. | 2018 | Int J Pharm | pmid:29549014 |
| Hwang DS et al. | Effects of Rhei Undulati Rhizoma on lipopolysaccharide-induced neuroinflammation in vitro and in vivo. | 2018 | Environ. Toxicol. | pmid:28984087 |
| Ting Y et al. | Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on Body Composition, Serum Lipid Profile, and Gene Expression. | 2018 | J. Agric. Food Chem. | pmid:29249156 |
| Kim YA et al. | Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant in Human Keratinocytes. | 2018 | Molecules | pmid:30216992 |
| Giuliani C et al. | Localization of phenolic compounds in the fruits of Silybum marianum characterized by different silymarin chemotype and altered colour. | 2018 | Fitoterapia | pmid:30213759 |
| Takabe W et al. | Identification of Antiglycative Compounds in Japanese Red Water Pepper (Red Leaf Variant of the Sprout). | 2018 | Molecules | pmid:30208642 |
| Gao Q et al. | A red-emitting indolium fluorescence probe for membranes - flavonoids interactions. | 2018 | Luminescence | pmid:29405584 |
| Wein S et al. | Bioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows. | 2018 | J. Agric. Food Chem. | pmid:30207714 |
| Ge F et al. | Taxifolin suppresses rat and human testicular androgen biosynthetic enzymes. | 2018 | Fitoterapia | pmid:29402482 |
| Ding Y et al. | Quercetin suppresses the chymotrypsin-like activity of proteasome via inhibition of MEK1/ERK1/2 signaling pathway in hepatocellular carcinoma HepG2 cells. | 2018 | Can. J. Physiol. Pharmacol. | pmid:29394494 |
| Ginex T et al. | Computational Study of the Aza-Michael Addition of the Flavonoid (+)-Taxifolin in the Inhibition of β-Amyloid Fibril Aggregation. | 2018 | Chemistry | pmid:29384229 |
| Hamilton KE et al. | Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1. | 2018 | Biochimie | pmid:29857184 |
| North MK et al. | The effects of quercetin supplementation on New Zealand White grower rabbit carcass and meat quality - A short communication. | 2018 | Meat Sci. | pmid:30031202 |
| Kruszewski M et al. | The effect of quercetin on the electrical properties of model lipid membranes and human glioblastoma cells. | 2018 | Bioelectrochemistry | pmid:30029034 |
| Alugoju P et al. | Quercetin Protects Yeast Saccharomyces cerevisiae pep4 Mutant from Oxidative and Apoptotic Stress and Extends Chronological Lifespan. | 2018 | Curr. Microbiol. | pmid:29224051 |
| Lee KM et al. | Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed human keratinocytes. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29857000 |
| Ramos-Pineda AM et al. | Effect of the addition of mannoproteins on the interaction between wine flavonols and salivary proteins. | 2018 | Food Chem | pmid:29853369 |
| Selvarajan S et al. | Fabrication of g-CN/NiO heterostructured nanocomposite modified glassy carbon electrode for quercetin biosensor. | 2018 | Ultrason Sonochem | pmid:29137797 |
| Singh A et al. | Curcumin loaded chitin-glucan quercetin conjugate: Synthesis, characterization, antioxidant, in vitro release study, and anticancer activity. | 2018 | Int. J. Biol. Macromol. | pmid:29128588 |
| Lei CS et al. | Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies. | 2018 | J. Nutr. Biochem. | pmid:29125991 |
| Lin M et al. | Quercetin improves postpartum hypogalactia in milk-deficient mice via stimulating prolactin production in pituitary gland. | 2018 | Phytother Res | pmid:29671937 |
| Seo S et al. | Prediction of GPCR-Ligand Binding Using Machine Learning Algorithms. | 2018 | Comput Math Methods Med | pmid:29666662 |
| Jayachandran M et al. | Isoquercetin ameliorates hyperglycemia and regulates key enzymes of glucose metabolism via insulin signaling pathway in streptozotocin-induced diabetic rats. | 2018 | Eur. J. Pharmacol. | pmid:29665363 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| Lu Q et al. | Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway. | 2018 | Acta Biochim. Pol. | pmid:29281744 |
| Dresch RR et al. | Potential use of secondary products of the agri-food industry for topical formulations and comparative analysis of antioxidant activity of grape leaf polyphenols. | 2018 | Nat. Prod. Res. | pmid:28403634 |
| Seong JS et al. | Surfactant-stable and pH-sensitive liposomes coated with N-succinyl-chitosan and chitooligosaccharide for delivery of quercetin. | 2018 | Carbohydr Polym | pmid:29254020 |
| Chatziathanasiadou MV et al. | Amplifying and broadening the cytotoxic profile of quercetin in cancer cell lines through bioconjugation. | 2018 | Amino Acids | pmid:29185031 |
| Shalini D et al. | Effect of size and shape on toxicity of zinc oxide (ZnO) nanomaterials in human peripheral blood lymphocytes. | 2018 | Toxicol. Mech. Methods | pmid:28805101 |
| Woźniak D et al. | Comparison of Polyphenol Profile and Antimutagenic and Antioxidant Activities in Two Species Used as Source of Solidaginis herba - Goldenrod. | 2018 | Chem. Biodivers. | pmid:29537689 |
| Slámová K et al. | "Sweet Flavonoids": Glycosidase-Catalyzed Modifications. | 2018 | Int J Mol Sci | pmid:30037103 |