quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Edema D004487 152 associated lipids
Carcinoma in Situ D002278 4 associated lipids
Precancerous Conditions D011230 48 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Carbon Tetrachloride Poisoning D002252 12 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Rodent Diseases D012376 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Testicular Diseases D013733 15 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Osteosarcoma D012516 50 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Kidney Diseases D007674 29 associated lipids
Hematuria D006417 13 associated lipids
Weight Gain D015430 101 associated lipids
Cadmium Poisoning D002105 6 associated lipids
Per page 10 20 50 100 | Total 205

PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Per page 10 20 50 100 | Total 12031
Authors Title Published Journal PubMed Link
Walkowiak A et al. Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. 2019 Spectrochim Acta A Mol Biomol Spectrosc pmid:30321862
Maurya AK and Vinayak M Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. 2019 In Vitro Cell. Dev. Biol. Anim. pmid:30413935
Li J et al. Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. 2019 Chem. Biol. Interact. pmid:30365939
Mu Y et al. Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. 2019 Carbohydr Polym pmid:30318192
Li F et al. The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. 2019 Pest Manag. Sci. pmid:29797492
Schröder L et al. Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. 2019 Oncol. Rep. pmid:30320348
Liu Y et al. Light quality affects flavonoid production and related gene expression in Cyclocarya paliurus. 2018 J. Photochem. Photobiol. B, Biol. pmid:29334625
Eftekhari A et al. Hepatoprotective and free radical scavenging actions of quercetin nanoparticles on aflatoxin B1-induced liver damage: in vitro/in vivo studies. 2018 Artif Cells Nanomed Biotechnol pmid:28423950
Xu MJ et al. Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2. 2018 Chem. Biol. Interact. pmid:29689254
Maturu P et al. Quercetin attenuates the hyperoxic lung injury in neonatal mice: Implications for Bronchopulmonary dysplasia (BPD). 2018 Food Chem. Toxicol. pmid:29432836
Wang D et al. Quercetin attenuates domoic acid-induced cognitive deficits in mice. 2018 Nutr Neurosci pmid:28277184
Zhou JL et al. Structures and bioactivities of seven flavonoids from Osmanthus fragrans 'Jinqiu' essential oil extraction residues. 2018 Nat. Prod. Res. pmid:28431473
Zhang X et al. Chemical Fingerprint and Quantitative Analysis for the Quality Evaluation of Docynia dcne Leaves by High-Performance Liquid Chromatography Coupled with Chemometrics Analysis. 2018 J Chromatogr Sci pmid:29800095
Abdelhalim MAK et al. The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats. 2018 Int J Nanomedicine pmid:29785108
Liu L et al. One-step synthesis of fluorescent carbon dots for sensitive and selective detection of hyperin. 2018 Talanta pmid:29784367
Singh A et al. Synthesis of chitin-glucan-aldehyde-quercetin conjugate and evaluation of anticancer and antioxidant activities. 2018 Carbohydr Polym pmid:29773403
Huang ZQ et al. Antioxidant Activity and Hepatoprotective Potential of Quercetin 7-Rhamnoside In Vitro and In Vivo. 2018 Molecules pmid:29772655
Omar SH et al. Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.). 2018 Fitoterapia pmid:29772299
Qi F et al. Anti-inflammatory effects of isorhamnetin on LPS-stimulated human gingival fibroblasts by activating Nrf2 signaling pathway. 2018 Microb. Pathog. pmid:29704670
Pilařová V et al. Simultaneous determination of quercetin and its metabolites in rat plasma by using ultra-high performance liquid chromatography tandem mass spectrometry. 2018 Talanta pmid:29759252
Lu X et al. Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice. 2018 Biomed. Pharmacother. pmid:29684859
Liu FC et al. Arthroprotective Effects of Cf-02 Sharing Structural Similarity with Quercetin. 2018 Int J Mol Sci pmid:29757957
Å ola I et al. Comparative Analysis of Native Crocus Taxa as a Great Source of Flavonoids with High Antioxidant Activity. 2018 Plant Foods Hum Nutr pmid:29860648
UylaÅŸ MU et al. Quercetin dose affects the fate of hepatic ischemia and reperfusion injury in rats: An experimental research. 2018 Int J Surg pmid:29578092
Yu Y et al. Nanostructured lipid carrier-based pH and temperature dual-responsive hydrogel composed of carboxymethyl chitosan and poloxamer for drug delivery. 2018 Int. J. Biol. Macromol. pmid:29578017
Borovskaya TG et al. Experimental Analysis of the Efficacy of Dihydroquercetin on the Model of Chronic Nonbacterial Inflammation of the Prostatic Gland. 2018 Bull. Exp. Biol. Med. pmid:29577199
Castillo RL et al. Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats. 2018 Oxid Med Cell Longev pmid:29576853
Liu J et al. Preparation, characterization, digestibility and antioxidant activity of quercetin grafted Cynanchum auriculatum starch. 2018 Int. J. Biol. Macromol. pmid:29572138
Boadi WY and Lo A Effects of Quercetin, Kaempferol, and Exogenous Glutathione on Phospho- and Total-AKT in 3T3-L1 Preadipocytes. 2018 J Diet Suppl pmid:29345961
Ma YK et al. Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media. 2018 Int. J. Mol. Med. pmid:29568908
Donno D et al. New Findings in Prunus padus L. Fruits as a Source of Natural Compounds: Characterization of Metabolite Profiles and Preliminary Evaluation of Antioxidant Activity. 2018 Molecules pmid:29565317
Park DJ et al. Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model. 2018 J. Vet. Med. Sci. pmid:29563391
Tsunekawa R et al. Synthesis of fisetin and 2',4',6'-trihydroxydihyrochalcone 4'-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation. 2018 Biosci. Biotechnol. Biochem. pmid:29699439
Li X et al. Quercetin suppresses breast cancer stem cells (CD44/CD24) by inhibiting the PI3K/Akt/mTOR-signaling pathway. 2018 Life Sci. pmid:29355544
Szopa A et al. The importance of monochromatic lights in the production of phenolic acids and flavonoids in shoot cultures of Aronia melanocarpa, Aronia arbutifolia and Aronia × prunifolia. 2018 J. Photochem. Photobiol. B, Biol. pmid:29351879
Suvarna VM and Sangave PC HPLC Estimation, Ex vivo Everted Sac Permeability and In Vivo Pharmacokinetic Studies of Darunavir. 2018 J Chromatogr Sci pmid:29342239
Li XM et al. Quercetin and aconitine synergistically induces the human cervical carcinoma HeLa cell apoptosis via endoplasmic reticulum (ER) stress pathway. 2018 PLoS ONE pmid:29324796
Hwang HV et al. Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. 2018 PLoS ONE pmid:29315311
Liaquat L et al. Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats. 2018 Life Sci. pmid:29287782
Zeng Y et al. Bioinformatics analysis to identify action targets in NCI-N87 gastric cancer cells exposed to quercetin. 2018 Pharm Biol pmid:30266078
Dymarska M et al. Glycosylation of 3-Hydroxyflavone, 3-Methoxyflavone, Quercetin and Baicalein in Fungal Cultures of the Genus . 2018 Molecules pmid:30262733
Chen Y et al. Beneficial effects of hyperoside on bone metabolism in ovariectomized mice. 2018 Biomed. Pharmacother. pmid:30257331
Rjeibi I et al. Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice. 2018 Oxid Med Cell Longev pmid:30254713
Babotă M et al. Phytochemical Analysis, Antioxidant and Antimicrobial Activities of Helichrysum arenarium (L.) Moench. and Antennaria dioica (L.) Gaertn. Flowers. 2018 Molecules pmid:29438342
Liu Y et al. Geographic Variation in the Chemical Composition and Antioxidant Properties of Phenolic Compounds from (Batal) Iljinskaja Leaves. 2018 Molecules pmid:30249997
Xiao L et al. Quercetin and iron metabolism: What we know and what we need to know. 2018 Food Chem. Toxicol. pmid:29432835
Naseer Z et al. Dietary quercetin maintains the semen quality in rabbits under summer heat stress. 2018 Theriogenology pmid:30243139
Nakhlband A et al. Marrubiin-loaded solid lipid nanoparticles' impact on TNF-α treated umbilical vein endothelial cells: A study for cardioprotective effect. 2018 Colloids Surf B Biointerfaces pmid:29413609
Fang J et al. Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy. 2018 Int J Nanomedicine pmid:30233175
Omwenga EO et al. Chitosan nanoencapsulation of flavonoids enhances their quorum sensing and biofilm formation inhibitory activities against an E.coli Top 10 biosensor. 2018 Colloids Surf B Biointerfaces pmid:29413589
Zhang M et al. Neurodevelopmental toxicity induced by maternal PM2.5 exposure and protective effects of quercetin and Vitamin C. 2018 Chemosphere pmid:30218877
Zhang C et al. Mechanistic insights into the inhibition of quercetin on xanthine oxidase. 2018 Int. J. Biol. Macromol. pmid:29410028
Kim YA et al. Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant in Human Keratinocytes. 2018 Molecules pmid:30216992
Ajaghaku DL et al. Upregulation of CD T-Lymphocytes by Isomeric Mixture of Quercetin-3-O-Rutinoside and Quercetin-3-O-Robinobioside Isolated from Millettia aboensis. 2018 Immunol. Invest. pmid:29405788
Rahvar M et al. Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain. 2018 Bratisl Lek Listy pmid:29405727
Gao Q et al. A red-emitting indolium fluorescence probe for membranes - flavonoids interactions. 2018 Luminescence pmid:29405584
Chatzikonstantinou AV et al. Enriching the biological space of natural products and charting drug metabolites, through real time biotransformation monitoring: The NMR tube bioreactor. 2018 Biochim Biophys Acta Gen Subj pmid:28974426
Liu T et al. Production of drug nanosuspensions: effect of drug physical properties on nanosizing efficiency. 2018 Drug Dev Ind Pharm pmid:28956456
Yao C et al. Inhibition of enterovirus 71 replication and viral 3C protease by quercetin. 2018 Virol. J. pmid:30064445
Khorshidi M et al. The effects of quercetin supplementation on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome. 2018 Phytother Res pmid:30062709
Wu D et al. Metabolite Profiles, Bioactivity, and HPLC Fingerprint of Different Varieties of Oliv.: Towards the Utilization of Medicinal and Commercial Chinese Endemic Tree. 2018 Molecules pmid:30061494
Fan HR et al. Quercetin Reduces Cortical GABAergic Transmission and Alleviates MK-801-Induced Hyperactivity. 2018 EBioMedicine pmid:30057312
Sheth U and Bahadur A In-vitro evaluation of cytotoxic and antioxidant properties of drugs solubilized in EO-PO star block copolymer micelles. 2018 Colloids Surf B Biointerfaces pmid:30056295
Chen X et al. Plant flavonoid taxifolin inhibits the growth, migration and invasion of human osteosarcoma cells. 2018 Mol Med Rep pmid:29257319
Borse SP et al. Potential synergistic effects of quercetin with other phytoconstituents of Costus pictus (insulin plant) extract in the control of hyperglycemia and prevention of NSAID-induced gastroenteropathy in diabetic rats. 2018 Food Chem. Toxicol. pmid:30055312
Samad N et al. Quercetin protects against stress-induced anxiety- and depression-like behavior and improves memory in male mice. 2018 Physiol Res pmid:30044120
Rauf A et al. Anticancer potential of quercetin: A comprehensive review. 2018 Phytother Res pmid:30039547
Sharma A et al. Therapeutic charm of quercetin and its derivatives: a review of research and patents. 2018 Pharm Pat Anal pmid:29227203
Pathak RK et al. Identification of new drug-like compounds from millets as Xanthine oxidoreductase inhibitors for treatment of Hyperuricemia: A molecular docking and simulation study. 2018 Comput Biol Chem pmid:29906649
Diamantis DA et al. Exploring the oxidation and iron binding profile of a cyclodextrin encapsulated quercetin complex unveiled a controlled complex dissociation through a chemical stimulus. 2018 Biochim Biophys Acta Gen Subj pmid:29886278
Aithal GC et al. Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations. 2018 Molecules pmid:29882751
Park J et al. Systematic metabolic profiling and bioactivity assays for bioconversion of Aceraceae family. 2018 PLoS ONE pmid:29879203
Nambooppha B et al. Quercetin manipulates the expression of genes involved in the reactive oxygen species (ROS) process in chicken heterophils. 2018 J. Vet. Med. Sci. pmid:29877311
Lin J et al. Steamed bread enriched with quercetin as an antiglycative food product: its quality attributes and antioxidant properties. 2018 Food Funct pmid:29872802
Yang Y et al. Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect. 2018 Int. Immunopharmacol. pmid:29149703
Qiu L et al. Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats. 2018 Biomed. Pharmacother. pmid:29864946
Ventura-Martínez R et al. Spasmolytic effect of aqueous extract of Tagetes erecta L. flowers is mediated through calcium channel blockade on the guinea-pig ileum. 2018 Biomed. Pharmacother. pmid:29864942
Selvarajan S et al. Fabrication of g-CN/NiO heterostructured nanocomposite modified glassy carbon electrode for quercetin biosensor. 2018 Ultrason Sonochem pmid:29137797
Jangde R et al. In vitro and In vivo characterization of quercetin loaded multiphase hydrogel for wound healing application. 2018 Int. J. Biol. Macromol. pmid:29730004
Zhuang M et al. Islet protection and amelioration of type 2 diabetes mellitus by treatment with quercetin from the flowers of . 2018 Drug Des Devel Ther pmid:29720871
Lotha R et al. Plant nutraceuticals (Quercetrin and Afzelin) capped silver nanoparticles exert potent antibiofilm effect against food borne pathogen Salmonella enterica serovar Typhi and curtail planktonic growth in zebrafish infection model. 2018 Microb. Pathog. pmid:29715535
Abdel Aziz RL et al. Dose- dependent ameliorative effects of quercetin and l-Carnitine against atrazine- induced reproductive toxicity in adult male Albino rats. 2018 Biomed. Pharmacother. pmid:29710542
Bedada SK and Neerati P The effect of quercetin on the pharmacokinetics of chlorzoxazone, a CYP2E1 substrate, in healthy subjects. 2018 Eur. J. Clin. Pharmacol. pmid:28983678
Yuan TY et al. Vasorelaxant effect of quercetin on cerebral basilar artery in vitro and the underlying mechanisms study. 2018 J Asian Nat Prod Res pmid:29693418
Kale A et al. Neuroprotective effects of Quercetin on radiation-induced brain injury in rats. 2018 J. Radiat. Res. pmid:29688418
Mbikay M et al. Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas. 2018 Mol Nutr Food Res pmid:29396908
Zou H et al. Synergistic Anti-tumour Effects of Quercetin and Oncolytic Adenovirus expressing TRAIL in Human Hepatocellular Carcinoma. 2018 Sci Rep pmid:29391509
Sturza A et al. Quercetin exerts an inhibitory effect on cellular bioenergetics of the B164A5 murine melanoma cell line. 2018 Mol. Cell. Biochem. pmid:29380243
Cornara L et al. Zornia latifolia: a smart drug being adulterated by Stylosanthes guianensis. 2018 Int. J. Legal Med. pmid:29362872
Alves MC et al. Taxifolin: Evaluation Through Ex vivo Permeations on Human Skin and Porcine Vaginal Mucosa. 2018 Curr Drug Deliv pmid:29336264
Wei X et al. Quercetin exerts cardiovascular protective effects in LPS-induced dysfunction in vivo by regulating inflammatory cytokine expression, NF-κB phosphorylation, and caspase activity. 2018 Mol. Cell. Biochem. pmid:29322353
Suzen A et al. Protective Effects of Hypericum perforatum and Quercetin in a Rat Model of Ischemia/Reperfusion Injury of Testes. 2018 Eur J Pediatr Surg pmid:28837999
Adhikary R et al. Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases. 2018 J Ethnopharmacol pmid:28826781
Shaalan YM et al. Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma. 2018 Nat. Prod. Res. pmid:28817968
de Oliveira Pedro R et al. Synergistic effect of quercetin and pH-responsive DEAE-chitosan carriers as drug delivery system for breast cancer treatment. 2018 Int. J. Biol. Macromol. pmid:28807690
Arif H et al. Flavonoids-induced redox cycling of copper ions leads to generation of reactive oxygen species: A potential role in cancer chemoprevention. 2018 Int. J. Biol. Macromol. pmid:28834706
Eren-Guzelgun B et al. In vitro antioxidant/prooxidant effects of combined use of flavonoids. 2018 Nat. Prod. Res. pmid:28669231
Kasmi S et al. Modulatory effects of quercetin on liver histopathological, biochemical, hematological, oxidative stress and DNA alterations in rats exposed to graded doses of score 250. 2018 Toxicol. Mech. Methods pmid:28679351
Khaligh F et al. Effects of in ovo injection of chrysin, quercetin and ascorbic acid on hatchability, somatic attributes, hepatic oxidative status and early post-hatch performance of broiler chicks. 2018 J Anim Physiol Anim Nutr (Berl) pmid:28636279
Jiménez-López J et al. Phytochemical profile and antioxidant activity of caper berries (Capparis spinosa L.): Evaluation of the influence of the fermentation process. 2018 Food Chem pmid:29412927