quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Sarcoma 180 D012510 21 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 205

PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Per page 10 20 50 100 | Total 12031
Authors Title Published Journal PubMed Link
Walkowiak A et al. Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. 2019 Spectrochim Acta A Mol Biomol Spectrosc pmid:30321862
Maurya AK and Vinayak M Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. 2019 In Vitro Cell. Dev. Biol. Anim. pmid:30413935
Li J et al. Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. 2019 Chem. Biol. Interact. pmid:30365939
Mu Y et al. Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. 2019 Carbohydr Polym pmid:30318192
Li F et al. The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. 2019 Pest Manag. Sci. pmid:29797492
Schröder L et al. Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. 2019 Oncol. Rep. pmid:30320348
Leng E et al. Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells. 2018 BMC Complement Altern Med pmid:29622007
Mohebali N et al. Effect of flavonoids rich extract of Capparis spinosa on inflammatory involved genes in amyloid-beta peptide injected rat model of Alzheimer's disease. 2018 Nutr Neurosci pmid:27778760
Patel RV et al. Therapeutic potential of quercetin as a cardiovascular agent. 2018 Eur J Med Chem pmid:29966915
Riva A et al. Quercetin phytosome® in triathlon athletes: a pilot registry study. 2018 Minerva Med. pmid:29947492
Asfaram A et al. Cu- and S- @SnO nanoparticles loaded on activated carbon for efficient ultrasound assisted dispersive µSPE-spectrophotometric detection of quercetin in Nasturtium officinale extract and fruit juice samples: CCD-RSM design. 2018 Ultrason Sonochem pmid:29908597
Mehrbod P et al. Immunomodulatory properties of quercetin-3-O-α-L-rhamnopyranoside from Rapanea melanophloeos against influenza a virus. 2018 BMC Complement Altern Med pmid:29903008
Laczkó-Zöld E et al. Extractability of polyphenols from black currant, red currant and gooseberry and their antioxidant activity. 2018 Acta. Biol. Hung. pmid:29888668
Wang WJ et al. Deciphering the chemoselectivity of nickel-dependent quercetin 2,4-dioxygenase. 2018 Phys Chem Chem Phys pmid:29869653
Zhou W et al. A two-step ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry with mass defect filtering method for rapid identification of analogues from known components of different chemical structure types in Fructus Gardeniae-Fructus Forsythiae herb pair extract and in rat's blood. 2018 J Chromatogr A pmid:29861306
Patra A et al. Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers. 2018 Int J Nanomedicine pmid:29844670
Šarić Mustapić D et al. The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. 2018 Molecules pmid:30301254
Dresler S et al. Methodological aspects of biologically active compounds quantification in the genus Hypericum. 2018 J Pharm Biomed Anal pmid:29621655
Gaudry A et al. The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells. 2018 Int J Mol Sci pmid:29621184
Du G et al. Quercetin protects rat cortical neurons against traumatic brain injury. 2018 Mol Med Rep pmid:29620218
Jahan S et al. Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study. 2018 J Ovarian Res pmid:29615083
Qureshi AA et al. Proteasome inhibitors modulate anticancer and anti-proliferative properties via NF-kB signaling, and ubiquitin-proteasome pathways in cancer cell lines of different organs. 2018 Lipids Health Dis pmid:29606130
Ge L et al. B-factor-saturation mutagenesis as a strategy to increase the thermostability of α-L-rhamnosidase from Aspergillus terreus. 2018 J. Biotechnol. pmid:29605638
Chen J et al. Pretreatment with dihydroquercetin, a dietary flavonoid, protected against concanavalin A-induced immunological hepatic injury in mice and TNF-α/ActD-induced apoptosis in HepG2 cells. 2018 Food Funct pmid:29589006
Zhu Q et al. Comparison of flavonoids and isoflavonoids to inhibit rat and human 11β-hydroxysteroid dehydrogenase 1 and 2. 2018 Steroids pmid:29425740
Farrag Y et al. Preparation of starch nanoparticles loaded with quercetin using nanoprecipitation technique. 2018 Int. J. Biol. Macromol. pmid:29580996
Sung YY et al. Aqueous and ethanolic extracts of welsh onion, Allium fistulosum, attenuate high-fat diet-induced obesity. 2018 BMC Complement Altern Med pmid:29558911
Rishitha N and Muthuraman A Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish. 2018 Life Sci. pmid:29522770
Khalil SR et al. Intermediate filament protein expression pattern and inflammatory response changes in kidneys of rats receiving doxorubicin chemotherapy and quercetin. 2018 Toxicol. Lett. pmid:29474904
Dai Y et al. Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway. 2018 Chem. Biol. Interact. pmid:29454613
Feng J et al. Quercetin restrains TGF-β1-induced epithelial-mesenchymal transition by inhibiting Twist1 and regulating E-cadherin expression. 2018 Biochem. Biophys. Res. Commun. pmid:29425820
Vovkun T et al. Water-soluble quercetin modulates the choleresis and bile lipid ratio in rats. 2018 Gen. Physiol. Biophys. pmid:29424356
Foti MC et al. Singlet oxygen quenching- and chain-breaking antioxidant-properties of a quercetin dimer able to prevent age-related macular degeneration. 2018 Biophys. Chem. pmid:30352336
Ebrahimpour S et al. Effect of quercetin-conjugated superparamagnetic iron oxide nanoparticles on diabetes-induced learning and memory impairment in rats. 2018 Int J Nanomedicine pmid:30349252
Xia F et al. Rapid Determination of Active Compounds and Antioxidant Activity of Okra Seeds Using Fourier Transform Near Infrared (FT-NIR) Spectroscopy. 2018 Molecules pmid:29498632
Donno D et al. Assessing Nutritional Traits and Phytochemical Composition of Artisan Jams Produced in Comoros Islands: Using Indigenous Fruits with High Health-Impact as an Example of Biodiversity Integration and Food Security in Rural Development. 2018 Molecules pmid:30347846
Wu Q et al. Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells. 2018 Food Funct pmid:29497723
Islami M et al. Controlled quercetin release from high-capacity-loading hyperbranched polyglycerol-functionalized graphene oxide. 2018 Int J Nanomedicine pmid:30323593
Ahmed OM et al. Quercetin and low level laser therapy promote wound healing process in diabetic rats via structural reorganization and modulatory effects on inflammation and oxidative stress. 2018 Biomed. Pharmacother. pmid:29477473
Li S et al. Quercetin enhances chemotherapeutic effect of doxorubicin against human breast cancer cells while reducing toxic side effects of it. 2018 Biomed. Pharmacother. pmid:29475141
Porcu EP et al. Aqueous injection of quercetin: An approach for confirmation of its direct in vivo cardiovascular effects. 2018 Int J Pharm pmid:29474897
Ray S et al. Modulation in phenolic root exudate profile of Abelmoschus esculentus expressing activation of defense pathway. 2018 Microbiol. Res. pmid:29458844
Sakalli S et al. In vitro effects of diosmin, naringenin, quercetin and indole-3-carbinol on fish hepatic CYP1A1 in the presence of clotrimazole and dexamethasone. 2018 Chemosphere pmid:29100118
Zhao QY et al. Selective recognition and fast enrichment of anthocyanins by dummy molecularly imprinted magnetic nanoparticles. 2018 J Chromatogr A pmid:30139620
Baksi R et al. In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles. 2018 Biomed. Pharmacother. pmid:30119227
Junyuan Z et al. Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition. 2018 Pancreatology pmid:30115563
Hobbs CA et al. Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential. 2018 Food Chem. Toxicol. pmid:29317330
Chen Z et al. Effects of Quercetin on Proliferation and Hâ‚‚Oâ‚‚-Induced Apoptosis of Intestinal Porcine Enterocyte Cells. 2018 Molecules pmid:30103566
Babaei F et al. Quercetin in Food: Possible Mechanisms of Its Effect on Memory. 2018 J. Food Sci. pmid:30103275
Ren K et al. Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARγ/LXRα pathway. 2018 Food Funct pmid:29292466
Wang R et al. A strategy for absolute quantitation of isomers using high performance liquid chromatography-ion mobility mass spectrometry and material balance principle. 2018 J Chromatogr A pmid:30097341
Chan ST et al. Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice. 2018 Food Funct pmid:29292417
Ma Y et al. Quercetin potentiates the concurrent hyper-accumulation of cellular biomass and lipids in Chlorella vulgaris. 2018 Bioresour. Technol. pmid:30093226
Guimarães GC et al. Binding investigation between M2-1protein from hRSV and acetylated quercetin derivatives: H NMR, fluorescence spectroscopy, and molecular docking. 2018 Int. J. Biol. Macromol. pmid:29292149
Wu Z et al. Simultaneous Enrichment and Separation of Four Flavonoids from Zanthoxylum bungeanum Leaves by Ultrasound-Assisted Extraction and Macroporous Resins with Evaluation of Antioxidant Activities. 2018 J. Food Sci. pmid:30080245
Chirumbolo S and Bjørklund G Quercetin in the experimental liver fibrosis induced by carbon tetrachloride (CCl). 2018 Int. Immunopharmacol. pmid:29287251
Verjee S et al. Hyperforin and Miquelianin from St. John's Wort Attenuate Gene Expression in Neuronal Cells After Dexamethasone-Induced Stress. 2018 Planta Med. pmid:29499586
Zhou YQ et al. Hyperoside Suppresses Lipopolysaccharide-induced Inflammation and Apoptosis in Human Umbilical Vein Endothelial Cells. 2018 Curr Med Sci pmid:30074179
Sommella E et al. Chemical profiling of bioactive constituents in hop cones and pellets extracts by online comprehensive two-dimensional liquid chromatography with tandem mass spectrometry and direct infusion Fourier transform ion cyclotron resonance mass spectrometry. 2018 J Sep Sci pmid:29282870
Mukhopadhyay P et al. Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment. 2018 Carbohydr Polym pmid:29279124
Li ZP et al. Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation. 2018 Molecules pmid:29958399
Cao L et al. Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways. 2018 Int. J. Mol. Med. pmid:29956731
Fan D et al. A comparison of mutagenic PhIP and beneficial 8-C-(E-phenylethenyl)quercetin and 6-C-(E-phenylethenyl)quercetin formation under microwave and conventional heating. 2018 Food Funct pmid:29953158
Kim JE et al. Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal. 2018 Pharm Biol pmid:29952685
Zahoor M et al. Isolation of quercetin and mandelic acid from Aesculus indica fruit and their biological activities. 2018 BMC Biochem. pmid:29940844
Yamina AM et al. Preparation of multifunctional PEG-graft-Halloysite Nanotubes for Controlled Drug Release, Tumor Cell Targeting, and Bio-imaging. 2018 Colloids Surf B Biointerfaces pmid:29936385
K N L et al. Augmentation of antioxidant and iron(III) chelation properties of tertiary mixture of bioactive ligands. 2018 J Trace Elem Med Biol pmid:29173467
Wang J et al. Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro. 2018 J Ovarian Res pmid:29929541
Suganya N et al. Quercetin improves endothelial function in diabetic rats through inhibition of endoplasmic reticulum stress-mediated oxidative stress. 2018 Eur. J. Pharmacol. pmid:29169872
Özbilgin S et al. In vivo wound-healing activity of Euphorbia characias subsp. wulfenii: Isolation and quantification of quercetin glycosides as bioactive compounds. 2018 J Ethnopharmacol pmid:29920357
Bedada SK and Neerati P Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers. 2018 Phytother Res pmid:29168292
Kuipers EN et al. Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice. 2018 Int J Mol Sci pmid:29914151
Kawabata K et al. Functional properties of anti-inflammatory substances from quercetin-treated Bifidobacterium adolescentis. 2018 Biosci. Biotechnol. Biochem. pmid:29165050
Zhang L et al. UV-Vis spectroscopy combined with chemometric study on the interactions of three dietary flavonoids with copper ions. 2018 Food Chem pmid:29784309
Tsukamoto Y et al. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. 2018 PLoS ONE pmid:29782545
Chalet C et al. Intestinal disposition of quercetin and its phase-II metabolites after oral administration in healthy volunteers. 2018 J. Pharm. Pharmacol. pmid:29761870
Li S et al. A novel electrochemical sensor for detecting hyperin with a nanocomposite of ZrO-SDS-SWCNTs as decoration. 2018 Talanta pmid:29759227
Trinh PTN et al. A new benzofuran derivative from the leaves of Ficus pumila L. 2018 Nat. Prod. Res. pmid:29072969
Ding M et al. A network pharmacology-integrated metabolomics strategy for clarifying the difference between effective compounds of raw and processed Farfarae flos by ultra high-performance liquid chromatography-quadrupole-time of flight mass spectrometry. 2018 J Pharm Biomed Anal pmid:29753281
Al-Asmari AK et al. Protective effects of a natural herbal compound quercetin against snake venom-induced hepatic and renal toxicities in rats. 2018 Food Chem. Toxicol. pmid:29751071
Chen Y et al. Hyperoside protects human kidney‑2 cells against oxidative damage induced by oxalic acid. 2018 Mol Med Rep pmid:29750296
Wang D et al. Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression. 2018 Mol Med Rep pmid:29749525
Sohn EJ et al. Restoring Effects of Natural Anti-Oxidant Quercetin on Cellular Senescent Human Dermal Fibroblasts. 2018 Am. J. Chin. Med. pmid:29737207
Wang Y et al. Development of a LC-MS/MS method to investigate the interference of pharmacokinetics of the main constituents in Saxifraga stolonifera: Involvement of drug metabolism enzymes. 2018 J Pharm Biomed Anal pmid:29017109
Kim J et al. Quercetin-3-O-α-l-arabinopyranoside protects against retinal cell death via blue light-induced damage in human RPE cells and Balb-c mice. 2018 Food Funct pmid:29541735
Safwat NA et al. Quercetin 3-O-glucoside recovered from the wild Egyptian Sahara plant, Euphorbia paralias L., inhibits glutamine synthetase and has antimycobacterial activity. 2018 Tuberculosis (Edinb) pmid:29523309
Osawe SO and Farombi EO Quercetin and rutin ameliorates sulphasalazine-induced spermiotoxicity, alterations in reproductive hormones and steroidogenic enzyme imbalance in rats. 2018 Andrologia pmid:29512831
Nile A et al. Valorization of onion solid waste and their flavonols for assessment of cytotoxicity, enzyme inhibitory and antioxidant activities. 2018 Food Chem. Toxicol. pmid:29496529
Vanden Braber NL et al. Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin. 2018 Int. J. Biol. Macromol. pmid:29421395
Afifi NA et al. Hepatoprotective influence of quercetin and ellagic acid on thioacetamide-induced hepatotoxicity in rats. 2018 Can. J. Physiol. Pharmacol. pmid:29414242
Pham-Hoang BN et al. Fluorescence Lifetime and UV-Vis Spectroscopy to Evaluate the Interactions Between Quercetin and Its Yeast Microcapsule. 2018 Biotechnol J pmid:28887909
Larit F et al. Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants. 2018 Phytomedicine pmid:29496172
Wu Q et al. Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells. 2018 J. Agric. Food Chem. pmid:29905475
Kajbafvala A et al. Formulation, characterization, and in vitro/ex vivo evaluation of quercetin-loaded microemulsion for topical application. 2018 Pharm Dev Technol pmid:27871215
Yamauchi K and Mitsunaga T Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model. 2018 J Nat Med pmid:29442220
Ujah GA et al. Effect of quercetin on cadmium chloride-induced impairments in sexual behaviour and steroidogenesis in male Wistar rats. 2018 Andrologia pmid:28703286
Shi H et al. Isorhamnetin, the active constituent of a Chinese herb Hippophae rhamnoides L, is a potent suppressor of dendritic-cell maturation and trafficking. 2018 Int. Immunopharmacol. pmid:29272818
Silinsin M and Bursal E UHPLC-MS/MS phenolic profiling and in vitro antioxidant activities of Inula graveolens (L.) Desf. 2018 Nat. Prod. Res. pmid:28697630
Bouratoua A et al. Chemical composition and antioxidant activity of aerial parts of Ferula longipes Coss. ex Bonnier and Maury. 2018 Nat. Prod. Res. pmid:28714345
Chung JO et al. Quercetin and fisetin enhanced the small intestine cellular uptake and plasma levels of epi-catechins in in vitro and in vivo models. 2018 Food Funct pmid:29168878