quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Neuroma D009463 1 associated lipids
Encephalitis, Arbovirus D004671 1 associated lipids
Neurofibromatoses D017253 1 associated lipids
Heat Stroke D018883 1 associated lipids
Post-Concussion Syndrome D038223 1 associated lipids
Alcohol-Induced Disorders, Nervous System D020268 2 associated lipids
Musculoskeletal Diseases D009140 2 associated lipids
Prenatal Exposure Delayed Effects D011297 2 associated lipids
CREST Syndrome D017675 2 associated lipids
Enterovirus Infections D004769 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Per page 10 20 50 100 | Total 12031
Authors Title Published Journal PubMed Link
Leng E et al. Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells. 2018 BMC Complement Altern Med pmid:29622007
Wu TC et al. Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. 2018 Chem. Biol. Interact. pmid:30016632
Lu N et al. Generation of a Diligand Complex of Bovine Serum Albumin with Quercetin and Carbon Nanotubes for the Protection of Bioactive Quercetin and Reduction of Cytotoxicity. 2018 J. Agric. Food Chem. pmid:30016096
Mohebali N et al. Effect of flavonoids rich extract of Capparis spinosa on inflammatory involved genes in amyloid-beta peptide injected rat model of Alzheimer's disease. 2018 Nutr Neurosci pmid:27778760
Arbain NH et al. Optimization of Quercetin loaded Palm Oil Ester Based Nanoemulsion Formulation for Pulmonary Delivery. 2018 J Oleo Sci pmid:30012897
Chirumbolo S and Bjørklund G Quercetin in collagen-induced arthritis. Some comments. 2018 Int. Immunopharmacol. pmid:29970297
Patel RV et al. Therapeutic potential of quercetin as a cardiovascular agent. 2018 Eur J Med Chem pmid:29966915
Riva A et al. Quercetin phytosome® in triathlon athletes: a pilot registry study. 2018 Minerva Med. pmid:29947492
Habtemariam S and Belai A Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin. 2018 Mini Rev Med Chem pmid:28117024
Kapur B et al. Health and taste related compounds in strawberries under various irrigation regimes and bio-stimulant application. 2018 Food Chem pmid:29784329
Váradyová Z et al. Ovicidal and larvicidal activity of extracts from medicinal-plants against Haemonchus contortus. 2018 Exp. Parasitol. pmid:30389531
Aghapour F et al. Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines. 2018 Biochem. Biophys. Res. Commun. pmid:29698680
Sun S et al. Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway. 2018 Gene pmid:29678660
Suke SG et al. Ameliorative effect of nanoencapsulated flavonoid against chlorpyrifos-induced hepatic oxidative damage and immunotoxicity in Wistar rats. 2018 J. Biochem. Mol. Toxicol. pmid:29667781
Zhu Y et al. Molecular Cloning and Functional Characterization of a Dihydroflavonol 4-Reductase from Vitis bellula. 2018 Molecules pmid:29642567
Dresler S et al. Methodological aspects of biologically active compounds quantification in the genus Hypericum. 2018 J Pharm Biomed Anal pmid:29621655
Jeong DW et al. Deastringent Peel Extracts of Persimmon ( Thunb. cv. Cheongdo-Bansi) Protect Neuronal PC-12 and SH-SY5Y Cells against Oxidative Stress. 2018 J. Microbiol. Biotechnol. pmid:29975999
Murota K et al. Flavonoid metabolism: the interaction of metabolites and gut microbiota. 2018 Biosci. Biotechnol. Biochem. pmid:29504827
Kim MK et al. In Vitro Synergism and Anti-biofilm Activity of Quercetin-Pivaloxymethyl Conjugate against Staphylococcus aureus and Enterococcus Species. 2018 Chem. Pharm. Bull. pmid:30381653
Silva W et al. Double emulsions as potential fat replacers with gallic acid and quercetin nanoemulsions in the aqueous phases. 2018 Food Chem pmid:29502846
Naeimi R et al. Querectin improves myelin repair of optic chiasm in lyolecithin-induced focal demyelination model. 2018 Biomed. Pharmacother. pmid:29501770
Foti MC et al. Singlet oxygen quenching- and chain-breaking antioxidant-properties of a quercetin dimer able to prevent age-related macular degeneration. 2018 Biophys. Chem. pmid:30352336
Ozdemir Olgun FA et al. A novel cerium oxide nanoparticles-based colorimetric sensor using tetramethyl benzidine reagent for antioxidant activity assay. 2018 Talanta pmid:29501192
Xia F et al. Rapid Determination of Active Compounds and Antioxidant Activity of Okra Seeds Using Fourier Transform Near Infrared (FT-NIR) Spectroscopy. 2018 Molecules pmid:29498632
Wu Q et al. Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells. 2018 Food Funct pmid:29497723
Pradhan AB et al. Role of hydroxyl groups in the B-ring of flavonoids in stabilization of the Hoogsteen paired third strand of Poly(U).Poly(A)*Poly(U) triplex. 2018 Arch. Biochem. Biophys. pmid:29162368
Zhou J et al. Determination of isoquercitrin in rat plasma by high performance liquid chromatography coupled with a novel synergistic cloud point extraction. 2018 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29153998
Wen P et al. Preparation and Characterization of Electrospun Colon-Specific Delivery System for Quercetin and Its Antiproliferative Effect on Cancer Cells. 2018 J. Agric. Food Chem. pmid:30148954
Erdogan S et al. Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway. 2018 Biomed. Pharmacother. pmid:30142541
Sunoqrot S et al. Facile synthesis and surface modification of bioinspired nanoparticles from quercetin for drug delivery. 2018 Biomater Sci pmid:30140818
Hussain J et al. New robust sensitive fluorescence spectroscopy coupled with PLSR for estimation of quercetin in Ziziphus mucronata and Ziziphus sativa. 2018 Spectrochim Acta A Mol Biomol Spectrosc pmid:29331816
Zhao QY et al. Selective recognition and fast enrichment of anthocyanins by dummy molecularly imprinted magnetic nanoparticles. 2018 J Chromatogr A pmid:30139620
Jadán-Piedra C et al. In vitro evaluation of dietary compounds to reduce mercury bioavailability. 2018 Food Chem pmid:29329865
Baksi R et al. In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles. 2018 Biomed. Pharmacother. pmid:30119227
Lu Z et al. Preparation and in vitro and in vivo evaluation of quercetin-loaded mixed micelles for oral delivery. 2018 Biosci. Biotechnol. Biochem. pmid:29327653
Hobbs CA et al. Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential. 2018 Food Chem. Toxicol. pmid:29317330
Xiao Y and Lee IS Microbial transformation of quercetin and its prenylated derivatives. 2018 Nat. Prod. Res. pmid:28826260
Yang H et al. Quercetin Treatment Improves Renal Function and Protects the Kidney in a Rat Model of Adenine-Induced Chronic Kidney Disease. 2018 Med. Sci. Monit. pmid:29987270
Farazuddin M et al. Quercetin prevents rhinovirus-induced progression of lung disease in mice with COPD phenotype. 2018 PLoS ONE pmid:29975735
Rastogi S and Haldar C Comparative effect of melatonin and quercetin in counteracting LPS induced oxidative stress in bone marrow mononuclear cells and spleen of Funambulus pennanti. 2018 Food Chem. Toxicol. pmid:29964085
Li ZP et al. Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation. 2018 Molecules pmid:29958399
Cao L et al. Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways. 2018 Int. J. Mol. Med. pmid:29956731
Steinborn C et al. In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica. 2018 Planta Med. pmid:29202511
Braun JBS et al. Pretreatment with quercetin prevents changes in lymphocytes E-NTPDase/E-ADA activities and cytokines secretion in hyperlipidemic rats. 2018 Mol. Cell. Biochem. pmid:29188537
Mandrone M et al. Identification of a Collagenase-Inhibiting Flavonoid from Alchemilla vulgaris Using NMR-Based Metabolomics. 2018 Planta Med. pmid:29797306
Escher GB et al. Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract. 2018 Food Chem. Toxicol. pmid:29787846
Crascì L et al. Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation. 2018 Drug Res (Stuttg) pmid:29108086
Zhang L et al. UV-Vis spectroscopy combined with chemometric study on the interactions of three dietary flavonoids with copper ions. 2018 Food Chem pmid:29784309
Pawlikowska-Pawlega B et al. Interaction of a quercetin derivative - lensoside Aβ with liposomal membranes. 2018 Biochim Biophys Acta Biomembr pmid:29106971
Tsukamoto Y et al. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. 2018 PLoS ONE pmid:29782545
Shu B et al. Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-κB signaling suppression. 2018 Cell. Signal. pmid:29080804
Trinh PTN et al. A new benzofuran derivative from the leaves of Ficus pumila L. 2018 Nat. Prod. Res. pmid:29072969
Wang XF et al. Protective Effect of Quercetin in LPS-Induced Murine Acute Lung Injury Mediated by cAMP-Epac Pathway. 2018 Inflammation pmid:29569077
Guazelli CFS et al. Quercetin attenuates zymosan-induced arthritis in mice. 2018 Biomed. Pharmacother. pmid:29554596
Kim J et al. Quercetin-3-O-α-l-arabinopyranoside protects against retinal cell death via blue light-induced damage in human RPE cells and Balb-c mice. 2018 Food Funct pmid:29541735
Safwat NA et al. Quercetin 3-O-glucoside recovered from the wild Egyptian Sahara plant, Euphorbia paralias L., inhibits glutamine synthetase and has antimycobacterial activity. 2018 Tuberculosis (Edinb) pmid:29523309
Mendel M et al. Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility-in vitro study. 2018 J. Vet. Pharmacol. Ther. pmid:28913883
Wang Y et al. Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats. 2018 J. Cell. Biochem. pmid:28865131
Jan S et al. Effect of environmental variables on phytonutrients of Origanum vulgare L. in the sub-humid region of the northwestern Himalayas. 2018 Environ Monit Assess pmid:30187208
Cerulli A et al. Phenolics from Castanea sativa leaves and their effects on UVB-induced damage. 2018 Nat. Prod. Res. pmid:28539059
Zhang XF et al. UPLC-MS/MS analysis for antioxidant components of Lycii Fructus based on spectrum-effect relationship. 2018 Talanta pmid:29332828
Zahid K et al. Phytochemical screening, antioxidant activity, total phenolic and total flavonoid contents of seven local varieties of Rosa indica L. 2018 Nat. Prod. Res. pmid:28539055
Bhattacharya D et al. Antibacterial activity of polyphenolic fraction of Kombucha against Vibrio cholerae: targeting cell membrane. 2018 Lett. Appl. Microbiol. pmid:29193174
Kameníková M et al. Influence of quercetin on the interaction of gliclazide with human serum albumin - spectroscopic and docking approaches. 2017 Luminescence pmid:28513070
Natesan S et al. Co-encapsulated resveratrol and quercetin in chitosan and peg modified chitosan nanoparticles: For efficient intra ocular pressure reduction. 2017 Int. J. Biol. Macromol. pmid:28472691
Trendafilova I et al. Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier. 2017 Mater Sci Eng C Mater Biol Appl pmid:28183610
Burak C et al. Effects of the flavonol quercetin and α-linolenic acid on n-3 PUFA status in metabolically healthy men and women: a randomised, double-blinded, placebo-controlled, crossover trial. 2017 Br. J. Nutr. pmid:28366181
Singh DP et al. Overcoming the exacerbating effects of ranitidine on NSAID-induced small intestinal toxicity with quercetin: Providing a complete GI solution. 2017 Chem. Biol. Interact. pmid:28400101
Anusuya S and Gromiha MM Quercetin derivatives as non-nucleoside inhibitors for dengue polymerase: molecular docking, molecular dynamics simulation, and binding free energy calculation. 2017 J. Biomol. Struct. Dyn. pmid:27608509
Ye P et al. Hyperoside attenuates OVA-induced allergic airway inflammation by activating Nrf2. 2017 Int. Immunopharmacol. pmid:28107754
Maurya AK and Vinayak M Quercetin Attenuates Cell Survival, Inflammation, and Angiogenesis via Modulation of AKT Signaling in Murine T-Cell Lymphoma. 2017 Nutr Cancer pmid:28107044
Roslan J et al. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. 2017 Biomed. Pharmacother. pmid:28027533
Gawlik M et al. Manganese neurotoxicity and protective effects of resveratrol and quercetin in preclinical research. 2017 Pharmacol Rep pmid:28183032
Mülek M et al. Distribution of Constituents and Metabolites of Maritime Pine Bark Extract (Pycnogenol) into Serum, Blood Cells, and Synovial Fluid of Patients with Severe Osteoarthritis: A Randomized Controlled Trial. 2017 Nutrients pmid:28452960
Jomova K et al. Protective role of quercetin against copper(II)-induced oxidative stress: A spectroscopic, theoretical and DNA damage study. 2017 Food Chem. Toxicol. pmid:29107026
Xia Y et al. Homogenization-assisted cavitation hybrid rotation extraction and macroporous resin enrichment of dihydroquercetin from Larix gmelinii. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29102245
Zhao H et al. A pair of taxifolin-3-O-arabinofuranoside isomers from Juglans regia L. 2017 Nat. Prod. Res. pmid:27852104
Teixeira TS et al. Biophysical characterization of the interaction between M2-1 protein of hRSV and quercetin. 2017 Int. J. Biol. Macromol. pmid:27851930
Xie X et al. Taxifolin protects RPE cells against oxidative stress-induced apoptosis. 2017 Mol. Vis. pmid:28761325
Massi A et al. Research Progress in the Modification of Quercetin Leading to Anticancer Agents. 2017 Molecules pmid:28758919
Kim A et al. Taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-κB activation-mediated cell death. 2017 Brain Res. Bull. pmid:28710022
Carvalho D et al. Structural evidence of quercetin multi-target bioactivity: A reverse virtual screening strategy. 2017 Eur J Pharm Sci pmid:28636950
Tian Y et al. Phenolic compounds extracted by acidic aqueous ethanol from berries and leaves of different berry plants. 2017 Food Chem pmid:27855899
Naseer Z et al. Quercetin supplemented diet improves follicular development, oocyte quality, and reduces ovarian apoptosis in rabbits during summer heat stress. 2017 Theriogenology pmid:28532829
Li J et al. Antitumor activity and safety evaluation of nanaparticle-based delivery of quercetin through intravenous administration in mice. 2017 Mater Sci Eng C Mater Biol Appl pmid:28532095
Zhang Y et al. Inhibitory effect of hyperoside isolated from Zanthoxylum bungeanum leaves on SW620 human colorectal cancer cells via induction of the p53 signaling pathway and apoptosis. 2017 Mol Med Rep pmid:29067453
Burak C et al. Higher plasma quercetin levels following oral administration of an onion skin extract compared with pure quercetin dihydrate in humans. 2017 Eur J Nutr pmid:26482244
Badolato M et al. Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators. 2017 Future Med Chem pmid:29064290
Wei CB et al. Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-κB pathway. 2017 Int. Immunopharmacol. pmid:29040945
Wong G et al. Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection. 2017 Virol Sin pmid:28884445
Alamdar A et al. Arsenic activates the expression of 3β-HSD in mouse Leydig cells through repression of histone H3K9 methylation. 2017 Toxicol. Appl. Pharmacol. pmid:28414027
Das A et al. Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. 2017 J. Photochem. Photobiol. B, Biol. pmid:28456117
Kumar A et al. Inhibition of the MurA enzyme in Fusobacterium nucleatum by potential inhibitors identified through computational and in vitro approaches. 2017 Mol Biosyst pmid:28358152
Rajnochová Svobodová A et al. The Phototoxic Potential of the Flavonoids, Taxifolin and Quercetin. 2017 Photochem. Photobiol. pmid:28303596
Gelen V et al. Therapeutic effect of quercetin on renal function and tissue damage in the obesity induced rats. 2017 Biomed. Pharmacother. pmid:28254664
Liu Z et al. Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells. 2017 Adv Healthc Mater pmid:27943644
Zhou J et al. Investigation of the anti-cancer effect of quercetin on HepG2 cells in vivo. 2017 PLoS ONE pmid:28264020
Ren KW et al. Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells. 2017 Int. J. Oncol. pmid:28259895
Lee S et al. The anti-HSV-1 effect of quercetin is dependent on the suppression of TLR-3 in Raw 264.7 cells. 2017 Arch. Pharm. Res. pmid:28258480
Jones RS et al. Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. 2017 Mol. Pharm. pmid:28513167