| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with quercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with quercetin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with quercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Bernd A et al. | Phototoxic effects of Hypericum extract in cultures of human keratinocytes compared with those of psoralen. | 1999 | Photochem. Photobiol. | pmid:10048312 |
| Slobodianyk HI | [The characteristics of peripheral nervous system regeneration in skin wounds by the use of an antioxidant-bound charcoal sorbent]. | 1998 | Klin Khir | pmid:10050406 |
| Tribrat TA et al. | [The correction of hemorheological disorders in patients with ischemic heart disease and concomitant chronic cholecystitis]. | 1998 Oct-Nov | Lik. Sprava | pmid:10050457 |
| Ondrizek RR et al. | An alternative medicine study of herbal effects on the penetration of zona-free hamster oocytes and the integrity of sperm deoxyribonucleic acid. | 1999 | Fertil. Steril. | pmid:10065791 |
| Kang TB and Liang NC | Effect of quercetin on activities of protein kinase C and tyrosine protein kinase from HL-60 cells. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072927 |
| Xiao D et al. | Quercetin induced apoptosis in human leukemia HL-60 cells. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072952 |
| Matsuse IT et al. | A search for anti-viral properties in Panamanian medicinal plants. The effects on HIV and its essential enzymes. | 1999 | J Ethnopharmacol | pmid:10075118 |
| Gordon MH and Roedig-Penman A | Antioxidant activity of quercetin and myricetin in liposomes. | 1998 | Chem. Phys. Lipids | pmid:10081150 |
| Yamashita N et al. | Mechanism of oxidative DNA damage induced by quercetin in the presence of Cu(II). | 1999 | Mutat. Res. | pmid:10082921 |
| Iwao K and Tsukamoto I | Quercetin inhibited DNA synthesis and induced apoptosis associated with increase in c-fos mRNA level and the upregulation of p21WAF1CIP1 mRNA and protein expression during liver regeneration after partial hepatectomy. | 1999 | Biochim. Biophys. Acta | pmid:10082992 |
| Wadsworth TL and Koop DR | Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages. | 1999 | Biochem. Pharmacol. | pmid:10086329 |
| Pagani F | [Plant constituents of Orchidaceae. I. Components of Orchis sambucina L., Orchis morio L]. | 1976 | Boll Chim Farm | pmid:1008946 |
| Re L et al. | Effects of some natural extracts on the acetylcholine release at the mouse neuromuscular junction. | 1999 | Pharmacol. Res. | pmid:10094851 |
| McAnlis GT et al. | Absorption and antioxidant effects of quercetin from onions, in man. | 1999 | Eur J Clin Nutr | pmid:10099940 |
| Mueller BM | St. John's Wort for depressive disorders: results of an outpatient study with the Hypericum preparation HYP 811. | 1998 Mar-Apr | Adv Ther | pmid:10180997 |
| Kurth H and Spreemann R | Phytochemical characterization of various St. John's Wort extracts. | 1998 Mar-Apr | Adv Ther | pmid:10180998 |
| Mueller BM | Effects of hypericum extract HYP 811 in patients with psychovegetative disorders. | 1998 Jul-Aug | Adv Ther | pmid:10186944 |
| Kaneko T and Baba N | Protective effect of flavonoids on endothelial cells against linoleic acid hydroperoxide-induced toxicity. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10192914 |
| Chen C et al. | Different effects of the constituents of EGb761 on apoptosis in rat cerebellar granule cells induced by hydroxyl radicals. | 1999 | Biochem. Mol. Biol. Int. | pmid:10204076 |
| ElAttar TM and Virji AS | Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. | 1999 | Anticancer Drugs | pmid:10211549 |
| Tsuruma T et al. | Heat-shock protein-73 protects against small intestinal warm ischemia-reperfusion injury in the rat. | 1999 | Surgery | pmid:10216529 |
| Lo YL and Huang JD | Comparison of effects of natural or artificial rodent diet on etoposide absorption in rats. | 1999 Jan-Feb | In Vivo | pmid:10218133 |
| Sanderson J et al. | Quercetin inhibits hydrogen peroxide-induced oxidation of the rat lens. | 1999 | Free Radic. Biol. Med. | pmid:10218652 |
| Kaku S et al. | Effect of dietary antioxidants on serum lipid contents and immunoglobulin productivity of lymphocytes in Sprague-Dawley rats. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10227146 |
| Randak C et al. | Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein. | 1999 | Biochem. J. | pmid:10229679 |
| Ko WC et al. | Relaxant effects of quercetin methyl ether derivatives in isolated guinea pig trachea and their structure-activity relationships. | 1999 | Planta Med. | pmid:10232080 |
| Aviram M et al. | Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. | 1999 | Free Radic. Biol. Med. | pmid:10232833 |
| Kudo M et al. | Effects of quercetin and sunphenon on responses of cancer cells to heat shock damage. | 1999 | Exp. Mol. Pathol. | pmid:10331966 |
| Duthie SJ and Dobson VL | Dietary flavonoids protect human colonocyte DNA from oxidative attack in vitro. | 1999 | Eur J Nutr | pmid:10338685 |
| Wiseman H | The bioavailability of non-nutrient plant factors: dietary flavonoids and phyto-oestrogens. | 1999 | Proc Nutr Soc | pmid:10343351 |
| Boulton DW et al. | Fate of the flavonoid quercetin in human cell lines: chemical instability and metabolism. | 1999 | J. Pharm. Pharmacol. | pmid:10344638 |
| Nagamine S et al. | Effect of androgen structures on the inhibition of metyraponeinreductase in rat, mouse, and human liver. | 1999 | Adv. Exp. Med. Biol. | pmid:10352713 |
| Rzymowska J et al. | The effect of quercetin on induction of apoptosis. | 1999 | Folia Histochem. Cytobiol. | pmid:10352990 |
| Shen F et al. | Synergistic down-regulation of signal transduction and cytotoxicity by tiazofurin and quercetin in human ovarian carcinoma cells. | 1999 | Life Sci. | pmid:10353585 |
| Ciolino HP et al. | Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. | 1999 | Biochem. J. | pmid:10359656 |
| Erlund I et al. | Validated method for the quantitation of quercetin from human plasma using high-performance liquid chromatography with electrochemical detection. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10360437 |
| Graefe EU et al. | Pharmacokinetics and bioavailability of the flavonol quercetin in humans. | 1999 | Int J Clin Pharmacol Ther | pmid:10363620 |
| Izzard RA et al. | Competitive and noncompetitive inhibition of the DNA-dependent protein kinase. | 1999 | Cancer Res. | pmid:10363977 |
| Safety assessment and potential health benefits of food components based on selected scientific criteria. ILSI North America Technical Committee on Food Components for Health Promotion. | 1999 | Crit Rev Food Sci Nutr | pmid:10367185 | |
| Blardi P et al. | Stimulation of endogenous adenosine release by oral administration of quercetin and resveratrol in man. | 1999 | Drugs Exp Clin Res | pmid:10370871 |
| Miodini P et al. | The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function. | 1999 | Br. J. Cancer | pmid:10376965 |
| Pelletier MK et al. | Disruption of specific flavonoid genes enhances the accumulation of flavonoid enzymes and end-products in Arabidopsis seedlings. | 1999 | Plant Mol. Biol. | pmid:10394944 |
| Lee E et al. | Anti-allergic actions of the leaves of Castanea crenata and isolation of an active component responsible for the inhibition of mast cell degranulation. | 1999 | Arch. Pharm. Res. | pmid:10403140 |
| Alexandrakis M et al. | Differential effect of flavonoids on inhibition of secretion and accumulation of secretory granules in rat basophilic leukemia cells. | 1999 | Int. J. Immunopharmacol. | pmid:10405873 |
| Ghosh JC et al. | Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation. | 1999 | J. Radiat. Res. | pmid:10408175 |
| Crespy V et al. | Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen. | 1999 | Am. J. Physiol. | pmid:10409158 |
| Roth A et al. | Phytoestrogen kaempferol (3,4',5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity. | 1999 | J. Neurosci. Res. | pmid:10412031 |
| Nail SL et al. | Structure of aluminum hydroxide gel III: mechanism of stabilization by sorbitol. | 1976 | J Pharm Sci | pmid:10415 |
| Johnson ET et al. | Cymbidium hybrida dihydroflavonol 4-reductase does not efficiently reduce dihydrokaempferol to produce orange pelargonidin-type anthocyanins. | 1999 | Plant J. | pmid:10417729 |
| Khanduja KL et al. | Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin in mice. | 1999 | Food Chem. Toxicol. | pmid:10418948 |
| Shimura M et al. | Inhibition of Vpr-induced cell cycle abnormality by quercetin: a novel strategy for searching compounds targeting Vpr. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425183 |
| Rossi G | [Trends in the treatment of cystic fibrosis]. | 1999 Jul-Aug | Recenti Prog Med | pmid:10429516 |
| Chen ZW and Ma CG | Effects of hyperin on free intracellular calcium in dissociated neonatal rat brain cells. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10437120 |
| Xiao D et al. | Quercetin down-regulated bcl-2 gene expression in human leukemia HL-60 cells. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10437144 |
| Viturro C et al. | Free radical scavengers from Mutisia friesiana (Asteraceae) and Sanicula graveolens (Apiaceae). | 1999 | Phytother Res | pmid:10441784 |
| Maekawa T et al. | Biochemical characterization of 60S acidic ribosomal P proteins associated with CK-II from bamboo shoots and potent inhibitors of their phosphorylation in vitro. | 1999 | Biol. Pharm. Bull. | pmid:10443459 |
| Kim DH et al. | Metabolism of quercitrin by human intestinal bacteria and its relation to some biological activities. | 1999 | Biol. Pharm. Bull. | pmid:10443478 |
| Richter M et al. | Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling. | 1999 | Nutr Cancer | pmid:10453447 |
| Manjeet K R and Ghosh B | Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages. | 1999 | Int. J. Immunopharmacol. | pmid:10454017 |
| Dunlap DY et al. | Differential toxicities of TCDD in vivo among normal, c-src knockout, geldanamycin- and quercetin-treated mice. | 1999 | Toxicology | pmid:10463766 |
| Kaltenbach RF et al. | Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1' substituents. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10465557 |
| Leitão GG et al. | Chemistry and pharmacology of Monimiaceae: a special focus on Siparuna and Mollinedia. | 1999 | J Ethnopharmacol | pmid:10465659 |
| Choudhury R et al. | Urinary excretion of hydroxycinnamates and flavonoids after oral and intravenous administration. | 1999 | Free Radic. Biol. Med. | pmid:10468199 |
| Weeks BS et al. | Laminin stimulates protein tyrosine dephosphorylation in PC12 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10471391 |
| Lim BO et al. | The antioxidative effect of ganhuangenin against lipid peroxidation. | 1999 | Phytother Res | pmid:10479757 |
| Spencer JP et al. | The small intestine can both absorb and glucuronidate luminal flavonoids. | 1999 | FEBS Lett. | pmid:10481070 |
| Kobuchi H et al. | Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway. | 1999 | Am. J. Physiol. | pmid:10484327 |
| Wang H and Joseph JA | Structure-activity relationships of quercetin in antagonizing hydrogen peroxide-induced calcium dysregulation in PC12 cells. | 1999 | Free Radic. Biol. Med. | pmid:10490289 |
| Plumb GW et al. | Antioxidant properties of flavonol glycosides from green beans. | 1999 | Redox Rep. | pmid:10496415 |
| Terao J and Piskula MK | Flavonoids and membrane lipid peroxidation inhibition. | 1999 | Nutrition | pmid:10501295 |
| Halonen SK et al. | Effect of cytokines and quercetin on Toxoplasma gondii cyst induction in murine astrocytes. | 1999 Sep-Oct | J. Eukaryot. Microbiol. | pmid:10519260 |
| Tanaka T et al. | Inhibition of azoxymethane-induced aberrant crypt foci in rats by natural compounds, caffeine, quercetin and morin. | 1999 Nov-Dec | Oncol. Rep. | pmid:10523707 |
| Babenkova IV et al. | [Antioxidative activity of histochrome and some other drugs used in ophthalmology]. | 1999 Jul-Aug | Vestn Oftalmol | pmid:10523962 |
| Walgren RA and Walle T | The influence of plasma binding on absorption/exsorption in the Caco-2 model of human intestinal absorption. | 1999 | J. Pharm. Pharmacol. | pmid:10528987 |
| Nagata H et al. | Antioxidative action of flavonoids, quercetin and catechin, mediated by the activation of glutathione peroxidase. | 1999 | Tokai J. Exp. Clin. Med. | pmid:10530620 |
| Ishikawa Y et al. | Bioflavonoid quercetin inhibits interleukin-1-induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB. | 1999 | J. Am. Soc. Nephrol. | pmid:10541287 |
| Yamano S et al. | Purification and characterization of rat liver naloxone reductase that is identical to 3alpha-hydroxysteroid dehydrogenase. | 1999 | Xenobiotica | pmid:10548452 |
| Peet GW and Li J | IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin. | 1999 | J. Biol. Chem. | pmid:10551820 |
| Beninger CW and Hosfield GL | Flavonol glycosides from Montcalm dark red kidney bean: implications for the genetics of seed coat color in Phaseolus vulgaris L. | 1999 | J. Agric. Food Chem. | pmid:10552769 |
| Kubo I and Kinst-Hori I | Flavonols from saffron flower: tyrosinase inhibitory activity and inhibition mechanism. | 1999 | J. Agric. Food Chem. | pmid:10552777 |
| Huang YT et al. | Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor. | 1999 | Br. J. Pharmacol. | pmid:10556937 |
| Ito T et al. | Protein synthesis inhibition by flavonoids: roles of eukaryotic initiation factor 2alpha kinases. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10558914 |
| Kubatiev AA et al. | [Effect of dikvertin on the cyclic nucleotide level in thrombocytes]. | 1999 | Biull Eksp Biol Med | pmid:10560042 |
| Jiménez M and GarcÃa-Carmona F | Oxidation of the flavonol quercetin by polyphenol oxidase. | 1999 | J. Agric. Food Chem. | pmid:10563849 |
| Vilegas W et al. | Isolation and structure elucidation of two new flavonoid glycosides from the infusion of maytenus aquifolium leaves. Evaluation of the antiulcer activity of the infusion. | 1999 | J. Agric. Food Chem. | pmid:10563907 |
| Rangan GK et al. | Inhibition of NFkappaB activation with antioxidants is correlated with reduced cytokine transcription in PTC. | 1999 | Am. J. Physiol. | pmid:10564243 |
| Aherne SA and O'Brien NM | Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells. | 1999 | Nutr Cancer | pmid:10578483 |
| Silva DH et al. | Dihydrochalcones and flavonolignans from Iryanthera lancifolia. | 1999 | J. Nat. Prod. | pmid:10579855 |
| Eagling VA et al. | Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. | 1999 | Br J Clin Pharmacol | pmid:10583025 |
| Graefe EU and Veit M | Urinary metabolites of flavonoids and hydroxycinnamic acids in humans after application of a crude extract from Equisetum arvense. | 1999 | Phytomedicine | pmid:10589442 |
| Li DP et al. | Inhibition of heat shock factor activity prevents heat shock potentiation of glucocorticoid receptor-mediated gene expression. | 1999 | Cell Stress Chaperones | pmid:10590836 |
| Yamamoto N et al. | Inhibitory effect of quercetin metabolites and their related derivatives on copper ion-induced lipid peroxidation in human low-density lipoprotein. | 1999 | Arch. Biochem. Biophys. | pmid:10600174 |
| Dimas K et al. | Cytotoxic activity of kaempferol glycosides against human leukaemic cell lines in vitro. | 2000 | Pharmacol. Res. | pmid:10600274 |
| Balabhadrapathruni S et al. | Effects of genistein and structurally related phytoestrogens on cell cycle kinetics and apoptosis in MDA-MB-468 human breast cancer cells. | 2000 Jan-Feb | Oncol. Rep. | pmid:10601582 |
| Varma SD et al. | Implications of aldose reductase in cataracts in human diabetes. | 1979 | Invest. Ophthalmol. Vis. Sci. | pmid:106020 |
| Shoskes DA et al. | Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. | 1999 | Urology | pmid:10604689 |
| Chahdi A et al. | Compound 48/80 activates mast cell phospholipase D via heterotrimeric GTP-binding proteins. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10604938 |
| Li W et al. | Ribavirin and quercetin synergistically downregulate signal transduction and are cytotoxic in human ovarian carcinoma cells. | 1999 | Oncol. Res. | pmid:10608619 |
| Kitamura M and Ishikawa Y | Oxidant-induced apoptosis of glomerular cells: intracellular signaling and its intervention by bioflavinoid. | 1999 | Kidney Int. | pmid:10610413 |