| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with quercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with quercetin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with quercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:5155019 | ||||
| Do SH et al. | Bone-protecting effect of Rubus coreanus by dual regulation of osteoblasts and osteoclasts. | Menopause | pmid:18709701 | |
| Tian Q et al. | Identification and determination of flavonoids in buckwheat (Fagopyrum esculentum Moench, Polygonaceae) by high-performance liquid chromatography with electrospray ionisation mass spectrometry and photodiode array ultraviolet detection. | Phytochem Anal | pmid:12918868 | |
| Bayes M et al. | Gateways to clinical trials. | Methods Find Exp Clin Pharmacol | pmid:16179960 | |
| Koru O et al. | In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens. | Anaerobe | pmid:17475517 | |
| Tomillero A and Moral MA | Gateways to clinical trials. July-August 2008. | Methods Find Exp Clin Pharmacol | pmid:18850047 | |
| Rosenblat M et al. | HDL3 stimulates paraoxonase 1 antiatherogenic catalytic and biological activities in a macrophage model system: in vivo and in vitro studies. | Biofactors | pmid:25230879 | |
| Kalveniene Z et al. | The qualitative analysis of ethanol extracts of herbal raw materials by method of high pressure liquid chromatography. | Acta Pol Pharm | pmid:18536158 | |
| pmid:11327318 | ||||
| Pi J et al. | Investigation of quercetin-induced HepG2 cell apoptosis-associated cellular biophysical alterations by atomic force microscopy. | Scanning | pmid:26179807 | |
| Mozzicafreddo M et al. | Antiplasmin activity of natural occurring polyphenols. | Biochim. Biophys. Acta | pmid:18456009 | |
| Oksala NK et al. | Preconditioning hyperthermia inhibits restitution of isolated Guinea pig gastric mucosa. | Eur Surg Res | pmid:12364817 | |
| Patil SL et al. | Antigenotoxic potential of rutin and quercetin in Swiss mice exposed to gamma radiation. | Biomed J | pmid:25179701 | |
| Priya Mohanty J et al. | Evaluation of Antioxidant Potential of Kaempferia rotunda Linn. | Indian J Pharm Sci | pmid:20046746 | |
| Jhong CH et al. | Screening alpha-glucosidase and alpha-amylase inhibitors from natural compounds by molecular docking in silico. | Biofactors | pmid:26154585 | |
| Kovácik J et al. | Physiological responses of Scenedesmus quadricauda (Chlorophyceae) to UV-A and UV-C light. | Photochem. Photobiol. | pmid:20202162 | |
| Li QC et al. | Enhanced therapeutic efficacy and amelioration of cisplatin-induced nephrotoxicity by quercetin in 1,2-dimethyl hydrazine-induced colon cancer in rats. | Indian J Pharmacol | pmid:27127319 | |
| Francik R et al. | Antioxidant activity of beta-carboline derivatives. | Acta Pol Pharm | pmid:21485291 | |
| Harput US et al. | Antinociceptive, free radical-scavenging, and cytotoxic activities of Acanthus hirsutus Boiss. | J Med Food | pmid:21480807 | |
| Liu D et al. | Determination of rutin and isoquercetin contents in Hibisci mutabilis Folium in different collection periods by HPLC. | J Chromatogr Sci | pmid:26089170 | |
| Filho JS et al. | Quercetin in equine frozen semen. | Cryo Letters | pmid:29734431 | |
| Viswanatha GL et al. | LC-MS/MS profiling and neuroprotective effects of Mentat® against transient global ischemia and reperfusion-induced brain injury in rats. | Nutrition | pmid:26059376 | |
| Bayés M et al. | Gateways to clinical trials. | Methods Find Exp Clin Pharmacol | pmid:17922073 | |
| pmid:12214854 | ||||
| Hu J et al. | The effects of natural flavonoids on lipoxygenase-mediated oxidation of compounds with a benzene ring structure--a new possible mechanism of flavonoid anti-chemical carcinogenesis and other toxicities. | Int. J. Toxicol. | pmid:16815818 | |
| Qi J et al. | Screening of peroxynitrite scavengers in Flos Lonicerae by using two new methods, an HPLC-DAD-CL technique and a peroxynitrite spiking test followed by HPLC-DAD analysis. | Phytochem Anal | pmid:26567775 | |
| Dodda D et al. | Targeting oxidative stress attenuates trinitrobenzene sulphonic acid induced inflammatory bowel disease like symptoms in rats: role of quercetin. | Indian J Pharmacol | pmid:24987175 | |
| Sakai-Kashiwabara M et al. | Suppressive activity of quercetin on the production of eosinophil chemoattractants from eosinophils in vitro. | In Vivo | pmid:24982217 | |
| Gerhardt KE et al. | The effects of far-red light on plant growth and flavonoid accumulation in Brassica napus in the presence of ultraviolet B radiation. | Photochem. Photobiol. | pmid:18466203 | |
| Lahaie-Collins V et al. | Sesamin modulates tyrosine hydroxylase, superoxide dismutase, catalase, inducible NO synthase and interleukin-6 expression in dopaminergic cells under MPP+-induced oxidative stress. | Oxid Med Cell Longev | pmid:19794909 | |
| Chekalina N et al. | Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease. | Indian Heart J | pmid:30392493 | |
| Verma S et al. | Modulation of ionizing radiation induced oxidative imbalance by semi-fractionated extract of Piper betle: an in vitro and in vivo assessment. | Oxid Med Cell Longev | pmid:20716927 | |
| Arikan S et al. | Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model. | Arq Bras Oftalmol | pmid:25945531 | |
| Owens DK and McIntosh CA | Identification, recombinant expression, and biochemical characterization of a flavonol 3-O-glucosyltransferase clone from Citrus paradisi. | Phytochemistry | pmid:19733370 | |
| Haghighi M et al. | On the formulation design and rheological evaluations of pectin-based functional gels. | J. Food Sci. | pmid:21535667 | |
| Chan PC et al. | Ginkgo biloba leave extract: biological, medicinal, and toxicological effects. | J Environ Sci Health C Environ Carcinog Ecotoxicol Rev | pmid:17763047 | |
| Gaboriau F et al. | A simple assay for the measurement of plasma antioxidant status using spontaneous autoxidation of homovanillic acid. | J Pharmacol Toxicol Methods | pmid:12387937 | |
| Xu CL et al. | Raddeanalin, a new flavonoid glycoside from the leaves of Salix raddeana Laksh. | J Asian Nat Prod Res | pmid:17701556 | |
| Apak R et al. | The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas. | Int J Food Sci Nutr | pmid:17135020 | |
| Onose G et al. | Integrative emphases on intimate, intrinsic propensity/pathological processes--causes of self recovery limits and also, subtle related targets for neuroprotectionl pleiotropicity/multimodal actions, by accessible therapeutic approaches--in spinal cord injuries. | J Med Life | pmid:20945817 | |
| Ferruelo A et al. | Effects of resveratrol and other wine polyphenols on the proliferation, apoptosis and androgen receptor expression in LNCaP cells. | Actas Urol Esp | pmid:24726691 | |
| Khorsandi L et al. | Quercetin induces apoptosis and necroptosis in MCF-7 breast cancer cells. | Bratisl Lek Listy | pmid:28814095 | |
| Schauss AG et al. | Toxicological and Genotoxicity Assessment of a Dihydroquercetin-Rich Dahurian Larch Tree (Larix gmelinii Rupr) Extract (Lavitol). | Int. J. Toxicol. | pmid:25850419 | |
| Chi KK et al. | Comparison of quercetin and resveratrol in the prevention of injury due to testicular torsion/detorsion in rats. | Asian J. Androl. | pmid:26620457 | |
| Mitani A et al. | Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease. | Exp. Lung Res. | pmid:29227717 | |
| Robles C et al. | Phenols and flavonoids in Aleppo pine needles as bioindicators of air pollution. | J. Environ. Qual. | pmid:14674550 | |
| Thomsen H et al. | Characterization of Constituents and Anthelmintic Properties of Hagenia abyssinica. | Sci Pharm | pmid:22896828 | |
| de Oliveira MR et al. | Quercetin and the mitochondria: A mechanistic view. | Biotechnol. Adv. | pmid:26740171 | |
| Kawanishi S et al. | Evaluation for safety of antioxidant chemopreventive agents. | Antioxid. Redox Signal. | pmid:16356133 | |
| Liu RN et al. | A new flavonol glycoside and activity of compounds from the flower of Nymphaea candida. | J Asian Nat Prod Res | pmid:17613618 | |
| Abo-Youssef AM | Protective effect of rosiglitazone, quercetin, and their combination on fructose-induced metabolic syndrome in rats. | Indian J Pharmacol | pmid:26729953 | |
| Irie S et al. | Suppressive Activity of Quercetin on Periostin Functions In Vitro. | In Vivo | pmid:26709124 | |
| Lorenz P et al. | Investigations into the phenolic constituents of dog's mercury (Mercurialis perennis L.) by LC-MS/MS and GC-MS analyses. | Phytochem Anal | pmid:21692118 | |
| Sapir M et al. | Molecular aspects of Anthocyanin fruit tomato in relation to high pigment-1. | J. Hered. | pmid:18344529 | |
| Singh KL et al. | Characterization of the molluscicidal activity of Bauhinia variegata and Mimusops elengi plant extracts against the fasciola vector Lymnaea acuminata. | Rev. Inst. Med. Trop. Sao Paulo | pmid:22634884 | |
| Bae DS et al. | Importance of NKG2D-NKG2D ligands interaction for cytolytic activity of natural killer cell. | Cell. Immunol. | pmid:22613008 | |
| Gülçin I et al. | Polyphenol contents and antioxidant activity of lyophilized aqueous extract of propolis from Erzurum, Turkey. | Food Chem. Toxicol. | pmid:20685228 | |
| pmid: | ||||
| BÅ‚aszczyk A and Skolimowski J | Synthesis and studies on antioxidants: ethoxyquin (EQ) and its derivatives. | Acta Pol Pharm | pmid:16161351 | |
| Mesbah MK et al. | HPLC determination of certain flavonoids and terpene lactones in selected Ginkgo biloba L. phytopharmaceuticals. | Farmaco | pmid:15936022 | |
| Taamalli A et al. | LC-MS-based metabolite profiling of methanolic extracts from the medicinal and aromatic species Mentha pulegium and Origanum majorana. | Phytochem Anal | pmid:25982347 | |
| Jani N et al. | Exogenous glutathione is essential in the testing of antioxidant capacity using radical-induced haemolysis. | J Pharmacol Toxicol Methods | pmid:22507255 | |
| Murakami Y et al. | Radical-scavenging and Anti-inflammatory Activity of Quercetin and Related Compounds and Their Combinations Against RAW264.7 Cells Stimulated with Porphyromonas gingivalis Fimbriae. Relationships between Anti-inflammatory Activity and Quantum Chemical Parameters. | In Vivo | pmid:26546527 | |
| Selloum L et al. | Scavenger effect of flavonols on HOCl-induced luminol chemiluminescence. | Luminescence | pmid:15287004 | |
| Guo Y et al. | Quercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults. | Nutrition | pmid:25280405 | |
| Rezazadeh F et al. | A Quercetin Biosensor Based on Chitosan-Entrapped Carbon Nanotube Paste Electrode Coated with DNA. | J AOAC Int | pmid:26525257 | |
| Oliveira DR et al. | Special metabolites isolated from Urochloa humidicola (Poaceae). | An. Acad. Bras. Cienc. | pmid:28640339 | |
| Pattanashetti LA et al. | Evaluation of neuroprotective effect of quercetin with donepezil in scopolamine-induced amnesia in rats. | Indian J Pharmacol | pmid:28458424 | |
| Boumaza S et al. | Therapeutic Role of Resveratrol and Quercetin on Aortic Fibroblasts of Psammomys obesus After Oxidative Stress by Hydrogen Peroxide. | Am J Ther | pmid:26766292 | |
| Choudhary MI et al. | Hemiterpene glucosides and other constituents from Spiraea canescens. | Phytochemistry | pmid:19747701 | |
| Theoharides TC and Sant GR | A pilot open label study of Cystoprotek in interstitial cystitis. | Int J Immunopathol Pharmacol | pmid:15698523 | |
| pmid:15113146 | ||||
| Tang YP et al. | Two new isoflavone triglycosides from the small branches of Sophora japonica. | J Asian Nat Prod Res | pmid:18058382 | |
| Azadi L et al. | Effects of Tempol and Quercetin on Human Sperm Function after Cryopreservation. | Cryo Letters | pmid:28376137 | |
| Bayés M and Rabasseda X | Gateways to clinical trials. | Methods Find Exp Clin Pharmacol | pmid:18389098 | |
| Kawakami K et al. | Identification of 2″-galloylated flavonol 3-o-glycosides accumulating in developing leaves of persimmon. | Phytochem Anal | pmid:21413094 | |
| Ramezani F et al. | Sequential Therapy of Breast Cancer Cell Lines with Vitamin C and Quercetin Improves the Efficacy of Chemotherapeutic Drugs. | Nutr Cancer | pmid:28742385 | |
| Forman V et al. | [Constituents of the leaves of Cornus officinalis Sieb. et Zucc.] | Ceska Slov Farm | pmid:27860471 | |
| Mandic P et al. | The effects of quercetin on liver regeneration after liver resection in rats. | Folia Morphol. (Warsz) | pmid:26711645 | |
| Kanter M et al. | The effects of quercetin on liver regeneration after liver resection in rats. | Folia Morphol. (Warsz) | pmid:26431047 | |
| pmid:23856528 | ||||
| Guo X et al. | Synergistic interactions of apigenin, naringin, quercetin and emodin on inhibition of 3T3-L1 preadipocyte differentiation and pancreas lipase activity. | Obes Res Clin Pract | pmid:26314502 | |
| Efferth T et al. | Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells. | Blood Cells Mol. Dis. | pmid:12064912 | |
| Oliveira VM et al. | Quercetin and rutin as potential agents antifungal against Cryptococcus spp. | Braz J Biol | pmid:27166572 | |
| pmid:14646188 | ||||
| Zheng J et al. | Therapeutic effects of quercetin on early inflammation in hypertriglyceridemia-related acute pancreatitis and its mechanism. | Pancreatology | pmid:26873426 | |
| GarcÃa MT and González EL | Natural antioxidants protect against cadmium-induced damage during pregnancy and lactation in rats' pups. | J. Food Sci. | pmid:20492210 | |
| MITCHELL JM et al. | Impressions on pediatric education. | 1948 | Pediatrics | pmid:18857912 |
| FUCHS L | [Not available]. | 1949 | Sci Pharm | pmid:24537012 |
| AMBROSE AM and DeEDS F | The value of rutin and quercetin in scurvy. | 1949 | J. Nutr. | pmid:18134235 |
| SWANN RV | The spectrophotometric determination of rutin and quercetin in mixtures. | 1949 | J. Pharm. Pharmacol. | pmid:18129267 |
| REDEMANN CT and WITTWER SH | The occurrence of quercetin in the pollen of Zea mays. | 1950 | Arch Biochem | pmid:15404817 |
| LAUGHNAN JR | The action of allelic forms of the gene A in maize. III. Studies on the occurrence of isoquercitrin in brown and purple plants and its lack of identity with the brown pigments. | 1950 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15417546 |
| NAGHSKI J et al. | Use of paper chromatography for the quantitative estimation of quercetin in rutin. | 1951 | J Am Pharm Assoc Am Pharm Assoc | pmid:14907473 |
| DECHENE EB | The relative stability of rutin and quercetin in alkaline solution. | 1951 | J Am Pharm Assoc Am Pharm Assoc | pmid:14907441 |
| BOOTH AN and DeEDS F | Isolation of quercitrin and quercetin from lemon flavine. | 1951 | J Am Pharm Assoc Am Pharm Assoc | pmid:14861094 |
| HALLETT FP and PARKS LM | A note on the isolation of quercitrin from Euphorbia pilulifera L. | 1951 | J Am Pharm Assoc Am Pharm Assoc | pmid:14813964 |
| STEVENS FA et al. | The isolation of isoquercitrin from giant ragweed pollen; the electrophoretic pattern and biologic activity of the pigment. | 1951 | J Allergy | pmid:14823829 |
| ICE CH and WENDER SH | A new method for the isolation of pure quercitrin from lemon flavin. | 1952 | Arch. Biochem. Biophys. | pmid:12997092 |
| AMBROSE AM et al. | Comparative toxicites of quercetin and quercitrin. | 1952 | J Am Pharm Assoc Am Pharm Assoc | pmid:14927476 |