quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Lead Poisoning D007855 4 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Per page 10 20 50 100 | Total 205

PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Authors Title Published Journal PubMed Link
Walkowiak A et al. Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. 2019 Spectrochim Acta A Mol Biomol Spectrosc pmid:30321862
Maurya AK and Vinayak M Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. 2019 In Vitro Cell. Dev. Biol. Anim. pmid:30413935
Li J et al. Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. 2019 Chem. Biol. Interact. pmid:30365939
Mu Y et al. Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. 2019 Carbohydr Polym pmid:30318192
Li F et al. The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. 2019 Pest Manag. Sci. pmid:29797492
Schröder L et al. Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. 2019 Oncol. Rep. pmid:30320348
Das S et al. Molecular recognition of bio-active flavonoids quercetin and rutin by bovine hemoglobin: an overview of the binding mechanism, thermodynamics and structural aspects through multi-spectroscopic and molecular dynamics simulation studies. 2018 Phys Chem Chem Phys pmid:30101248
Yamashita K et al. Assessment of the skin sensitizing potential of chemicals, contained in foods and/or cosmetic ingredients, using a modified local lymph node assay with an elicitation phase (LLNA:DAE) method. 2018 J Toxicol Sci pmid:30078837
Tutino V et al. Cannabinoid Receptor-1 Up-regulation in Azoxymethane (AOM)-treated Mice After Dietary Treatment with Quercetin. 2018 Anticancer Res. pmid:30061214
Jia L et al. Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction. 2018 Life Sci. pmid:30025823
Wu TC et al. Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. 2018 Chem. Biol. Interact. pmid:30016632
Lu N et al. Generation of a Diligand Complex of Bovine Serum Albumin with Quercetin and Carbon Nanotubes for the Protection of Bioactive Quercetin and Reduction of Cytotoxicity. 2018 J. Agric. Food Chem. pmid:30016096
Arbain NH et al. Optimization of Quercetin loaded Palm Oil Ester Based Nanoemulsion Formulation for Pulmonary Delivery. 2018 J Oleo Sci pmid:30012897
Chirumbolo S and Bjørklund G Quercetin in collagen-induced arthritis. Some comments. 2018 Int. Immunopharmacol. pmid:29970297
Habtemariam S and Belai A Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin. 2018 Mini Rev Med Chem pmid:28117024
Kapur B et al. Health and taste related compounds in strawberries under various irrigation regimes and bio-stimulant application. 2018 Food Chem pmid:29784329
Váradyová Z et al. Ovicidal and larvicidal activity of extracts from medicinal-plants against Haemonchus contortus. 2018 Exp. Parasitol. pmid:30389531
Xia J et al. Shufeng Jiedu Capsule and its active ingredients induce apoptosis, inhibit migration and invasion, and enhances doxorubicin therapeutic efficacy in hepatocellular carcinoma. 2018 Biomed. Pharmacother. pmid:29710492
Lu N et al. Inhibitive Effects of Quercetin on Myeloperoxidase-Dependent Hypochlorous Acid Formation and Vascular Endothelial Injury. 2018 J. Agric. Food Chem. pmid:29708335
Zhang Y et al. Amelioration of Alcoholic Liver Steatosis by Dihydroquercetin through the Modulation of AMPK-Dependent Lipogenesis Mediated by P2X7R-NLRP3-Inflammasome Activation. 2018 J. Agric. Food Chem. pmid:29706079
Lu J et al. Quercetin Inhibits the Migration and Invasion of HCCLM3 Cells by Suppressing the Expression of p-Akt1, Matrix Metalloproteinase (MMP) MMP-2, and MMP-9. 2018 Med. Sci. Monit. pmid:29701200
Aghapour F et al. Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines. 2018 Biochem. Biophys. Res. Commun. pmid:29698680
Sun S et al. Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway. 2018 Gene pmid:29678660
Suke SG et al. Ameliorative effect of nanoencapsulated flavonoid against chlorpyrifos-induced hepatic oxidative damage and immunotoxicity in Wistar rats. 2018 J. Biochem. Mol. Toxicol. pmid:29667781
Zhu Y et al. Molecular Cloning and Functional Characterization of a Dihydroflavonol 4-Reductase from Vitis bellula. 2018 Molecules pmid:29642567
Jeong DW et al. Deastringent Peel Extracts of Persimmon ( Thunb. cv. Cheongdo-Bansi) Protect Neuronal PC-12 and SH-SY5Y Cells against Oxidative Stress. 2018 J. Microbiol. Biotechnol. pmid:29975999
Abdelhalim MAK et al. Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo. 2018 Int J Nanomedicine pmid:30538457
Ding T et al. Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome. 2018 Phytomedicine pmid:29519318
de Oliveira TS et al. Neuroprotective Effect of Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties. 2018 Oxid Med Cell Longev pmid:30420910
Patrizio F et al. The acute effect of Quercetin on muscle performance following a single resistance training session. 2018 Eur. J. Appl. Physiol. pmid:29511920
Song YY et al. Phenolic Compounds from Belamcanda chinensis Seeds. 2018 Molecules pmid:29510567
Murota K et al. Flavonoid metabolism: the interaction of metabolites and gut microbiota. 2018 Biosci. Biotechnol. Biochem. pmid:29504827
Kim MK et al. In Vitro Synergism and Anti-biofilm Activity of Quercetin-Pivaloxymethyl Conjugate against Staphylococcus aureus and Enterococcus Species. 2018 Chem. Pharm. Bull. pmid:30381653
Silva W et al. Double emulsions as potential fat replacers with gallic acid and quercetin nanoemulsions in the aqueous phases. 2018 Food Chem pmid:29502846
Naeimi R et al. Querectin improves myelin repair of optic chiasm in lyolecithin-induced focal demyelination model. 2018 Biomed. Pharmacother. pmid:29501770
Ozdemir Olgun FA et al. A novel cerium oxide nanoparticles-based colorimetric sensor using tetramethyl benzidine reagent for antioxidant activity assay. 2018 Talanta pmid:29501192
Xia F et al. Rapid Determination of Active Compounds and Antioxidant Activity of Okra Seeds Using Fourier Transform Near Infrared (FT-NIR) Spectroscopy. 2018 Molecules pmid:29498632
Hidaka M et al. Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1. 2018 Biochem. Biophys. Res. Commun. pmid:29608894
Wang X et al. Hyperoside Protects Against Pressure Overload-Induced Cardiac Remodeling via the AKT Signaling Pathway. 2018 Cell. Physiol. Biochem. pmid:30466089
Hayamizu K et al. Cardiotonic actions of quercetin and its metabolite tamarixetin through a digitalis-like enhancement of Ca transients. 2018 Arch. Biochem. Biophys. pmid:29169900
Pradhan AB et al. Role of hydroxyl groups in the B-ring of flavonoids in stabilization of the Hoogsteen paired third strand of Poly(U).Poly(A)*Poly(U) triplex. 2018 Arch. Biochem. Biophys. pmid:29162368
Zhou J et al. Determination of isoquercitrin in rat plasma by high performance liquid chromatography coupled with a novel synergistic cloud point extraction. 2018 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29153998
Carbone ML et al. Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. 2018 Int J Mol Sci pmid:30200670
Mazhar M et al. Quercetin modulates iron homeostasis and iNOS expression of splenic macrophages in a rat model of iron deficiency anemia. 2018 Chin J Nat Med pmid:30197123
Song JE et al. Quercetin Inlaid Silk Fibroin/Hydroxyapatite Scaffold Promotes Enhanced Osteogenesis. 2018 ACS Appl Mater Interfaces pmid:30188112
Hyun HB et al. Quercetin Suppresses CYR61-Mediated Multidrug Resistance in Human Gastric Adenocarcinoma AGS Cells. 2018 Molecules pmid:29364834
Wen P et al. Preparation and Characterization of Electrospun Colon-Specific Delivery System for Quercetin and Its Antiproliferative Effect on Cancer Cells. 2018 J. Agric. Food Chem. pmid:30148954
Akintunde JK et al. Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey inhibits oxidative damage and econucleotidase followed by increased cellular ATP in testicular cells of rats exposed to metropolitan polluted river water. 2018 J Basic Clin Physiol Pharmacol pmid:29360627
Erdogan S et al. Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway. 2018 Biomed. Pharmacother. pmid:30142541
Wang R et al. Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM). 2018 Med. Sci. Monit. pmid:29353288
Sunoqrot S et al. Facile synthesis and surface modification of bioinspired nanoparticles from quercetin for drug delivery. 2018 Biomater Sci pmid:30140818
Hussain J et al. New robust sensitive fluorescence spectroscopy coupled with PLSR for estimation of quercetin in Ziziphus mucronata and Ziziphus sativa. 2018 Spectrochim Acta A Mol Biomol Spectrosc pmid:29331816
Jadán-Piedra C et al. In vitro evaluation of dietary compounds to reduce mercury bioavailability. 2018 Food Chem pmid:29329865
Lu Z et al. Preparation and in vitro and in vivo evaluation of quercetin-loaded mixed micelles for oral delivery. 2018 Biosci. Biotechnol. Biochem. pmid:29327653
Xiao Y and Lee IS Microbial transformation of quercetin and its prenylated derivatives. 2018 Nat. Prod. Res. pmid:28826260
Farrag Y et al. Starch films loaded with donut-shaped starch-quercetin microparticles: Characterization and release kinetics. 2018 Int. J. Biol. Macromol. pmid:30012488
Li JJ et al. Fast dissolving drug delivery membrane based on the ultra-thin shell of electrospun core-shell nanofibers. 2018 Eur J Pharm Sci pmid:30008429
Teppabut Y et al. Change of Petals' Color and Chemical Components in Flowers during Senescence. 2018 Molecules pmid:30002287
Liu S et al. Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation. 2018 Food Funct pmid:29993075
Vimalraj S et al. Mixed-ligand copper(II) complex of quercetin regulate osteogenesis and angiogenesis. 2018 Mater Sci Eng C Mater Biol Appl pmid:29208278
Yang H et al. Quercetin Treatment Improves Renal Function and Protects the Kidney in a Rat Model of Adenine-Induced Chronic Kidney Disease. 2018 Med. Sci. Monit. pmid:29987270
Yang X et al. Quercetin synergistically reactivates human immunodeficiency virus type 1 latency by activating nuclear factor‑κB. 2018 Mol Med Rep pmid:29207194
Farazuddin M et al. Quercetin prevents rhinovirus-induced progression of lung disease in mice with COPD phenotype. 2018 PLoS ONE pmid:29975735
Lee HN et al. Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models. 2018 Int. J. Mol. Med. pmid:29207037
Rastogi S and Haldar C Comparative effect of melatonin and quercetin in counteracting LPS induced oxidative stress in bone marrow mononuclear cells and spleen of Funambulus pennanti. 2018 Food Chem. Toxicol. pmid:29964085
Shen XY et al. Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells. 2018 Int. J. Mol. Med. pmid:29207020
Li ZP et al. Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation. 2018 Molecules pmid:29958399
Steinborn C et al. In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica. 2018 Planta Med. pmid:29202511
Braun JBS et al. Pretreatment with quercetin prevents changes in lymphocytes E-NTPDase/E-ADA activities and cytokines secretion in hyperlipidemic rats. 2018 Mol. Cell. Biochem. pmid:29188537
Li S et al. Quercetin protects against ox‑LDL‑induced injury via regulation of ABCAl, LXR‑α and PCSK9 in RAW264.7 macrophages. 2018 Mol Med Rep pmid:29845234
Haque MW et al. Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway. 2018 Biomed. Pharmacother. pmid:29843042
Younas M et al. Differential accumulation of silymarin induced by exposure of Silybum marianum L. callus cultures to several spectres of monochromatic lights. 2018 J. Photochem. Photobiol. B, Biol. pmid:29803074
Sherif IO The effect of natural antioxidants in cyclophosphamide-induced hepatotoxicity: Role of Nrf2/HO-1 pathway. 2018 Int. Immunopharmacol. pmid:29800788
Zhang Y et al. Anti-hypoglycemic and hepatocyte-protective effects of hyperoside from Zanthoxylum bungeanum leaves in mice with high-carbohydrate/high-fat diet and alloxan-induced diabetes. 2018 Int. J. Mol. Med. pmid:29115390
Yin C et al. Phytochemical analysis and antibacterial activity of Gentiana macrophylla extract against bacteria isolated from burn wound infections. 2018 Microb. Pathog. pmid:29111322
Mandrone M et al. Identification of a Collagenase-Inhibiting Flavonoid from Alchemilla vulgaris Using NMR-Based Metabolomics. 2018 Planta Med. pmid:29797306
Escher GB et al. Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract. 2018 Food Chem. Toxicol. pmid:29787846
Crascì L et al. Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation. 2018 Drug Res (Stuttg) pmid:29108086
Pawlikowska-Pawlega B et al. Interaction of a quercetin derivative - lensoside Aβ with liposomal membranes. 2018 Biochim Biophys Acta Biomembr pmid:29106971
Shu B et al. Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-κB signaling suppression. 2018 Cell. Signal. pmid:29080804
Trinh PTN et al. A new benzofuran derivative from the leaves of Ficus pumila L. 2018 Nat. Prod. Res. pmid:29072969
Wang XF et al. Protective Effect of Quercetin in LPS-Induced Murine Acute Lung Injury Mediated by cAMP-Epac Pathway. 2018 Inflammation pmid:29569077
Li S et al. Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation. 2018 Phytother Res pmid:29635751
Xiao J Stability of dietary polyphenols: It's never too late to mend? 2018 Food Chem. Toxicol. pmid:29626578
Wang L et al. Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers. 2018 J Microencapsul pmid:29624090
Guazelli CFS et al. Quercetin attenuates zymosan-induced arthritis in mice. 2018 Biomed. Pharmacother. pmid:29554596
Mendel M et al. Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility-in vitro study. 2018 J. Vet. Pharmacol. Ther. pmid:28913883
Quintero-Soto MF et al. Phenolic profiles and their contribution to the antioxidant activity of selected chickpea genotypes from Mexico and ICRISAT collections. 2018 Plant Foods Hum Nutr pmid:29516285
Andres S et al. Safety Aspects of the Use of Quercetin as a Dietary Supplement. 2018 Mol Nutr Food Res pmid:29127724
Bondonno NP et al. Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial. 2018 Mol Nutr Food Res pmid:29086478
Singh S and Kumar P Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration in experimental rats: Biochemical and neurochemical evidences. 2018 Neurosci. Res. pmid:29056550
Palle S and Neerati P Quercetin nanoparticles alter pharmacokinetics of bromocriptine, reflecting its enhanced inhibitory action on liver and intestinal CYP 3A enzymes in rats. 2018 Xenobiotica pmid:28990837
Wang Y et al. Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats. 2018 J. Cell. Biochem. pmid:28865131
Deng M et al. Effect of Storage Conditions on Phenolic Profiles and Antioxidant Activity of Litchi Pericarp. 2018 Molecules pmid:30200581
Jan S et al. Effect of environmental variables on phytonutrients of Origanum vulgare L. in the sub-humid region of the northwestern Himalayas. 2018 Environ Monit Assess pmid:30187208
Wang J et al. Isorhamnetin prevents H2O2‑induced oxidative stress in human retinal pigment epithelial cells. 2018 Mol Med Rep pmid:29115489
Cerulli A et al. Phenolics from Castanea sativa leaves and their effects on UVB-induced damage. 2018 Nat. Prod. Res. pmid:28539059
Zhang XF et al. UPLC-MS/MS analysis for antioxidant components of Lycii Fructus based on spectrum-effect relationship. 2018 Talanta pmid:29332828
Zahid K et al. Phytochemical screening, antioxidant activity, total phenolic and total flavonoid contents of seven local varieties of Rosa indica L. 2018 Nat. Prod. Res. pmid:28539055
Bhattacharya D et al. Antibacterial activity of polyphenolic fraction of Kombucha against Vibrio cholerae: targeting cell membrane. 2018 Lett. Appl. Microbiol. pmid:29193174