| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with quercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with quercetin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with quercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:5155019 | ||||
| pmid:11327318 | ||||
| pmid:12214854 | ||||
| pmid: | ||||
| pmid:15113146 | ||||
| pmid:23856528 | ||||
| pmid:14646188 | ||||
| Morris ME and Felmlee MA | Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. | 2008 | AAPS J | pmid:18523892 |
| Wang HJ et al. | Dietary flavonoids modulate CYP2C to improve drug oral bioavailability and their qualitative/quantitative structure-activity relationship. | 2014 | AAPS J | pmid:24431079 |
| Georgetti SR et al. | Evaluation of the antioxidant activity of different flavonoids by the chemiluminescence method. | 2003 | AAPS PharmSci | pmid:12866943 |
| Liu T et al. | Preparation Nanocrystals of Poorly Soluble Plant Compounds Using an Ultra-Small-Scale Approach. | 2017 | AAPS PharmSciTech | pmid:28243886 |
| Vicentini FT et al. | Quercetin in lyotropic liquid crystalline formulations: physical, chemical and functional stability. | 2008 | AAPS PharmSciTech | pmid:18454320 |
| Vijayakumar A et al. | Quercetin-Loaded Solid Lipid Nanoparticle Dispersion with Improved Physicochemical Properties and Cellular Uptake. | 2017 | AAPS PharmSciTech | pmid:27368922 |
| Casagrande R et al. | Evaluation of functional stability of quercetin as a raw material and in different topical formulations by its antilipoperoxidative activity. | 2006 | AAPS PharmSciTech | pmid:16584140 |
| Borghetti GS et al. | Quercetin/beta-cyclodextrin solid complexes prepared in aqueous solution followed by spray-drying or by physical mixture. | 2009 | AAPS PharmSciTech | pmid:19280349 |
| Zorzi GK et al. | Antioxidant Effect of Nanoemulsions Containing Extract of Achyrocline satureioides (Lam) D.C.-Asteraceae. | 2016 | AAPS PharmSciTech | pmid:26361953 |
| Lv X et al. | Preparation of Essential Oil-Based Microemulsions for Improving the Solubility, pH Stability, Photostability, and Skin Permeation of Quercetin. | 2017 | AAPS PharmSciTech | pmid:28516411 |
| Córdoba A et al. | Bioinspired Quercitrin Nanocoatings: A Fluorescence-Based Method for Their Surface Quantification, and Their Effect on Stem Cell Adhesion and Differentiation to the Osteoblastic Lineage. | 2015 | ACS Appl Mater Interfaces | pmid:26167954 |
| Liu Y et al. | Platinum Nanoparticles: Efficient and Stable Catechol Oxidase Mimetics. | 2015 | ACS Appl Mater Interfaces | pmid:26305170 |
| Song JE et al. | Quercetin Inlaid Silk Fibroin/Hydroxyapatite Scaffold Promotes Enhanced Osteogenesis. | 2018 | ACS Appl Mater Interfaces | pmid:30188112 |
| Sun D et al. | Transcriptome Analysis Reveals Silver Nanoparticle-Decorated Quercetin Antibacterial Molecular Mechanism. | 2017 | ACS Appl Mater Interfaces | pmid:28240544 |
| Yang S et al. | A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation. | 2016 | ACS Chem Neurosci | pmid:27015590 |
| Primikyri A et al. | Direct binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity. | 2014 | ACS Chem. Biol. | pmid:25211642 |
| Sturgill TW and Hall MN | Activating mutations in TOR are in similar structures as oncogenic mutations in PI3KCalpha. | 2009 | ACS Chem. Biol. | pmid:19902965 |
| Darras FH et al. | Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer. | 2012 | ACS Med Chem Lett | pmid:24900407 |
| El-Gogary RI et al. | Polyethylene glycol conjugated polymeric nanocapsules for targeted delivery of quercetin to folate-expressing cancer cells in vitro and in vivo. | 2014 | ACS Nano | pmid:24397686 |
| Niu G et al. | Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells. | 2011 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:21173056 |
| Xiao J et al. | The role of AMP-activated protein kinase in quercetin-induced apoptosis of HL-60 cells. | 2014 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:24705122 |
| Wu L et al. | Study of MMLV RT- binding with DNA using surface plasmon resonance biosensor. | 2005 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:16143819 |
| Cui X et al. | Changes of intracellular Ca2+ in quercetin-induced autophagy progression. | 2015 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:26423114 |
| Zielińska M et al. | The flavonoids, quercetin and isorhamnetin 3-O-acylglucosides diminish neutrophil oxidative metabolism and lipid peroxidation. | 2001 | Acta Biochim. Pol. | pmid:11440168 |
| Czeczot H | Mutagenic activity of quercetin in derivatives of Escherichia coli WP2 uvrA with increased permeability. | 1994 | Acta Biochim. Pol. | pmid:7976027 |
| Czeczot H | The effect of flavonoids on the mutagenic activity of aromatic amines. | 1992 | Acta Biochim. Pol. | pmid:1441824 |
| Czeczot H and Kusztelak J | A study of the genotoxic potential of flavonoids using short-term bacterial assays. | 1993 | Acta Biochim. Pol. | pmid:8140830 |
| Czeczot H et al. | Quercetin introduces strand breaks into bacterial DNA. | 1993 | Acta Biochim. Pol. | pmid:8372571 |
| Zargar S et al. | Protective effects of quercetin on cadmium fluoride induced oxidative stress at different intervals of time in mouse liver. | 2015 | Acta Biochim. Pol. | pmid:25856559 |
| Marcinkiewicz C et al. | EF-1 alpha is a target site for an inhibitory effect of quercetin in the peptide elongation process. | 1995 | Acta Biochim. Pol. | pmid:8588487 |
| Papież MA | The effect of quercetin on oxidative DNA damage and myelosuppression induced by etoposide in bone marrow cells of rats. | 2014 | Acta Biochim. Pol. | pmid:24644549 |
| Papież MA and Krzyściak W | The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide. | 2014 | Acta Biochim. Pol. | pmid:25493440 |
| Lu Q et al. | Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway. | 2018 | Acta Biochim. Pol. | pmid:29281744 |
| Gebicka L and Banasiak E | Flavonoids as reductants of ferryl hemoglobin. | 2009 | Acta Biochim. Pol. | pmid:19774231 |
| Forte L et al. | Antioxidant and bone repair properties of quercetin-functionalized hydroxyapatite: An in vitro osteoblast-osteoclast-endothelial cell co-culture study. | 2016 | Acta Biomater | pmid:26689470 |
| Ramasamy T et al. | Engineering of cell microenvironment-responsive polypeptide nanovehicle co-encapsulating a synergistic combination of small molecules for effective chemotherapy in solid tumors. | 2017 | Acta Biomater | pmid:27794477 |
| Huang X et al. | Investigation of functional selenium nanoparticles as potent antimicrobial agents against superbugs. | 2016 | Acta Biomater | pmid:26518106 |
| Castangia I et al. | Fabrication of quercetin and curcumin bionanovesicles for the prevention and rapid regeneration of full-thickness skin defects on mice. | 2014 | Acta Biomater | pmid:24239901 |
| Castangia I et al. | Therapeutic efficacy of quercetin enzyme-responsive nanovesicles for the treatment of experimental colitis in rats. | 2015 | Acta Biomater | pmid:25463498 |
| Zhai W et al. | Quercetin-crosslinked porcine heart valve matrix: mechanical properties, stability, anticalcification and cytocompatibility. | 2010 | Acta Biomater | pmid:19651252 |
| Wattamwar PP et al. | Synthesis and characterization of poly(antioxidant β-amino esters) for controlled release of polyphenolic antioxidants. | 2012 | Acta Biomater | pmid:22426289 |
| Gupta P et al. | Quercetin conjugated poly(β-amino esters) nanogels for the treatment of cellular oxidative stress. | 2015 | Acta Biomater | pmid:26318804 |
| Szabó A et al. | Mucosal permeability changes during intestinal reperfusion injury. The role of mast cells. | 1997 | Acta Chir Hung | pmid:9408393 |