| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with quercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with quercetin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with quercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Walkowiak A et al. | Detection of adulterants in dietary supplements with Ginkgo biloba extract by attenuated total reflectance Fourier transform infrared spectroscopy and multivariate methods PLS-DA and PCA. | 2019 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:30321862 |
| Maurya AK and Vinayak M | Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7 cells. | 2019 | In Vitro Cell. Dev. Biol. Anim. | pmid:30413935 |
| Li J et al. | Isoquercitrin, a flavonoid glucoside, exerts a positive effect on osteogenesis in vitro and in vivo. | 2019 | Chem. Biol. Interact. | pmid:30365939 |
| Mu Y et al. | Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug. | 2019 | Carbohydr Polym | pmid:30318192 |
| Li F et al. | The regulation of three new members of the cytochrome P450 CYP6 family and their promoters in the cotton aphid Aphis gossypii by plant allelochemicals. | 2019 | Pest Manag. Sci. | pmid:29797492 |
| Schröder L et al. | Effects of green tea, matcha tea and their components epigallocatechin gallate and quercetin on MCF‑7 and MDA-MB-231 breast carcinoma cells. | 2019 | Oncol. Rep. | pmid:30320348 |
| Yang T et al. | Interactions of quercetin, curcumin, epigallocatechin gallate and folic acid with gelatin. | 2018 | Int. J. Biol. Macromol. | pmid:29908276 |
| Wang WJ et al. | Deciphering the chemoselectivity of nickel-dependent quercetin 2,4-dioxygenase. | 2018 | Phys Chem Chem Phys | pmid:29869653 |
| Zhou W et al. | A two-step ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry with mass defect filtering method for rapid identification of analogues from known components of different chemical structure types in Fructus Gardeniae-Fructus Forsythiae herb pair extract and in rat's blood. | 2018 | J Chromatogr A | pmid:29861306 |
| Patra A et al. | Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers. | 2018 | Int J Nanomedicine | pmid:29844670 |
| Šarić Mustapić D et al. | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. | 2018 | Molecules | pmid:30301254 |
| Ge L et al. | B-factor-saturation mutagenesis as a strategy to increase the thermostability of α-L-rhamnosidase from Aspergillus terreus. | 2018 | J. Biotechnol. | pmid:29605638 |
| Chen J et al. | Pretreatment with dihydroquercetin, a dietary flavonoid, protected against concanavalin A-induced immunological hepatic injury in mice and TNF-α/ActD-induced apoptosis in HepG2 cells. | 2018 | Food Funct | pmid:29589006 |
| Zhu Q et al. | Comparison of flavonoids and isoflavonoids to inhibit rat and human 11β-hydroxysteroid dehydrogenase 1 and 2. | 2018 | Steroids | pmid:29425740 |
| Farrag Y et al. | Preparation of starch nanoparticles loaded with quercetin using nanoprecipitation technique. | 2018 | Int. J. Biol. Macromol. | pmid:29580996 |
| Dai Y et al. | Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway. | 2018 | Chem. Biol. Interact. | pmid:29454613 |
| Feng J et al. | Quercetin restrains TGF-β1-induced epithelial-mesenchymal transition by inhibiting Twist1 and regulating E-cadherin expression. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29425820 |
| Vovkun T et al. | Water-soluble quercetin modulates the choleresis and bile lipid ratio in rats. | 2018 | Gen. Physiol. Biophys. | pmid:29424356 |
| Zhang L et al. | Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats. | 2018 | J. Agric. Food Chem. | pmid:29359554 |
| Nakamura M et al. | Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. | 2018 | J Toxicol Sci | pmid:30298849 |
| Ray S et al. | Modulation in phenolic root exudate profile of Abelmoschus esculentus expressing activation of defense pathway. | 2018 | Microbiol. Res. | pmid:29458844 |
| Zhu X et al. | Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway. | 2018 | Food Chem. Toxicol. | pmid:29438776 |
| Ma Y et al. | Quercetin potentiates the concurrent hyper-accumulation of cellular biomass and lipids in Chlorella vulgaris. | 2018 | Bioresour. Technol. | pmid:30093226 |
| Wu Z et al. | Simultaneous Enrichment and Separation of Four Flavonoids from Zanthoxylum bungeanum Leaves by Ultrasound-Assisted Extraction and Macroporous Resins with Evaluation of Antioxidant Activities. | 2018 | J. Food Sci. | pmid:30080245 |
| Zhou YQ et al. | Hyperoside Suppresses Lipopolysaccharide-induced Inflammation and Apoptosis in Human Umbilical Vein Endothelial Cells. | 2018 | Curr Med Sci | pmid:30074179 |
| Sommella E et al. | Chemical profiling of bioactive constituents in hop cones and pellets extracts by online comprehensive two-dimensional liquid chromatography with tandem mass spectrometry and direct infusion Fourier transform ion cyclotron resonance mass spectrometry. | 2018 | J Sep Sci | pmid:29282870 |
| Mukhopadhyay P et al. | Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment. | 2018 | Carbohydr Polym | pmid:29279124 |
| Rácz A et al. | Selective responses of class III plant peroxidase isoforms to environmentally relevant UV-B doses. | 2018 | J. Plant Physiol. | pmid:29272746 |
| Yan S et al. | Silk fabric dyed with extract of sophora flower bud. | 2018 | Nat. Prod. Res. | pmid:28748727 |
| Wang J et al. | Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro. | 2018 | J Ovarian Res | pmid:29929541 |
| Özbilgin S et al. | In vivo wound-healing activity of Euphorbia characias subsp. wulfenii: Isolation and quantification of quercetin glycosides as bioactive compounds. | 2018 | J Ethnopharmacol | pmid:29920357 |
| Kuipers EN et al. | Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice. | 2018 | Int J Mol Sci | pmid:29914151 |
| Kawabata K et al. | Functional properties of anti-inflammatory substances from quercetin-treated Bifidobacterium adolescentis. | 2018 | Biosci. Biotechnol. Biochem. | pmid:29165050 |
| Yun J et al. | Effect of isoquercitrin on membrane dynamics and apoptosis-like death in Escherichia coli. | 2018 | Biochim Biophys Acta Biomembr | pmid:29155212 |
| Chen Y et al. | Hyperoside protects human kidney‑2 cells against oxidative damage induced by oxalic acid. | 2018 | Mol Med Rep | pmid:29750296 |
| Wang D et al. | Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression. | 2018 | Mol Med Rep | pmid:29749525 |
| Sohn EJ et al. | Restoring Effects of Natural Anti-Oxidant Quercetin on Cellular Senescent Human Dermal Fibroblasts. | 2018 | Am. J. Chin. Med. | pmid:29737207 |
| Pang XG et al. | Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway. | 2018 | Biomed Res Int | pmid:29736392 |
| Wang Y et al. | Development of a LC-MS/MS method to investigate the interference of pharmacokinetics of the main constituents in Saxifraga stolonifera: Involvement of drug metabolism enzymes. | 2018 | J Pharm Biomed Anal | pmid:29017109 |
| Yang JX et al. | Effects of phyto-oestrogen quercetin on productive performance, hormones, reproductive organs and apoptotic genes in laying hens. | 2018 | J Anim Physiol Anim Nutr (Berl) | pmid:28986927 |
| Vanden Braber NL et al. | Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin. | 2018 | Int. J. Biol. Macromol. | pmid:29421395 |
| Afifi NA et al. | Hepatoprotective influence of quercetin and ellagic acid on thioacetamide-induced hepatotoxicity in rats. | 2018 | Can. J. Physiol. Pharmacol. | pmid:29414242 |
| Mao T et al. | Protective Effects of Quercetin Against Cadmium Chloride-Induced Oxidative Injury in Goat Sperm and Zygotes. | 2018 | Biol Trace Elem Res | pmid:29397540 |
| Chen X et al. | Coencapsulation of (-)-Epigallocatechin-3-gallate and Quercetin in Particle-Stabilized W/O/W Emulsion Gels: Controlled Release and Bioaccessibility. | 2018 | J. Agric. Food Chem. | pmid:29578697 |
| Kajbafvala A et al. | Formulation, characterization, and in vitro/ex vivo evaluation of quercetin-loaded microemulsion for topical application. | 2018 | Pharm Dev Technol | pmid:27871215 |
| Zhu JX et al. | Quercetin, Kaempferol and Isorhamnetin in Elaeagnus pungens Thunb. Leaf: Pharmacological Activities and Quantitative Determination Studies. | 2018 | Chem. Biodivers. | pmid:29802806 |
| Yamauchi K and Mitsunaga T | Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model. | 2018 | J Nat Med | pmid:29442220 |
| Shi H et al. | Isorhamnetin, the active constituent of a Chinese herb Hippophae rhamnoides L, is a potent suppressor of dendritic-cell maturation and trafficking. | 2018 | Int. Immunopharmacol. | pmid:29272818 |
| Zhang P and Zhang X | Stimulatory effects of curcumin and quercetin on posttranslational modifications of p53 during lung carcinogenesis. | 2018 | Hum Exp Toxicol | pmid:28681665 |
| Shi Q et al. | Comparative Analysis of Pigments, Phenolics, and Antioxidant Activity of Chinese Jujube ( Mill.) during Fruit Development. | 2018 | Molecules | pmid:30071615 |