quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Lead Poisoning D007855 4 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Per page 10 20 50 100 | Total 205

PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Per page 10 20 50 100 | Total 12031
Authors Title Published Journal PubMed Link
pmid:5155019
Koru O et al. In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens. Anaerobe pmid:17475517
Tomillero A and Moral MA Gateways to clinical trials. July-August 2008. Methods Find Exp Clin Pharmacol pmid:18850047
Rosenblat M et al. HDL3 stimulates paraoxonase 1 antiatherogenic catalytic and biological activities in a macrophage model system: in vivo and in vitro studies. Biofactors pmid:25230879
Kalveniene Z et al. The qualitative analysis of ethanol extracts of herbal raw materials by method of high pressure liquid chromatography. Acta Pol Pharm pmid:18536158
Pi J et al. Investigation of quercetin-induced HepG2 cell apoptosis-associated cellular biophysical alterations by atomic force microscopy. Scanning pmid:26179807
Mozzicafreddo M et al. Antiplasmin activity of natural occurring polyphenols. Biochim. Biophys. Acta pmid:18456009
Kovácik J et al. Physiological responses of Scenedesmus quadricauda (Chlorophyceae) to UV-A and UV-C light. Photochem. Photobiol. pmid:20202162
Bayés M et al. Gateways to clinical trials. Methods Find Exp Clin Pharmacol pmid:17922073
Hu J et al. The effects of natural flavonoids on lipoxygenase-mediated oxidation of compounds with a benzene ring structure--a new possible mechanism of flavonoid anti-chemical carcinogenesis and other toxicities. Int. J. Toxicol. pmid:16815818
Gerhardt KE et al. The effects of far-red light on plant growth and flavonoid accumulation in Brassica napus in the presence of ultraviolet B radiation. Photochem. Photobiol. pmid:18466203
Chekalina N et al. Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease. Indian Heart J pmid:30392493
Verma S et al. Modulation of ionizing radiation induced oxidative imbalance by semi-fractionated extract of Piper betle: an in vitro and in vivo assessment. Oxid Med Cell Longev pmid:20716927
Haghighi M et al. On the formulation design and rheological evaluations of pectin-based functional gels. J. Food Sci. pmid:21535667
Chan PC et al. Ginkgo biloba leave extract: biological, medicinal, and toxicological effects. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev pmid:17763047
Khorsandi L et al. Quercetin induces apoptosis and necroptosis in MCF-7 breast cancer cells. Bratisl Lek Listy pmid:28814095
Schauss AG et al. Toxicological and Genotoxicity Assessment of a Dihydroquercetin-Rich Dahurian Larch Tree (Larix gmelinii Rupr) Extract (Lavitol). Int. J. Toxicol. pmid:25850419
Thomsen H et al. Characterization of Constituents and Anthelmintic Properties of Hagenia abyssinica. Sci Pharm pmid:22896828
Kawanishi S et al. Evaluation for safety of antioxidant chemopreventive agents. Antioxid. Redox Signal. pmid:16356133
Lorenz P et al. Investigations into the phenolic constituents of dog's mercury (Mercurialis perennis L.) by LC-MS/MS and GC-MS analyses. Phytochem Anal pmid:21692118
Jani N et al. Exogenous glutathione is essential in the testing of antioxidant capacity using radical-induced haemolysis. J Pharmacol Toxicol Methods pmid:22507255
Oliveira DR et al. Special metabolites isolated from Urochloa humidicola (Poaceae). An. Acad. Bras. Cienc. pmid:28640339
Pattanashetti LA et al. Evaluation of neuroprotective effect of quercetin with donepezil in scopolamine-induced amnesia in rats. Indian J Pharmacol pmid:28458424
Boumaza S et al. Therapeutic Role of Resveratrol and Quercetin on Aortic Fibroblasts of Psammomys obesus After Oxidative Stress by Hydrogen Peroxide. Am J Ther pmid:26766292
Azadi L et al. Effects of Tempol and Quercetin on Human Sperm Function after Cryopreservation. Cryo Letters pmid:28376137
Kawakami K et al. Identification of 2″-galloylated flavonol 3-o-glycosides accumulating in developing leaves of persimmon. Phytochem Anal pmid:21413094
Ramezani F et al. Sequential Therapy of Breast Cancer Cell Lines with Vitamin C and Quercetin Improves the Efficacy of Chemotherapeutic Drugs. Nutr Cancer pmid:28742385
Oliveira VM et al. Quercetin and rutin as potential agents antifungal against Cryptococcus spp. Braz J Biol pmid:27166572
pmid:14646188
Zheng J et al. Therapeutic effects of quercetin on early inflammation in hypertriglyceridemia-related acute pancreatitis and its mechanism. Pancreatology pmid:26873426
García MT and González EL Natural antioxidants protect against cadmium-induced damage during pregnancy and lactation in rats' pups. J. Food Sci. pmid:20492210