quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Lead Poisoning D007855 4 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Per page 10 20 50 100 | Total 205

PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Per page 10 20 50 100 | Total 12031
Authors Title Published Journal PubMed Link
Bustos AS et al. Interaction Between Phenolic Compounds and Lipase: The Influence of Solubility and Presence of Particles in the IC Value. 2018 J. Food Sci. pmid:30020550
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Khlupova ME et al. Laccase-Catalyzed Heterocoupling of Dihydroquercetin and p-Aminobenzoic Acid: Effect of the Reaction Product on Cultured Cells. 2018 Biochemistry Mosc. pmid:30208835
Ashraf AHMZ et al. Differential Mechanism of Action of 3,4',7-O-trimethylquercetin in Three Types of Ovarian Cancer Cells. 2018 Anticancer Res. pmid:30194160
Rubio V et al. Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells. 2018 Chem. Biol. Interact. pmid:30171828
Jang SA et al. Hyperoside suppresses tumor necrosis factor α-mediated vascular inflammatory responses by downregulating mitogen-activated protein kinases and nuclear factor-κB signaling. 2018 Chem. Biol. Interact. pmid:30125551
Chen X et al. Gastrointestinal Fate of Fluid and Gelled Nutraceutical Emulsions: Impact on Proteolysis, Lipolysis, and Quercetin Bioaccessibility. 2018 J. Agric. Food Chem. pmid:30102529
Das S et al. Molecular recognition of bio-active flavonoids quercetin and rutin by bovine hemoglobin: an overview of the binding mechanism, thermodynamics and structural aspects through multi-spectroscopic and molecular dynamics simulation studies. 2018 Phys Chem Chem Phys pmid:30101248
Yamashita K et al. Assessment of the skin sensitizing potential of chemicals, contained in foods and/or cosmetic ingredients, using a modified local lymph node assay with an elicitation phase (LLNA:DAE) method. 2018 J Toxicol Sci pmid:30078837
Lu X et al. Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice. 2018 Biomed. Pharmacother. pmid:29684859
Kumar M et al. N-desmethyl tamoxifen and quercetin-loaded multiwalled CNTs: A synergistic approach to overcome MDR in cancer cells. 2018 Mater Sci Eng C Mater Biol Appl pmid:29752099
Niu X et al. Three-dimensional reduced graphene oxide aerogel modified electrode for the sensitive quercetin sensing and its application. 2018 Mater Sci Eng C Mater Biol Appl pmid:29752093
Chen Z et al. Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells. 2018 Phytomedicine pmid:29747752
Liu Y et al. Antidiabetic Effect of Leaves Depends on the Contents of Antihyperglycemic Flavonoids and Antihyperlipidemic Triterpenoids. 2018 Molecules pmid:29710841
Xia J et al. Shufeng Jiedu Capsule and its active ingredients induce apoptosis, inhibit migration and invasion, and enhances doxorubicin therapeutic efficacy in hepatocellular carcinoma. 2018 Biomed. Pharmacother. pmid:29710492
Lu N et al. Inhibitive Effects of Quercetin on Myeloperoxidase-Dependent Hypochlorous Acid Formation and Vascular Endothelial Injury. 2018 J. Agric. Food Chem. pmid:29708335
Zhang Y et al. Amelioration of Alcoholic Liver Steatosis by Dihydroquercetin through the Modulation of AMPK-Dependent Lipogenesis Mediated by P2X7R-NLRP3-Inflammasome Activation. 2018 J. Agric. Food Chem. pmid:29706079
Å ola I et al. Comparative Analysis of Native Crocus Taxa as a Great Source of Flavonoids with High Antioxidant Activity. 2018 Plant Foods Hum Nutr pmid:29860648
Negi S et al. Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. 2018 Toxicol In Vitro pmid:29933105
Jin UH et al. Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. 2018 Toxicol. Sci. pmid:29584932
Forney LA et al. Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner. 2018 Int J Mol Sci pmid:29562620
Hatahet T et al. Liposomes, lipid nanocapsules and smartCrystals®: A comparative study for an effective quercetin delivery to the skin. 2018 Int J Pharm pmid:29549014
Hwang DS et al. Effects of Rhei Undulati Rhizoma on lipopolysaccharide-induced neuroinflammation in vitro and in vivo. 2018 Environ. Toxicol. pmid:28984087
Ma C et al. Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway. 2018 Mol Med Rep pmid:29532872
Fusi J et al. An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds. 2018 Biomed. Pharmacother. pmid:29525677
Abdelhalim MAK et al. Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo. 2018 Int J Nanomedicine pmid:30538457
Ding T et al. Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome. 2018 Phytomedicine pmid:29519318
Patrizio F et al. The acute effect of Quercetin on muscle performance following a single resistance training session. 2018 Eur. J. Appl. Physiol. pmid:29511920
Ting Y et al. Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on Body Composition, Serum Lipid Profile, and Gene Expression. 2018 J. Agric. Food Chem. pmid:29249156
Sarangowa O et al. Botanical origin of Mei-gui Hua in Chinese markets. 2018 J Nat Med pmid:29188415
Zhang M et al. Neurodevelopmental toxicity induced by maternal PM2.5 exposure and protective effects of quercetin and Vitamin C. 2018 Chemosphere pmid:30218877
Kim YA et al. Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant in Human Keratinocytes. 2018 Molecules pmid:30216992
Giuliani C et al. Localization of phenolic compounds in the fruits of Silybum marianum characterized by different silymarin chemotype and altered colour. 2018 Fitoterapia pmid:30213759
Rahvar M et al. Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain. 2018 Bratisl Lek Listy pmid:29405727
Takabe W et al. Identification of Antiglycative Compounds in Japanese Red Water Pepper (Red Leaf Variant of the Sprout). 2018 Molecules pmid:30208642
Gao Q et al. A red-emitting indolium fluorescence probe for membranes - flavonoids interactions. 2018 Luminescence pmid:29405584
Wein S et al. Bioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows. 2018 J. Agric. Food Chem. pmid:30207714
Ge F et al. Taxifolin suppresses rat and human testicular androgen biosynthetic enzymes. 2018 Fitoterapia pmid:29402482
Li JP et al. Hyperoside and let-7a-5p synergistically inhibits lung cancer cell proliferation via inducing G1/S phase arrest. 2018 Gene pmid:30201337
Ding Y et al. Quercetin suppresses the chymotrypsin-like activity of proteasome via inhibition of MEK1/ERK1/2 signaling pathway in hepatocellular carcinoma HepG2 cells. 2018 Can. J. Physiol. Pharmacol. pmid:29394494
Tanaka S et al. Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin. 2018 Biosci. Biotechnol. Biochem. pmid:30200823
Ginex T et al. Computational Study of the Aza-Michael Addition of the Flavonoid (+)-Taxifolin in the Inhibition of β-Amyloid Fibril Aggregation. 2018 Chemistry pmid:29384229
Carbone ML et al. Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. 2018 Int J Mol Sci pmid:30200670
Kim Y and Chang KO Protein disulfide isomerases as potential therapeutic targets for influenza A and B viruses. 2018 Virus Res. pmid:29382552
Hyun HB et al. Quercetin Suppresses CYR61-Mediated Multidrug Resistance in Human Gastric Adenocarcinoma AGS Cells. 2018 Molecules pmid:29364834
Hamilton KE et al. Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1. 2018 Biochimie pmid:29857184
North MK et al. The effects of quercetin supplementation on New Zealand White grower rabbit carcass and meat quality - A short communication. 2018 Meat Sci. pmid:30031202
Kruszewski M et al. The effect of quercetin on the electrical properties of model lipid membranes and human glioblastoma cells. 2018 Bioelectrochemistry pmid:30029034
Song JY et al. Quercetin Shows the Pharmacological Activity to Simultaneously Downregulate the Inflammatory and Fibrotic Responses to Tissue Injury in Association with its Ability to Target Multi-Kinases. 2018 Pharmacology pmid:30016781
Alugoju P et al. Quercetin Protects Yeast Saccharomyces cerevisiae pep4 Mutant from Oxidative and Apoptotic Stress and Extends Chronological Lifespan. 2018 Curr. Microbiol. pmid:29224051
Farrag Y et al. Starch films loaded with donut-shaped starch-quercetin microparticles: Characterization and release kinetics. 2018 Int. J. Biol. Macromol. pmid:30012488
Li JJ et al. Fast dissolving drug delivery membrane based on the ultra-thin shell of electrospun core-shell nanofibers. 2018 Eur J Pharm Sci pmid:30008429
Zhu Y et al. Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model. 2018 Food Funct pmid:29215110
Teppabut Y et al. Change of Petals' Color and Chemical Components in Flowers during Senescence. 2018 Molecules pmid:30002287
Vimalraj S et al. Mixed-ligand copper(II) complex of quercetin regulate osteogenesis and angiogenesis. 2018 Mater Sci Eng C Mater Biol Appl pmid:29208278
Yang X et al. Quercetin synergistically reactivates human immunodeficiency virus type 1 latency by activating nuclear factor‑κB. 2018 Mol Med Rep pmid:29207194
Lee HN et al. Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models. 2018 Int. J. Mol. Med. pmid:29207037
Kalinová JP et al. Contribution to the study of rutin stability in the achenes of Tartary buckwheat (Fagopyrum tataricum). 2018 Food Chem pmid:29655739
Ventura-Martínez R et al. Spasmolytic effect of aqueous extract of Tagetes erecta L. flowers is mediated through calcium channel blockade on the guinea-pig ileum. 2018 Biomed. Pharmacother. pmid:29864942
Lee KM et al. Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed human keratinocytes. 2018 Biochem. Biophys. Res. Commun. pmid:29857000
Ramos-Pineda AM et al. Effect of the addition of mannoproteins on the interaction between wine flavonols and salivary proteins. 2018 Food Chem pmid:29853369
Selvarajan S et al. Fabrication of g-CN/NiO heterostructured nanocomposite modified glassy carbon electrode for quercetin biosensor. 2018 Ultrason Sonochem pmid:29137797
Wang L et al. Fermentation and complex enzyme hydrolysis for improving the total soluble phenolic contents, flavonoid aglycones contents and bio-activities of guava leaves tea. 2018 Food Chem pmid:29853365
Abdullah AA et al. The performance of cathodically pretreated boron-doped diamond electrode in cationic surfactant media for enhancing the adsorptive stripping voltammetric determination of catechol-containing flavonoid quercetin in apple juice. 2018 Talanta pmid:29853029
Singh A et al. Curcumin loaded chitin-glucan quercetin conjugate: Synthesis, characterization, antioxidant, in vitro release study, and anticancer activity. 2018 Int. J. Biol. Macromol. pmid:29128588
Li S et al. Quercetin protects against ox‑LDL‑induced injury via regulation of ABCAl, LXR‑α and PCSK9 in RAW264.7 macrophages. 2018 Mol Med Rep pmid:29845234
Lei CS et al. Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies. 2018 J. Nutr. Biochem. pmid:29125991
Haque MW et al. Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway. 2018 Biomed. Pharmacother. pmid:29843042
He K et al. LPS ameliorates renal ischemia/reperfusion injury via Hsp27 up-regulation. 2018 Int Urol Nephrol pmid:29124510
Kellett ME et al. Modification of the cellular antioxidant activity (CAA) assay to study phenolic antioxidants in a Caco-2 cell line. 2018 Food Chem pmid:29120793
Zhang Y et al. Anti-hypoglycemic and hepatocyte-protective effects of hyperoside from Zanthoxylum bungeanum leaves in mice with high-carbohydrate/high-fat diet and alloxan-induced diabetes. 2018 Int. J. Mol. Med. pmid:29115390
Lin M et al. Quercetin improves postpartum hypogalactia in milk-deficient mice via stimulating prolactin production in pituitary gland. 2018 Phytother Res pmid:29671937
Seo S et al. Prediction of GPCR-Ligand Binding Using Machine Learning Algorithms. 2018 Comput Math Methods Med pmid:29666662
Jayachandran M et al. Isoquercetin ameliorates hyperglycemia and regulates key enzymes of glucose metabolism via insulin signaling pathway in streptozotocin-induced diabetic rats. 2018 Eur. J. Pharmacol. pmid:29665363
Hatware KV et al. Evidence for gastroprotective, anti-inflammatory and antioxidant potential of methanolic extract of Cordia dichotoma leaves on indomethacin and stress induced gastric lesions in Wistar rats. 2018 Biomed. Pharmacother. pmid:29660650
Li S et al. Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation. 2018 Phytother Res pmid:29635751
Xiao J Stability of dietary polyphenols: It's never too late to mend? 2018 Food Chem. Toxicol. pmid:29626578
Wang L et al. Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers. 2018 J Microencapsul pmid:29624090
Li Y et al. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. 2018 Toxicol. Lett. pmid:29753067
Quintero-Soto MF et al. Phenolic profiles and their contribution to the antioxidant activity of selected chickpea genotypes from Mexico and ICRISAT collections. 2018 Plant Foods Hum Nutr pmid:29516285
Lu Q et al. Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway. 2018 Acta Biochim. Pol. pmid:29281744
Dresch RR et al. Potential use of secondary products of the agri-food industry for topical formulations and comparative analysis of antioxidant activity of grape leaf polyphenols. 2018 Nat. Prod. Res. pmid:28403634
Seong JS et al. Surfactant-stable and pH-sensitive liposomes coated with N-succinyl-chitosan and chitooligosaccharide for delivery of quercetin. 2018 Carbohydr Polym pmid:29254020
de Lacerda Neto LJ et al. Modulation of antibiotic activity by the hydroalcoholic extract from leaves of Caryocar coriaceum WITTM. 2018 Nat. Prod. Res. pmid:28391717
Chatziathanasiadou MV et al. Amplifying and broadening the cytotoxic profile of quercetin in cancer cell lines through bioconjugation. 2018 Amino Acids pmid:29185031
Bonechi C et al. Protective effect of quercetin and rutin encapsulated liposomes on induced oxidative stress. 2018 Biophys. Chem. pmid:29174505
Curgali K et al. Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells. 2018 Acta Histochem. pmid:29129327
Andres S et al. Safety Aspects of the Use of Quercetin as a Dietary Supplement. 2018 Mol Nutr Food Res pmid:29127724
Bondonno NP et al. Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial. 2018 Mol Nutr Food Res pmid:29086478
Singh S and Kumar P Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration in experimental rats: Biochemical and neurochemical evidences. 2018 Neurosci. Res. pmid:29056550
Shalini D et al. Effect of size and shape on toxicity of zinc oxide (ZnO) nanomaterials in human peripheral blood lymphocytes. 2018 Toxicol. Mech. Methods pmid:28805101
Zhao TT et al. Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes. 2018 Gene pmid:29730426
Deng M et al. Effect of Storage Conditions on Phenolic Profiles and Antioxidant Activity of Litchi Pericarp. 2018 Molecules pmid:30200581
Wang J et al. Isorhamnetin prevents H2O2‑induced oxidative stress in human retinal pigment epithelial cells. 2018 Mol Med Rep pmid:29115489
Ahmad N et al. Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia. 2018 Artif Cells Nanomed Biotechnol pmid:28604104
Woźniak D et al. Comparison of Polyphenol Profile and Antimutagenic and Antioxidant Activities in Two Species Used as Source of Solidaginis herba - Goldenrod. 2018 Chem. Biodivers. pmid:29537689
Liu ZH et al. Synergistic effects and related bioactive mechanisms of Potentilla fruticosa Linn. leaves combined with green tea polyphenols studied with microbial test system (MTS). 2018 Nat. Prod. Res. pmid:28602107
Yang T et al. Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats. 2018 Mol Med Rep pmid:30015887
Ojo OA et al. Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill bark. 2018 J Basic Clin Physiol Pharmacol pmid:29381472
Slámová K et al. "Sweet Flavonoids": Glycosidase-Catalyzed Modifications. 2018 Int J Mol Sci pmid:30037103