| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with quercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with quercetin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with quercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu Y et al. | Light quality affects flavonoid production and related gene expression in Cyclocarya paliurus. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29334625 |
| Wang D et al. | Quercetin attenuates domoic acid-induced cognitive deficits in mice. | 2018 | Nutr Neurosci | pmid:28277184 |
| Kinger M et al. | Some Important Dietary Polyphenolic Compounds: An Anti-inflammatory and Immunoregulatory Perspective. | 2018 | Mini Rev Med Chem | pmid:28183265 |
| Huang ZQ et al. | Antioxidant Activity and Hepatoprotective Potential of Quercetin 7-Rhamnoside In Vitro and In Vivo. | 2018 | Molecules | pmid:29772655 |
| Omar SH et al. | Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.). | 2018 | Fitoterapia | pmid:29772299 |
| Qi F et al. | Anti-inflammatory effects of isorhamnetin on LPS-stimulated human gingival fibroblasts by activating Nrf2 signaling pathway. | 2018 | Microb. Pathog. | pmid:29704670 |
| Pilařová V et al. | Simultaneous determination of quercetin and its metabolites in rat plasma by using ultra-high performance liquid chromatography tandem mass spectrometry. | 2018 | Talanta | pmid:29759252 |
| Lu X et al. | Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice. | 2018 | Biomed. Pharmacother. | pmid:29684859 |
| Liu FC et al. | Arthroprotective Effects of Cf-02 Sharing Structural Similarity with Quercetin. | 2018 | Int J Mol Sci | pmid:29757957 |
| Kumar M et al. | N-desmethyl tamoxifen and quercetin-loaded multiwalled CNTs: A synergistic approach to overcome MDR in cancer cells. | 2018 | Mater Sci Eng C Mater Biol Appl | pmid:29752099 |
| Negi S et al. | Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. | 2018 | Toxicol In Vitro | pmid:29933105 |
| Liu J et al. | Preparation, characterization, digestibility and antioxidant activity of quercetin grafted Cynanchum auriculatum starch. | 2018 | Int. J. Biol. Macromol. | pmid:29572138 |
| Boadi WY and Lo A | Effects of Quercetin, Kaempferol, and Exogenous Glutathione on Phospho- and Total-AKT in 3T3-L1 Preadipocytes. | 2018 | J Diet Suppl | pmid:29345961 |
| Ma YK et al. | Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media. | 2018 | Int. J. Mol. Med. | pmid:29568908 |
| Donno D et al. | New Findings in Prunus padus L. Fruits as a Source of Natural Compounds: Characterization of Metabolite Profiles and Preliminary Evaluation of Antioxidant Activity. | 2018 | Molecules | pmid:29565317 |
| Park DJ et al. | Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model. | 2018 | J. Vet. Med. Sci. | pmid:29563391 |
| Tsunekawa R et al. | Synthesis of fisetin and 2',4',6'-trihydroxydihyrochalcone 4'-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation. | 2018 | Biosci. Biotechnol. Biochem. | pmid:29699439 |
| Forney LA et al. | Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner. | 2018 | Int J Mol Sci | pmid:29562620 |
| Li XM et al. | Quercetin and aconitine synergistically induces the human cervical carcinoma HeLa cell apoptosis via endoplasmic reticulum (ER) stress pathway. | 2018 | PLoS ONE | pmid:29324796 |
| Hwang HV et al. | Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. | 2018 | PLoS ONE | pmid:29315311 |
| Liaquat L et al. | Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats. | 2018 | Life Sci. | pmid:29287782 |
| Ting Y et al. | Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on Body Composition, Serum Lipid Profile, and Gene Expression. | 2018 | J. Agric. Food Chem. | pmid:29249156 |
| Liu Y et al. | Geographic Variation in the Chemical Composition and Antioxidant Properties of Phenolic Compounds from (Batal) Iljinskaja Leaves. | 2018 | Molecules | pmid:30249997 |
| Naseer Z et al. | Dietary quercetin maintains the semen quality in rabbits under summer heat stress. | 2018 | Theriogenology | pmid:30243139 |
| Fang J et al. | Quercetin and doxorubicin co-delivery using mesoporous silica nanoparticles enhance the efficacy of gastric carcinoma chemotherapy. | 2018 | Int J Nanomedicine | pmid:30233175 |
| Zhang M et al. | Neurodevelopmental toxicity induced by maternal PM2.5 exposure and protective effects of quercetin and Vitamin C. | 2018 | Chemosphere | pmid:30218877 |
| Zhang C et al. | Mechanistic insights into the inhibition of quercetin on xanthine oxidase. | 2018 | Int. J. Biol. Macromol. | pmid:29410028 |
| Kim YA et al. | Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant in Human Keratinocytes. | 2018 | Molecules | pmid:30216992 |
| Ajaghaku DL et al. | Upregulation of CD T-Lymphocytes by Isomeric Mixture of Quercetin-3-O-Rutinoside and Quercetin-3-O-Robinobioside Isolated from Millettia aboensis. | 2018 | Immunol. Invest. | pmid:29405788 |
| Rahvar M et al. | Effect of quercetin on the brain-derived neurotrophic factor gene expression in the rat brain. | 2018 | Bratisl Lek Listy | pmid:29405727 |
| Gao Q et al. | A red-emitting indolium fluorescence probe for membranes - flavonoids interactions. | 2018 | Luminescence | pmid:29405584 |
| Sheth U and Bahadur A | In-vitro evaluation of cytotoxic and antioxidant properties of drugs solubilized in EO-PO star block copolymer micelles. | 2018 | Colloids Surf B Biointerfaces | pmid:30056295 |
| Borse SP et al. | Potential synergistic effects of quercetin with other phytoconstituents of Costus pictus (insulin plant) extract in the control of hyperglycemia and prevention of NSAID-induced gastroenteropathy in diabetic rats. | 2018 | Food Chem. Toxicol. | pmid:30055312 |
| Samad N et al. | Quercetin protects against stress-induced anxiety- and depression-like behavior and improves memory in male mice. | 2018 | Physiol Res | pmid:30044120 |
| Rauf A et al. | Anticancer potential of quercetin: A comprehensive review. | 2018 | Phytother Res | pmid:30039547 |
| Sharma A et al. | Therapeutic charm of quercetin and its derivatives: a review of research and patents. | 2018 | Pharm Pat Anal | pmid:29227203 |
| Nambooppha B et al. | Quercetin manipulates the expression of genes involved in the reactive oxygen species (ROS) process in chicken heterophils. | 2018 | J. Vet. Med. Sci. | pmid:29877311 |
| Lin J et al. | Steamed bread enriched with quercetin as an antiglycative food product: its quality attributes and antioxidant properties. | 2018 | Food Funct | pmid:29872802 |
| Qiu L et al. | Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats. | 2018 | Biomed. Pharmacother. | pmid:29864946 |
| Ventura-MartÃnez R et al. | Spasmolytic effect of aqueous extract of Tagetes erecta L. flowers is mediated through calcium channel blockade on the guinea-pig ileum. | 2018 | Biomed. Pharmacother. | pmid:29864942 |
| Selvarajan S et al. | Fabrication of g-CN/NiO heterostructured nanocomposite modified glassy carbon electrode for quercetin biosensor. | 2018 | Ultrason Sonochem | pmid:29137797 |
| Yuan TY et al. | Vasorelaxant effect of quercetin on cerebral basilar artery in vitro and the underlying mechanisms study. | 2018 | J Asian Nat Prod Res | pmid:29693418 |
| Kale A et al. | Neuroprotective effects of Quercetin on radiation-induced brain injury in rats. | 2018 | J. Radiat. Res. | pmid:29688418 |
| Alves MC et al. | Taxifolin: Evaluation Through Ex vivo Permeations on Human Skin and Porcine Vaginal Mucosa. | 2018 | Curr Drug Deliv | pmid:29336264 |
| Wei X et al. | Quercetin exerts cardiovascular protective effects in LPS-induced dysfunction in vivo by regulating inflammatory cytokine expression, NF-κB phosphorylation, and caspase activity. | 2018 | Mol. Cell. Biochem. | pmid:29322353 |
| Lu Q et al. | Antidiabetic cataract effects of GbE, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway. | 2018 | Acta Biochim. Pol. | pmid:29281744 |
| Shaalan YM et al. | Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma. | 2018 | Nat. Prod. Res. | pmid:28817968 |
| de Oliveira Pedro R et al. | Synergistic effect of quercetin and pH-responsive DEAE-chitosan carriers as drug delivery system for breast cancer treatment. | 2018 | Int. J. Biol. Macromol. | pmid:28807690 |
| Khaligh F et al. | Effects of in ovo injection of chrysin, quercetin and ascorbic acid on hatchability, somatic attributes, hepatic oxidative status and early post-hatch performance of broiler chicks. | 2018 | J Anim Physiol Anim Nutr (Berl) | pmid:28636279 |
| Slámová K et al. | "Sweet Flavonoids": Glycosidase-Catalyzed Modifications. | 2018 | Int J Mol Sci | pmid:30037103 |