quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Lead Poisoning D007855 4 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Per page 10 20 50 100 | Total 205

PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Authors Title Published Journal PubMed Link
Tutino V et al. Cannabinoid Receptor-1 Up-regulation in Azoxymethane (AOM)-treated Mice After Dietary Treatment with Quercetin. 2018 Anticancer Res. pmid:30061214
Jia L et al. Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction. 2018 Life Sci. pmid:30025823
Wu TC et al. Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells. 2018 Chem. Biol. Interact. pmid:30016632
Lu N et al. Generation of a Diligand Complex of Bovine Serum Albumin with Quercetin and Carbon Nanotubes for the Protection of Bioactive Quercetin and Reduction of Cytotoxicity. 2018 J. Agric. Food Chem. pmid:30016096
Arbain NH et al. Optimization of Quercetin loaded Palm Oil Ester Based Nanoemulsion Formulation for Pulmonary Delivery. 2018 J Oleo Sci pmid:30012897
Chirumbolo S and Bjørklund G Quercetin in collagen-induced arthritis. Some comments. 2018 Int. Immunopharmacol. pmid:29970297
Habtemariam S and Belai A Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin. 2018 Mini Rev Med Chem pmid:28117024
Kapur B et al. Health and taste related compounds in strawberries under various irrigation regimes and bio-stimulant application. 2018 Food Chem pmid:29784329
Váradyová Z et al. Ovicidal and larvicidal activity of extracts from medicinal-plants against Haemonchus contortus. 2018 Exp. Parasitol. pmid:30389531
Lu J et al. Quercetin Inhibits the Migration and Invasion of HCCLM3 Cells by Suppressing the Expression of p-Akt1, Matrix Metalloproteinase (MMP) MMP-2, and MMP-9. 2018 Med. Sci. Monit. pmid:29701200
Aghapour F et al. Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines. 2018 Biochem. Biophys. Res. Commun. pmid:29698680
Sun S et al. Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway. 2018 Gene pmid:29678660
Suke SG et al. Ameliorative effect of nanoencapsulated flavonoid against chlorpyrifos-induced hepatic oxidative damage and immunotoxicity in Wistar rats. 2018 J. Biochem. Mol. Toxicol. pmid:29667781
Zhu Y et al. Molecular Cloning and Functional Characterization of a Dihydroflavonol 4-Reductase from Vitis bellula. 2018 Molecules pmid:29642567
Jeong DW et al. Deastringent Peel Extracts of Persimmon ( Thunb. cv. Cheongdo-Bansi) Protect Neuronal PC-12 and SH-SY5Y Cells against Oxidative Stress. 2018 J. Microbiol. Biotechnol. pmid:29975999
de Oliveira TS et al. Neuroprotective Effect of Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties. 2018 Oxid Med Cell Longev pmid:30420910
Song YY et al. Phenolic Compounds from Belamcanda chinensis Seeds. 2018 Molecules pmid:29510567
Murota K et al. Flavonoid metabolism: the interaction of metabolites and gut microbiota. 2018 Biosci. Biotechnol. Biochem. pmid:29504827
Kim MK et al. In Vitro Synergism and Anti-biofilm Activity of Quercetin-Pivaloxymethyl Conjugate against Staphylococcus aureus and Enterococcus Species. 2018 Chem. Pharm. Bull. pmid:30381653
Silva W et al. Double emulsions as potential fat replacers with gallic acid and quercetin nanoemulsions in the aqueous phases. 2018 Food Chem pmid:29502846
Naeimi R et al. Querectin improves myelin repair of optic chiasm in lyolecithin-induced focal demyelination model. 2018 Biomed. Pharmacother. pmid:29501770
Ozdemir Olgun FA et al. A novel cerium oxide nanoparticles-based colorimetric sensor using tetramethyl benzidine reagent for antioxidant activity assay. 2018 Talanta pmid:29501192
Hidaka M et al. Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1. 2018 Biochem. Biophys. Res. Commun. pmid:29608894
Hayamizu K et al. Cardiotonic actions of quercetin and its metabolite tamarixetin through a digitalis-like enhancement of Ca transients. 2018 Arch. Biochem. Biophys. pmid:29169900
Pradhan AB et al. Role of hydroxyl groups in the B-ring of flavonoids in stabilization of the Hoogsteen paired third strand of Poly(U).Poly(A)*Poly(U) triplex. 2018 Arch. Biochem. Biophys. pmid:29162368
Zhou J et al. Determination of isoquercitrin in rat plasma by high performance liquid chromatography coupled with a novel synergistic cloud point extraction. 2018 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29153998
Mazhar M et al. Quercetin modulates iron homeostasis and iNOS expression of splenic macrophages in a rat model of iron deficiency anemia. 2018 Chin J Nat Med pmid:30197123
Song JE et al. Quercetin Inlaid Silk Fibroin/Hydroxyapatite Scaffold Promotes Enhanced Osteogenesis. 2018 ACS Appl Mater Interfaces pmid:30188112
Wen P et al. Preparation and Characterization of Electrospun Colon-Specific Delivery System for Quercetin and Its Antiproliferative Effect on Cancer Cells. 2018 J. Agric. Food Chem. pmid:30148954
Akintunde JK et al. Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey inhibits oxidative damage and econucleotidase followed by increased cellular ATP in testicular cells of rats exposed to metropolitan polluted river water. 2018 J Basic Clin Physiol Pharmacol pmid:29360627
Erdogan S et al. Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway. 2018 Biomed. Pharmacother. pmid:30142541
Wang R et al. Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM). 2018 Med. Sci. Monit. pmid:29353288
Sunoqrot S et al. Facile synthesis and surface modification of bioinspired nanoparticles from quercetin for drug delivery. 2018 Biomater Sci pmid:30140818
Hussain J et al. New robust sensitive fluorescence spectroscopy coupled with PLSR for estimation of quercetin in Ziziphus mucronata and Ziziphus sativa. 2018 Spectrochim Acta A Mol Biomol Spectrosc pmid:29331816
Jadán-Piedra C et al. In vitro evaluation of dietary compounds to reduce mercury bioavailability. 2018 Food Chem pmid:29329865
Lu Z et al. Preparation and in vitro and in vivo evaluation of quercetin-loaded mixed micelles for oral delivery. 2018 Biosci. Biotechnol. Biochem. pmid:29327653
Xiao Y and Lee IS Microbial transformation of quercetin and its prenylated derivatives. 2018 Nat. Prod. Res. pmid:28826260
Liu S et al. Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation. 2018 Food Funct pmid:29993075
Yang H et al. Quercetin Treatment Improves Renal Function and Protects the Kidney in a Rat Model of Adenine-Induced Chronic Kidney Disease. 2018 Med. Sci. Monit. pmid:29987270
Farazuddin M et al. Quercetin prevents rhinovirus-induced progression of lung disease in mice with COPD phenotype. 2018 PLoS ONE pmid:29975735
Rastogi S and Haldar C Comparative effect of melatonin and quercetin in counteracting LPS induced oxidative stress in bone marrow mononuclear cells and spleen of Funambulus pennanti. 2018 Food Chem. Toxicol. pmid:29964085
Shen XY et al. Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells. 2018 Int. J. Mol. Med. pmid:29207020
Steinborn C et al. In Vitro Anti-inflammatory Effects of Equisetum arvense Are Not Solely Mediated by Silica. 2018 Planta Med. pmid:29202511
Braun JBS et al. Pretreatment with quercetin prevents changes in lymphocytes E-NTPDase/E-ADA activities and cytokines secretion in hyperlipidemic rats. 2018 Mol. Cell. Biochem. pmid:29188537
Younas M et al. Differential accumulation of silymarin induced by exposure of Silybum marianum L. callus cultures to several spectres of monochromatic lights. 2018 J. Photochem. Photobiol. B, Biol. pmid:29803074
Sherif IO The effect of natural antioxidants in cyclophosphamide-induced hepatotoxicity: Role of Nrf2/HO-1 pathway. 2018 Int. Immunopharmacol. pmid:29800788
Yin C et al. Phytochemical analysis and antibacterial activity of Gentiana macrophylla extract against bacteria isolated from burn wound infections. 2018 Microb. Pathog. pmid:29111322
Mandrone M et al. Identification of a Collagenase-Inhibiting Flavonoid from Alchemilla vulgaris Using NMR-Based Metabolomics. 2018 Planta Med. pmid:29797306
Escher GB et al. Chemical study, antioxidant, anti-hypertensive, and cytotoxic/cytoprotective activities of Centaurea cyanus L. petals aqueous extract. 2018 Food Chem. Toxicol. pmid:29787846
Crascì L et al. Anti-degenerative effect of Apigenin, Luteolin and Quercetin on human keratinocyte and chondrocyte cultures: SAR evaluation. 2018 Drug Res (Stuttg) pmid:29108086
Pawlikowska-Pawlega B et al. Interaction of a quercetin derivative - lensoside Aβ with liposomal membranes. 2018 Biochim Biophys Acta Biomembr pmid:29106971
Shu B et al. Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-κB signaling suppression. 2018 Cell. Signal. pmid:29080804
Wang XF et al. Protective Effect of Quercetin in LPS-Induced Murine Acute Lung Injury Mediated by cAMP-Epac Pathway. 2018 Inflammation pmid:29569077
Wang L et al. Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers. 2018 J Microencapsul pmid:29624090
Guazelli CFS et al. Quercetin attenuates zymosan-induced arthritis in mice. 2018 Biomed. Pharmacother. pmid:29554596
Mendel M et al. Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility-in vitro study. 2018 J. Vet. Pharmacol. Ther. pmid:28913883
Palle S and Neerati P Quercetin nanoparticles alter pharmacokinetics of bromocriptine, reflecting its enhanced inhibitory action on liver and intestinal CYP 3A enzymes in rats. 2018 Xenobiotica pmid:28990837
Wang Y et al. Quercetin reduces neural tissue damage and promotes astrocyte activation after spinal cord injury in rats. 2018 J. Cell. Biochem. pmid:28865131
Jan S et al. Effect of environmental variables on phytonutrients of Origanum vulgare L. in the sub-humid region of the northwestern Himalayas. 2018 Environ Monit Assess pmid:30187208
Cerulli A et al. Phenolics from Castanea sativa leaves and their effects on UVB-induced damage. 2018 Nat. Prod. Res. pmid:28539059
Zhang XF et al. UPLC-MS/MS analysis for antioxidant components of Lycii Fructus based on spectrum-effect relationship. 2018 Talanta pmid:29332828
Zahid K et al. Phytochemical screening, antioxidant activity, total phenolic and total flavonoid contents of seven local varieties of Rosa indica L. 2018 Nat. Prod. Res. pmid:28539055
Bhattacharya D et al. Antibacterial activity of polyphenolic fraction of Kombucha against Vibrio cholerae: targeting cell membrane. 2018 Lett. Appl. Microbiol. pmid:29193174
Olennikov DN et al. Isorhamnetin and Quercetin Derivatives as Anti-Acetylcholinesterase Principles of Marigold (Calendula officinalis) Flowers and Preparations. 2017 Int J Mol Sci pmid:28767066
Liu Y et al. Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer. 2017 Apoptosis pmid:28188387
Wei L et al. A kinetic study of bitter taste receptor sensing using immobilized porcine taste bud tissues. 2017 Biosens Bioelectron pmid:28187302
Cho CH et al. Sea Buckthorn ( L.) Leaf Extracts Protect Neuronal PC-12 Cells from Oxidative Stress. 2017 J. Microbiol. Biotechnol. pmid:28535611
Yadav S et al. α-l-rhamnosidase selective for rutin to isoquercitrin transformation from Penicillium griseoroseum MTCC-9224. 2017 Bioorg. Chem. pmid:28110962
Baral S et al. Quercetin-3-O-glucuronide promotes the proliferation and migration of neural stem cells. 2017 Neurobiol. Aging pmid:28110104
Khorsandi L et al. Beneficial effects of quercetin on titanium dioxide nanoparticles induced spermatogenesis defects in mice. 2017 Environ Sci Pollut Res Int pmid:28035607
Mahdavimehr M et al. Inhibition of HEWL fibril formation by taxifolin: Mechanism of action. 2017 PLoS ONE pmid:29131828
Britti D et al. A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models. 2017 BMC Vet. Res. pmid:28768536
Tong F et al. Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium. 2017 Int J Nanomedicine pmid:29123394
Sahebkar A Effects of quercetin supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials. 2017 Crit Rev Food Sci Nutr pmid:25897620
Vedakumari WS et al. Quercetin impregnated chitosan-fibrin composite scaffolds as potential wound dressing materials - Fabrication, characterization and in vivo analysis. 2017 Eur J Pharm Sci pmid:27864063
Bhuiya S et al. Inhibitory effects of the dietary flavonoid quercetin on the enzyme activity of zinc(II)-dependent yeast alcohol dehydrogenase: Spectroscopic and molecular docking studies. 2017 Int. J. Biol. Macromol. pmid:27864057
Li X et al. The mechanism of (+) taxifolin's protective antioxidant effect for •OH-treated bone marrow-derived mesenchymal stem cells. 2017 Cell. Mol. Biol. Lett. pmid:29299033
Anantaworasakul P et al. Biological activities and antibacterial biomarker of Sesbania grandiflora bark extract. 2017 Drug Discov Ther pmid:28458298
Thakur S et al. Effect of Extrusion on Physicochemical Properties, Digestibility, and Phenolic Profiles of Grit Fractions Obtained from Dry Milling of Normal and Waxy Corn. 2017 J. Food Sci. pmid:28369955
Fang Y et al. Study of Structure and Permeability Relationship of Flavonoids in Caco-2 Cells. 2017 Nutrients pmid:29186068
Mandrone M et al. Phytochemical profile and α-glucosidase inhibitory activity of Sardinian Hypericum scruglii and Hypericum hircinum. 2017 Fitoterapia pmid:28647480
Wu L et al. Hepatoprotective effect of quercetin via TRAF6/JNK pathway in acute hepatitis. 2017 Biomed. Pharmacother. pmid:29174851
Yang J et al. Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction. 2017 Nutrients pmid:28644409
Ramasamy T et al. Engineering of cell microenvironment-responsive polypeptide nanovehicle co-encapsulating a synergistic combination of small molecules for effective chemotherapy in solid tumors. 2017 Acta Biomater pmid:27794477
Aluani D et al. Еvaluation of biocompatibility and antioxidant efficiency of chitosan-alginate nanoparticles loaded with quercetin. 2017 Int. J. Biol. Macromol. pmid:28536020
Valentová K et al. Chemoenzymatic Preparation and Biophysical Properties of Sulfated Quercetin Metabolites. 2017 Int J Mol Sci pmid:29068411
Navarro M and Morales FJ Effect of hydroxytyrosol and olive leaf extract on 1,2-dicarbonyl compounds, hydroxymethylfurfural and advanced glycation endproducts in a biscuit model. 2017 Food Chem pmid:27664677
Kocahan S et al. Protective Effect of Quercetin Against Oxidative Stress-induced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue. 2017 Iran J Kidney Dis pmid:28270644
Chen MM et al. Quercetin promotes motor and sensory function recovery following sciatic nerve-crush injury in C57BL/6J mice. 2017 J. Nutr. Biochem. pmid:28458138
Qian Y et al. Metabolites of flavonoid compounds preserve indices of endothelial cell nitric oxide bioavailability under glucotoxic conditions. 2017 Nutr Diabetes pmid:28892039
Strugała P et al. Bioactivity In Vitro of Quercetin Glycoside Obtained in Beauveria bassiana Culture and Its Interaction with Liposome Membranes. 2017 Molecules pmid:28891998
Yamauchi K et al. Structure-Activity Relationships of Methylquercetin on Anti-migration and Anti-proliferation Activity in B16 Melanoma Cells. 2017 Anticancer Res. pmid:28373417
Ranjbar Banforuzi S and Hadjmohammadi MR Two-phase hollow fiber-liquid microextraction based on reverse micelle for the determination of quercetin in human plasma and vegetables samples. 2017 Talanta pmid:28602186
Zhang S et al. Quercetin from Polygonum capitatum Protects against Gastric Inflammation and Apoptosis Associated with Helicobacter pylori Infection by Affecting the Levels of p38MAPK, BCL-2 and BAX. 2017 Molecules pmid:28481232
Sassi N et al. Potential anti-cancer activity of 7-O-pentyl quercetin: Efficient, membrane-targeted kinase inhibition and pro-oxidant effect. 2017 Pharmacol. Res. pmid:28728925
Liu XF et al. Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress. 2017 Aging Cell pmid:28722304
Du LY et al. Metabolic profiles of the Flos Abelmoschus manihot extract by intestinal bacteria from the normal and CKD model rats based on UPLC-Q-TOF/MS. 2017 Biomed. Chromatogr. pmid:27451133
Yuan YG et al. Effects of Silver Nanoparticles on Multiple Drug-Resistant Strains of Staphylococcus aureus and Pseudomonas aeruginosa from Mastitis-Infected Goats: An Alternative Approach for Antimicrobial Therapy. 2017 Int J Mol Sci pmid:28272303
Choi J et al. Telodendrimers for Physical Encapsulation and Covalent Linking of Individual or Combined Therapeutics. 2017 Mol. Pharm. pmid:28520445
Lv X et al. Preparation of Essential Oil-Based Microemulsions for Improving the Solubility, pH Stability, Photostability, and Skin Permeation of Quercetin. 2017 AAPS PharmSciTech pmid:28516411