| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with quercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with quercetin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with quercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bustos AS et al. | Interaction Between Phenolic Compounds and Lipase: The Influence of Solubility and Presence of Particles in the IC Value. | 2018 | J. Food Sci. | pmid:30020550 |
| Khlupova ME et al. | Laccase-Catalyzed Heterocoupling of Dihydroquercetin and p-Aminobenzoic Acid: Effect of the Reaction Product on Cultured Cells. | 2018 | Biochemistry Mosc. | pmid:30208835 |
| Ashraf AHMZ et al. | Differential Mechanism of Action of 3,4',7-O-trimethylquercetin in Three Types of Ovarian Cancer Cells. | 2018 | Anticancer Res. | pmid:30194160 |
| Rubio V et al. | Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells. | 2018 | Chem. Biol. Interact. | pmid:30171828 |
| Jang SA et al. | Hyperoside suppresses tumor necrosis factor α-mediated vascular inflammatory responses by downregulating mitogen-activated protein kinases and nuclear factor-κB signaling. | 2018 | Chem. Biol. Interact. | pmid:30125551 |
| Chen X et al. | Gastrointestinal Fate of Fluid and Gelled Nutraceutical Emulsions: Impact on Proteolysis, Lipolysis, and Quercetin Bioaccessibility. | 2018 | J. Agric. Food Chem. | pmid:30102529 |
| Niu X et al. | Three-dimensional reduced graphene oxide aerogel modified electrode for the sensitive quercetin sensing and its application. | 2018 | Mater Sci Eng C Mater Biol Appl | pmid:29752093 |
| Chen Z et al. | Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells. | 2018 | Phytomedicine | pmid:29747752 |
| Å ola I et al. | Comparative Analysis of Native Crocus Taxa as a Great Source of Flavonoids with High Antioxidant Activity. | 2018 | Plant Foods Hum Nutr | pmid:29860648 |
| Jin UH et al. | Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids. | 2018 | Toxicol. Sci. | pmid:29584932 |
| Hatahet T et al. | Liposomes, lipid nanocapsules and smartCrystals®: A comparative study for an effective quercetin delivery to the skin. | 2018 | Int J Pharm | pmid:29549014 |
| Hwang DS et al. | Effects of Rhei Undulati Rhizoma on lipopolysaccharide-induced neuroinflammation in vitro and in vivo. | 2018 | Environ. Toxicol. | pmid:28984087 |
| Ma C et al. | Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway. | 2018 | Mol Med Rep | pmid:29532872 |
| Sarangowa O et al. | Botanical origin of Mei-gui Hua in Chinese markets. | 2018 | J Nat Med | pmid:29188415 |
| Giuliani C et al. | Localization of phenolic compounds in the fruits of Silybum marianum characterized by different silymarin chemotype and altered colour. | 2018 | Fitoterapia | pmid:30213759 |
| Takabe W et al. | Identification of Antiglycative Compounds in Japanese Red Water Pepper (Red Leaf Variant of the Sprout). | 2018 | Molecules | pmid:30208642 |
| Wein S et al. | Bioavailability of Quercetin from Onion Extracts after Intraruminal Application in Cows. | 2018 | J. Agric. Food Chem. | pmid:30207714 |
| Ge F et al. | Taxifolin suppresses rat and human testicular androgen biosynthetic enzymes. | 2018 | Fitoterapia | pmid:29402482 |
| Li JP et al. | Hyperoside and let-7a-5p synergistically inhibits lung cancer cell proliferation via inducing G1/S phase arrest. | 2018 | Gene | pmid:30201337 |
| Ding Y et al. | Quercetin suppresses the chymotrypsin-like activity of proteasome via inhibition of MEK1/ERK1/2 signaling pathway in hepatocellular carcinoma HepG2 cells. | 2018 | Can. J. Physiol. Pharmacol. | pmid:29394494 |
| Ginex T et al. | Computational Study of the Aza-Michael Addition of the Flavonoid (+)-Taxifolin in the Inhibition of β-Amyloid Fibril Aggregation. | 2018 | Chemistry | pmid:29384229 |
| Kim Y and Chang KO | Protein disulfide isomerases as potential therapeutic targets for influenza A and B viruses. | 2018 | Virus Res. | pmid:29382552 |
| Hamilton KE et al. | Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1. | 2018 | Biochimie | pmid:29857184 |
| North MK et al. | The effects of quercetin supplementation on New Zealand White grower rabbit carcass and meat quality - A short communication. | 2018 | Meat Sci. | pmid:30031202 |
| Kruszewski M et al. | The effect of quercetin on the electrical properties of model lipid membranes and human glioblastoma cells. | 2018 | Bioelectrochemistry | pmid:30029034 |
| Song JY et al. | Quercetin Shows the Pharmacological Activity to Simultaneously Downregulate the Inflammatory and Fibrotic Responses to Tissue Injury in Association with its Ability to Target Multi-Kinases. | 2018 | Pharmacology | pmid:30016781 |
| Alugoju P et al. | Quercetin Protects Yeast Saccharomyces cerevisiae pep4 Mutant from Oxidative and Apoptotic Stress and Extends Chronological Lifespan. | 2018 | Curr. Microbiol. | pmid:29224051 |
| Zhu Y et al. | Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model. | 2018 | Food Funct | pmid:29215110 |
| Lee KM et al. | Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed human keratinocytes. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29857000 |
| Ramos-Pineda AM et al. | Effect of the addition of mannoproteins on the interaction between wine flavonols and salivary proteins. | 2018 | Food Chem | pmid:29853369 |
| Wang L et al. | Fermentation and complex enzyme hydrolysis for improving the total soluble phenolic contents, flavonoid aglycones contents and bio-activities of guava leaves tea. | 2018 | Food Chem | pmid:29853365 |
| Abdullah AA et al. | The performance of cathodically pretreated boron-doped diamond electrode in cationic surfactant media for enhancing the adsorptive stripping voltammetric determination of catechol-containing flavonoid quercetin in apple juice. | 2018 | Talanta | pmid:29853029 |
| Singh A et al. | Curcumin loaded chitin-glucan quercetin conjugate: Synthesis, characterization, antioxidant, in vitro release study, and anticancer activity. | 2018 | Int. J. Biol. Macromol. | pmid:29128588 |
| Lei CS et al. | Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies. | 2018 | J. Nutr. Biochem. | pmid:29125991 |
| He K et al. | LPS ameliorates renal ischemia/reperfusion injury via Hsp27 up-regulation. | 2018 | Int Urol Nephrol | pmid:29124510 |
| Kellett ME et al. | Modification of the cellular antioxidant activity (CAA) assay to study phenolic antioxidants in a Caco-2 cell line. | 2018 | Food Chem | pmid:29120793 |
| Lin M et al. | Quercetin improves postpartum hypogalactia in milk-deficient mice via stimulating prolactin production in pituitary gland. | 2018 | Phytother Res | pmid:29671937 |
| Seo S et al. | Prediction of GPCR-Ligand Binding Using Machine Learning Algorithms. | 2018 | Comput Math Methods Med | pmid:29666662 |
| Jayachandran M et al. | Isoquercetin ameliorates hyperglycemia and regulates key enzymes of glucose metabolism via insulin signaling pathway in streptozotocin-induced diabetic rats. | 2018 | Eur. J. Pharmacol. | pmid:29665363 |
| Hatware KV et al. | Evidence for gastroprotective, anti-inflammatory and antioxidant potential of methanolic extract of Cordia dichotoma leaves on indomethacin and stress induced gastric lesions in Wistar rats. | 2018 | Biomed. Pharmacother. | pmid:29660650 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| Dresch RR et al. | Potential use of secondary products of the agri-food industry for topical formulations and comparative analysis of antioxidant activity of grape leaf polyphenols. | 2018 | Nat. Prod. Res. | pmid:28403634 |
| Seong JS et al. | Surfactant-stable and pH-sensitive liposomes coated with N-succinyl-chitosan and chitooligosaccharide for delivery of quercetin. | 2018 | Carbohydr Polym | pmid:29254020 |
| de Lacerda Neto LJ et al. | Modulation of antibiotic activity by the hydroalcoholic extract from leaves of Caryocar coriaceum WITTM. | 2018 | Nat. Prod. Res. | pmid:28391717 |
| Chatziathanasiadou MV et al. | Amplifying and broadening the cytotoxic profile of quercetin in cancer cell lines through bioconjugation. | 2018 | Amino Acids | pmid:29185031 |
| Bonechi C et al. | Protective effect of quercetin and rutin encapsulated liposomes on induced oxidative stress. | 2018 | Biophys. Chem. | pmid:29174505 |
| Shalini D et al. | Effect of size and shape on toxicity of zinc oxide (ZnO) nanomaterials in human peripheral blood lymphocytes. | 2018 | Toxicol. Mech. Methods | pmid:28805101 |
| Zhao TT et al. | Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes. | 2018 | Gene | pmid:29730426 |
| Ahmad N et al. | Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia. | 2018 | Artif Cells Nanomed Biotechnol | pmid:28604104 |
| Woźniak D et al. | Comparison of Polyphenol Profile and Antimutagenic and Antioxidant Activities in Two Species Used as Source of Solidaginis herba - Goldenrod. | 2018 | Chem. Biodivers. | pmid:29537689 |