quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Lead Poisoning D007855 4 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Per page 10 20 50 100 | Total 205

PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Authors Title Published Journal PubMed Link
Kameníková M et al. Influence of quercetin on the interaction of gliclazide with human serum albumin - spectroscopic and docking approaches. 2017 Luminescence pmid:28513070
Natesan S et al. Co-encapsulated resveratrol and quercetin in chitosan and peg modified chitosan nanoparticles: For efficient intra ocular pressure reduction. 2017 Int. J. Biol. Macromol. pmid:28472691
Lin W et al. Quercetin protects against atherosclerosis by inhibiting dendritic cell activation. 2017 Mol Nutr Food Res pmid:28457022
Han Y et al. Pentamethylquercetin induces adipose browning and exerts beneficial effects in 3T3-L1 adipocytes and high-fat diet-fed mice. 2017 Sci Rep pmid:28442748
Zou L et al. The protective effect of hyperoside on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2. 2017 Exp. Toxicol. Pathol. pmid:28434817
Qi L et al. Metabonomic analysis of the protective effect of quercetin on the toxicity induced by mixture of organophosphate pesticides in rat urine. 2017 Hum Exp Toxicol pmid:27251765
Trendafilova I et al. Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier. 2017 Mater Sci Eng C Mater Biol Appl pmid:28183610
Alzaharna M et al. Taxifolin synergizes Andrographolide-induced cell death by attenuation of autophagy and augmentation of caspase dependent and independent cell death in HeLa cells. 2017 PLoS ONE pmid:28182713
Zhang JL et al. Quercetin, a natural product supplement, impairs mitochondrial bioenergetics and locomotor behavior in larval zebrafish (Danio rerio). 2017 Toxicol. Appl. Pharmacol. pmid:28450151
Shahzad H et al. Quercetin interferes with the fluid volume and receptivity development of the uterus in rats during the peri-implantation period. 2017 Reprod. Toxicol. pmid:28431985
Burak C et al. Effects of the flavonol quercetin and α-linolenic acid on n-3 PUFA status in metabolically healthy men and women: a randomised, double-blinded, placebo-controlled, crossover trial. 2017 Br. J. Nutr. pmid:28366181
Anusuya S and Gromiha MM Quercetin derivatives as non-nucleoside inhibitors for dengue polymerase: molecular docking, molecular dynamics simulation, and binding free energy calculation. 2017 J. Biomol. Struct. Dyn. pmid:27608509
Schafer MJ et al. Cellular senescence: Implications for metabolic disease. 2017 Mol. Cell. Endocrinol. pmid:27591120
Ravichandiran V et al. Quercetin-Decorated Curcumin Liposome Design for Cancer Therapy: In-Vitro and In-Vivo Studies. 2017 Curr Drug Deliv pmid:27572089
Corina D et al. Physico-chemical and Biological Evaluation of Flavonols: Fisetin, Quercetin and Kaempferol Alone and Incorporated in beta Cyclodextrins. 2017 Anticancer Agents Med Chem pmid:27338298
Ye P et al. Hyperoside attenuates OVA-induced allergic airway inflammation by activating Nrf2. 2017 Int. Immunopharmacol. pmid:28107754
Maurya AK and Vinayak M Quercetin Attenuates Cell Survival, Inflammation, and Angiogenesis via Modulation of AKT Signaling in Murine T-Cell Lymphoma. 2017 Nutr Cancer pmid:28107044
Kanazawa LK et al. Effects of acute and chronic quercetin administration on methylphenidate-induced hyperlocomotion and oxidative stress. 2017 Life Sci. pmid:28104366
Saenger T et al. Short-term biomarkers of apple consumption. 2017 Mol Nutr Food Res pmid:27794196
Lin X et al. Quercetin protects against heat stroke-induced myocardial injury in male rats: Antioxidative and antiinflammatory mechanisms. 2017 Chem. Biol. Interact. pmid:28104348
Omidian K et al. Polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation in an in vitro model of carcinogenesis. 2017 Food Chem. Toxicol. pmid:28533128
de Araújo GR et al. Baccharis trimera inhibits reactive oxygen species production through PKC and down-regulation p47 phosphorylation of NADPH oxidase in SK Hep-1 cells. 2017 Exp. Biol. Med. (Maywood) pmid:28103717
Hussain N et al. Two new prenylated flavonoids from the roots of Berberis thunbergii DC. 2017 Nat. Prod. Res. pmid:27788592
Roslan J et al. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. 2017 Biomed. Pharmacother. pmid:28027533
Mehta V et al. Quercetin ameliorates chronic unpredicted stress-mediated memory dysfunction in male Swiss albino mice by attenuating insulin resistance and elevating hippocampal GLUT4 levels independent of insulin receptor expression. 2017 Horm Behav pmid:28025042
Wang X et al. Metabolomic profiling of prostate cancer by matrix assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry imaging using Matrix Coating Assisted by an Electric Field (MCAEF). 2017 Biochim Biophys Acta Proteins Proteom pmid:28017863
Arumugam S et al. Effects of A.marina-Derived Isoquercitrin on TNF-Related Apoptosis-Inducing Ligand Receptor (TRAIL-R) Expression and Apoptosis Induction in Cervical Cancer Cells. 2017 Appl. Biochem. Biotechnol. pmid:28013431
Lozano-Pérez AA et al. Silk fibroin nanoparticles: Efficient vehicles for the natural antioxidant quercetin. 2017 Int J Pharm pmid:28012995
Ferramosca A et al. Antioxidant dietary approach in treatment of fatty liver: New insights and updates. 2017 World J. Gastroenterol. pmid:28694655
Kasai N et al. Effect of epigallocatechin-3-o-gallate and quercetin on the cryopreservation of cartilage tissue. 2017 Biosci. Biotechnol. Biochem. pmid:27648863
Cormier M et al. Influence of flavonols and quercetin derivative compounds on MA-10 Leydig cells steroidogenic genes expressions. 2017 Toxicol In Vitro pmid:28668616
Gawlik M et al. Manganese neurotoxicity and protective effects of resveratrol and quercetin in preclinical research. 2017 Pharmacol Rep pmid:28183032
Güney G et al. Effects of quercetin and surgicel for preventing adhesions after gynecological surgery: A rat uterine horn model. 2017 J. Obstet. Gynaecol. Res. pmid:27943594
Uzun Y et al. Sempervivum davisii: phytochemical composition, antioxidant and lipase-inhibitory activities. 2017 Pharm Biol pmid:27937045
Mutlur Krishnamoorthy R and Carani Venkatraman A Polyphenols activate energy sensing network in insulin resistant models. 2017 Chem. Biol. Interact. pmid:28751004
Mülek M et al. Distribution of Constituents and Metabolites of Maritime Pine Bark Extract (Pycnogenol) into Serum, Blood Cells, and Synovial Fluid of Patients with Severe Osteoarthritis: A Randomized Controlled Trial. 2017 Nutrients pmid:28452960
Jomova K et al. Protective role of quercetin against copper(II)-induced oxidative stress: A spectroscopic, theoretical and DNA damage study. 2017 Food Chem. Toxicol. pmid:29107026
Adaszyńska-Skwirzyńska M and Dzięcioł M Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland. 2017 Nat. Prod. Res. pmid:28449600
Xia Y et al. Homogenization-assisted cavitation hybrid rotation extraction and macroporous resin enrichment of dihydroquercetin from Larix gmelinii. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:29102245
Nishimura K et al. Effect of quercetin on cell protection via erythropoietin and cell injury of HepG2 cells. 2017 Arch. Biochem. Biophys. pmid:29080630
Iacopetta D et al. New insights for the use of quercetin analogs in cancer treatment. 2017 Future Med Chem pmid:29076772
Wang CP et al. Isoquercetin Ameliorates Cerebral Impairment in Focal Ischemia Through Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Effects in Primary Culture of Rat Hippocampal Neurons and Hippocampal CA1 Region of Rats. 2017 Mol. Neurobiol. pmid:26924319
Zhao H et al. A pair of taxifolin-3-O-arabinofuranoside isomers from Juglans regia L. 2017 Nat. Prod. Res. pmid:27852104
Teixeira TS et al. Biophysical characterization of the interaction between M2-1 protein of hRSV and quercetin. 2017 Int. J. Biol. Macromol. pmid:27851930
Xie X et al. Taxifolin protects RPE cells against oxidative stress-induced apoptosis. 2017 Mol. Vis. pmid:28761325
Massi A et al. Research Progress in the Modification of Quercetin Leading to Anticancer Agents. 2017 Molecules pmid:28758919
Dong F et al. Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in d-galactose-induced neurotoxicity in mice. 2017 Biochem. Biophys. Res. Commun. pmid:28757412
Xiao R et al. Hyperoside protects against hypoxia/reoxygenation induced injury in cardiomyocytes by suppressing the Bnip3 expression. 2017 Gene pmid:28754633
Iriti M et al. Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells. 2017 Phytother Res pmid:28752532
Yoshida T et al. Apocynin and enzymatically modified isoquercitrin suppress the expression of a NADPH oxidase subunit p22phox in steatosis-related preneoplastic liver foci of rats. 2017 Exp. Toxicol. Pathol. pmid:27789131
Kim A et al. Taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-κB activation-mediated cell death. 2017 Brain Res. Bull. pmid:28710022
Shi W et al. Bioactive flavonoids from Flos Sophorae. 2017 J Nat Med pmid:28357634
Carvalho D et al. Structural evidence of quercetin multi-target bioactivity: A reverse virtual screening strategy. 2017 Eur J Pharm Sci pmid:28636950
Sha Y et al. The Interaction Mode of Groove Binding Between Quercetin and Calf Thymus DNA Based on Spectrometry and Simulation. 2017 Chem. Biodivers. pmid:28631897
Mohammed GM et al. A Study of the Modulating Action of Quercetin on Biochemical and Histological Alterations Induced by Lead Exposure in the Liver and Kidney of Rats. 2017 Chin J Physiol pmid:28629212
Lee M et al. Quercetin Mitigates Inflammatory Responses Induced by Vascular Endothelial Growth Factor in Mouse Retinal Photoreceptor Cells through Suppression of Nuclear Factor Kappa B. 2017 Int J Mol Sci pmid:29165402
Gao L et al. Isorhamnetin protects against cardiac hypertrophy through blocking PI3K-AKT pathway. 2017 Mol. Cell. Biochem. pmid:28176246
Tian Y et al. Phenolic compounds extracted by acidic aqueous ethanol from berries and leaves of different berry plants. 2017 Food Chem pmid:27855899
Naseer Z et al. Quercetin supplemented diet improves follicular development, oocyte quality, and reduces ovarian apoptosis in rabbits during summer heat stress. 2017 Theriogenology pmid:28532829
Li J et al. Antitumor activity and safety evaluation of nanaparticle-based delivery of quercetin through intravenous administration in mice. 2017 Mater Sci Eng C Mater Biol Appl pmid:28532095
Mirpoor SF et al. Efficient delivery of quercetin after binding to beta-lactoglobulin followed by formation soft-condensed core-shell nanostructures. 2017 Food Chem pmid:28530576
Zhang Y et al. Inhibitory effect of hyperoside isolated from Zanthoxylum bungeanum leaves on SW620 human colorectal cancer cells via induction of the p53 signaling pathway and apoptosis. 2017 Mol Med Rep pmid:29067453
Burak C et al. Higher plasma quercetin levels following oral administration of an onion skin extract compared with pure quercetin dihydrate in humans. 2017 Eur J Nutr pmid:26482244
Liu Y et al. Effects of quercetin on proliferation and migration of human glioblastoma U251 cells. 2017 Biomed. Pharmacother. pmid:28528183
Badolato M et al. Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators. 2017 Future Med Chem pmid:29064290
Sandhu PS et al. Surface-tailored nanomixed micelles containing quercetin-salicylic acid physical complex for enhanced cellular and in vivo activities: a quality by design perspective. 2017 Nanomedicine (Lond) pmid:28524720
Wei CB et al. Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-κB pathway. 2017 Int. Immunopharmacol. pmid:29040945
Zhang Y et al. Quercetrin from Toona sinensis leaves induces cell cycle arrest and apoptosis via enhancement of oxidative stress in human colorectal cancer SW620 cells. 2017 Oncol. Rep. pmid:29039609
Duan Y et al. Synthesis of regioselectively acylated quercetin analogues with improved antiplatelet activity. 2017 Mol Med Rep pmid:29039540
Horniblow RD et al. Modulation of iron transport, metabolism and reactive oxygen status by quercetin-iron complexes in vitro. 2017 Mol Nutr Food Res pmid:27794191
Mikulic-Petkovsek M et al. Bioactive Components and Antioxidant Capacity of Fruits from Nine Sorbus Genotypes. 2017 J. Food Sci. pmid:28182841
Gaur T and Rao PB Analysis of Antibacterial Activity and Bioactive Compounds of the Giant Mushroom, Macrocybe gigantea (Agaricomycetes), from India. 2017 Int J Med Mushrooms pmid:29431069
Walter A et al. Effect of Enzogenol® Supplementation on Cognitive, Executive, and Vestibular/Balance Functioning in Chronic Phase of Concussion. 2017 Dev Neuropsychol pmid:28452602
Bhattacharjee P and Das S Deltamethrin Induced Alteration of Biochemical Parameters in Channa punctata, Bloch and its Amelioration by Quercetin. 2017 Bull Environ Contam Toxicol pmid:28451725
Wang X et al. Extraction and Determination of Quercetin from Ginkgo biloba by DESs-Based Polymer Monolithic Cartridge. 2017 J Chromatogr Sci pmid:28449063
Wong G et al. Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection. 2017 Virol Sin pmid:28884445
Lee CW et al. 3-O-Glucosylation of quercetin enhances inhibitory effects on the adipocyte differentiation and lipogenesis. 2017 Biomed. Pharmacother. pmid:28869898
Alamdar A et al. Arsenic activates the expression of 3β-HSD in mouse Leydig cells through repression of histone H3K9 methylation. 2017 Toxicol. Appl. Pharmacol. pmid:28414027
Forte L et al. Quercetin and alendronate multi-functionalized materials as tools to hinder oxidative stress damage. 2017 J Biomed Mater Res A pmid:28865182
Shi Y et al. Combination of quercetin, cinnamaldehyde and hirudin protects rat dorsal root ganglion neurons against high glucose-induced injury through Nrf-2/HO-1 activation and NF-κB inhibition. 2017 Chin J Integr Med pmid:28861887
Tóth Š et al. Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa. 2017 Biomed. Pharmacother. pmid:28858733
Das A et al. Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. 2017 J. Photochem. Photobiol. B, Biol. pmid:28456117
Kumar A et al. Inhibition of the MurA enzyme in Fusobacterium nucleatum by potential inhibitors identified through computational and in vitro approaches. 2017 Mol Biosyst pmid:28358152
Xiao L et al. Quercetin attenuates high fat diet-induced atherosclerosis in apolipoprotein E knockout mice: A critical role of NADPH oxidase. 2017 Food Chem. Toxicol. pmid:28351769
Biegańska-Hensoldt S and Rosołowska-Huszcz D Polyphenols in preventing endothelial dysfunction. 2017 Postepy Hig Med Dosw (Online) pmid:28345531
Lee SW et al. A new flavonol from the kino of Eucalyptus citriodora. 2017 Nat. Prod. Res. pmid:27426624
Rajnochová Svobodová A et al. The Phototoxic Potential of the Flavonoids, Taxifolin and Quercetin. 2017 Photochem. Photobiol. pmid:28303596
Gelen V et al. Therapeutic effect of quercetin on renal function and tissue damage in the obesity induced rats. 2017 Biomed. Pharmacother. pmid:28254664
Sun D et al. Transcriptome Analysis Reveals Silver Nanoparticle-Decorated Quercetin Antibacterial Molecular Mechanism. 2017 ACS Appl Mater Interfaces pmid:28240544
Domiciano TP et al. Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis. 2017 Sci Rep pmid:28148962
Liu Z et al. Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells. 2017 Adv Healthc Mater pmid:27943644
Queiroz M et al. New grape stems' isolated phenolic compounds modulate reactive oxygen species, glutathione, and lipid peroxidation in vitro: Combined formulations with vitamins C and E. 2017 Fitoterapia pmid:28625733
Zhou J et al. Investigation of the anti-cancer effect of quercetin on HepG2 cells in vivo. 2017 PLoS ONE pmid:28264020
Ren KW et al. Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells. 2017 Int. J. Oncol. pmid:28259895
Lee S et al. The anti-HSV-1 effect of quercetin is dependent on the suppression of TLR-3 in Raw 264.7 cells. 2017 Arch. Pharm. Res. pmid:28258480
Shahzad H et al. Combinatorial effects of quercetin and sex-steroids on fluid and electrolytes' (Na+, Cl-, HCO3-) secretory mechanisms in the uterus of ovariectomised female Sprague-Dawley rats. 2017 PLoS ONE pmid:28253299
Brüll V et al. Acute intake of quercetin from onion skin extract does not influence postprandial blood pressure and endothelial function in overweight-to-obese adults with hypertension: a randomized, double-blind, placebo-controlled, crossover trial. 2017 Eur J Nutr pmid:26924303
Chang JL et al. Quercetin simultaneously induces G /G -phase arrest and caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells. 2017 Environ. Toxicol. pmid:28251795
Lv X et al. Preparation of Essential Oil-Based Microemulsions for Improving the Solubility, pH Stability, Photostability, and Skin Permeation of Quercetin. 2017 AAPS PharmSciTech pmid:28516411
Jones RS et al. Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. 2017 Mol. Pharm. pmid:28513167