| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
quercetin
quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with quercetin?
quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with quercetin
PubChem Associated disorders and diseases
What pathways are associated with quercetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with quercetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with quercetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with quercetin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with quercetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with quercetin?
Mouse Model
Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).
Xenograft Model
Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).
Cancer Model
Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with quercetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Das S et al. | Molecular recognition of bio-active flavonoids quercetin and rutin by bovine hemoglobin: an overview of the binding mechanism, thermodynamics and structural aspects through multi-spectroscopic and molecular dynamics simulation studies. | 2018 | Phys Chem Chem Phys | pmid:30101248 |
| Yamashita K et al. | Assessment of the skin sensitizing potential of chemicals, contained in foods and/or cosmetic ingredients, using a modified local lymph node assay with an elicitation phase (LLNA:DAE) method. | 2018 | J Toxicol Sci | pmid:30078837 |
| Tutino V et al. | Cannabinoid Receptor-1 Up-regulation in Azoxymethane (AOM)-treated Mice After Dietary Treatment with Quercetin. | 2018 | Anticancer Res. | pmid:30061214 |
| Jia L et al. | Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction. | 2018 | Life Sci. | pmid:30025823 |
| Liu Y et al. | Antidiabetic Effect of Leaves Depends on the Contents of Antihyperglycemic Flavonoids and Antihyperlipidemic Triterpenoids. | 2018 | Molecules | pmid:29710841 |
| Xia J et al. | Shufeng Jiedu Capsule and its active ingredients induce apoptosis, inhibit migration and invasion, and enhances doxorubicin therapeutic efficacy in hepatocellular carcinoma. | 2018 | Biomed. Pharmacother. | pmid:29710492 |
| Lu N et al. | Inhibitive Effects of Quercetin on Myeloperoxidase-Dependent Hypochlorous Acid Formation and Vascular Endothelial Injury. | 2018 | J. Agric. Food Chem. | pmid:29708335 |
| Zhang Y et al. | Amelioration of Alcoholic Liver Steatosis by Dihydroquercetin through the Modulation of AMPK-Dependent Lipogenesis Mediated by P2X7R-NLRP3-Inflammasome Activation. | 2018 | J. Agric. Food Chem. | pmid:29706079 |
| Lu J et al. | Quercetin Inhibits the Migration and Invasion of HCCLM3 Cells by Suppressing the Expression of p-Akt1, Matrix Metalloproteinase (MMP) MMP-2, and MMP-9. | 2018 | Med. Sci. Monit. | pmid:29701200 |
| Fusi J et al. | An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds. | 2018 | Biomed. Pharmacother. | pmid:29525677 |
| Abdelhalim MAK et al. | Effects of quercetin and arginine on the nephrotoxicity and lipid peroxidation induced by gold nanoparticles in vivo. | 2018 | Int J Nanomedicine | pmid:30538457 |
| Ding T et al. | Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome. | 2018 | Phytomedicine | pmid:29519318 |
| Patrizio F et al. | The acute effect of Quercetin on muscle performance following a single resistance training session. | 2018 | Eur. J. Appl. Physiol. | pmid:29511920 |
| Hidaka M et al. | Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29608894 |
| Wang X et al. | Hyperoside Protects Against Pressure Overload-Induced Cardiac Remodeling via the AKT Signaling Pathway. | 2018 | Cell. Physiol. Biochem. | pmid:30466089 |
| Tanaka S et al. | Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin. | 2018 | Biosci. Biotechnol. Biochem. | pmid:30200823 |
| Carbone ML et al. | Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity. | 2018 | Int J Mol Sci | pmid:30200670 |
| Mazhar M et al. | Quercetin modulates iron homeostasis and iNOS expression of splenic macrophages in a rat model of iron deficiency anemia. | 2018 | Chin J Nat Med | pmid:30197123 |
| Song JE et al. | Quercetin Inlaid Silk Fibroin/Hydroxyapatite Scaffold Promotes Enhanced Osteogenesis. | 2018 | ACS Appl Mater Interfaces | pmid:30188112 |
| Hyun HB et al. | Quercetin Suppresses CYR61-Mediated Multidrug Resistance in Human Gastric Adenocarcinoma AGS Cells. | 2018 | Molecules | pmid:29364834 |
| Akintunde JK et al. | Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey inhibits oxidative damage and econucleotidase followed by increased cellular ATP in testicular cells of rats exposed to metropolitan polluted river water. | 2018 | J Basic Clin Physiol Pharmacol | pmid:29360627 |
| Wang R et al. | Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM). | 2018 | Med. Sci. Monit. | pmid:29353288 |
| Farrag Y et al. | Starch films loaded with donut-shaped starch-quercetin microparticles: Characterization and release kinetics. | 2018 | Int. J. Biol. Macromol. | pmid:30012488 |
| Li JJ et al. | Fast dissolving drug delivery membrane based on the ultra-thin shell of electrospun core-shell nanofibers. | 2018 | Eur J Pharm Sci | pmid:30008429 |
| Teppabut Y et al. | Change of Petals' Color and Chemical Components in Flowers during Senescence. | 2018 | Molecules | pmid:30002287 |
| Liu S et al. | Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation. | 2018 | Food Funct | pmid:29993075 |
| Vimalraj S et al. | Mixed-ligand copper(II) complex of quercetin regulate osteogenesis and angiogenesis. | 2018 | Mater Sci Eng C Mater Biol Appl | pmid:29208278 |
| Yang X et al. | Quercetin synergistically reactivates human immunodeficiency virus type 1 latency by activating nuclear factor‑κB. | 2018 | Mol Med Rep | pmid:29207194 |
| Lee HN et al. | Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models. | 2018 | Int. J. Mol. Med. | pmid:29207037 |
| Shen XY et al. | Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells. | 2018 | Int. J. Mol. Med. | pmid:29207020 |
| Kalinová JP et al. | Contribution to the study of rutin stability in the achenes of Tartary buckwheat (Fagopyrum tataricum). | 2018 | Food Chem | pmid:29655739 |
| Li S et al. | Quercetin protects against ox‑LDL‑induced injury via regulation of ABCAl, LXR‑α and PCSK9 in RAW264.7 macrophages. | 2018 | Mol Med Rep | pmid:29845234 |
| Haque MW et al. | Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway. | 2018 | Biomed. Pharmacother. | pmid:29843042 |
| Younas M et al. | Differential accumulation of silymarin induced by exposure of Silybum marianum L. callus cultures to several spectres of monochromatic lights. | 2018 | J. Photochem. Photobiol. B, Biol. | pmid:29803074 |
| Sherif IO | The effect of natural antioxidants in cyclophosphamide-induced hepatotoxicity: Role of Nrf2/HO-1 pathway. | 2018 | Int. Immunopharmacol. | pmid:29800788 |
| Zhang Y et al. | Anti-hypoglycemic and hepatocyte-protective effects of hyperoside from Zanthoxylum bungeanum leaves in mice with high-carbohydrate/high-fat diet and alloxan-induced diabetes. | 2018 | Int. J. Mol. Med. | pmid:29115390 |
| Yin C et al. | Phytochemical analysis and antibacterial activity of Gentiana macrophylla extract against bacteria isolated from burn wound infections. | 2018 | Microb. Pathog. | pmid:29111322 |
| Li S et al. | Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation. | 2018 | Phytother Res | pmid:29635751 |
| Xiao J | Stability of dietary polyphenols: It's never too late to mend? | 2018 | Food Chem. Toxicol. | pmid:29626578 |
| Wang L et al. | Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers. | 2018 | J Microencapsul | pmid:29624090 |
| Quintero-Soto MF et al. | Phenolic profiles and their contribution to the antioxidant activity of selected chickpea genotypes from Mexico and ICRISAT collections. | 2018 | Plant Foods Hum Nutr | pmid:29516285 |
| Curgali K et al. | Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells. | 2018 | Acta Histochem. | pmid:29129327 |
| Andres S et al. | Safety Aspects of the Use of Quercetin as a Dietary Supplement. | 2018 | Mol Nutr Food Res | pmid:29127724 |
| Bondonno NP et al. | Flavonoid-Rich Apple Improves Endothelial Function in Individuals at Risk for Cardiovascular Disease: A Randomized Controlled Clinical Trial. | 2018 | Mol Nutr Food Res | pmid:29086478 |
| Singh S and Kumar P | Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration in experimental rats: Biochemical and neurochemical evidences. | 2018 | Neurosci. Res. | pmid:29056550 |
| Deng M et al. | Effect of Storage Conditions on Phenolic Profiles and Antioxidant Activity of Litchi Pericarp. | 2018 | Molecules | pmid:30200581 |
| Wang J et al. | Isorhamnetin prevents H2O2‑induced oxidative stress in human retinal pigment epithelial cells. | 2018 | Mol Med Rep | pmid:29115489 |
| Liu ZH et al. | Synergistic effects and related bioactive mechanisms of Potentilla fruticosa Linn. leaves combined with green tea polyphenols studied with microbial test system (MTS). | 2018 | Nat. Prod. Res. | pmid:28602107 |
| Yang T et al. | Quercetin‑3‑O‑β‑D‑glucoside decreases the bioavailability of cyclosporin A through regulation of drug metabolizing enzymes, transporters and nuclear receptors in rats. | 2018 | Mol Med Rep | pmid:30015887 |
| Ojo OA et al. | Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill bark. | 2018 | J Basic Clin Physiol Pharmacol | pmid:29381472 |