quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

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Introduction

To understand associated biological information of quercetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with quercetin?

quercetin is suspected in Hypertensive disease, Cardiovascular Diseases, Atherosclerosis, Infection, Obesity, Coronary heart disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with quercetin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Lead Poisoning D007855 4 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Per page 10 20 50 100 | Total 205

PubChem Associated disorders and diseases

What pathways are associated with quercetin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with quercetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with quercetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with quercetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with quercetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with quercetin?

Mouse Model

Mouse Model are used in the study 'Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.' (Mutch DM et al., 2006), Mouse Model are used in the study 'Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.' (Aghdassi A et al., 2007), Mouse Model are used in the study 'Proatherogenic macrophage activities are targeted by the flavonoid quercetin.' (Lara-Guzman OJ et al., 2012) and Mouse Model are used in the study 'Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.' (Ho L et al., 2013).

Xenograft Model

Xenograft Model are used in the study 'Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.' (Cheng S et al., 2010) and Xenograft Model are used in the study 'Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations.' (Lambert JD et al., 2005).

Cancer Model

Cancer Model are used in the study 'Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).' (Volate SR et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with quercetin

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Authors Title Published Journal PubMed Link
Kunasegaran T et al. Quercetin and pioglitazone synergistically reverse endothelial dysfunction in isolated aorta from fructose-streptozotocin (F-STZ)-induced diabetic rats. 2017 Eur. J. Pharmacol. pmid:28213289
Yang Y et al. Screening active components of modified Xiaoyao powder as NRF2 agonists. 2017 Cell Biochem. Funct. pmid:29214656
Sgherri C et al. Elevated CO and salinity are responsible for phenolics-enrichment in two differently pigmented lettuces. 2017 Plant Physiol. Biochem. pmid:28411511
Chen H et al. Constituent analysis of the ethanol extracts of Chimonanthus nitens Oliv. leaves and their inhibitory effect on α-glucosidase activity. 2017 Int. J. Biol. Macromol. pmid:28223131
Liu T et al. Preparation Nanocrystals of Poorly Soluble Plant Compounds Using an Ultra-Small-Scale Approach. 2017 AAPS PharmSciTech pmid:28243886
Khor CM et al. Preparation and characterization of quercetin/dietary fiber nanoformulations. 2017 Carbohydr Polym pmid:28189219
Han G et al. MIL-101(Cr) as matrix for sensitive detection of quercetin by matrix-assisted laser desorption/ionization mass spectrometry. 2017 Talanta pmid:28107941
Somerville V et al. Polyphenols and Performance: A Systematic Review and Meta-Analysis. 2017 Sports Med pmid:28097488
Jana S and Rastogi H Effects of Caffeic Acid and Quercetin on In Vitro Permeability, Metabolism and In Vivo Pharmacokinetics of Melatonin in Rats: Potential for Herb-Drug Interaction. 2017 Eur J Drug Metab Pharmacokinet pmid:28070878
Adedara IA et al. Quercetin Improves Neurobehavioral Performance Through Restoration of Brain Antioxidant Status and Acetylcholinesterase Activity in Manganese-Treated Rats. 2017 Neurochem. Res. pmid:28144805
Sohaib M et al. Oxidative stability and lipid oxidation flavoring volatiles in antioxidants treated chicken meat patties during storage. 2017 Lipids Health Dis pmid:28143531
Kulkarni TS et al. Crystal structure of β-glucosidase 1A from Thermotoga neapolitana and comparison of active site mutants for hydrolysis of flavonoid glucosides. 2017 Proteins pmid:28142197
Zizkova P et al. Novel quercetin derivatives: From redox properties to promising treatment of oxidative stress related diseases. 2017 Chem. Biol. Interact. pmid:28137512
Nwaeburu CC et al. Quercetin-induced miR-200b-3p regulates the mode of self-renewing divisions in pancreatic cancer. 2017 Mol. Cancer pmid:28137273
Poór M et al. Interaction of quercetin and its metabolites with warfarin: Displacement of warfarin from serum albumin and inhibition of CYP2C9 enzyme. 2017 Biomed. Pharmacother. pmid:28135601
Kumar M et al. Molecular and biochemical evidence on the protective effects of quercetin in isoproterenol-induced acute myocardial injury in rats. 2017 J. Biochem. Mol. Toxicol. pmid:27527349
Gupta R et al. Protective Role of Quercetin in Cadmium-Induced Cholinergic Dysfunctions in Rat Brain by Modulating Mitochondrial Integrity and MAP Kinase Signaling. 2017 Mol. Neurobiol. pmid:27389774
Galleggiante V et al. Dendritic Cells Modulate Iron Homeostasis and Inflammatory Abilities Following Quercetin Exposure. 2017 Curr. Pharm. Des. pmid:28079005
Zhu Y et al. 7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation. 2017 Biomed. Pharmacother. pmid:28076833
Mehta V et al. Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress. 2017 Physiol. Behav. pmid:28069457
A P et al. Polyphenol rich ethanolic extract from Boerhavia diffusa L. mitigates angiotensin II induced cardiac hypertrophy and fibrosis in rats. 2017 Biomed. Pharmacother. pmid:28068633
Khor CM et al. Hot-melt extrusion microencapsulation of quercetin for taste-masking. 2017 J Microencapsul pmid:28067579
Singh T et al. Adjuvant quercetin therapy for combined treatment of epilepsy and comorbid depression. 2017 Neurochem. Int. pmid:28065794
Wu C et al. Taxifolin inhibits rat and human 11β-hydroxysteroid dehydrogenase 2. 2017 Fitoterapia pmid:28709706
Al-Rasheed NM et al. Quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing Bax, HIF1-α, TGF-β, Smad-2, and AKT pathways. 2017 J. Biochem. Mol. Toxicol. pmid:28000380
Chis IC et al. Quercetin in association with moderate exercise training attenuates injuries induced by experimental diabetes in sciatic nerves. 2017 J. Physiol. Pharmacol. pmid:29550800
Miladpour B et al. Quercetin potentiates transdifferentiation of bone marrow mesenchymal stem cells into the beta cells in vitro. 2017 J. Endocrinol. Invest. pmid:28000178
Kimura Y et al. Synthesis of 8-Aryl-O-methylcyanidins and Their Usage for Dye-Sensitized Solar Cell Devices. 2017 Int J Mol Sci pmid:28212330
Carullo G et al. Quercetin and derivatives: useful tools in inflammation and pain management. 2017 Future Med Chem pmid:27995808
Santos MS et al. Dissection of the Effects of Quercetin on Mouse Myocardium. 2017 Basic Clin. Pharmacol. Toxicol. pmid:27992670
Wen L et al. An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC. 2017 Molecules pmid:28486427
Liu H and Zhou M Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways. 2017 BMC Complement Altern Med pmid:29237430
Yang X et al. Quercetin loading CdSe/ZnS nanoparticles as efficient antibacterial and anticancer materials. 2017 J. Inorg. Biochem. pmid:27898345
Porras D et al. Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation. 2017 Free Radic. Biol. Med. pmid:27890642
Sassa-Deepaeng T et al. Investigation of antiaromatase activity using hepatic microsomes of Nile tilapia (Oreochromis niloticus). 2017 Drug Discov Ther pmid:28320984
Wu P et al. Apoptosis triggered by isoquercitrin in bladder cancer cells by activating the AMPK-activated protein kinase pathway. 2017 Food Funct pmid:28948276
Subramanian P et al. Influence of Quercetin in the Temporal Regulation of Redox Homeostasis in Drosophila melanogaster. 2017 J. Insect Sci. pmid:28931163
Scott IM et al. Plant growth regulator-mediated anti-herbivore responses of cabbage (Brassica oleracea) against cabbage looper Trichoplusia ni Hübner (Lepidoptera: Noctuidae). 2017 Pestic Biochem Physiol pmid:28911746
Niu C et al. Hyperin protects against cisplatin-induced liver injury in mice. 2017 Acta Cir Bras pmid:28902939
Kellici TF et al. Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL. 2017 Org. Biomol. Chem. pmid:28902204
Komirishetty P et al. Combination strategy of PARP inhibitor with antioxidant prevent bioenergetic deficits and inflammatory changes in CCI-induced neuropathy. 2017 Neuropharmacology pmid:27712995
Li L et al. Chemical and genetic diversity of Astragalus mongholicus grown in different eco-climatic regions. 2017 PLoS ONE pmid:28945770
Weng S et al. Role of quercetin in protecting ARPE‑19 cells against H2O2‑induced injury via nuclear factor erythroid 2 like 2 pathway activation and endoplasmic reticulum stress inhibition. 2017 Mol Med Rep pmid:28713895
Romero M et al. Protective vascular effects of quercitrin in acute TNBS-colitis in rats: the role of nitric oxide. 2017 Food Funct pmid:28703832
Sun L et al. Simultaneous separation and purification of chlorogenic acid, epicatechin, hyperoside and phlorizin from thinned young Qinguan apples by successive use of polyethylene and polyamide resins. 2017 Food Chem pmid:28407923
Kita K et al. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. 2017 Cancer Sci. pmid:28691182
Chang XY et al. Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats. 2017 Biomed Res Int pmid:28691026
Bao D et al. Protective Effect of Quercetin against Oxidative Stress-Induced Cytotoxicity in Rat Pheochromocytoma (PC-12) Cells. 2017 Molecules pmid:28684704
Saik AY et al. Enzymatic synthesis of quercetin oleate esters using Candida antarctica lipase B. 2017 Biotechnol. Lett. pmid:27812823
Singh DP et al. Co-administration of quercetin with pantoprazole sodium prevents NSAID-induced severe gastroenteropathic damage efficiently: Evidence from a preclinical study in rats. 2017 Exp. Toxicol. Pathol. pmid:27780667
Pennesi CM et al. Use of Isoquercetin in the Treatment of Prurigo Nodularis. 2017 J Drugs Dermatol pmid:29141065
Plotnikov MB et al. Dihydroquercetin Improves Microvascularization and Microcirculation in the Brain Cortex of SHR Rats during the Development of Arterial Hypertension. 2017 Bull. Exp. Biol. Med. pmid:28577102
Thanh Nguyen H and Goycoolea FM Chitosan/Cyclodextrin/TPP Nanoparticles Loaded with Quercetin as Novel Bacterial Quorum Sensing Inhibitors. 2017 Molecules pmid:29140285
Marunaka Y Actions of quercetin, a flavonoid, on ion transporters: its physiological roles. 2017 Ann. N. Y. Acad. Sci. pmid:28574574
Zhao Y et al. The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity. 2017 Oxid Med Cell Longev pmid:29138673
Neveux S et al. Natural Compounds as Occult Ototoxins? Ginkgo biloba Flavonoids Moderately Damage Lateral Line Hair Cells. 2017 J. Assoc. Res. Otolaryngol. pmid:27896487
Liu W et al. The Influence of Quercetin on Maternal Immunity, Oxidative Stress, and Inflammation in Mice with Exposure of Fine Particulate Matter during Gestation. 2017 Int J Environ Res Public Health pmid:28574437
Pilipenko N et al. Effect of Naringenin, Quercetin, and Sesamin on Xenobiotica-Metabolizing CYP1A and CYP3A in Mice Offspring after Maternal Exposure to Persistent Organic Pollutants. 2017 Biomed Res Int pmid:28567424
Maksymchuk O et al. Quercetin prevents type 1 diabetic liver damage through inhibition of CYP2E1. 2017 Pharmacol Rep pmid:29132096
Ledoux A et al. Antimalarial Activities of Alkyl Cyclohexenone Derivatives Isolated from the Leaves of Poupartia borbonica. 2017 J. Nat. Prod. pmid:28557449
Wu MJ et al. Metabolic profiling of quercetin in rats using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. 2017 Biomed. Chromatogr. pmid:28556969
Lim W et al. Inhibitory Effects of Quercetin on Progression of Human Choriocarcinoma Cells Are Mediated Through PI3K/AKT and MAPK Signal Transduction Cascades. 2017 J. Cell. Physiol. pmid:27714811
Javadi F et al. The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial. 2017 J Am Coll Nutr pmid:27710596
Cortesi R et al. Monoolein aqueous dispersions as a delivery system for quercetin. 2017 Biomed Microdevices pmid:28484916
Viapiana A and Wesolowski M The Phenolic Contents and Antioxidant Activities of Infusions of Sambucus nigra L. 2017 Plant Foods Hum Nutr pmid:28084608
Erady V et al. A novel and sensitive hexadecyltrimethylammoniumbromide functionalized Fe decorated MWCNTs modified carbon paste electrode for the selective determination of Quercetin. 2017 Mater Sci Eng C Mater Biol Appl pmid:28482479
Raja SB et al. Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression. 2017 Food Chem. Toxicol. pmid:28479391
Xue Y et al. Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O157:H7. 2017 Free Radic. Biol. Med. pmid:28476502
Nayak VS et al. The effects of Mucuna pruriens extract on histopathological and biochemical features in the rat model of ischemia. 2017 Neuroreport pmid:28953092
Giménez-Bastida JA et al. Buckwheat bioactive compounds, their derived phenolic metabolites and their health benefits. 2017 Mol Nutr Food Res pmid:27709826
Szejk M et al. A comparative study on the radioprotective potential of the polyphenolic glycoconjugates from medicinal plants of Rosaceae and Asteraceae families versus their aglycones. 2017 J. Photochem. Photobiol. B, Biol. pmid:28475935
Penalva R et al. Zein nanoparticles for oral delivery of quercetin: Pharmacokinetic studies and preventive anti-inflammatory effects in a mouse model of endotoxemia. 2017 Nanomedicine pmid:27615118
Rusanov AL et al. Changes in the Proteome of HaCaT Keratinocytes Induced by Cytotoxic Substance Triton X-100. 2017 Bull. Exp. Biol. Med. pmid:28952047
Quagliariello V et al. Hyaluronic Acid Nanohydrogel Loaded With Quercetin Alone or in Combination to a Macrolide Derivative of Rapamycin RAD001 (Everolimus) as a New Treatment for Hormone-Responsive Human Breast Cancer. 2017 J. Cell. Physiol. pmid:27607841
Gavrilova SA et al. Changes in Sympathetic Innervation of the Heart in Rats with Experimental Myocardial Infarction. Effect of Semax. 2017 Bull. Exp. Biol. Med. pmid:28948544
Rjeibi I et al. Phytochemical characterization and bioactivity of Lycium europaeum: A focus on antioxidant, antinociceptive, hepatoprotective and nephroprotective effects. 2017 Biomed. Pharmacother. pmid:28946192
Mehta V et al. Quercetin ameliorates chronic unpredicted stress-induced behavioral dysfunction in male Swiss albino mice by modulating hippocampal insulin signaling pathway. 2017 Physiol. Behav. pmid:28939429
Xu JQ et al. Biotransformation of quercetin by Gliocladium deliquescens NRRL 1086. 2017 Chin J Nat Med pmid:28939024
Polansky H et al. Human papillomavirus (HPV): systemic treatment with Gene-Eden-VIR/Novirin safely and effectively clears virus. 2017 Drug Des Devel Ther pmid:28424535
Erkekoglou I et al. Functional Teas from the Leaves of Arbutus unedo: Phenolic Content, Antioxidant Activity, and Detection of Efficient Radical Scavengers. 2017 Plant Foods Hum Nutr pmid:28421300
Ye Y et al. [Protective effect of taxifolin on H2O2-induced 
H9C2 cell pyroptosis]. 2017 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:29317576
Huang WY et al. Quercetin, Hyperin, and Chlorogenic Acid Improve Endothelial Function by Antioxidant, Antiinflammatory, and ACE Inhibitory Effects. 2017 J. Food Sci. pmid:28407238
Shen C et al. Self-discriminating fluorescent hybrid nanocrystals: efficient and accurate tracking of translocation via oral delivery. 2017 Nanoscale pmid:29227499
Lagoa R et al. Correlation between the potency of flavonoids for cytochrome c reduction and inhibition of cardiolipin-induced peroxidase activity. 2017 Biofactors pmid:28317253
Tang Q et al. Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin. 2017 Eur J Pharm Sci pmid:28822757
Kim AY et al. Selective Release System for Antioxidative and Anti-Inflammatory Activities Using HO-Responsive Therapeutic Nanoparticles. 2017 Biomacromolecules pmid:28806055
Chae MR et al. Onion (Allium cepa L.) peel extract (OPE) regulates human sperm motility via protein kinase C-mediated activation of the human voltage-gated proton channel. 2017 Andrology pmid:28805023
Sun Y et al. Hepatoprotective effect against CCl4-induced acute liver damage in mice and High-performance liquid chromatography mass spectrometric method for analysis of the constituents of extract of Rubus crataegifolius. 2017 Nat. Prod. Res. pmid:28322066
Chen F et al. Streptococcus suis sortase A is Ca2+ independent and is inhibited by acteoside, isoquercitrin and baicalin. 2017 PLoS ONE pmid:28319184
Xing LZ et al. Quercitrin attenuates osteoporosis in ovariectomized rats by regulating mitogen-activated protein kinase (MAPK) signaling pathways. 2017 Biomed. Pharmacother. pmid:28314242
Panchal H and Shah MB Development and Validation of a Rapid LC-MS/MS Method for Simultaneous Determination of Kaempferol and Quercetin in Extract. 2017 J AOAC Int pmid:28300024
Sousa-Batista AJ et al. Lipid-core nanocapsules increase the oral efficacy of quercetin in cutaneous leishmaniasis. 2017 Parasitology pmid:28653597
Ma W et al. Exploration of a ternary deep eutectic solvent of methyltriphenylphosphonium bromide/chalcone/formic acid for the selective recognition of rutin and quercetin in Herba Artemisiae Scopariae. 2017 J Sep Sci pmid:28631409
Fan AQ et al. [Antagonistic effect of quercetin on PM toxicity in the rat's embryonic development in vitro]. 2017 Beijing Da Xue Xue Bao pmid:28628137
Yarahmadi A et al. Protective effects of quercetin on nicotine induced oxidative stress in 'HepG2 cells'. 2017 Toxicol. Mech. Methods pmid:28627253
Fan HH et al. Hyperoside inhibits lipopolysaccharide-induced inflammatory responses in microglial cells via p38 and NFκB pathways. 2017 Int. Immunopharmacol. pmid:28622577
de Souza CES et al. Anti-Trypanosoma, anti-Leishmania and cytotoxic activities of natural products from Psidium brownianum Mart. ex DC. and Psidium guajava var. Pomifera analysed by LC-MS. 2017 Acta Trop. pmid:28935551
Guan CJ et al. Biotransformation of Rutin Using Crude Enzyme from Rhodopseudomonas palustris. 2017 Curr. Microbiol. pmid:28213661
Li H et al. Purification of quercetin-3-O-sophoroside and isoquercitrin from Poacynum hendersonii leaves using macroporous resins followed by Sephadex LH-20 column chromatography. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:28213296
Wang P et al. Hepatoprotective effect of 2'-O-galloylhyperin against oxidative stress-induced liver damage through induction of Nrf2/ARE-mediated antioxidant pathway. 2017 Food Chem. Toxicol. pmid:28213291